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poly lysine

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Maria Morga et al.
Journal of colloid and interface science, 456, 116-124 (2015-06-27)
Physicochemical properties of poly-l-lysine and its monolayers on mica were thoroughly investigated by dynamic light scattering, electrokinetic methods and atomic force microscopy. The hydrodynamic diameter of PLL was equal to 25.5 nm within a wide range of pH and ionic...
Simon Messner et al.
Nucleic acids research, 38(19), 6350-6362 (2010-06-08)
The chromatin-associated enzyme PARP1 has previously been suggested to ADP-ribosylate histones, but the specific ADP-ribose acceptor sites have remained enigmatic. Here, we show that PARP1 covalently ADP-ribosylates the amino-terminal histone tails of all core histones. Using biochemical tools and novel...
F Simonin et al.
The Journal of biological chemistry, 265(31), 19249-19256 (1990-11-05)
Bacterially expressed fusion proteins containing the COOH-terminal domain of the human poly(ADP-ribose)polymerase were analyzed by means of a novel assay, the "activity blot," which allows the detection of transferred polypeptides involved in poly(ADP-ribose) synthesis. Deletion analysis demonstrated that the 40-kDa...
Masae Ikura et al.
Molecular and cellular biology, 36(10), 1595-1607 (2016-03-16)
The dynamic exchange of histones alleviates the nucleosome barrier and simultaneously facilitates various aspects of cellular DNA metabolism, such as DNA repair and transcription. In response to DNA damage, the acetylation of Lys5 in the histone variant H2AX, catalyzed by...
Xiaoxiao Huang et al.
The Journal of biological chemistry, 294(33), 12459-12471 (2019-06-30)
NSD2 is a histone methyltransferase that specifically dimethylates histone H3 lysine 36 (H3K36me2), a modification associated with gene activation. Dramatic overexpression of NSD2 in t(4;14) multiple myeloma (MM) and an activating mutation of NSD2 discovered in acute lymphoblastic leukemia are...
Ingrid Kassner et al.
Open biology, 3(10), 120173-120173 (2013-10-04)
ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1, formerly PARP1) is localized in the nucleus, where it ADP-ribosylates specific target proteins. The post-translational modification (PTM) with a single ADP-ribose unit or with polymeric ADP-ribose (PAR) chains regulates protein function as well as protein-protein...
Kai Shi et al.
International journal of biological macromolecules, 72, 1441-1450 (2014-12-03)
This work presents new spherical nanoparticles that are fabricated from supramolecular self-assembly of therapeutic proteins for inhalation treatment. The formation involved self-assembly of insulin into nanospheres (INS) by a novel thermal induced phase separation method. Surface functional modification of INS...
Sandra S Haenni et al.
The international journal of biochemistry & cell biology, 40(10), 2274-2283 (2008-04-26)
Poly-ADP-ribose polymerase-2 (PARP-2) was described to regulate cellular functions comprising DNA surveillance, inflammation and cell differentiation by co-regulating different transcription factors. Using an in vitro and in vivo approach, we identified PARP-2 as a new substrate for the histone acetyltransferases...
Lei Li et al.
Nature communications, 7, 12235-12235 (2016-07-21)
Although SIRT7 is a member of sirtuin family proteins that are described as NAD(+)-dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein remains to be investigated and the cellular function of SIRT7 remains to be explored....
Digambara Patra et al.
Analytica chimica acta, 795, 60-68 (2013-09-04)
We introduce a novel method for encapsulation of curcumin by synthesizing microcapsule containing self-assembled nanoparticles using poly (L-lysine), trisodium citrate and silica sol. Such microcapsules can only be prepared in neutral and alkaline environment and unencapsulated curcumin can be effectively...
Viktor Korzhikov-Vlakh et al.
Polymers, 12(5) (2020-05-14)
Photo-triggered release of biopharmaceutical drugs inside the cells is a challenging direction of modern science, which requires obtaining new polymeric systems. The interpolyelectrolyte complexes (IPECs) of poly-l-lysine with heparin capable of encapsulation of genetic constructions-such as model oligonucleotide, siRNA, and...
Peter Rigsby et al.
Biologicals : journal of the International Association of Biological Standardization, 66, 21-29 (2020-06-24)
Typhoid vaccines based on protein-conjugated capsular Vi polysaccharide (TCVs) prevent typhoid in infants and young children. Analysis of the serum anti-Vi IgG response following immunisation against typhoid confirms the immunogenicity of TCVs and forms an important part of the pathway...
S Contente et al.
Genomics, 16(2), 395-400 (1993-05-01)
Lysyl oxidase, an extracellular enzyme involved in the maturation of collagen and elastin, also appears to function as a phenotypic suppressor of transformation by the ras gene product, p21. Genomic clones of the mouse lysyl oxidase gene have been isolated...
Mehmet Emin Çorman
Colloids and surfaces. B, Biointerfaces, 167, 291-298 (2018-04-22)
In this study, poly-l-lysine (PLL) immobilized PHEMA cryogel was designed for the specific bilirubin removal from human plasma. The surface of PHEMA cryogels is surrounded by PLL chains to enhance specific binding of bilirubin molecules via specific complementary electrostatic interactions....
Janeesh Plakkal Ayyappan et al.
Chemical biology & drug design, 84(3), 292-299 (2014-03-05)
Poly-L-Lysine (PLL) nanocapsules are the emerging drug-delivery vehicle for the therapeutics of targeted diseases. The study was designed for the synthesis and characterization of PLL nanocapsules and to know its immunocompatibility and toxicity behavior for in vivo drug-delivery applications. Alteration...
Amira El Merhie et al.
Colloids and surfaces. B, Biointerfaces, 191, 110991-110991 (2020-05-15)
We compared the proliferation and differentiation of mouse neuroblastoma Neuro 2A cell line on single layer graphene and glass substrates. Quantitative and qualitative analysis of the cell proliferation and differentiation were performed, considering also the effect of a common adhesion...
Fiorela Ghilini et al.
ACS applied materials & interfaces, 10(28), 23657-23666 (2018-06-22)
The increasing incidence of infections in implantable devices has encouraged the search for biocompatible antimicrobial surfaces. To inhibit the bacterial adhesion and proliferation on biomaterials, several surface functionalization strategies have been developed. However, most of these strategies lead to bacteriostatic...
Dae Hyeok Yang et al.
Drug delivery, 25(1), 950-960 (2018-04-17)
Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer was compared to that of CUR solution in vitro and in vivo. Deoxycholic acid (DOCA), methoxy polyethylene...
Minmin Zhang et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(12), 2569-2574 (2014-05-23)
Liquid-crystal (LC) droplet patterns are formed on a glass slide by evaporating a solution of nematic LC dissolved in heptane. In the presence of an anionic phospholipid, 1,2-dioleoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DOPG), the LCs display a dark cross pattern, indicating a homeotropic orientation....
Hanyang Zhang et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 2391-2404 (2019-06-12)
The surface modification of polymeric materials has become critical for improving the bone repair capability of materials. In this study, we used a poly-L-lysine (PLL) coating method to prepare functional poly (lactic acid-glycolic acid) (PLGA) cell microcarriers, and bone morphogenetic...
Jia-Dong Pang et al.
Materials science & engineering. C, Materials for biological applications, 49, 485-492 (2015-02-18)
Although amylose as a naturally-occurring helical polysaccharide has been widely used for biomedical applications, few studies have dealt with its chemical modification for non-viral gene delivery. In this work, the click modification of amylose by poly(l-lysine) dendrons was carried out...
Simon Messner et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(11), 3978-3989 (2009-07-23)
Poly(ADP-ribose) polymerase 1 (PARP1) is a chromatin-associated nuclear protein and functions as a molecular stress sensor. At the cellular level, PARP1 has been implicated in a wide range of processes, such as maintenance of genome stability, cell death, and transcription....
Simon Messner et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(11), 3978-3989 (2009-07-23)
Poly(ADP-ribose) polymerase 1 (PARP1) is a chromatin-associated nuclear protein and functions as a molecular stress sensor. At the cellular level, PARP1 has been implicated in a wide range of processes, such as maintenance of genome stability, cell death, and transcription....
Martin Müller
Molecules (Basel, Switzerland), 25(10) (2020-05-21)
The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied. In situ...
E R Hämäläinen et al.
Genomics, 17(3), 544-548 (1993-09-01)
Lysyl oxidase (EC 1.4.3.13), an extracellular copper enzyme, initiates the crosslinking of collagens and elastin by catalyzing oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues. We report here that the human lysyl oxidase gene is about...
Ya-Chen Liang et al.
Biochemical and biophysical research communications, 431(1), 58-64 (2013-01-08)
Poly(ADP-ribose) polymerase-2 (PARP-2) catalyzes poly(ADP-ribosyl)ation (PARylation) and regulates numerous nuclear processes, including transcription. Depletion of PARP-2 alters the activity of transcription factors and global gene expression. However, the molecular action of how PARP-2 controls the transcription of target promoters remains...
Qianming Lin et al.
Acta biomaterialia, 49, 456-471 (2016-12-05)
Hydrogels have attracted much attention in cancer therapy and tissue engineering due to their sustained gene delivery ability. To obtain an injectable and high-efficiency gene delivery hydrogel, methoxypolyethylene glycol (MPEG) was used to conjugate with the arginine-functionalized poly(l-lysine) dendron (PLLD-Arg)...
Nobuhito Mori et al.
Journal of bioscience and bioengineering, 122(6), 753-757 (2016-06-22)
Vessel-like channels fabricated by embedding sacrificial structures in three-dimensional (3D) cellular constructs and then removing the sacrificial structures have been proposed as a means of providing nutrition to the cells. Alginate gel fibers have been used in the design of...
Ping Li et al.
Cell reports, 25(2), 437-448 (2018-10-12)
Tankyrase (Tnks) transfers poly(ADP-ribose) on substrates. Whereas studies have highlighted the pivotal roles of Tnks in cancer, cherubism, systemic sclerosis, and viral infection, the requirement for Tnks under physiological contexts remains unclear. Here, we report that the loss of Tnks...
Raquel M Forsythe et al.
Shock (Augusta, Ga.), 17(3), 180-184 (2002-03-20)
Studies indicate that endotoxin (LPS) causes intestinal injury, increases inducible nitric oxide synthase (iNOS) activity, leads to increased NO production, and promotes bacterial translocation (BT). To investigate the mechanism by which LPS causes gut injury and to test the hypothesis...
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