Showing 1-30 of 46 results for "P9797"
Noushin Bolourchian et al.
Pakistan journal of pharmaceutical sciences, 25(3), 607-616 (2012-06-21)
The aim of this study was to design and optimize a prolonged release matrix formulation of pyridostigmine bromide, an effective drug in myasthenia gravis and poisoning with nerve gas, using hydrophilic - hydrophobic polymers via D-optimal experimental design. HPMC and...
Adil E Bharucha et al.
Gut, 62(5), 708-715 (2012-06-09)
Chronic constipation in diabetes mellitus is associated with colonic motor dysfunction and is managed with laxatives. Cholinesterase inhibitors increase colonic motility. This study evaluated the effects of a cholinesterase inhibitor on gastrointestinal and colonic transit and bowel function in diabetic...
João Paulo J Sabino et al.
Autonomic neuroscience : basic & clinical, 173(1-2), 58-64 (2012-12-12)
Sympathetic hyperactivity and its outcome in heart failure have been thoroughly investigated to determine the focus of pharmacologic approaches targeting the sympathetic nervous system in the treatment of this pathophysiological condition. On the other hand, therapeutic approaches aiming to protect...
James J Dowling et al.
Disease models & mechanisms, 5(6), 852-859 (2012-05-31)
Myotubular myopathy (MTM) is a severe congenital muscle disease characterized by profound weakness, early respiratory failure and premature lethality. MTM is defined by muscle biopsy findings that include centralized nuclei and disorganization of perinuclear organelles. No treatments currently exist for...
M Iqbal et al.
Irish medical journal, 105(6), 183-184 (2012-09-15)
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder of neuromuscular transmission (NMJ) that shares many clinical features with myasthenia gravis (MG). We report a 73 year-old lady who presented 10 years previously with stiffness of both calves, dry mouth...
Gaurav Dixit et al.
The Journal of the Association of Physicians of India, 60, 56-58 (2012-07-18)
Neuropathy is a well known side effect of vincristine, however cranial nerve toxicities are reported less frequently which can involve any cranial nerve in mostly bilateral pattern. As many patients have primary tumors or metastatic lesions in sites that could...
Unusual case of recurrent falls: myasthenia gravis in an elderly patient.
Tareef Alaama et al.
Canadian family physician Medecin de famille canadien, 58(11), 1231-1232 (2012-11-16)
[Myasthenia gravis].
Jennifer Spillane et al.
Praxis, 102(10), 603-606 (2013-05-07)
J I Moss
Medical hypotheses, 79(2), 283-284 (2012-05-29)
Gulf War illnesses (GWI share many of the features of chronic fatigue syndrome (CFS) and both CFS and GWI may be the result of chronic immune system processes. The main suspected cause for GWI, the drug pyridostigmine bromide (PB), has...
Alon Bajayo et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(38), 15455-15460 (2012-09-06)
Bone mass accrual is a major determinant of skeletal mass, governed by bone remodeling, which consists of bone resorption by osteoclasts and bone formation by osteoblasts. Bone mass accrual is inhibited by sympathetic signaling centrally regulated through activation of receptors...
P A Ferchmin et al.
Neurotoxicology, 44, 80-90 (2014-06-15)
Many organophosphorous esters synthesized for applications in industry, agriculture, or warfare irreversibly inhibit acetylcholinesterase, and acute poisoning with these compounds causes life-threatening cholinergic overstimulation. Following classical emergency treatment with atropine, an oxime, and a benzodiazepine, surviving victims often suffer brain...
Shin J Oh et al.
Journal of clinical neuromuscular disease, 14(2), 57-65 (2012-11-23)
To find the characteristic phenotypes of 3 different types of myasthenia gravis (MG). The clinical and electrophysiological features among 15 cases of muscle-specific kinase antibody positive (MuSK Ab+) MG, 59 cases of double seronegative (DSN) MG, and 161 cases of...
Zuchra Zakirova et al.
PloS one, 10(3), e0119579-e0119579 (2015-03-19)
Gulf War Illness (GWI) is a chronic multisymptom illness with a central nervous system component such as memory deficits, neurological, and musculoskeletal problems. There are ample data that demonstrate that exposure to Gulf War (GW) agents, such as pyridostigmine bromide...
Marcus Paulo Ribeiro Machado et al.
Experimental physiology, 97(11), 1186-1202 (2012-06-19)
The aim of the present study was to evaluate the effects of changes to the autonomic nervous system in mice during the acute phase of Chagas disease, which is an infection caused by the parasite Trypanosoma cruzi. The following types...
Duygu Selcen et al.
Neurology, 81(4), 370-378 (2013-06-25)
To identify patients with GFPT1-related limb-girdle myasthenia and analyze phenotypic consequences of the mutations. We performed genetic analysis, histochemical, immunoblot, and ultrastructural studies and in vitro electrophysiologic analysis of neuromuscular transmission. We identified 16 recessive mutations in GFPT1 in 11...
João H D Blanco et al.
Autonomic neuroscience : basic & clinical, 193, 97-103 (2015-10-17)
Hypertension is often accompanied by autonomic dysfunction, which is detrimental to cardiac regulation. On the other hand, cholinergic stimulation through inhibition of acetylcholinesterase appears to have beneficial effects on cardiac autonomic control. Thus, our objective was to investigate the effects...
Successful desensitization protocol for pyridostigmine hypersensitivity in a patient with myasthenia gravis.
Tania Aung et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(4), 308-308 (2013-03-29)
Qunyou Tan et al.
International journal of nanomedicine, 8, 737-745 (2013-03-06)
Pyridostigmine bromide (3-[[(dimethylamino)-carbonyl]oxy]-1-methylpyridinium bromide), a reversible inhibitor of cholinesterase, is given orally in tablet form, and a treatment schedule of multiple daily doses is recommended for adult patients. Nanotechnology was used in this study to develop an alternative sustained-release delivery...
Ashwati Raghunath
BMJ case reports, 2013, doi:10-doi:10 (2013-01-04)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyramidal side...
[The use of sugammadex in a patient with myasthenia gravis].
A Challan Belval et al.
Annales francaises d'anesthesie et de reanimation, 31(6), 569-570 (2012-06-09)
Cardiomyocyte-secreted acetylcholine is required for maintenance of homeostasis in the heart
Roy A, et al.
Faseb Journal, 27(12), 5072-5082 (2013)
Cardiac acetylcholine inhibits ventricular remodeling and dysfunction under pathologic conditions
Roy A, et al.
Faseb Journal, 30(2), 688-701 (2015)
Laila Abdullah et al.
Neuromolecular medicine, 14(4), 349-361 (2012-07-17)
The central nervous system (CNS)-based symptoms of Gulf War Illness (GWI) include motor dysfunction, anxiety, and cognitive impairment. Gulf War (GW) agents, such as pyridostigmine bromide (PB), permethrin (PER), N,N-diethyl-meta-toluamide (DEET), and stress, are among the contributory factors to the...
Paul Maddison
Annals of the New York Academy of Sciences, 1275, 78-84 (2013-01-03)
Besides antitumor therapy for patients with the paraneoplastic form of Lambert-Eaton myasthenic syndrome (LEMS), the mainstay of symptomatic treatment in LEMS is 3,4-diaminopyridine (3,4-DAP). Data from four randomized, placebo-controlled trials have revealed that muscle strength scores increased significantly with 3,4-DAP....
Sara Rodrigues et al.
Drug and chemical toxicology, 38(2), 126-132 (2014-05-23)
In recent decades, scientific research about the effects of anthropogenic xenobiotics on non-target organisms has increased. Among the likely effects, some studies reported the evaluation of biochemical and morphological changes in specific tissues or organs of fishes, such as gills...
Overlooked myasthenia gravis in an elderly adult.
Lei Jiang et al.
Journal of the American Geriatrics Society, 61(5), 840-841 (2013-05-16)
Kurt Kimpinski et al.
Mayo Clinic proceedings, 87(8), 746-752 (2012-07-17)
To prospectively evaluate patients who met standard criteria for postural tachycardia syndrome (POTS), at baseline and 1-year follow-up, using standard clinical and laboratory methods to assess autonomic function. Fifty-eight patients met the study criteria (orthostatic symptoms and a heart rate...
Qunyou Tan et al.
Drug development and industrial pharmacy, 39(9), 1364-1371 (2012-09-22)
The purpose of this study was to evaluate the taste masking potential of novel solid dispersions (SDs) using Eudragit® EPO as the excipient when incorporated into the orally disintegrating tablets (ODTs) for delivering a highly soluble drug with an extremely...
Gulf War and health Depleted uranium, pyridostigmine bromide, sarin, and vaccines (2000)
Renske I Wadman et al.
Neurology, 79(20), 2050-2055 (2012-11-02)
Spinal muscular atrophy (SMA) is pathologically characterized by degeneration of anterior horn cells. Recent observations in animal models of SMA and muscle tissue from patients with SMA suggest additional abnormalities in the development and maturation of the neuromuscular junction. We...

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