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phr1111

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Xiaoyan Lin et al.
Nucleic acids research, 43(1), 446-460 (2014-12-19)
The replication enzyme of RNA viruses must preferentially recognize their RNAs in an environment that contains an abundance of cellular RNAs. The factors responsible for specific RNA recognition are not well understood, in part because viral RNA synthesis takes place...
Christian M Karsten et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1841-1855 (2015-01-16)
Many of the biological properties of C5a are mediated through activation of its receptor (C5aR1), the expression of which has been demonstrated convincingly on myeloid cells, such as neutrophils, monocytes, and macrophages. In contrast, conflicting results exist regarding C5aR1 expression...
Eva F G Naninck et al.
Hippocampus, 25(3), 309-328 (2014-10-02)
Early life stress (ES) increases vulnerability to psychopathology and impairs cognition in adulthood. These ES-induced deficits are associated with lasting changes in hippocampal plasticity. Detailed information on the neurobiological basis, the onset, and progression of such changes and their sex-specificity...
Mallappa K Kolar et al.
Stem cells and development, 23(14), 1659-1674 (2014-05-08)
Spinal cord injury triggers a cascade of degenerative changes leading to cell death and cavitation. Severed axons fail to regenerate across the scar tissue and are only capable of limited sprouting. In this study, we investigated the effects of adult...
Hong Ji et al.
PloS one, 9(10), e110314-e110314 (2014-10-21)
Secreted microRNAs (miRNAs) enclosed within extracellular vesicles (EVs) play a pivotal role in intercellular communication by regulating recipient cell gene expression and affecting target cell function. Here, we report the isolation of three distinct EV subtypes from the human colon...
L A Ruocco et al.
Amino acids, 47(3), 637-650 (2015-01-18)
The Disrupted-in-schizophrenia 1 (DISC1) gene is involved in vulnerability to neuropsychiatric disorders. Naples high-excitability (NHE) rat model neuropsychiatric problems characterized by an unbalanced mesocortical dopamine system. Here, we assessed behavioral and neurochemical effects of immunization against multimeric rat DISC1 protein...
Zai Ahmad et al.
PloS one, 10(3), e0119834-e0119834 (2015-03-19)
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. While the pathways that are deregulated in MB remain to be fully characterized, amplification and/or overexpression of the MYCN gene, which is has a critical role in cerebellar development as...
Olgary Figueroa-Santiago et al.
Infection and immunity, 82(12), 5005-5012 (2014-09-17)
The liver fluke Fasciola hepatica is a highly evolved parasite that uses sophisticated mechanisms to evade the host immune response. The immunosuppressive capabilities of the parasite have been associated with antigens secreted through the parasite's tegument, called excretory-secretory products (ESPs)....
Siddhesh S Kamat et al.
Nature, 497(7447), 132-136 (2013-04-26)
Methane is a potent greenhouse gas that is produced in significant quantities by aerobic marine organisms. These bacteria apparently catalyse the formation of methane through the cleavage of the highly unreactive carbon-phosphorus bond in methyl phosphonate (MPn), but the biological...
Patrick R Visperas et al.
The Biochemical journal, 465(1), 149-161 (2014-10-08)
Zeta-chain associated protein of 70 kDa (ZAP-70) and spleen tyrosine kinase (Syk) are non-receptor tyrosine kinases that are essential for T-cell and B-cell antigen receptor signalling respectively. They are recruited, via their tandem-SH2 (Src-homology domain 2) domains, to doubly phosphorylated immunoreceptor...
Srinivas Mutalik et al.
Systems biology in reproductive medicine, 60(3), 183-188 (2014-03-25)
Cryopreservation of spermatozoa plays a significant role in reproductive medicine and fertility preservation. Chicken egg yolk is used as an extender in cryopreservation of human spermatozoa using glycerol egg yolk citrate (GEYC) buffered medium. Even though 50% survival of spermatozoa...
Kanae Yumimoto et al.
The Journal of clinical investigation, 125(2), 621-635 (2015-01-03)
The gene encoding F-box protein FBXW7 is frequently mutated in many human cancers. Although most previous studies have focused on the tumor-suppressive capacity of FBXW7 in tumor cells themselves, we determined that FBXW7 in the host microenvironment also suppresses cancer...
Elena Rosini et al.
The FEBS journal, 281(15), 3460-3472 (2014-06-14)
Glycine is involved in several physiological functions, e.g. as a neurotransmitter in the central nervous system, and sarcosine has been identified as a differential metabolite greatly enhanced during prostate cancer progression and metastasis. Glycine oxidase from Bacillus subtilis (GO) was...
Kazushige Morishita et al.
Cell structure and function, 39(2), 113-124 (2014-10-15)
The dedicator of cytokinesis (DOCK) family proteins that are conserved in a wide variety of species are known as DOCK1-DOCK11 in mammals. The Sponge (Spg) is a Drosophila counterpart to the mammalian DOCK3. Specific knockdown of spg by pannir-GAL4 or...
Brian M De Borba et al.
Journal of chromatography. A, 1369, 131-137 (2014-12-03)
An ion chromatography (IC) method was developed for the simultaneous determination of total nitrogen and total phosphorus after alkaline persulfate digestion. This study takes advantage of advances in construction of high-resolution, high-capacity anion-exchange columns that can better tolerate the matrices...
Elaheh Gheybi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 11489-11497 (2014-08-17)
Breast cancer is the most common cancer among women in the world. One of the approaches for diagnosis of breast cancer is detection of its tumor-associated markers. Mucin 1 (MUC1), a tumor-associated antigen, is a transmembrane glycoprotein expressed by normal...
X L Jin et al.
Biology of reproduction, 80(2), 286-294 (2008-10-17)
A universal response to cellular stress is the expression of transformation-related protein 53 (TRP53). This transcription factor reduces cell proliferation and/or survival and is classed as a tumour suppressor protein. Several stresses (including culture) cause increased TRP53 expression in blastocysts...
Florian Mayer et al.
Journal of neurophysiology, 112(11), 2901-2915 (2014-09-05)
Neurons in the medial nucleus of the trapezoid body (MNTB) are well known for their prominent excitatory inputs, mediated by the calyx of Held. Less attention has been paid to the prominent inhibitory inputs that MNTB neurons also receive. Because...
M S Weiss et al.
Integrative biology : quantitative biosciences from nano to macro, 6(12), 1170-1182 (2014-10-11)
Tissue development and disease progression are multi-stage processes controlled by an evolving set of key regulatory factors, and identifying these factors necessitates a dynamic analysis spanning relevant time scales. Current omics approaches depend on incomplete biological databases to identify critical...
Fabien Tourrel et al.
Anesthesia and analgesia, 118(5), 1041-1051 (2014-05-02)
The use of remifentanil in a context of potential prematurity led us to explore ex vivo the opioid effects on the immature mouse brain. Remifentanil enhances medullary glutamatergic N-methyl-D-aspartate (NMDA) receptor activity. Furthermore, in neonatal mouse cortex, NMDA was previously...
Estela Giménez et al.
Analytica chimica acta, 866, 59-68 (2015-03-04)
In this work we demonstrate the potential of glycan reductive isotope labeling (GRIL) using [(12)C]- and [(13)C]-coded aniline and zwitterionic hydrophilic interaction capillary liquid chromatography electrospray mass spectrometry (μZIC-HILIC-ESI-MS) for relative quantitation of glycosylation variants in selected glycoproteins present in...
Tiphaine Belleville et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 86-90 (2015-03-31)
Abiraterone acetate is an oral prodrug of abiraterone, a selective inhibitor of CYP17, used for patients with metastatic castration-resistant prostate cancer (mCRPC). To date, a single liquid chromatographic-tandem mass spectroscopy method has been reported to assay abiraterone concentration in plasma...
Huinan Weng et al.
Journal of translational medicine, 12, 306-306 (2014-11-05)
Endometriosis is a benign chronic gynecological disease that affects women of reproductive age, characterized by the presence of functional endometrial tissues outside the uterine cavity. GnRH agonists exhibit anti-proliferative and apoptosis-enhancing activities and have long been used for the treatment...
Xin Xiao et al.
Scientific reports, 5, 9409-9409 (2015-03-24)
The porous architectural characteristics of biomaterials play an important role in scaffold revascularization. However, no consensus exists regarding optimal interconnection sizes for vascularization and its scaffold bioperformance with different interconnection sizes. Therefore, a series of disk-type beta-tricalcium phosphates with the...
Robert G Hahn
Urologia internationalis, 91(3), 249-255 (2013-09-21)
Glycine 1.5% has long maintained a dominating role as an irrigating solution for monopolar transurethral resection of the prostate (TURP), as well as for certain other transurethral procedures. This review summarizes the findings of systematic experimental and clinical studies in...
Steven Tran et al.
Behavioural brain research, 276, 161-170 (2014-03-07)
The zebrafish is emerging as a popular animal model for alcohol (ethanol or EtOH) addiction due to its simplicity and practical advantages. Two phenomena associated with ethanol addiction are the development of tolerance and withdrawal. Using a multi-level approach in...
Jing-Ru Li et al.
Nucleic acids research, 42(13), 8527-8536 (2014-07-02)
Telomerase, a ribonucleoprotein complex, is responsible for maintaining the telomere length at chromosome ends. Using its RNA component as a template, telomerase uses its reverse transcriptase activity to extend the 3'-end single-stranded, repetitive telomeric DNA sequence. Pif1, a 5'-to-3' helicase...
Jaleh Varshosaz et al.
Pharmaceutical development and technology, 20(2), 183-196 (2013-11-14)
Haloperidol (Hal) is a ligand that can target sigma 2 receptors over-expressed in non-small cell lung cancer. Hal targeted nanoparticles of bovine serum albumin (BSA) were prepared for pulmonary delivery of doxorubicin (DOX). The conjugation was confirmed by Fourier transform...
Maria G A Hägglund et al.
Journal of molecular biology, 427(6 Pt B), 1495-1512 (2014-12-03)
Glutamine transporters are important for regulating levels of glutamate and GABA in the brain. To date, six members of the SLC38 family (SNATs) have been characterized and functionally subdivided them into System A (SNAT1, SNAT2 and SNAT4) and System N...
Fabio Leonardo Meza-Joya et al.
Environmental and molecular mutagenesis, 54(5), 362-373 (2013-04-30)
The aerial spraying of glyphosate formulations in Colombia to eradicate illegal crops has generated great concern about its possible impact on nontarget organisms, particularly amphibians. This study evaluated the toxic, cytotoxic, and genotoxic effects of a glyphosate formulation (Roundup®SL-Cosmoflux®411F) in...
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