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Showing 1-21 of 21 results for "pdk1 inhibitor" within Technical Documents
Data Sheet - P3110
proteins. Anti-PDK1 recognizes human PDK1 (60 kDa). Appli- cations include the detection of PDK1 by immuno- blotting. Staining of PDK1 in immunoblotting is specifically inhibited with PDK1 immunizing peptide
Protein Sample Preparation Tools for Signal Transduction Research & Proteomics
required for activation of PDK1) and Thr308 Phospho-AKT/PKB. The reduced PDK1 mRNA level result- ed in a diminished level of PDK1 protein and phosphorylated activat- ed PDK1 to about 40% and 22%, respectively
Biologics 33.2
. PDK1/Akt/Flt Dual Pathway Inhibitor (6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1- e]tetrazolo[1,5-b][1,2,4]triazin-10-one) A cell-permeable, direct inhibitor of both
Biologics 31.1
towards PKA, PKC, PDK1, p42/44 MAPK, and p38 MAPK. Purity: ≥95% by HPLC. M.W. 3412.9. Ref.: Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407. NOW Available… Foxm1b Inhibitor, Cell-permeable
The Effective Use of Protein Kinase Inhibitors
136) Medium Conventional PKCs 1 Ro 31-8220** (R-136) Medium PKCs, MSKs, RSKs, etc 5 UCN01 Quite low PDK1 and CHK1, but not CHK2 0.3-1 * The suggested concentrations are only guidelines. The optimal concentrations
The Effective Use of Protein Kinase Inhibitors
66 97 91 104 104 96 96 70 99 87 PKCα 79 98 86 95 95 92 99 93 89 92 100 91 70 99 98 97 3 4 7 PDK1 104 115 92 36 70 99 85
STAR phospho-Akt (Ser473)
generation of PIP3, which in turn, binds to and activates the PI3 Dependent Protein Kinase, PDK1. Activated PDK1 is known to phosphorylate Akt on Thr308. This site is also the target of the phosphatase
Product Information Sheet - CS0120
phosphorylated by MAPKAP2 and PDK1. One Unit of standard = the amount of Phospho- Akt/PKB (pSer473) derived from 100 pg of Akt/PKB which was phosphorylated by MAPKAP2 and PDK1. Subsequent lots of standard
Apoptosis - Antibodies, Reagents and Kits
$235 PDK1 Immunoprecipitation Kinase Assay Kit IPK 1 kit 17-279 $459 PDK1 Immunoprecipitation Kinase Assay Kit IPK 1 kit 17-279 $459 PDK1 Kinase Assay Kit KA 1 kit 17-280 $459 PDK1 Kinase
STAR AKT1 ELISA Kit
PIP3, resulting from PI3 Kinase activation, results in the subsequent binding and activation of PDK1. PDK1 is known to phosphorylate Akt on Thr308. The Thr308 site is the site of activation for PP2A that
New Research Tools for Signal Transduction and Life Science Research
2/MMP-� Inhibitor III, PD16679� 444284 17 PDGF Receptor Tyrosine Kinase Inhibitor IV 5212�� �0 PDGF Receptor Tyrosine Kinase Inhibitor V 5212�4 �0 PDK1/Akt/Flt Dual Pathway Inhibitor 521275
Product Information Sheet - CS0110
full- length recombinant Akt/PKB protein, expressed in Sf21 cells and phosphorylated by MAPKAP2 and PDK1. Refer to vial label for quantity and reconstitution volume. • Standard Diluent Buffer, 25 mL
Hallmarks of Cancer - Solutions for life science research
PI 3-Kγ Inhibitor • PI 3-Kγ Inhibitor II • PI 3-Kα Inhibitor IV • PI 3-Kα Inhibitor VIII • Wortmannin • PDK1-Akt-Flt Dual Pathway Inhibitor • Akt Inhibitor IV, Akt Inhibitor VIII • PDK1-Akt-Flt
Calbiochem Biologics 29.2
PI 3-K-dependent kinase (PDK1) and Akt from the cytoplasm to the plasma membrane. This leads to conformational changes in Akt that gets phosphorylated on Thr308 and Ser473 by PDK1 and becomes activated.
Comprehensive solutions for studying cell health - Life, death, and everything in between.
PI 3-Kγ Inhibitor • PI 3-Kγ Inhibitor II • PI 3-Kα Inhibitor IV • PI 3-Kα Inhibitor VIII • Wortmannin • PDK1-Akt-Flt Dual Pathway Inhibitor • Akt Inhibitor IV, Akt Inhibitor VIII • PDK1-Akt-Flt
Inhibitor Sourcebook 3rd Edition
. No.440203); 5 mg of PDK1/Akt/Flt Dual Pathway Inhibitor (Cat. No.521275); 1 mg of PI-103 (Cat. No.528100); 5 mg of PI 3-Kg Inhibitor (Cat. No.528106); 5 mg of PI 3-Kg Inhibitor II (Cat. No.528108);
Cytoskeletal Signaling Antibodies, Reagents and Kits
Polyclonal Antibody Anti-PDK1 H R IPK WB APur Rb IgG 100 µL 07-707 Assay PDK1 Immunoprecipitation Kinase Assay Kit IPK 1 kit 17-279 PDK1 Kinase Assay Kit KA 1 kit 17-280 PDK1 Assay Dilution Buffer
Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?
are mediated by the downstream target Akt, which together with its main activating kinase, PDK1, is recruited to the plasma membrane through its affinity for the product of class I PI3K
New Products Flyer- Vol 4 Signaling Feature- NEW! Phosphohistidine Antibody
14-530M-D CDK1/CyclinB1 14-450M-D cRAF (RAF1) 14-352-D GSK3β 14-306-D IKKβ 14-485-D PDK1 14-452-D PI3 kinase (p110α/p85α) 14-602-D PI3 kinase (p110δ/p85α) 14-604M-D PI3 kinase (p120Υ
Panorama Human Protein Functional Array-Signal Transduction
cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 CDKN2B cyclin-dependent kinase inhibitor 2B 1030 CDKN2C cyclin-dependent kinase inhibitor 2C 1031 CDKN2D cyclin-dependent kinase inhibitor 2D 1032 CGEF2
Product Information Sheet - HPFM3
PCTK1 PCTAIRE protein kinase 1, transcript variant 3 5127 PCTK2 PCTAIRE protein kinase 2 5128 PDK1 pyruvate dehydrogenase kinase, isoenzyme 1 5163 PDK2 pyruvate dehydrogenase kinase, isoenzyme 2