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Boutheina Cherif et al.
Toxicology, 416, 44-53 (2019-02-06)
Imipenem is a beta-Lactam antibiotic characterized by a broad spectrum of activity. It is prescribed to treat severe infections. Our goal is to investigate toxicity induced in male rat reproductive systems following exposure to this drug (15, 50 or 100 mg/kg)
Björn Berglund et al.
International journal of antimicrobial agents, 51(5), 789-793 (2017-11-29)
Resistance among Klebsiella pneumoniae to the last-resort antibiotics carbapenems and colistin is increasing worldwide. In this study, whole-genome sequencing was used to determine the colistin resistance mechanisms in clinical isolates of carbapenem- and colistin-resistant K. pneumoniae from Vietnam. Alterations in
Efthymia Protonotariou et al.
International journal of antimicrobial agents, 56(2), 106060-106060 (2020-06-24)
Carbapenem-resistant Enterobacterales have become a major public-health issue worldwide. Here we report an outbreak caused by a clonal multidrug-resistant Proteus mirabilis strain producing VIM-4 metallo-β-lactamase (MBL) and TEM-2 β-lactamase in a Greek tertiary-care hospital. From July 2015 to February 2016
In Vitro Activity of Cefepime-Zidebactam, Ceftazidime-Avibactam, and Other Comparators against Clinical Isolates of Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii: Results from China Antimicrobial Surveillance Network (CHINET) in 2018.
Yang, et al.
Antimicrobial Agents and Chemotherapy, 65 (2021)
Flor Y Ramírez-Castillo et al.
Annals of clinical microbiology and antimicrobials, 17(1), 34-34 (2018-07-26)
Uropathogenic Escherichia coli (UPEC) are one of the main bacteria causing urinary tract infections (UTIs). The rates of UPEC with high resistance towards antibiotics and multidrug-resistant bacteria have increased dramatically in recent years and could difficult the treatment. The aim
Branka Bedenić et al.
Acta clinica Croatica, 58(1), 113-118 (2019-08-01)
Phenotypic detection of metallo-β-lactamases (MBLs) in Acinetobacter (A.) baumannii is a serious challenge to clinical microbiologists. MBLs are inhibited by metal chelators such as ethylenediaminetetraacetic acid) (EDTA). Production of MBLs cannot be recognized based on resistance phenotype. Therefore, phenotypic tests
Andrea Sass et al.
Antimicrobial agents and chemotherapy, 62(5) (2018-02-15)
The nonmevalonate pathway is the sole pathway for isoprenoid biosynthesis in Burkholderia cenocepacia and is possibly a novel target for the development of antibacterial chemotherapy. The goals of the present study were to evaluate the essentiality of dxr, the second
Bernhard Schauer et al.
Animals : an open access journal from MDPI, 11(2) (2021-01-28)
The present study describes an outbreak of Pseudomonas (P.) aeruginosa mastitis in a 20-cow dairy herd where throughout genotyping of isolates reusable udder towels were identified as the source of infection. Sampling of cows during three herd surveys and bacteriological
Ying Li et al.
Journal of medical microbiology, 67(3), 273-281 (2018-02-21)
Persister cells, a subpopulation of tolerant cells within the bacterial culture, are commonly thought to be responsible for antibiotic therapy failure and infection recurrence. Klebsiella pneumoniae is a notorious human pathogen for its increasing resistance to antibiotics and wide involvement
Emilie Racine et al.
Antimicrobial agents and chemotherapy, 62(9) (2018-07-11)
Antibacterial activity screening of a collection of Xenorhabdus strains led to the discovery of the odilorhabdins, a new antibiotic class with broad-spectrum activity against Gram-positive and Gram-negative pathogens. Odilorhabdins inhibit bacterial translation by a new mechanism of action on ribosomes.
Lili Jiang et al.
Journal of global antimicrobial resistance, 17, 84-89 (2018-11-18)
Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a worldwide issue. This study aimed to characterise the epidemiology and genetic relationships of A. baumannii isolates in Guangdong Province, China. CRAB isolates were collected from five municipal hospitals from June-December 2017. The 16S-23S
Zichen Yang et al.
Archives of virology, 164(6), 1527-1533 (2019-03-23)
A novel virulent bacteriophage, φAbp2, infecting multidrug-resistant (MDR) Acinetobacter baumannii was isolated from the wastewater of a sewage management centre at Southwest Hospital, China. Transmission electron microscopy and phylogenetic analysis revealed that φAbp2 belongs to the subfamily Peduovirinae. A one-step
Yingbo Shen et al.
Environment international, 130, 104708-104708 (2019-06-16)
Since its discovery in 2015, the mobile colistin resistance gene mcr-1 has been reported in bacteria from >50 countries. Although aquaculture-associated bacteria may act as a significant reservoir for colistin resistance, systematic investigations of mcr-1 in the aquaculture supply chain
David Ortega-Paredes et al.
Journal of water and health, 18(1), 67-76 (2020-03-05)
Urban river pollution by multidrug-resistant (MDR) bacteria constitutes an important public health concern. Epidemiologically important strains of MDR Escherichia coli transmissible at the human-animal-environment interfaces are especially worrying. Quantifying and characterizing MDR E. coli at a molecular level is thus
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Scott J Denstaedt et al.
Journal of immunology (Baltimore, Md. : 1950), 200(9), 3188-3200 (2018-03-23)
Sepsis commonly results in acute and chronic brain dysfunction, which dramatically increases the morbidity associated with this common disease. Chronic brain dysfunction in animal models of sepsis survival is linked to persistent neuroinflammation and expression of multiple cytokines. However, we
Raquel Parra-Millán et al.
The Journal of antimicrobial chemotherapy, 73(12), 3405-3412 (2018-09-07)
Preventing bacterial contact with host cells can provide an additional approach to tackling MDR Acinetobacter baumannii. Recently, we identified AOA-2 as a potential blocker of A. baumannii outer membrane protein A without presenting bactericidal activity. Here, we aimed to study
Hamid Solgi et al.
Microbial pathogenesis, 149, 104507-104507 (2020-09-21)
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) has been increasingly reported and is now recognized as a public health concern. The aim of this study was to investigate the molecular epidemiology of CR-hvKp strains that were isolated from an Iranian hospital. A
Rabab R Makharita et al.
Infection and drug resistance, 13, 3991-4002 (2020-11-13)
Carbapenems are considered the most efficient antibiotic used in the treatment of nosocomial infections. Carbapenem-resistant Gram-negative rods are becoming a serious hazard in hospitals threatening public health. The aim of the current study was to investigate the prevalence of carbapenem-resistant
Kunling Sun et al.
Annals of laboratory medicine, 37(4), 305-312 (2017-04-27)
We compared the performance of the modified Hodge test (MHT), Triton Hodge test (THT), Carba NP test (CNPt), simplified Carba NP test (CNPt-direct), blue-Carba NP test (BCT), and carbapenem inactivation method (CIM) for rapid and accurate carbapenemase detection. The methods
Kamonwan Lunha et al.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 85, 104577-104577 (2020-10-03)
The global emergence of colistin resistance in carbapenem-resistant Acinetobacter baumannii (CRAB) clinical isolates is a serious public health concern. We therefore aimed to investigate colistin resistance mechanisms in 5 colistin-resistant (COL-R) CRAB isolates collected from Thai patients in 2016 by
Carole Ayoub Moubareck et al.
International journal of antimicrobial agents, 52(1), 90-95 (2018-03-14)
Few studies have addressed the molecular epidemiology of carbapenem-resistant Enterobacteriaceae (CRE) isolates in the Arabian Peninsula, and such investigations have been missing from Dubai, a major economical, tourism and medical centre of the region. The antibiotic susceptibility, the carbapenemase type
Tomasz Bogiel et al.
Polish journal of microbiology, 66(4), 427-431 (2018-01-10)
Pseudomonas aeruginosa rods are one of the most commonly isolated microorganisms from clinical specimens, usually responsible for nosocomial infections. Antibiotic-resistant P. aeruginosa strains may present reduced expression of virulence factors. This fact may be caused by appropriate genome management to
Mouna Hamel et al.
International journal of antimicrobial agents, 55(4), 105930-105930 (2020-03-05)
In Greece, the spread of carbapenem-resistant Enterobacteriaceae in humans has led to the reintroduction of colistin as a therapeutic agent. Unfortunately, colistin resistance with different mechanisms has emerged. The present work aims to determine the prevalence of carbapenem and colistin
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Fabrice Compain et al.
Antimicrobial agents and chemotherapy, 62(9) (2018-06-27)
Single amino acid substitutions in the Ω loop of KPC β-lactamases are known to lead to resistance to the ceftazidime-avibactam combination. Here, we investigate this mechanism of resistance in CTX-M enzymes, which are the most widely spread extended-spectrum β-lactamases worldwide.
Alessandro Bidossi et al.
Frontiers in microbiology, 11, 1368-1368 (2020-07-28)
Recent in vitro studies reported the exceptional ability of some bacterial species to form biofilm-like aggregates in human and animal synovial fluids (SF), but evidences from infected clinical samples are still lacking. In this study, we investigated whether this bacterial
Islam M Ghazi et al.
Clinical therapeutics, 42(3), 475-485 (2020-03-07)
Imipenem/cilastatin/relebactam has shown efficacy in complicated intra-abdominal and urinary tract infections in the RESTORE IMI-1 study, and it was recently approved by the US Food and Drug Administration. A press release announced that another Phase III study (RESTORE IMI-2) in
Zhe Li et al.
Clinical therapeutics, 42(8), 1564-1577 (2020-08-04)
This study explores factors that affect behavior in critically ill patients receiving continuous renal replacement therapy (CRRT) with imipenem and provides dosing regimens for these patients. A prospective, open-label study was conducted in a clinical setting. Both blood and effluent
James A Karlowsky et al.
Antimicrobial agents and chemotherapy, 62(7) (2018-05-16)
Relebactam is a non-β-lactam, bicyclic diazabicyclooctane β-lactamase inhibitor of class A and class C β-lactamases, including Klebsiella pneumoniae carbapenemases (KPCs). It is in phase 3 clinical development in combination with imipenem/cilastatin. The in vitro activities of imipenem-relebactam, imipenem, and comparators
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