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Takanobu Hara et al.
Regenerative therapy, 14, 79-86 (2020-01-29)
Cell sheets consisting of adipose-derived stem cells (ADSCs) have been reported to be effective for wound healing. We conducted this study to clarify the efficacy of ADSC sheets in wound healing at the duct-to-duct biliary anastomotic site in pigs. Eleven
Martha I Betancur et al.
ACS biomaterials science & engineering, 3(3), 420-430 (2017-03-13)
There are currently no effective treatments for moderate-to-severe traumatic brain injuries (TBIs). The paracrine functions of undifferentiated neural stem cells (NSCs) are believed to play a significant role in stimulating the repair and regeneration of injured brain tissue. We therefore
Imran Ullah et al.
Scientific reports, 8(1), 15795-15795 (2018-10-27)
Previously, we reported the successful regeneration of injured peripheral nerves using human dental pulp stem cells (DPSCs) or differentiated neuronal cells from DPSCs (DF-DPSCs) in a rat model. Here, we attempted to evaluate oxidative stress and supraspinal neuro-inflammation in rat
Zheng Fu et al.
Cell research, 31(6), 631-648 (2021-03-31)
RNAi therapy has undergone two stages of development, direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands; both have not solved the problem of efficient in vivo siRNA delivery. Here, we present a proof-of-principle strategy that
Jun Tian et al.
Autophagy, 17(9), 2586-2603 (2020-09-11)
Mesenchymal stem cell transplantation (MSCT) has been applied to treat a variety of autoimmune and inflammatory diseases. Psychosocial stress can aggravate disease progression in chronic inflammatory patients. Whether psychological stress affects MSCT is largely unknown. In this study we show
Yu Jun Tan et al.
Scientific reports, 6, 39140-39140 (2016-12-15)
A hybrid 3D bioprinting approach using porous microscaffolds and extrusion-based printing method is presented. Bioink constitutes of cell-laden poly(D,L-lactic-co-glycolic acid) (PLGA) porous microspheres with thin encapsulation of agarose-collagen composite hydrogel (AC hydrogel). Highly porous microspheres enable cells to adhere and
Xiaoxuan Zhuang et al.
Frontiers in immunology, 10, 2879-2879 (2020-01-11)
The anti-leukemia activity of NK cells helps prevent relapse during hematopoietic stem cell transplantation (HSCT) in leukemia patients. However, the factors that determine the sensitivity or resistance of leukemia cells in the context of NK-mediated cytotoxicity are not well-established. Here
Yukyeong Lee et al.
Frontiers in cellular neuroscience, 12, 198-198 (2018-08-10)
Oligodendrocyte progenitor cells (OPCs) are attracting attention as the ideal cell therapy for spinal cord injury (SCI). Recently, advanced reprogramming and differentiation techniques have made it possible to generate therapeutic cells for treating SCI. In the present study, we used
Luer Bao et al.
Journal of cardiac failure, 23(5), 403-415 (2017-03-13)
Stem cell transplantation offers a promising treatment for heart failure. Recent studies show that both c-kit positive cardiac stem cells (CSCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) are good candidates for stem cell therapy to treat heart failure; however
V Du et al.
Integrative biology : quantitative biosciences from nano to macro, 7(2), 170-177 (2015-01-13)
A current challenge for tissue engineering while restoring the function of diseased or damaged tissue is to customize the tissue according to the target area. Scaffold-free approaches usually yield spheroid shapes with the risk of necrosis at the center due
Naotsugu Haraguchi et al.
The Journal of clinical investigation, 120(9), 3326-3339 (2010-08-11)
Cancer stem cells (CSCs) are generally dormant or slowly cycling tumor cells that have the ability to reconstitute tumors. They are thought to be involved in tumor resistance to chemo/radiation therapy and tumor relapse and progression. However, neither their existence
Yasuhiro Maruya et al.
Regenerative therapy, 7, 24-33 (2017-07-17)
Adipose-derived stem cells (ASCs) are capable of multiple differentiation pathways, imparting immunomodulatory effects, and secreting factors that are important for wound healing. These characteristics can be exploited to decrease the incidence of anastomotic leakage. In order to delay local wound
Ofra Ben Menachem-Zidon et al.
PloS one, 14(6), e0218081-e0218081 (2019-06-14)
The beneficial effect of mesenchymal stem cells (MSCs) on wound healing is mostly attributed to a trophic effect that promotes angiogenesis. Whether MSCs can contribute to the formation of new blood vessels by direct differentiation is still controversial. Pelvic floor
Takuji Torimura et al.
Cancer science, 103(3), 542-548 (2011-12-14)
The drug delivery system to tumors is a critical factor in upregulating the effect of anticancer drugs and reducing adverse events. Recent studies indicated selective migration of bone marrow-derived endothelial progenitor cells (EPC) into tumor tissues. Cytosine deaminase (CD) transforms
S K Lee et al.
Thrombosis and haemostasis, 112(3), 580-588 (2014-07-11)
Tumour necrosis factor-α (TNF-α) is upregulated in many inflammatory diseases and is also a potent agent for microparticle (MP) generation. Here, we describe an essential role of TNF-α in the production of endothelial cell-derived microparticles (EMPs) in vivo and the
Qingju Li et al.
Science translational medicine, 13(584) (2021-03-12)
Stem cell-derived small extracellular vesicles (sEVs) promote angiogenesis after myocardial infarction (MI). However, the components of sEVs that contribute to these effects and the safety and efficiency of engineered sEV treatment for MI remain unresolved. Here, we observed improved cardiac
Rusty Kelley et al.
American journal of physiology. Renal physiology, 299(5), F1026-F1039 (2010-09-10)
Established chronic kidney disease (CKD) may be identified by severely impaired renal filtration that ultimately leads to the need for dialysis or kidney transplant. Dialysis addresses only some of the sequelae of CKD, and a significant gap persists between patients
Vien Khach Lai et al.
Journal of molecular medicine (Berlin, Germany), 90(6), 719-730 (2012-01-13)
We previously reported that mesenchymal stem cells (MSC) co-expressing Akt and angiopoietin-1 (Ang-1) preserved infarcted heart function via angiomyogenesis. The present study determined the mechanism of co-overexpression of Akt and Ang-1 in promoting endothelial commitment of MSC. The cells were
John D Belcher et al.
PloS one, 10(2), e0117772-e0117772 (2015-02-24)
2-Fluorofucose (2FF) blocks the fucosylation and the tethering of sialyl-Lewisx tetrasaccharide and structural variants on leukocytes and red blood cells to P- and E-selectins on activated endothelial cell surfaces. Because P- and E-selectin are required for vaso-occlusion in murine sickle
Mallika Ghosh et al.
Immunology, 142(4), 636-647 (2014-03-19)
CD13/Aminopeptidase N is a transmembrane metalloproteinase that is expressed in many tissues where it regulates various cellular functions. In inflammation, CD13 is expressed on myeloid cells, is up-regulated on endothelial cells at sites of inflammation and mediates monocyte/endothelial adhesion by
Sonia M Najjar et al.
American journal of physiology. Endocrinology and metabolism, 305(4), E519-E529 (2013-06-27)
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1-/-) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence
Rebecca L Matz et al.
Molecular pharmaceutics, 10(4), 1306-1317 (2013-03-06)
We sought to evaluate the relationship between cell division and protein expression when using commercial poly(ethylenimine) (PEI)-based polyplexes. The membrane dye PKH26 was used to assess cell division, and cyan fluorescent protein (CFP) was used to monitor protein expression. When
Hebah A Sindi et al.
Nature communications, 11(1), 1185-1185 (2020-03-07)
Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH. Here, we show that KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324-5p
Reciprocal repression between P53 and TCTP
Amson, R., et al.
Nature, 18, 91-99 (2012)
Ji-Young Kang et al.
Clinical science (London, England : 1979), 134(8), 985-999 (2020-04-17)
Small extracellular vesicles (sEVs) as natural membranous vesicles are on the frontiers of nanomedical research, due to their ability to deliver therapeutic molecules such as microRNAs (miRNAs). The miRNA-21 (miR-21) is thought to be involved in the initiation and development
Jess Morhayim et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 274-285 (2014-11-02)
Beyond forming bone, osteoblasts play pivotal roles in various biologic processes, including hematopoiesis and bone metastasis. Extracellular vesicles (EVs) have been implicated in intercellular communication via transfer of proteins and nucleic acids between cells. We focused on the proteomic characterization
Tracking antigen-driven responses by flow cytometry: Monitoring proliferation by dye dilution
Paul KW, et al.
Cytometry. Part A : the Journal of the International Society For Analytical Cytology, 73(11), 1019-1034 (2008)
Anjali P Kusumbe et al.
Cancer research, 69(24), 9245-9253 (2009-12-03)
Tumor formation involves substantial cell division and genetic instability, but the relationship between quiescent cancer stem cells (CSC) and dividing progenitors in these events is poorly understood. Likewise, the implication of aneuploid cells in solid tumors is uncertain. CSCs are
Eitaro Taniguchi et al.
Gastroenterology, 130(2), 521-531 (2006-02-14)
Neovascularization, which is vital to the healing of injured tissues, recently has been found to include both angiogenesis, which involves in mature endothelial cells, and vasculogenesis, involving endothelial progenitor cells. The aim of this study was to clarify the possible
Hepatocyte growth factor promotes liver regeneration induced by transfusion of bone marrow mononuclear cells in a murine acute liver failure model
Jin, S.Z., et al.
Journal of Hepatology, 18, 397-405 (2011)
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