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PHR1125

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Alison C Macleod et al.
Molecular cancer therapeutics, 13(12), 2840-2851 (2014-09-26)
Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibition of KIT and calcineurin...
Catarina Mota et al.
Journal of immunology (Baltimore, Md. : 1950), 193(12), 5854-5862 (2014-11-05)
FOXP3-expressing regulatory T cells (Treg) are essential for the prevention of autoimmunity and were shown to be reduced and/or dysfunctional in several autoimmune diseases. Although Treg-based adoptive transfer represents a promising therapy, the large cell number required to achieve clinical...
Manuel Torres et al.
Apoptosis : an international journal on programmed cell death, 20(5), 712-724 (2015-02-11)
The unfolded protein response (UPR) and autophagy are two cellular processes involved in the clearing of intracellular misfolded proteins. Both pathways are targets for molecules that may serve as treatments for several diseases, including neurodegenerative disorders like Alzheimer's disease (AD)....
Florian Noulin et al.
PloS one, 9(11), e112496-e112496 (2014-11-14)
The predilection of Plasmodium vivax (P. vivax) for reticulocytes is a major obstacle for its establishment in a long-term culture system, as this requires a continuous supply of large quantities of reticulocytes, representing only 1-2% of circulating red blood cells....
Ting Zhao et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1942-1953 (2014-07-09)
The underlying mechanisms that lysosomal acid lipase (LAL) deficiency causes infiltration of myeloid-derived suppressor cells (MDSCs) in multiple organs and subsequent inflammation remain incompletely understood. Endothelial cells (ECs), lining the inner layer of blood vessels, constitute barriers regulating leukocytes transmigration...
Patrícia Severino et al.
European journal of medicinal chemistry, 81, 28-34 (2014-05-14)
Insulin was used as model protein to developed innovative Solid Lipid Nanoparticles (SLNs) for the delivery of hydrophilic biotech drugs, with potential use in medicinal chemistry. SLNs were prepared by double emulsion with the purpose of promoting stability and enhancing...
P Mabeta
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(5), 611-617 (2014-04-30)
The phosphoinositide 3-kinase (PI3k) signaling pathway is involved in the regulation of numerous cellular activities. The pathway has also been implicated in the development of various tumors. In the context of vascular tumors, the role of the PI3k signaling still...
Reed A Goodwin et al.
Journal of bacteriology, 196(10), 1901-1907 (2014-03-19)
In Sinorhizobium meliloti, catabolite repression is influenced by a noncanonical nitrogen-type phosphotransferase system (PTS(Ntr)). In this PTS(Ntr), the protein HPr is phosphorylated on histidine-22 by the enzyme EI(Ntr) and the flux of phosphate through this residue onto downstream proteins leads...
Hila Confino et al.
Cancer immunology, immunotherapy : CII, 64(2), 191-199 (2014-10-19)
The current systemic anti-metastatic treatment is chemotherapy. Chemotherapy reacts mostly against replicating cells, which makes this therapy not specific. Moreover, resting cancer cells will not be destroyed. A better alternative is an engagement of the host immune system to react...
Armin Wiegering et al.
Neoplasia (New York, N.Y.), 16(11), 972-981 (2014-11-27)
Clinical prognosis of metastasized colorectal carcinoma (CRC) is still not at desired levels and novel drugs are needed. Here, we focused on the multi-tyrosine kinase inhibitor E7080 (Lenvatinib) and assessed its therapeutic efficacy against human CRC cell lines in vitro...
Kristine Yee et al.
PloS one, 9(12), e113805-e113805 (2014-12-03)
Epicardial injection of heart-derived cell products is safe and effective post-myocardial infarction (MI), but clinically-translatable transendocardial injection has never been evaluated. We sought to assess the feasibility, safety and efficacy of percutaneous transendocardial injection of heart-derived cells in porcine chronic...
Chiara Agnoletto et al.
Oncotarget, 6(4), 2385-2396 (2014-12-30)
B-chronic lymphocytic leukemia (B-CLL) patients harboring p53 mutations are invariably refractory to therapies based on purine analogues and have limited treatment options and poor survival. Having recently demonstrated that the mitochondria-targeting small molecule sodium dichloroacetate (DCA) exhibits anti-leukemic activity in...
Tianfei Luo et al.
International journal of molecular sciences, 15(9), 15426-15442 (2014-09-27)
Lethal autophagy is a pathway leading to neuronal death caused by transient global ischemia. In this study, we examined the effect of Ginsenoside Rb1 (GRb1) on ischemia/reperfusion-induced autophagic neuronal death and investigated the role of PI3K/Akt. Ischemic neuronal death in...
Stephanie A Lamb et al.
Virology, 464-465, 134-145 (2014-07-30)
Although the production of single gene knockout viruses is a useful strategy to study viral gene functions, the redundancy of many host interactive genes within a complex viral genome can obscure their collective functions. In this study, a rabbit-specific poxvirus...
Colm E Nestor et al.
Genome biology, 16, 11-11 (2015-02-05)
The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the...
Jie Zhou et al.
Parasites & vectors, 8, 73-73 (2015-02-05)
Toxoplasma gondii, an obligate intracellular pathogen, has a strong affinity for the nervous system. TgCtwh3, a representative Chinese 1 Toxoplasma strain prevalent in China, has the polymorphic features of the effectors ROP16I/III with type I and GRA15II with type II...
Chan-Chan Shan et al.
Oncology letters, 9(4), 1549-1556 (2015-03-20)
Radiofrequency ablation (RFA) causes coagulative necrosis of tumor tissue and the production of local tumor protein debris. These fragments of tumor protein debris contain a large number of various antigens, which can stimulate a specific cellular immune response. In the...
Peter Tessarz et al.
Nature, 505(7484), 564-568 (2013-12-20)
Nucleosomes are decorated with numerous post-translational modifications capable of influencing many DNA processes. Here we describe a new class of histone modification, methylation of glutamine, occurring on yeast histone H2A at position 105 (Q105) and human H2A at Q104. We...
Georg Karpel-Massler et al.
Journal of neuro-oncology, 122(1), 21-33 (2014-12-20)
The poor prognosis of patients with glioblastoma fuels the search for more effective therapeutic compounds. We previously hypothesised that the neuroleptic olanzapine may enhance antineoplastic effects of temozolomide the standard chemotherapeutic agent used in this disease. This study tested this...
Sandra Burghoff et al.
BMC cancer, 14, 898-898 (2014-12-04)
Recent studies have suggested that adenosine generated by ecto-5'-nucleotidase (CD73) in the tumor microenvironment plays a major role in promoting tumor growth by suppressing the immune response and stimulating angiogenesis via A2A and A2B receptors. However, adenosine has also been...
F Cerrato et al.
British journal of pharmacology, 172(5), 1379-1394 (2014-11-15)
Treatment with selective oestrogen receptor modulators (SERMs) reduces low-density lipoprotein (LDL) cholesterol levels. We assessed the effect of tamoxifen, raloxifene and toremifene and their combinations with lovastatin on LDL receptor activity in lymphocytes from normolipidaemic and familial hypercholesterolaemic (FH) subjects...
M Olivan et al.
BioMed research international, 2015, 762178-762178 (2015-02-05)
Nowadays prostate cancer is the most common solid tumor in men from industrialized countries and the second leading cause of death. At the ages when PCa is usually diagnosed, mortality related to cardiovascular morbidity is high; therefore, men at risk...
Lumin Wei et al.
Pathogens and disease, 72(1), 45-54 (2014-04-23)
Regulatory T (Treg) cells play a critical role in Helicobacter pylori immune evasion and persistent infection. In addition to Treg cells, it is still unknown whether a newly defined B-cell subset, interleukin (IL)-10-producing B cells, is involved. Using a mouse...
Elizabeth E Crouch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(11), 4528-4539 (2015-03-20)
Adult neural stem cells reside in specialized niches. In the ventricular-subventricular zone (V-SVZ), quiescent neural stem cells (qNSCs) become activated (aNSCs), and generate transit amplifying cells (TACs), which give rise to neuroblasts that migrate to the olfactory bulb. The vasculature...
Shibai Yi et al.
PloS one, 9(5), e96336-e96336 (2014-05-08)
MicroRNAs are endogenous, small non-coding RNAs approximately 18-26 nucleotides in length that regulate target gene expression at the post-transcription level. Interferon-γ (IFN-γ) is a Th1 cytokine that is involved in both the innate and adaptive immune responses. We previously identified...
Gheyath K Nasrallah et al.
International journal of medical microbiology : IJMM, 304(5-6), 703-716 (2014-06-15)
L. pneumophila is an intracellular pathogen that replicates in a membrane-bound compartment known as the Legionella-containing vacuole (LCV). We previously observed that the polyamine spermidine, produced by host cells or added exogenously, enhances the intracellular growth of L. pneumophila. To...
Cody C Wyles et al.
Clinical orthopaedics and related research, 473(3), 1155-1164 (2014-09-05)
Corticosteroids are a common, short-term, local antiinflammatory and analgesic for treating patients with musculoskeletal disorders. Studies have shown the deleterious effects of corticosteroids on chondrocytes, suggesting a potentiation of degenerative joint disease. Mesenchymal stem cells (MSCs) are the direct progenitors...
Yuanhu Tian et al.
Chinese medical journal, 127(17), 3121-3126 (2014-09-06)
The possible role of substance P (SP) during wound healing has been the primary research focus in recent years, but its effect on the healing process after bile duct injury is little understood. This study aimed to investigate the effects...
Kirsten Neubert et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5830-5838 (2014-05-16)
Dendritic cells (DCs) are central modulators of immune responses and, therefore, interesting target cells for the induction of antitumor immune responses. Ag delivery to select DC subpopulations via targeting Abs to DC inhibitory receptor 2 (DCIR2, clone 33D1) or to...
Nour Mammari et al.
PloS one, 9(6), e98491-e98491 (2014-06-03)
The severity of toxoplasmic infection depends mainly on the immune status of the host, but also on the Toxoplasma gondii strains, which differ by their virulence profile. The relationship between the human host and T. gondii has not yet been...
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