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Akiko Nanri
Journal of epidemiology, 23(4), 243-250 (2013-06-12)
In Japan, the prevalences of type 2 diabetes and depression are increasing, but evidence linking these diseases to diet is limited. The present study reviewed the association of type 2 diabetes with intakes of rice, fish/seafood, and soy product and...
BP targets in renal transplant recipients: too high or too low?
Hallvard Holdaas et al.
Journal of the American Society of Nephrology : JASN, 25(7), 1371-1373 (2014-03-15)
Maternal prenatal folic acid supplementation is associated with a reduction in development of autistic disorder.
Robert J Berry
The Journal of pediatrics, 163(1), 303-304 (2013-06-26)
Young-Min Kim et al.
Biomaterials, 35(27), 7970-7977 (2014-06-22)
We developed a targetable micelleplex hydrogel as a new efficient systemic siRNA delivery material that functions as a targetable gene carrier, and a hydrogel capable of controlled release to overcome drawbacks of multiple administrations of systemic siRNA carriers due to...
Kenji Kishimoto et al.
Clinical immunology (Orlando, Fla.), 153(1), 17-22 (2014-04-03)
Hereditary folate malabsorption (HFM) is a rare autosomal recessive disorder. Severe folate deficiency in HFM can result in immunodeficiency. We describe a female infant with HFM who acquired severe Pneumocystis pneumonia. The objective of the present study was to elucidate...
Małgorzata Kantorowicz et al.
Przeglad lekarski, 70(1), 28-30 (2013-06-26)
The aim of this paper is to review the available literature pertaining the influence of specific nutritional elements (e.g. vitamin C, vitamin B-complex and dietary calcium) on periodontal status. Effect of food intake on the oral cavity is complex. Proper...
Rocío Pérez-Masiá et al.
Food chemistry, 168, 124-133 (2014-08-31)
In this work, two different technologies (electrospraying and nanospray drying) were evaluated for the encapsulation of folic acid using both a whey protein concentrate (WPC) matrix and a commercial resistant starch. The morphology of the capsules, molecular organization of the...
Birgit Hoeft et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 316-320 (2013-06-26)
The link between a sufficient intake of vitamins and long term health, cognition, healthy development and aging is increasingly supported by experimental animal, human and epidemiology studies. In low income countries billions of people still suffer from the burden of...
Diep Ngoc Thi Pham et al.
The American journal of clinical nutrition, 98(2), 413-422 (2013-06-28)
β,β-Carotene 15,15'-monooxygenase (BCMO1) converts β-carotene to retinaldehyde. Increased β-carotene consumption is linked to antitumor effects. Retinoic acid reduces the invasiveness in cancer, through inhibition of matrix metalloproteinases (MMPs). In our studies of a mouse model that develops intestinal tumors after...
Maternal folic acid supplementation and risk of autism.
Arshya Vahabzadeh et al.
JAMA, 309(21), 2208-2208 (2013-06-06)
M C F J de Rotte et al.
Arthritis and rheumatism, 65(11), 2803-2813 (2013-10-30)
To investigate whether baseline concentrations of one-carbon metabolism biomarkers are associated with treatment nonresponse and adverse events in rheumatoid arthritis (RA) patients receiving methotrexate (MTX). A prospective derivation cohort (n = 285) and validation cohort (n = 102) of RA...
Ling-Wei Chen et al.
The Journal of nutrition, 145(1), 113-120 (2014-12-21)
Maternal folate, vitamin B-12, and vitamin B-6 concentrations during pregnancy have been shown to influence birth outcomes, but the evidence is inconclusive. We aimed to examine the associations of maternal B-vitamin status with gestational age, birth weight, and length in...
Lijiao Ao et al.
Nanoscale, 6(18), 10710-10716 (2014-08-07)
This paper devotes a novel micellar structure for cancer theranostics by incorporating magnetic and therapeutic functionalities into a natural sourced targeting polymer vehicle. Heparin-folic acid micelles taking advantage of both excellent loading capability and cancer targeting ability have been employed...
Devinder Ubhi et al.
Journal of molecular biology, 426(8), 1839-1847 (2014-02-15)
The cobalamin-independent methionine synthase from Candida albicans, known as Met6p, is a 90-kDa enzyme that consists of two (βα)8 barrels. The active site is located between the two domains and has binding sites for a zinc ion and substrates L-homocysteine...
M V Hryhor'ieva
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 149-153 (2014-02-01)
The development of new bioactive polymeric materials is very topical. The goal of the present work was to use an optimized reversed-phase HPLC method to determine the release of folic acid (FA) from polyurethane carriers of different structures in vitro....
Diego Moretti et al.
Annals of the New York Academy of Sciences, 1312, 54-65 (2013-12-18)
Several strategies appear suitable to improve iron and zinc bioavailability from fortified maize, and fortification per se will increase the intake of bioavailable iron and zinc. Corn masa flour or whole maize should be fortified with sodium iron ethylenediaminetetraacetate (NaFeEDTA)...
Qiusha Tang et al.
PloS one, 9(9), e106483-e106483 (2014-09-05)
A practical and effective strategy for synthesis of Folate-NIR 797-conjugated Magnetic Albumin Nanospheres (FA-NIR 797-MAN) was developed. For this strategy, Magnetic Albumin Nanospheres (MAN), composed of superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA), were covalently conjugated with...
Jacob Joseph et al.
Nutrients, 5(8), 3235-3256 (2013-08-21)
Over the last four decades, abnormalities in the methionine-homocysteine cycle and associated folate metabolism have garnered great interest due to the reported link between hyperhomocysteinemia and human pathology, especially atherothrombotic cardiovascular disease. However, clinical trials of B-vitamin supplementation including high...
Van-Minh Le et al.
European journal of medicinal chemistry, 92, 882-889 (2015-02-14)
Traditional chemotherapeutic drugs remain the major treatment for advanced colorectal cancer. However, due to the lack of tumor specificity these drug also destroy healthy tissue and organs, which has been the main reason for treatment failure and mortality. Folate-based drug...
Nikita L van der Zwaluw et al.
Neurology, 83(23), 2158-2166 (2014-11-14)
We investigated the effects of 2-year folic acid and vitamin B12 supplementation on cognitive performance in elderly people with elevated homocysteine (Hcy) levels. This multicenter, double-blind, randomized, placebo-controlled trial included 2,919 elderly participants (65 years and older) with Hcy levels...
Jian-Zhuang Tan et al.
Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)
The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:...
András Jeney
Orvosi hetilap, 154(44), 1754-1758 (2013-10-29)
Increased blood cell regeneration in exsanguinated experimental animals treated either with liver or with aqueous liver extracts was reported by Whipple and by Jeney and Jobling, respectively. These findings stimulated Minot and Murphy to provide evidence for the efficacy of...
Xiali Zhu et al.
Journal of drug targeting, 22(9), 822-828 (2014-06-26)
This report focuses on the in vitro and in vivo anti-cancer effects evaluation of targeting and photothermal sensitive solid lipid nanoparticles (SLN) for the co-loading of docetaxel (DTX), oxidized single-walled carbon nanotubes (OSWNT) and folic acid (FA). Compared with free...
Per Ashorn et al.
The American journal of clinical nutrition, 101(2), 387-397 (2015-02-04)
Small birth size, often associated with insufficient maternal nutrition, contributes to a large share of global child undernutrition, morbidity, and mortality. We developed a small-quantity lipid-based nutrient supplement (SQ-LNS) to enrich the diets of pregnant women. The objective was to...
Jeffrey J Tomaszewski et al.
The Journal of urology, 191(4), 971-976 (2013-10-08)
A randomized, placebo controlled clinical trial of folic acid supplementation for the chemoprevention of colorectal adenoma revealed an increased incidence of prostate cancer in the treatment group. Limited data exist on postdiagnostic folate/folic acid intake and the risk of prostate...
Apolline Imbard et al.
International journal of environmental research and public health, 10(9), 4352-4389 (2013-09-21)
Neural tube defects (NTDs) are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. It is established that folic acid supplementation decreases the prevalence of NTDs, which has led to national public health policies regarding...
Suhair Sunoqrot et al.
Journal of controlled release : official journal of the Controlled Release Society, 191, 115-122 (2014-05-20)
Nanoparticle (NP)-based drug delivery platforms have received a great deal of attention over the past two decades for their potential in targeted cancer therapies. Despite the promises, passive targeting approaches utilizing relatively larger NPs (typically 50-200nm in diameter) allow for...
Sachin Yadav et al.
Artificial cells, nanomedicine, and biotechnology, 43(2), 93-102 (2013-11-08)
Breast cancer accounts for 23% of all newly occurring cancers in women worldwide and represents 13.7% of all cancer deaths. Available chemotherapeutic agents are limited largely due to the low accumulation of chemotherapeutics at the tumors relative to their accumulation...
Roxana Daneshjou et al.
Blood, 124(14), 2298-2305 (2014-08-01)
The anticoagulant warfarin has >30 million prescriptions per year in the United States. Doses can vary 20-fold between patients, and incorrect dosing can result in serious adverse events. Variation in warfarin pharmacokinetic and pharmacodynamic genes, such as CYP2C9 and VKORC1...
Alan H Maurer et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(5), 701-704 (2014-04-16)
Folate receptor (FR) can be used as a therapeutic target because of its expression on different epithelial cancers, such as ovarian, non-small cell lung, endometrial, and breast cancer. Assessing FR expression in tumors may help to identify patients who can...
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