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PHR1279

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Toshio Inui et al.
Anticancer research, 33(7), 2917-2919 (2013-06-20)
Immunotherapy has become an attractive new strategy in the treatment of cancer. The laboratory and clinical study of cancer immunotherapy is rapidly advancing. However, in the clinical setting, the results of cancer immunotherapy are mixed. We therefore contend that cancer
Martin F Pera
Nature genetics, 45(12), 1412-1413 (2013-11-26)
The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or
Max Leenders et al.
International journal of cancer, 135(12), 2930-2939 (2014-04-29)
Carotenoids and vitamins A, C and E are possibly associated with a reduced colorectal cancer (CRC) risk through antioxidative properties. The association of prediagnostic plasma concentrations and dietary consumption of carotenoids and vitamins A, C and E with the risk
Yanling Wang et al.
Experimental cell research, 328(1), 143-155 (2014-08-08)
The physiological agonist norepinephrine promotes cell proliferation of brown preadipocytes during the process of tissue recruitment. In a primary culture system, cAMP mediates these adrenergic effects. In the present study, we demonstrated that, in contrast to other systems where the
Sodium Ascorbate
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 35(6), 4018-4018 (2018)
Maria Teresa Valenti et al.
Anticancer research, 34(4), 1617-1627 (2014-04-03)
Osteosarcoma originates from mesenchymal stem cells with impaired bone differentiation. In the present study we investigated the effect of ascorbic acid (AsA) on osteogenic differentiation and apoptosis of the MG-63 osteosarcoma cell line. We evaluated the expression of runt-related transcription
Vijayalakshmi Thamilselvan et al.
BJU international, 114(1), 140-150 (2014-01-28)
To test our hypothesis that physiological levels of urinary oxalate induce oxidative renal cell injury, as studies to date have shown that oxalate causes oxidative injury only at supra-physiological levels. To study the combined effect of α-tocopherol and ascorbic acid
Oana Ciofu et al.
The Cochrane database of systematic reviews, 8(8), CD007020-CD007020 (2014-08-08)
Airway infection leads to progressive damage of the lungs in cystic fibrosis and oxidative stress has been implicated in the etiology. Supplementation of antioxidant micronutrients (vitamin E, vitamin C, ß-carotene and selenium) or glutathione may therefore potentially help maintain an
Vishal Chugh et al.
Indian journal of biochemistry & biophysics, 50(2), 150-158 (2013-06-01)
The role of oxidative stress management was evaluated in two maize (Zea mays L.) genotypes - Parkash (drought-resistant) and Paras (drought-sensitive), subjected to drought stress during reproductive stage. Alterations in their antioxidant pools - glutathione (GSH) and ascorbic acid (AsA)
Yunes Panahi et al.
Clinical laboratory, 59(5-6), 579-587 (2013-07-20)
Smoking is among the established yet modifiable risk factors for cancers, cardiovascular diseases, and pulmonary disorders. Oxidative stress has been proposed as a key mechanism mediating the deleterious consequences of smoking. The present study evaluated the effect of supplementation with
Scott B Swarbreck et al.
The Journal of surgical research, 191(2), 432-440 (2014-05-13)
Sepsis, a potential risk associated with surgery, leads to a systemic inflammatory response including the plugging of capillary beds. This plugging may precipitate organ failure and subsequent death. We have shown that capillary plugging can be reversed rapidly within 1
Amit Kumar Mishra et al.
Indian journal of biochemistry & biophysics, 50(2), 139-149 (2013-06-01)
The effects of elevated CO2 and O3, singly and in combination were investigated on various physiological, biochemical and yield parameters of two locally grown wheat (Triticum aestivum L.) cultivars (HUW-37 and K-9107) in open top chambers (OTCs). Elevated CO2 stimulated
Sasmita Tripathy et al.
Journal of lipid research, 55(7), 1448-1464 (2014-05-13)
Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5
David L Choveaux et al.
Experimental parasitology, 148, 30-39 (2014-12-03)
Copper is an essential micronutrient for all living organisms as an important catalytic co-factor for key enzymes. In higher eukaryotes intracellular copper is distributed by copper metallochaperones. Copper chelators such as neocuproine and tetrathiomolybdate inhibit Plasmodium falciparum erythrocytic development, indicating
Jiangnan Zheng et al.
Journal of chromatography. A, 1358, 29-38 (2014-07-22)
Selective enrichment of glycopeptides from complex biological samples is essential for MS-based glycoproteomics, but challenges still remain. In this work, glucose-functionalized magnetic mesoporous nanoparticles (MMNs), which hold the attractive features of well-defined core/shell structure, high specific surface area (324m(2)/g), narrow
K E Hwang et al.
Poultry science, 92(12), 3244-3250 (2013-11-16)
We investigated the inhibition of lipid oxidation of raw chicken patties by the antioxidants ascorbic acid (Aa), ganghwayakssuk extracts (GE), and their combination (Aa + GE). All antioxidant combinations were effective at delaying lipid oxidation compared with the control or
Ulrich Moser
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 327-332 (2013-06-26)
Deficiencies of essential nutrients have been responsible for many epidemic outbreaks of deficiency diseases in the past. Large observational studies point at possible links between nutrition and chronic diseases. Low intake of antioxidant vitamins e. g. have been correlated to
Gábor Bánhegyi et al.
Biochimica et biophysica acta, 1843(9), 1909-1916 (2014-06-08)
Beyond its general role as antioxidant, specific functions of ascorbate are compartmentalized within the eukaryotic cell. The list of organelle-specific functions of ascorbate has been recently expanded with the epigenetic role exerted as a cofactor for DNA and histone demethylases
Zhi Jian Wang et al.
The Canadian journal of cardiology, 30(1), 96-101 (2013-12-25)
This small study has determined the effect of vitamin C on myocardial reperfusion in patients undergoing elective percutaneous coronary intervention (PCI). This study was to explore whether antioxidant vitamin C infusion before the procedure is able to affect the incidence
S Yaich et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 25(1), 113-116 (2014-01-18)
Renal oxalate deposition can be seen with primary hyperoxaluria, malabsorptive states, ethylene glycol toxicity and, rarely, with excessive vitamin C ingestion. We report a case of secondary hyperoxaluria in which the diagnosis was not considered initially because there was no
Pedro Cisternas et al.
Journal of neurochemistry, 129(4), 663-671 (2014-01-28)
Vitamin C is an essential factor for neuronal function and survival, existing in two redox states, ascorbic acid (AA), and its oxidized form, dehydroascorbic acid (DHA). Here, we show uptake of both AA and DHA by primary cultures of rat
Jianjing Tong et al.
Archives of biochemistry and biophysics, 554, 1-5 (2014-05-02)
Cytoglobin (Cygb) plays a role in regulating vasodilation in response to changes in local oxygen concentration by altering the rate of nitric oxide (NO) metabolism. Because the reduction of Cygb(Fe(3+)) by a reductant is the control step for Cygb-mediated NO
Keita Takahashi et al.
Biochimica et biophysica acta, 1840(7), 2289-2298 (2014-04-08)
We sought to elucidate the effect of an ascorbic acid (AA) deficiency on gene expression, because the water soluble antioxidant AA is an important bioactive substance in vivo. We performed microarray analyses of the transcriptome in the liver from senescence
Eman Al-Sayed et al.
Pharmaceutical biology, 52(12), 1581-1590 (2014-09-23)
Liver disease is a serious problem. Polyphenolic compounds have marked antioxidant effect and can prevent the liver damage caused by free radicals. In vitro studies have revealed the strong antioxidant activity of an ellagitannin-rich plant, namely, Melaleuca styphelioides Sm. (Myrtaceae).
Teresa M Curto et al.
BJU international, 115(1), 134-142 (2014-01-30)
To examine the association between long-term dietary vitamin C intake and recent use of vitamin C supplements with the progression and severity of lower urinary tract symptoms (LUTS). Baseline and 5-year follow-up interviews were completed by 2825 black, Hispanic or
Yoon-Hyeong Choi et al.
The American journal of clinical nutrition, 99(1), 148-155 (2013-11-08)
The protective effects of antioxidant vitamins on hearing loss are well established in animal studies but in few human studies. Recent animal studies suggest that magnesium intake along with antioxidants may act in synergy to prevent hearing loss. We examined
Choon Young Lee et al.
Biochimie, 111, 125-134 (2015-02-11)
Numerous studies have reported the beneficial effects of antioxidants in human diseases. Among their biological effects, a majority of antioxidants scavenge reactive radicals in the body, thereby reducing oxidative stress that is associated with the pathogenesis of many diseases. Antioxidant
Junitsu Ito et al.
Life sciences, 95(1), 1-8 (2013-12-21)
Aldehyde reductase (AKR1A), a member of the aldo-keto reductase superfamily, is highly expressed in the liver and is involved in both the detoxification of carbonyl compounds and ascorbic acid biosynthesis. By comparison with wild-type mice, Akr1a-knockout (Akr1a(-/-)) mice and human
Mohamed M Darweish et al.
The Journal of pharmacy and pharmacology, 66(7), 1032-1045 (2014-03-13)
Epigallocatechin-gallate (EGCG) claims a plethora of health benefits including protection against neoplastic diseases. Meanwhile, heparan-sulfate proteoglycans (HSPGs) have defensive role against tumour cell invasion. Therefore, the chemopreventive and hepatoprotective effects of EGCG were studied in hepatocellular carcinoma (HCC) in vivo
Uwe Gröber et al.
Medizinische Monatsschrift fur Pharmazeuten, 36(4), 133-143 (2013-05-10)
Many patients receiving cancer treatment use micronutrient supplements, with the intention to complement their cancer treatment, or help them cope with the therapy- and disease-associated side-effects. Up to 90% of the cancer patients are adding antioxidants without the knowledge of
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