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Gang Wang et al.
PloS one, 6(11), e27605-e27605 (2011-11-24)
Mucosal vaccination has been demonstrated to be an effective means of eliciting protective immunity against aerosol infections of foot and mouth disease virus (FMDV) and various approaches have been used to improve mucosal response to this pathogen. In this study
In Vitro Developmental Competence of In Vitro-Matured Bovine Oocytes Fertilized and Cultured in Completely Defined Media
Keskintepe L and Brackett BG
Biology of Reproduction, 55, 333-339 (1996)
Roger F Falkenstern-Ge et al.
Journal of bronchology & interventional pulmonology, 20(1), 58-62 (2013-01-19)
Emphysema is a progressive and irreversible disease for which there is no cure to date. The patients experience debilitating shortness of breath with repetitive exacerbations and poor quality of daily life. At present, patients with severe emphysema have limited treatment
Bai-wen Qi et al.
Experimental biology and medicine (Maywood, N.J.), 238(1), 23-30 (2013-03-13)
The aim of this work is to explore the feasibility and therapeutic effect of repairing rabbit articular cartilage defects using thermo-sensitive chitosan/poly (vinyl alcohol) composite hydrogel engineered Ad-hTGF-β1-transfected bone marrow mesenchymal stem cells. Rabbit's bone marrow stromal cells (BMSCs) were
Li Xin Su et al.
The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA), 17(2), 85-89 (2014-12-23)
Arteriovenous malformations (AVMs) are congenital vascular malformations (CVMs) resulting from birth defects of the vasculature. It is rarely seen, only accounting for 1.5% of all vascular anomalies, and 50% of the lesions are located in the oral and maxillofacial region.
Tim Waterboer et al.
Clinical chemistry, 51(10), 1845-1853 (2005-08-16)
More than 100 different human papillomaviruses (HPVs) can cause proliferative diseases, many of which are malignant, such as cervical cancer. HPV serology is complex because infection and disease lead to distinct type-specific antibody responses. Using bead-based technology, we have developed
Atchalalt Khurchabilig et al.
Zygote (Cambridge, England), 1-7 (2020-06-03)
The efficiency of in vitro embryo production technologies would be improved by the development of suitable non-invasive biomarkers that allow the selection of good quality cumulus-oocyte complexes (COCs). The present study used whole, single oocyte culture to investigate whether the
Daniele Di Mascolo et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(3), 460-468 (2013-06-25)
PPARγ nuclear receptor agonists have been shown to attenuate macrophage inflammatory responses implicated in the metabolic complications of obesity and in atherosclerosis. However, PPARγ agonists currently in clinical use, including rosiglitazone (RSG), are often associated with severe side effects that
Nora Mecklenburg et al.
Development (Cambridge, England), 148(17) (2021-09-01)
Pathogenic gene variants in humans that affect the sonic hedgehog (SHH) pathway lead to severe brain malformations with variable penetrance due to unknown modifier genes. To identify such modifiers, we established novel congenic mouse models. LRP2-deficient C57BL/6N mice suffer from
Liuliu Yang et al.
Cell stem cell, 27(1), 125-136 (2020-06-25)
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present
Satoshi Nishikawa et al.
The Journal of reproduction and development, 59(3), 258-265 (2013-03-02)
Degradation of maternally stored mRNAs after fertilization is an essential process for mammalian embryogenesis. Maternal mRNA degradation depending on deadenylases in mammalian early embryos has been mostly speculated, rather than directly demonstrated. Previously, we found that gene expression of nocturnin
Vitor Braga Rissi et al.
Epigenetics, 14(11), 1088-1101 (2019-06-21)
There is growing evidence that histone lysine demethylases (KDMs) play critical roles in the regulation of embryo development. This study investigated if KDM7A, a lysine demethylase known to act on mono-(me1) and di-(me2) methylation of H3K9 and H3K27, participates in
Antonin Blot et al.
Neuron, 109(12), 1996-2008 (2021-05-13)
Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as the pulvinar or lateral posterior nucleus (LP) in the visual
Solmaz Hajizadeh et al.
Journal of chromatography. A, 1274, 6-12 (2013-01-08)
In this work, a new macroporous molecularly imprinted cryogel (MIP composite cryogel) was synthesized by glutaraldehyde cross-linking reaction of poly(vinyl alcohol) (PVA) particles and amino-modified molecularly imprinted core-shell nanoparticles. The MIP core-shell nanoparticles were prepared using propranolol as a template
Tomoyuki Yamaguchi et al.
Scientific reports, 8(1), 15289-15289 (2018-10-18)
To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid complementation between mouse and rat. Overall contribution of donor PSC-derived cells was lower in interspecies chimeras than in intraspecies chimeras, and high
Nguyen Viet Linh et al.
Animal science journal = Nihon chikusan Gakkaiho, 89(8), 1079-1084 (2018-05-29)
The aim of the present study was to improve the penetration during in vitro fertilization (IVF) of a frozen lot of epididymal sperm with a notoriously low fertilization ability of a Ban boar which is a native Vietnamese breed by optimizing
Andrés Gambini et al.
Developmental cell, 53(5), 545-560 (2020-05-23)
Embryonic genome activation (EGA) is orchestrated by an intrinsic developmental program initiated during oocyte maturation with translation of stored maternal mRNAs. Here, we show that tankyrase, a poly(ADP-ribosyl) polymerase that regulates β-catenin levels, undergoes programmed translation during oocyte maturation and
Mohammad Mujahid Ali Khan et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 2360-2366 (2013-03-19)
The aim of this study was to investigate the preparation of novel membrane and the characterization of their properties. A new class of polyvinyl chloride (PVC) based polyvinyl alcohol Ce(IV) phosphate composite membrane was successfully prepared by solution casting method.
Kazushi Suzuki et al.
Nature communications, 7, 13718-13718 (2016-12-15)
Luminescence imaging has gained attention as a promising bio-imaging modality in situations where fluorescence imaging cannot be applied. However, wider application to multicolour and dynamic imaging is limited by the lack of bright luminescent proteins with emissions across the visible
Kimi Drobin et al.
Cancers, 12(3) (2020-04-03)
Nearly half of all cancers are treated with radiotherapy alone or in combination with other treatments, where damage to normal tissues is a limiting factor for the treatment. Radiotherapy-induced adverse health effects, mostly of importance for cancer patients with long-term
Emily N Abada et al.
Biomedical microdevices, 20(4), 86-86 (2018-10-07)
While extracorporeal membrane oxygenation (ECMO) is a valuable therapy for patients with lung or heart failure, clinical use of ECMO remains limited due to hemocompatibility concerns with pro-coagulatory hollow fiber membrane geometries. Previously, we demonstrated the feasibility of silicon nanopore
Huaqiang Yang et al.
Cell research, 24(4), 464-481 (2014-03-01)
Mutations in the human copper/zinc superoxide dismutase 1 (hSOD1) gene cause familial amyotrophic lateral sclerosis (ALS). It remains unknown whether large animal models of ALS mimic more pathological events seen in ALS patients via novel mechanisms. Here, we report the
Oral misoprostol does not hasten oviductal transport of day-5 horse embryos.
Checura, et al.
Animal Reproduction Science, 223, 106626-106626 (2020)
Tea Dodig-Crnković et al.
EBioMedicine, 57, 102854-102854 (2020-07-07)
Precision medicine approaches aim to tackle diseases on an individual level through molecular profiling. Despite the growing knowledge about diseases and the reported diversity of molecular phenotypes, the descriptions of human health on an individual level have been far less
Janice P Evans et al.
Methods in molecular biology (Clifton, N.J.), 1818, 163-171 (2018-07-02)
Just as it is important to understand the cell biology of signaling pathways, it is valuable also to understand mechanical forces in cells. The field of mechanobiology has a rich history, including study of cellular mechanics during mitosis and meiosis
Kotaro Sasaki et al.
Cell reports, 35(5), 109075-109075 (2021-05-06)
In the early fetal stage, the gonads are bipotent and only later become the ovary or testis, depending on the genetic sex. Despite many studies examining how sex determination occurs from biopotential gonads, the spatial and temporal organization of bipotential
Masahito Tachibana et al.
Nature protocols, 5(6), 1138-1147 (2010-06-12)
In this article, we describe detailed protocols for the isolation and transfer of spindle-chromosomal complexes between mature, metaphase II-arrested oocytes. In brief, the spindle-chromosomal complex is visualized using a polarized microscope and extracted into a membrane-enclosed karyoplast. Chromosomes are then
Han Zhu et al.
Biosensors & bioelectronics, 49, 210-215 (2013-06-15)
A novel, facile and green approach for the fabrication of H2O2, glutathione (GSH) and glucose detection biosensor using water-stable PVA and PVA/PEI nanofibers decorated with AgNPs by combining an in situ reduction approach and electrospinning technique has been demonstrated. Small
Dan Hoff et al.
International journal of nanomedicine, 8, 703-710 (2013-02-22)
In the present study, the permeability of 11 different iron oxide nanoparticle (IONP) samples (eight fluids and three powders) was determined using an in vitro blood-brain barrier model. Importantly, the results showed that the ferrofluid formulations were statistically more permeable
J H Seol et al.
Rhinology, 51(2), 137-142 (2013-05-15)
A number of different nasal packing materials are available for prevention of nasal bleeding after endoscopic sinus surgery. Polyvinyl alcohol (PVA) coated nasal packing is an expandable packing for use in rhinological surgery. This innovative surf- ace treatment helps to
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