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Elham Moniri et al.
Journal of AOAC International, 98(1), 206-212 (2015-04-11)
A simple ion imprinted amino-functionalized sorbent was synthesized by coupling activated carbon with iminodiacetic acid, a functional compound for metal chelating, through cyanoric chloride spacer. The resulting sorbent has been characterized using FTIR spectroscopy, elemental analysis, and thermogravimetric analysis and...
Homayon Ahmad Panahi et al.
Journal of chromatography. A, 1345, 37-42 (2014-05-02)
In this research, a novel method is reported for the surface grafting of N-isopropylacrylamide as a thermosensitive agent and 1-(N,N-bis-carboxymethyl)amino-3-allylglycerol with an affinity toward fluvoxamine onto magnetic nano-particles modified by 3-mercaptopropyltrimethoxysilane. The grafted nano-particles were characterized by Fourier transform infrared...
P Láng et al.
Journal of pharmaceutical and biomedical analysis, 102, 229-235 (2014-10-12)
The effects of solvents, temperature and humidity on the stability of a former drug candidate obtained from Sanofi (Hungary) were examined by a slurry equilibration method, variable temperature and humidity X-ray powder diffractometry (VT/VH-XRPD) and differential scanning calorimetry (DSC). The...
Tatsuya Nishiyama et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17152-17157 (2014-11-21)
Organocatalysts, low-molecular mass organic compounds composed of nonmetallic elements, are often used in organic synthesis, but there have been no reports of organocatalysts of biological origin that function in vivo. Here, we report that actinorhodin (ACT), a natural product derived...
Gui-Peng Tian et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 70(12), 1934-1940 (2014-12-19)
1,4-Dioxane is a probable human carcinogenic and refractory substance that is widely detected in aquatic environments. Traditional wastewater treatment processes, including activated sludge, cannot remove 1,4-dioxane. Removing 1,4-dioxane with a reaction kinetic constant of 0.32 L/(mol·s) by using ozone, a...
Andrey G Pradko et al.
Steroids, 97, 78-86 (2014-09-10)
Starting from (22R,23R)-2α,3α,22,23,26-pentahydroxy-5α-cholestan-6-one 26-hemisuccinate, conjugates of 28-norcastasterone with horse radish peroxidase and bovine serum albumin were prepared. The latter conjugate was injected into rabbits; produced polyclonal antibodies were used to quantitate 6-keto-brassinosteroids. The newly developed analytical system was used in...
Da Huang et al.
Biomaterials, 52, 417-425 (2015-03-31)
Bone tuberculosis (TB) is one of the most common extrapulmonary TB. Effective integration of chemotherapy and bone regeneration is an optimal solution for bone TB therapy. Herein, we produce a composite scaffold drug delivery system fabricated with an isoniazid conjugated...
Marzieh Rashidipour et al.
Journal of AOAC International, 97(4), 1109-1113 (2014-08-26)
Matrix solid-phase dispersion (MSPD) methodology as a quick and easy extraction method has been developed to extract oleuropein from Olea europaea leaves. This method has been compared with conventional maceration and Soxhlet extraction (SOXE) methods. Variables affecting MSPD, such as...
Junichi Kasuya et al.
Journal of tissue engineering and regenerative medicine, 9(3), 247-256 (2012-10-23)
In liver sinusoids, hepatic stellate cells (HSCs) locate the outer surface of microvessels to form a functional unit with endothelia and hepatocytes. To reconstruct functional liver tissue in vitro, formation of the HSC-incorporated sinusoidal structure is essential. We previously demonstrated...
Katsuyuki Yamanaka et al.
Dental materials journal, 34(1), 78-85 (2015-03-10)
An appropriate physical support provided by scaffolds creates a supportive environment that directs proliferation and differentiation of stem cells. However, it is difficult to homogenously inoculate stem cells into the inner part of scaffolds at high cell densities. In this...
Małgorzata Sztanke et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 68, 114-126 (2014-12-22)
The chromatographic behaviour and significant lipophilicity/hydrophobicity indices (log k(w), S, φ(0)) are presented for 21 biologically active fused 1,2,4-triazinones based on the linear relationship: log k = log k(w)-Sφ established for the retention on LC-18 HPLC column, using as mobile...
John R Horsley et al.
Journal of the American Chemical Society, 136(35), 12479-12488 (2014-08-15)
Electrochemical studies are reported on a series of peptides constrained into either a 310-helix (1-6) or β-strand (7-9) conformation, with variable numbers of electron rich alkene containing side chains. Peptides (1 and 2) and (7 and 8) are further constrained...
Establishment of a knowledge base for prescreening residual solvents in pharmaceuticals
Qin L, et al.
Chromatographia, 59(7-8), 475-480 (2004)
Suha Altarawneh et al.
Environmental science & technology, 49(7), 4715-4723 (2015-03-03)
Benzimidazole-linked polymers (BILPs) are emerging candidates for gas storage and separation applications; however, their current synthetic methods offer limited control over textural properties which are vital for their multifaceted use. In this study, we investigate the impact of acid-catalyzed formation...
Noriko Harada et al.
Biomaterials, 35(27), 7800-7810 (2014-06-24)
Mesenchymal stem cells (MSCs) are multipotent cells capable of proliferating and differentiating into several lineages. In regenerative medicine, their potential as a resource for tissue-replacement therapy is receiving much attention. However, transplanting MSCs to repair larger bone defects in animal...
Diana Guzman-Villanueva et al.
International journal of pharmaceutics, 473(1-2), 579-590 (2014-07-27)
The RNA interference (RNAi) constitutes a conservative mechanism in eukaryotic cells that induces silencing of target genes. In mammalians, the RNAi is triggered by siRNA (small interfering RNA) molecules. Due to its potential in silencing specific genes, the siRNA has...
Jatinder Kumar et al.
PloS one, 9(6), e98696-e98696 (2014-06-18)
Fourteen saxicolous lichens from trans-Himalayan Ladakh region were identified by morpho-anatomical and chemical characteristics. The n-hexane, methanol and water extracts of the lichens were evaluated for their antioxidant capacities. The lichen extracts showing high antioxidant capacities and rich phenolic content...
Toshiki Matsui et al.
Acta biomaterialia, 13, 32-41 (2014-12-03)
Polylactic acid (PLA) is a candidate material to prepare scaffolds for 3-D tissue regeneration. However, cells do not adhere or proliferate well on the surface of PLA because it is hydrophobic. We report a simple and rapid method for inducing...
Màrius Tarrés et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(48), 15808-15815 (2014-10-09)
This paper presents a novel and unique feature of metallacarboranes, consisting of the linkage of this redox electro-active site to a stretchable polymer. This is based on polyTHF, a known and applied material. This hybrid material has the two ends...
Ayşegül Doğan et al.
Materials science & engineering. C, Materials for biological applications, 44, 246-253 (2014-10-05)
Scaffold-based bone defect reconstructions still face many challenges due to their inadequate osteoinductive and osteoconductive properties. Various biocompatible and biodegradable scaffolds, combined with proper cell type and biochemical signal molecules, have attracted significant interest in hard tissue engineering approaches. In...
Jonathan B Grimm et al.
Nature methods, 12(3), 244-250 (2015-01-20)
Specific labeling of biomolecules with bright fluorophores is the keystone of fluorescence microscopy. Genetically encoded self-labeling tag proteins can be coupled to synthetic dyes inside living cells, resulting in brighter reporters than fluorescent proteins. Intracellular labeling using these techniques requires...
Shahul Hameed P et al.
Nature communications, 6, 6715-6715 (2015-04-01)
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds, the triaminopyrimidines (TAPs), which emerged...
Joshua J Pacheco et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8363-8367 (2014-06-10)
Terephthalic acid (PTA), a monomer in the synthesis of polyethylene terephthalate (PET), is obtained by the oxidation of petroleum-derived p-xylene. There is significant interest in the synthesis of renewable, biomass-derived PTA. Here, routes to PTA starting from oxidized products of...
Niels M B Smeets et al.
Acta biomaterialia, 10(10), 4143-4155 (2014-06-10)
The potential of poly(oligoethylene glycol methacrylate) (POEGMA) hydrogels with varying thermosensitivities as soft materials for biomedical applications is demonstrated. Hydrogels are prepared from hydrazide and aldehyde functionalized POEGMA precursors, yielding POEGMA hydrogels with a volume phase transition temperature (VPTT) below...
Árpád Könczöl et al.
Journal of ethnopharmacology, 155(1), 776-784 (2014-06-20)
Oxybaphus nyctagineus (Michx.) Sweet has traditionally been used by several Native American tribes predominantly as a topical anti-inflammatory and analgesic agent. To evaluate the antioxidant, analgesic and anti-inflammatory activity of the extracts prepared from the aerial parts of Oxybaphus nyctagineus...
S K Jain et al.
Indian journal of pharmaceutical sciences, 76(5), 415-422 (2014-11-27)
Curcumin-diclofenac conjugate as been synthesized by esterification of phenolic group of curcumin with the acid moiety of diclofenac, and characterized by mass spectrometry, NMR, FTIR, DSC, thermogravimetric analysis and X-ray diffraction analysis. The relative solubility of curcumin-diclofenac conjugate, curcumin and...
A capillary gas chromatographic procedure for the analysis of nine common residual solvents in water-insoluble bulk pharmaceuticals
Li QC, et al.
Journal of Chromatographic Science, 36(3), 119-124 (1998)
Simultaneous determination of 22 volatile organic compounds, methyl-tert-butyl ether, 1, 4-dioxane, 2-methylisoborneol and geosmin in water by headspace solid phase microextraction-gas chromatography-mass spectrometry
Nakamura S and Daishima S
Analytica Chimica Acta, 548(1-2), 79-85 (2005)
Lidia Zapała et al.
Journal of solution chemistry, 43, 1167-1183 (2014-07-30)
The acid-base chemistry of three zwitterionic compounds, namely anthranilic (2-aminobenzoic acid)
Christopher C Waller et al.
Steroids, 92, 74-80 (2014-10-07)
Steroid sulfates are a major class of steroid metabolite that are of growing importance in fields such as anti-doping analysis, the detection of residues in agricultural produce or medicine. Despite this, many steroid sulfate reference materials may have limited or...
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