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Jane Ru Choi et al.
Biochemical and biophysical research communications, 448(2), 218-224 (2014-05-03)
Adipose-derived stem cells (ASCs) have been found adapted to a specific niche with low oxygen tension (hypoxia) in the body. As an important component of this niche, oxygen tension has been known to play a critical role in the maintenance...
Alex M Lench et al.
Neuropharmacology, 83, 118-127 (2014-04-22)
Presynaptic NMDA receptors facilitate the release of glutamate at excitatory cortical synapses and are involved in regulation of synaptic dynamics and plasticity. At synapses in the entorhinal cortex these receptors are tonically activated and provide a positive feedback modulation of...
Peng Deng et al.
Biochemical and biophysical research communications, 458(1), 123-127 (2015-02-01)
Mammalian cysteine dioxygenase type 1 (CDO1) is an essential enzyme for taurine biosynthesis and the biodegradation of toxic cysteine. As previously suggested, Cdo1 may be a marker of liposarcoma progression and adipogenic differentiation, but the role of Cdo1 in adipogenesis...
Priyanka Prakash et al.
Biochemistry, 52(42), 7461-7469 (2013-09-27)
Prolonged usage of nonsteroidal anti-inflammatory drugs (NSAIDs) causes gastrointestinal injury. Bile acids and phospholipids have been shown to exasperate and attenuate NSAIDs' toxicity, respectively. However, the molecular mechanisms underlying these effects remain undetermined. We have investigated the molecular interactions in...
Benedetta Savino et al.
Cancer immunology research, 2(7), 679-689 (2014-05-23)
D6 is an atypical chemokine receptor acting as a decoy and scavenger for inflammatory CC chemokines expressed in lymphatic endothelial cells. Here, we report that D6 is expressed in Kaposi sarcoma (KS), a tumor ontogenetically related to the lymphatic endothelium....
Christina Maria Anna Pia Schuh et al.
Cytotherapy, 16(12), 1666-1678 (2014-09-02)
Adipose-derived progenitor/stem cells (ASCs) are discussed as a promising candidate for various tissue engineering approaches. However, its applicability for the clinic is still difficult due to intra- and inter-donor heterogeneity and limited life span in vitro, influencing differentiation capacity as...
Rajasekharan Somasundaram et al.
The Journal of investigative dermatology, 134(5), 1198-1199 (2014-04-16)
Patients with melanomas develop resistance to both conventional- and targeted-therapy drugs. Promising clinical responses with immune checkpoint reagents have resulted in renewed interest in the use of biological therapies, although only subsets of individuals are known to respond to these...
Elizabeth J Dial et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(3), G217-G222 (2014-12-06)
Indomethacin is a powerful analgesic nonsteroidal anti-inflammatory drug (NSAID), but is limited in use by its primary side effect to cause gastrointestinal bleeding and serious injury. One factor important for exacerbating NSAID injury is the presence of bile acids, which...
Tian Wang et al.
Toxicology mechanisms and methods, 24(8), 560-566 (2014-08-20)
Escin, a natural mixture of triterpenoid saponin isolated from the seed of the horse chestnut, is reported to have a potent antiulcer activity against ethanol-induced gastric mucosal lesions. This study investigated the possible mechanisms underlying the gastroprotective effect of escin...
Increased vulnerability of the aging stomach to NSAIDs.
Mario Guslandi
Digestive diseases and sciences, 58(5), 1443-1443 (2013-03-19)
Min Jung Lee et al.
European journal of pharmacology, 735, 115-122 (2014-04-29)
DA-6886, the gastrointestinal prokinetic benzamide derivative is a novel 5-HT4 receptor agonist being developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C). The purpose of this study was to characterize in vitro and in vivo pharmacological profile of DA-6886....
A L Rozza et al.
Chemico-biological interactions, 206(2), 272-278 (2013-10-15)
Based on ethnopharmacological indications that Mentha species may be used in the treatment of gastrointestinal diseases, this study aimed to characterize the gastroprotective mechanisms of menthol (ME), the major compound of the essential oil from species of the genus Mentha....
Zoltán S Zádori et al.
Brain research bulletin, 108, 51-59 (2014-08-31)
Agmatine (decarboxylated arginine) exerts cytoprotective action in several tissues, such as in the brain, heart or kidneys, but there is still controversy over the effects of agmatine on the gastric mucosa. The aim of the present study was to reveal...
Dongfei Liu et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(2), 268-278 (2013-06-13)
Nanoparticulate drug delivery systems offer remarkable opportunities for clinical treatment. However, there are several challenges when they are employed to deliver multiple cargos/payloads, particularly concerning the synchronous delivery of small molecular weight drugs and relatively larger peptides. Since porous silicon...
Evanthia Nikolopoulou et al.
Journal of lipid research, 55(12), 2479-2490 (2014-10-18)
Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation. AA caused the upregulation of fatty acid...
Jeffery J Auletta et al.
Stem cells (Dayton, Ohio), 33(2), 601-614 (2014-10-23)
We sought to define the effects and underlying mechanisms of human, marrow-derived mesenchymal stromal cells (hMSCs) on graft-versus-host disease (GvHD) and graft-versus-leukemia (GvL) activity. Irradiated B6D2F1 mice given C57BL/6 BM and splenic T cells and treated with hMSCs had reduced...
M Y Jeong et al.
International journal of obesity (2005), 39(3), 456-464 (2014-08-12)
To investigate the anti-obesity effect of Rubi Fructus (RF) extract using brown adipose tissue (BAT) and primary brown preadipocytes in vivo and in vitro. Male C57BL/6 J mice (n=5 per group) were fed a high-fat diet (HFD) for 10 weeks with...
James R F Hockley et al.
Pain, 155(10), 1962-1975 (2014-06-28)
Chronic visceral pain affects millions of individuals worldwide and remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral pain is strongly associated with inflammation and distension of the gut. Here we report that the voltage-gated sodium...
Dane Salazar et al.
Clinical orthopaedics and related research, 472(7), 2269-2275 (2014-04-09)
Heterotopic ossification is the most common extrinsic cause of elbow contracture and may lead to clinically important stiffness, and rarely, complete bony ankylosis. Surgery sometimes is performed to treat this problem, and published reports differ regarding the factors that are...
Karin Pfisterer et al.
The Journal of investigative dermatology, 135(1), 130-141 (2014-07-23)
The skin has to effectively combat external attacks, while maintaining skin immune homeostasis under steady-state conditions. To fulfill these challenging tasks, the dermis harbors a variety of heterogeneous cell types that are able to suppress T-cell proliferation similar to bone...
Rekha Jakhar et al.
International immunopharmacology, 22(2), 356-365 (2014-07-30)
Morin, a natural flavonoid that is the primary bioactive constituent of the family Moraceae, has been found to be associated with many therapeutic properties. In this study, we evaluated the immunomodulatory activities of increasing concentration of morin hydrate in vitro....
K C Sekar et al.
Journal of perinatology : official journal of the California Perinatal Association, 28 Suppl 1, S60-S62 (2008-06-18)
Persistent patent ductus arteriosus (PDA) in preterm infants can result in serious hemodynamic changes causing respiratory, gastrointestinal and renal morbidities if not treated within the first week of life. The treatment options available are a conservative approach, pharmacological treatment with...
JID VisualDx quiz: May 2014.
Tejas Patel et al.
The Journal of investigative dermatology, 134(5), 1-2 (2014-04-16)
Philip M Sobolesky et al.
PloS one, 9(9), e107530-e107530 (2014-09-10)
The transcription factor FOXO3 is a well-established tumor suppressor whose activity, stability, and localization are regulated by phosphorylation and acetylation. Previous data by our laboratory demonstrated amplified thromboxane-A2 signaling was associated with poor prognoses in bladder cancer patients and overexpression...
Waseem Kaialy et al.
International journal of pharmaceutics, 477(1-2), 282-293 (2014-12-03)
The purpose of this work was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced pharmaceutical performance without altering polymorphic form of xylitol. Xylitol was crystallized using antisolvent crystallization technique in the presence of various hydrophilic...
Anke Prudic et al.
Molecular pharmaceutics, 11(7), 2294-2304 (2014-05-30)
To improve the bioavailability of poorly soluble active pharmaceutical ingredients (APIs), these materials are often integrated into a polymer matrix that acts as a carrier. The resulting mixture is called a solid dispersion. In this work, the phase behaviors of...
Yang-peng Sun et al.
PloS one, 9(7), e101896-e101896 (2014-07-09)
Multipotent mesenchymal stem cells (MSCs) found in the synovial fluid (SFMSCs) of the tempromandibular joint (TMJ) remain poorly understood. During TMJ arthrocentesis, we discovered that synovial fluid collected from some patients with TMJ disorders contained not only SFMSCs but also...
Małgorzata Zygmunt et al.
Acta poloniae pharmaceutica, 70(5), 899-904 (2013-10-24)
This work aimed to investigate the effect of lipoic acid (LA) on sulfane sulfur (S*) level, infiltration of neutrophils and vascular permeability in a model of zymosan-induced peritonitis. The study showed that lipoic acid increased the sulfane sulfur level. Also...
Yong Sang Kim et al.
The American journal of sports medicine, 42(10), 2424-2434 (2014-08-12)
Marrow stimulation for the treatment of osteochondral lesions of the talus (OLTs) is controversial in patients with poor prognostic factors of OLTs. Currently, mesenchymal stem cells (MSCs) are expected to biologically augment the treatment of OLTs. To compare the clinical...
Ana S F Ribeiro et al.
Neurourology and urodynamics, 33(5), 558-565 (2013-07-13)
The current study investigates the role played by bradykinin (BK) receptors in the contractility to the pig bladder neck smooth muscle. Bladder neck strips were mounted in myographs for isometric force recordings and BK receptors expression was also determined by...
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