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Shih Han Tsai et al.
Immunity, 42(2), 279-293 (2015-02-19)
Crosslinking of the immunoglobulin receptor FcεRI activates basophils and mast cells to induce immediate and chronic allergic inflammation. However, it remains unclear how the chronic allergic inflammation is regulated. Here, we showed that ecto-nucleotide pyrophosphatase-phosphodiesterase 3 (E-NPP3), also known as
Amy J Ullmann et al.
PloS one, 10(6), e0128868-e0128868 (2015-06-16)
Borrelia burgdorferi synthesizes an HtrA protease (BbHtrA) which is a surface-exposed, conserved protein within Lyme disease spirochetes with activity toward CheX and BmpD of Borrelia spp, as well as aggrecan, fibronectin and proteoglycans found in skin, joints and neural tissues
Sin-Hye Park et al.
PloS one, 10(11), e0143526-e0143526 (2015-11-26)
Mucus hypersecretion is an important pathological feature of chronic airway diseases, such as asthma and pulmonary diseases. MUC5AC is a major component of the mucus matrix forming family of mucins in the airways. The initiation of endoplasmic reticulum (ER)-mediated stress
Takenori Matsuda et al.
Immunity & ageing : I & A, 12, 1-1 (2015-03-03)
We originally cloned and identified murine Zizimin2 (Ziz2, Dock11) as a guanine nucleotide exchange factor (GEF) for Cdc42 and demonstrated that it activated the formation of filopodia. Since its expression pattern is restricted in immune tissues and Rho GTPases such
C Song et al.
Scandinavian journal of immunology, 79(2), 98-104 (2013-12-10)
Myeloid-derived suppressor cells (MDSCs), a heterogeneous population including myeloid progenitor and immature myeloid cells, are known to inhibit T cell responses. The issue of whether tumour-derived MDSCs regulate the immune response in an asthma environment is currently unclear. Here, we
Naeem Khan et al.
Clinical and vaccine immunology : CVI, 22(1), 99-107 (2014-11-21)
The shortcomings of the licensed polysaccharide-based pneumococcal vaccine are driving efforts toward development of a protein-based vaccine that is serotype independent and effective in all age groups. An opsonophagocytic killing assay (OPKA) is used to evaluate the antibody response against
Xin Chen et al.
Protein & cell, 6(11), 825-832 (2015-09-26)
How follicular T-helper (Tfh) cells develop is incompletely understood. We find that, upon antigen exposure in vivo, both naïve and antigen-experienced T cells sequentially upregulate CXCR5 and Bcl6 within the first 24 h, relocate to the T-B border, and give
Akihiro Maeta et al.
Journal of nutritional science and vitaminology, 61(5), 400-405 (2015-12-08)
Oral immunotherapy (OIT) is a promising therapeutic approach for treating food allergy. Past studies have shown that OIT reduces allergic response only in severe allergy model mice. We worked to establish mild allergy model mice, and investigated whether 'rush' OIT
Andrew T Miller et al.
PloS one, 10(6), e0131071-e0131071 (2015-06-30)
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inositol kinase Itpkb in mature T lymphocytes
Anthony Joetham et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2238-2247 (2014-07-30)
Glucocorticoid-induced TNFR family-related protein (GITR)-mediated activation of JNK was shown to regulate the suppressive activity of CD4(+)CD25(+) naturally occurring T regulatory cells (nTregs) in wild-type (WT) hosts. In this study, CD4(+)CD25(+) T cells were shown to be capable of becoming
S S Mohtar et al.
Bioresource technology, 192, 212-218 (2015-06-04)
The objective of this study is to extract and characterize lignin from oil palm biomass (OPB) by dissolution in 1-butyl-3-methylimidazolium chloride ([bmim][Cl]), followed by the lignin extraction through the CO2 gas purging prior to addition of aluminum potassium sulfate dodecahydrate
Chia-Chen Pi et al.
SpringerPlus, 3, 297-297 (2014-07-16)
Allergic asthma is an inflammatory disease of the airways mediated by Th2 immune responses and characterized by airway hyperresponsiveness (AHR). Fungi of the genus Ganoderma are basidiomycetes that have been used in traditional Asian medicine for centuries. We recently found
Kavithaa Loganathan et al.
Journal of environmental management, 161, 113-123 (2015-07-15)
Through sustainable water management, oil sands companies are working to reduce their reliance on fresh water by minimizing the amount of water required for their operations and by recycling water from tailings ponds. This study was the first pilot-scale testing
Ki-Suk Kim et al.
The American journal of Chinese medicine, 43(3), 425-441 (2015-05-15)
As a treatment for allergic asthma, inhaled treatments such as bronchodilators that contain β2-agonists have an immediate effect, which attenuates airway obstructions and decreases airway hypersensitivity. However, bronchodilators only perform on a one off basis, but not consistently. Asthma is
Jiu Jiang et al.
Vaccine, 32(23), 2696-2702 (2014-04-01)
Influenza is one of the most common infectious diseases endangering the health of humans, especially young children and the elderly. Although vaccination is the most effective means of protection against influenza, frequent mutations in viral surface antigens, low protective efficacy
David P Sester et al.
Journal of immunology (Baltimore, Md. : 1950), 194(1), 455-462 (2014-11-19)
Inflammasomes are large protein complexes induced by a wide range of microbial, stress, and environmental stimuli that function to induce cell death and inflammatory cytokine processing. Formation of an inflammasome involves dramatic relocalization of the inflammasome adapter protein apoptosis-associated speck-like
Subhashree Mahapatra et al.
The Journal of investigative dermatology, 135(10), 2418-2426 (2015-09-12)
We have previously shown that T helper type 2 (Th2)-polarized airway inflammation can facilitate priming to new antigens in the lungs, which we called "collateral priming". To investigate whether allergic skin inflammation can also facilitate priming toward new antigens, we
R J Keeley et al.
Behavioural brain research, 288, 132-152 (2015-01-17)
Marijuana is one of the most highly used psychoactive substances in the world, and its use typically begins during adolescence, a period of substantial brain development. Females across species appear to be more susceptible to the long-term consequences of marijuana
Chunqing Ai et al.
Applied microbiology and biotechnology, 99(10), 4309-4319 (2015-02-11)
Allergic asthma caused by house dust mite (HDM) is becoming a public health problem. Specific immunotherapy is considered to be the only curative treatment, but it is always associated with IgE-mediated side effects in the therapy process. A few studies
Chanil Jung et al.
Environmental science and pollution research international, 22(13), 10058-10069 (2015-02-15)
The combined coagulation and adsorption of targeted acetaminophen and naproxen using activated biochar and aluminum sulfate were studied under various synthetic "combined sewer overflow" (CSO) conditions. The biochar demonstrated better adsorption performance for both acetaminophen and naproxen (removal, 94.1 and
Daan de Gouw et al.
PloS one, 9(8), e105011-e105011 (2014-08-19)
Pertussis is a highly infectious respiratory disease of humans caused by the bacterium Bordetella pertussis. Despite high vaccination coverage, pertussis has re-emerged globally. Causes for the re-emergence of pertussis include limited duration of protection conferred by acellular pertussis vaccines (aP)
Pengwei Zhang et al.
PloS one, 9(6), e101373-e101373 (2014-07-01)
We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response. Importantly, CJ2-gD2 expresses gD2, the HSV-2 major antigen glycoprotein D, as efficiently as
Abhinav Shrestha et al.
Vaccine, 33(1), 133-140 (2014-12-03)
Zona pellucida (ZP) glycoproteins based contraceptive vaccines have been proposed for the management of wildlife population. In the present study, a fusion protein encompassing promiscuous T cell epitope of tetanus toxoid [TT; amino acid (aa) residues 830-844] followed by a
Yonglian Sun et al.
Science signaling, 8(405), ra122-ra122 (2015-12-03)
Interleukin-2 (IL-2)-inducible T cell kinase (ITK) mediates T cell receptor (TCR) signaling primarily to stimulate the production of cytokines, such as IL-4, IL-5, and IL-13, from T helper 2 (TH2) cells. Compared to wild-type mice, ITK knockout mice are resistant
Nicole A Marjon et al.
Molecular cancer research : MCR, 12(11), 1644-1654 (2014-07-18)
The role of 17β-estradiol (E2) in breast cancer development and tumor growth has traditionally been attributed exclusively to the activation of estrogen receptor-α (ERα). Although targeted inhibition of ERα is a successful approach for patients with ERα(+) breast cancer, many
Yuan Wang et al.
Journal of immunology (Baltimore, Md. : 1950), 195(3), 1171-1181 (2015-06-28)
Complement is implicated in asthma pathogenesis, but its mechanism of action in this disease remains incompletely understood. In this study, we investigated the role of properdin (P), a positive alternative pathway complement regulator, in allergen-induced airway inflammation. Allergen challenge stimulated
Housam Eidi et al.
BMC medicine, 13, 144-144 (2015-06-18)
Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunologic adjuvant of vaccines. Concerns linked to alum particles have emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion in patients with myalgic encephalomyelitis
Lin Dang et al.
Molecular medicine reports, 11(6), 4183-4189 (2015-02-05)
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic background. The C5a‑receptor (C5aR) pathway has been reported to be involved in AD; however, the precise pathogenesis remains to be elucidated. In the present study, the contribution of
Ying-Hua Shieh et al.
International immunopharmacology, 24(2), 383-391 (2015-01-13)
Zerumbone is a sesquiterpene compound isolated from the rhizome of wild ginger, Zingiber zerumbet Smith. The rhizomes of the plant are used as a spice and traditional medicine. Zerumbone was shown to possess anticarcinogenic, anti-inflammatory, and antioxidant properties. However, the
Anke Schennink et al.
Reproductive toxicology (Elmsford, N.Y.), 54, 93-100 (2014-12-03)
The voluntary consumption of alcohol by humans is a modifiable lifestyle factor that has been consistently linked to a woman's risk of developing breast cancer. We have used an animal model that closely recapitulates breast development in humans to study
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