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Xuming Zhang
Cell reports, 27(12), 3672-3683 (2019-06-20)
Activation of Gαq-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gαq and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) inhibit TRPM8. Here, I demonstrate that direct Gαq gating is essential for both the...
Inhibition of endothelial cell survival and angiogenesis by protein kinase A
Kim S, et al.
The Journal of Clinical Investigation (2002)
Keietsu Kikuchi et al.
Journal of neurochemistry, 148(2), 204-218 (2018-09-24)
The expression of immediate early genes (IEGs) is thought to be an essential molecular basis of neuronal plasticity for higher brain function. Many IEGs contain serum response element in their transcriptional regulatory regions and their expression is controlled by serum...
Phillip A Angart et al.
Applied microbiology and biotechnology, 101(14), 5645-5652 (2017-05-04)
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family critical for neuronal cell survival and differentiation, with therapeutic potential for the treatment of neurological disorders and spinal cord injuries. The production of recombinant, bioactive BDNF is not practical...
Jingli Cao et al.
G3 (Bethesda, Md.) (2021-03-22)
Intellectual disability is closely related to impaired GABA neurotransmission. Brpf1 was specifically expressed in medial ganglionic eminence (MGE), a developmental niche of GABAergic interneurons, and patients with BRPF1 mutations showed intellectual disability. To test its role in development and function...
Hiroyuki Kojima et al.
STAR protocols, 1(1), 100036-100036 (2020-10-29)
Turn-on fluorescent probe mediated by conjugate addition and cyclization (TCC probe) is a small molecule that reacts with a protein of interest in cells. TCC probe is applicable to various types of proteins by exchanging the ligand unit for target...
Trial evaluation of bone marrow derived mesenchymal stem cells (MSCs) transplantation in revival of spermatogenesis in testicular torsion
Sabbaghi MA, et al.
Middle East Fertility Society journal, 17(4), 243-249 (2012)
Aleksandra N Mladenovic Djordjevic et al.
Free radical biology & medicine, 162, 88-103 (2020-12-07)
Alzheimer's disease (AD) is the most common form of dementia worldwide, characterized by a progressive decline in a variety of cognitive and non-cognitive functions. The amyloid beta protein cascade hypothesis places the formation of amyloid beta protein aggregates on the...
Yosuke Tashiro et al.
Journal of bacteriology, 190(11), 3969-3978 (2008-04-09)
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that is one of the most refractory to therapy when it forms biofilms in the airways of cystic fibrosis patients. To date, studies regarding the production of an immunogenic and protective antigen to...
Myron K Evans et al.
Nature communications, 11(1), 4060-4060 (2020-08-15)
Chromatin modifiers affect spatiotemporal gene expression programs that underlie organismal development. The Polycomb repressive complex 2 (PRC2) is a crucial chromatin modifier in executing neurodevelopmental programs. Here, we find that PRC2 interacts with the nucleic acid-binding protein Ybx1. In the...
Eleanor A Latomanski et al.
Autophagy, 14(10), 1710-1725 (2018-07-06)
Coxiella burnetii is an intracellular bacterial pathogen which causes Q fever, a human infection with the ability to cause chronic disease with potentially life-threatening outcomes. In humans, Coxiella infects alveolar macrophages where it replicates to high numbers in a unique...
Simona Dedoni et al.
Journal of neurochemistry, 146(5), 526-539 (2018-05-18)
The chemokine CCL5 prevents neuronal cell death mediated both by amyloid β, as well as the human immunodeficiency virus viral proteins gp120 and Tat. Because CCL5 binds to CCR5, CCR3 and/or CCR1 receptors, it remains unclear which of these receptors...
Kyeong Won Lee et al.
FEBS open bio, 9(4), 769-780 (2019-04-16)
Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3-L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage...
Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models
Bi J, et al.
Journal of Neurochemistry, 120(2), 334-346 (2012)
Parker L Andersen et al.
Colloids and surfaces. B, Biointerfaces, 159, 166-173 (2017-08-13)
This study describes a method to screen biomimetic surfaces based on intracellular insulin content of either fully or partly dissociated primary endocrine islet tissue. It is challenging to maintain endocrine pancreatic islets and more so, dissociated ones. Physiological activity of...
Emma Carley et al.
eLife, 10 (2021-03-30)
While the mechanisms by which chemical signals control cell fate have been well studied, the impact of mechanical inputs on cell fate decisions is not well understood. Here, using the well-defined system of keratinocyte differentiation in the skin, we examine...
Hailong Li et al.
Journal of visualized experiments : JoVE, (158) (2020-04-21)
It has been reported that the size and shape of dendritic spines is related to their structural plasticity. To identify the morphological structure of pyramidal neurons and dendritic spines, a ballistic labeling technique can be utilized. In the present protocol...
Simone Chiola et al.
Molecular psychiatry (2021-02-10)
Genetic abnormalities in synaptic proteins are common in individuals with autism; however, our understanding of the cellular and molecular mechanisms disrupted by these abnormalities is limited. SHANK3 is a postsynaptic scaffolding protein of excitatory synapses that has been found mutated...
Megan Davis-Fields et al.
Biophysical journal, 117(8), 1496-1507 (2019-10-07)
Biofilm infections can consist of bacterial aggregates that are an order of magnitude larger than neutrophils, phagocytic immune cells that densely surround aggregates but do not enter them. Because a neutrophil is too small to engulf the entire aggregate, it...
Peng Zhai et al.
Biomedical materials (Bristol, England), 10(4), 045016-045016 (2015-08-05)
The adult mammalian central nervous system has limited ability to regenerate after injury. This is due, in part, to the presence of myelin-associated axon growth inhibitory proteins such as Nogo-A that bind and activate the Nogo receptor, leading to profound...
Jillian Belgrad et al.
Glia, 67(11), 2107-2124 (2019-07-25)
Low level sarin nerve gas and other anti-cholinesterase agents have been implicated in Gulf War illness (GWI), a chronic multi-symptom disorder characterized by cognitive, pain and fatigue symptoms that continues to afflict roughly 32% of veterans from the 1990-1991 Gulf...
Qini Gan et al.
Journal of Alzheimer's disease : JAD, 70(4), 1025-1040 (2019-07-16)
Recent studies demonstrate that peripheral amylin treatment reduces pathology in mouse models of Alzheimer's disease (AD). However, soluble and aggregated amylin are distinct species; while amylin is a physiological neuropeptide, amylin aggregation is a pathological factor for diabetes. We thus...
William Binning et al.
Brain, behavior, and immunity, 88, 791-801 (2020-05-21)
Microglia express muscarinic G protein-coupled receptors (GPCRs) that sense cholinergic activity and are activated by acetylcholine to potentially regulate microglial functions. Knowledge about how distinct types of muscarinic GPCR signaling regulate microglia function in vivo is still poor, partly due...