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Eli I Lev et al.
Journal of the American College of Cardiology, 47(1), 27-33 (2006-01-03)
We evaluated the response to clopidogrel among aspirin-resistant versus aspirin-sensitive patients undergoing elective coronary stenting. Patients (n = 150) treated with aspirin but not clopidogrel had blood samples drawn at baseline and 24 h after clopidogrel loading. Depending on the...
Sinan Demirtas et al.
The Kaohsiung journal of medical sciences, 31(3), 115-122 (2015-03-07)
The aim of this study was to investigate whether anticoagulant and antiaggregant agents have protective effects against oxidative damage induced by peripheral ischemia-reperfusion (I/R). Groups were created as follows: control group, I/R group (sham group), I/R plus acetylsalicylic acid (Group...
Aspirin may prevent blood clots in the legs from recurring.
Harvard heart letter : from Harvard Medical School, 23(6), 8-8 (2013-07-24)
Kazuhiro Iguchi et al.
Oncology letters, 7(5), 1665-1668 (2014-04-26)
Prostate cancer occurs more frequently among older males and such elderly individuals often have chronic underlying disorders for which various drugs are administered for treatment. The levels of prostate-specific antigen (PSA), a widely used prostate cancer marker, are influenced by...
Sarpogrelate- another new antiplatelet agent?
Quratulain Shaikh et al.
JPMA. The Journal of the Pakistan Medical Association, 62(11), 1253-1253 (2013-07-23)
Margarita Gutiérrez et al.
Platelets, 25(4), 234-238 (2013-07-12)
Abstract Nine synthetic isoxazoles were evaluated as antiplatelet agents and studied the possible mechanism of more active compound. The initial screening was evaluating all compounds against platelet aggregation assays. The most active compound was isoxazole 8 showing an inhibition of...
Weighing the risks of perioperative aspirin.
John Serak et al.
World neurosurgery, 82(6), 928-929 (2014-10-15)
C C N Chong et al.
Alimentary pharmacology & therapeutics, 41(2), 199-208 (2014-11-22)
The effect of antiviral therapy on the post-hepatectomy long-term survival in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains uncertain. To evaluate the effect of antiviral therapy on post-hepatectomy survival and recurrence in patients with HBV-related HCC. This...
Pei-Yuan He et al.
Chinese medical journal, 128(5), 638-643 (2015-02-24)
The impact of body mass index (BMI) on the clinical outcomes after percutaneous coronary intervention (PCI) in patients ≥ 75 years old remained unclear. A total of 1098 elderly patients undergoing PCI with stent implantation were recruited. Patients were divided...
Thirada Thongbai
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(11), 1423-1427 (2014-01-17)
Aspirin is a widely used medication for primary and secondary prevention of cardiovascular and cerebrovascular events. The gastrointestinal risks of aspirin are well known, but the frequency of gastroduodenal mucosal injuries in aspirin users in Thailand is currently unknown. The...
Tino Jaschinski et al.
Rapid communications in mass spectrometry : RCM, 28(13), 1521-1529 (2014-05-28)
Laser desorption ionization for mass spectrometric measurements (LDI MS) is supported by nanostructured materials. This technique helps to overcome known limitations of matrix-assisted laser desorption/ionization (MALDI) and especially avoids interfering signals caused by matrix components. LDI can be supported by...
Kadriye Orta Kilickesmez et al.
Coronary artery disease, 26(1), 37-41 (2014-09-18)
Spontaneous reperfusion (SR) was associated with better clinical outcomes and lower incidence of major adverse cardiovascular events. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and elevated systemic ET-1 levels predict a poor prognosis in patients with ST-segment elevation myocardial...
Laura Mauri et al.
The New England journal of medicine, 371(23), 2155-2166 (2014-11-18)
Dual antiplatelet therapy is recommended after coronary stenting to prevent thrombotic complications, yet the benefits and risks of treatment beyond 1 year are uncertain. Patients were enrolled after they had undergone a coronary stent procedure in which a drug-eluting stent...
Côme Tissandier et al.
Pediatrics, 134(6), e1695-e1699 (2014-11-12)
We describe a case of recurrent Kawasaki disease (KD) in a non-Asian 6-year-old boy who had been diagnosed with typical KD without cardiac involvement at age 3 years. He was admitted to the PICU 3 years later for heart failure...
You can't get there from here without more robust data.
Simon Body et al.
The Journal of thoracic and cardiovascular surgery, 148(6), 3125-3126 (2014-12-01)
Yue Zou et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 25(7), 660-664 (2014-04-04)
This study aimed to compare the efficacy and safety of aspirin, rivaroxaban and low-molecular-weight heparin (LMWH) for post total knee arthroplasty (TKA) deep vein thrombosis (DVT) prophylaxis. Between July 2011 and July 2013, a prospective randomized controlled trial was performed...
Chisa Matsumoto et al.
The American journal of clinical nutrition, 101(2), 362-367 (2015-02-04)
Previous studies reported beneficial effects of cocoa or chocolate on insulin resistance, oxidative stress, and inflammation, which are important risk factors of type 2 diabetes mellitus (DM). However, it is unclear whether chocolate consumption is associated with risk of DM....
NSAID-associated gastrointestinal bleeding: assessing the role of concomitant medications.
Loren Laine
Gastroenterology, 147(4), 730-733 (2014-08-30)
András Kovács et al.
Thrombosis research, 135(4), 760-766 (2015-02-18)
Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. Thrombi removed by thromboaspiration following acute...
Alexandra Briggs et al.
The Journal of surgical research, 193(2), 802-806 (2014-09-15)
Both aspirin therapy and trauma impair platelet function. Platelet dysfunction is associated with worse outcomes in patients with traumatic intracranial hemorrhage (ICH). Platelet transfusion is often used to limit progression of ICH in patients on aspirin, but has not been...
Ludger Klimek et al.
Current allergy and asthma reports, 14(6), 441-441 (2014-04-01)
Aspirin intolerance syndrome is due to disturbances in the arachidonic acid metabolism implicating both the lipoxygenase and cyclooxygenase pathways. This results in imbalances of eicosanoid, leukotriene and prostaglandin synthesis. Thus, preinflammatory cysteinyl leukotrienes increase and antiinflammatory prostaglandins (PG) such as...
JeongWoo Kang et al.
Applied biochemistry and biotechnology, 174(1), 1-5 (2014-07-30)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the group of drugs having the therapeutic efficacy of analgesic and antipyretic. To detect health-threatening residues of NSAIDs, a fast and easy multiresidue method based on liquid chromatography tandem mass spectrometry (LC-MS/MS) was described. Ten...
Daniela Ribeiro et al.
Inflammation, 38(2), 858-870 (2014-08-21)
Cyclooxygenase 2 (COX-2) and the production of cytokines/chemokines are important targets for the modulation of the inflammatory response. Although a large variety of inhibitors of these pathways have been commercialized, some of those inhibitors present severe side effects, governing the...
X-F Ye et al.
British journal of cancer, 111(11), 2172-2179 (2014-09-03)
Epidemiological evidence suggests that use of aspirin after the diagnosis of colorectal cancer can lengthen survival. However, the supporting data vary between studies, and this hypothesis remains controversial. We conducted a meta-analysis to provide a quantitative assessment of the association...
Platelet function assays--not all are created equal.
Wayne L Chandler
Clinical chemistry, 60(12), 1469-1470 (2014-10-22)
A Schäfer et al.
Deutsche medizinische Wochenschrift (1946), 139(4), 152-158 (2014-01-17)
Dual antiplatelet therapy is the cornerstone of maintenance medication following invasive treatment of patients with acute coronary syndromes (ST elevation myocardial infarction, non-ST elevation myocardial infarction, unstable angina). Over the last decade, P2Y12 inhibition in addition to low-dose acetylsalicylic acid...
Aspirin allergy in patients with myocardial infarction: the allergist's role.
Kathryn L McMullan
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 112(2), 90-93 (2014-01-29)
Yasuo Ikeda et al.
JAMA, 312(23), 2510-2520 (2014-11-18)
Prevention of atherosclerotic cardiovascular diseases is an important public health priority in Japan due to an aging population. To determine whether daily, low-dose aspirin reduces the incidence of cardiovascular events in older Japanese patients with multiple atherosclerotic risk factors. The...
Prophylaxis against venous thromboembolism after arthroplasty: establishing value requires more than one perspective. Commentary on an article by John T. Schousboe, MD, PhD, and Gregory A. Brown, MD, PhD: "Cost-effectiveness of low-molecular-weight heparin compared with aspirin for prophylaxis against venous thromboembolism after total joint arthroplasty".
Adolph J Yates
The Journal of bone and joint surgery. American volume, 95(14), e102 1-e102 2 (2013-07-19)
Maria Pichler et al.
International journal of dermatology, 53(12), 1520-1525 (2014-09-12)
The classical "reading man flap" is a recently described flap named after its appearance and mainly used for reconstruction of circular malar or infraorbital skin defects. It avoids surgical complications such as lower lid retraction and ectropion but is limited...
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