Showing 1-30 of 97 results for "potassium sulfide"
José M Centeno et al.
European journal of pharmacology, 853, 33-40 (2019-03-17)
Hydrogen sulfide (H2S) is a potential endothelium-derived hyperpolarizing factor (EDHF) and adventitium- or adipocyte-derived relaxing factor (ADRF) which vasorelaxant action is mediated by potassium channels. H2S could also play an important role in the pathophysiology of diabetic cardiovascular complications. The...
Aravind R Gade et al.
Molecular pharmacology, 83(1), 294-306 (2012-11-02)
The ATP-sensitive potassium channel (K(ATP)) in mouse colonic smooth muscle cell is a complex containing a pore-forming subunit (Kir6.1) and a sulfonylurea receptor subunit (SUR2B). These channels contribute to the cellular excitability of smooth muscle cells and hence regulate the...
Xingmei Feng et al.
Molecular pain, 9, 4-4 (2013-02-19)
Hydrogen sulfide (H2S), an endogenous gaseotransmitter/modulator, is becoming appreciated that it may be involved in a wide variety of processes including inflammation and nociception. However, the role and mechanism for H2S in nociceptive processing in trigeminal ganglion (TG) neuron remains...
Elise R Hedegaard et al.
The Journal of pharmacology and experimental therapeutics, 356(1), 53-63 (2015-10-24)
Endogenous hydrogen sulfide (H2S) is involved in the regulation of vascular tone. We hypothesized that the lowering of calcium and opening of potassium (K) channels as well as calcium-independent mechanisms are involved in H2S-induced relaxation in rat mesenteric small arteries....
Vijay Kumar Akkilagunta et al.
The Journal of organic chemistry, 76(16), 6819-6824 (2011-07-08)
The synthesis of unsymmetrical sulfides has been achieved in good to excellent yields with inexpensive ethyl potassium xanthogenate via cross-coupling reaction using recyclable CuO nanoparticles under ligand-free conditions.The copper oxide nanoparticles can be recovered and reused up to five cycles...
Shan-Feng Ma et al.
Antioxidants & redox signaling, 23(2), 129-147 (2015-03-11)
The mechanisms underlying numerous biological roles of hydrogen sulfide (H2S) remain largely unknown. We have previously reported an inhibitory role of H2S in the L-type calcium channels in cardiomyocytes. This prompts us to examine the mechanisms underlying the potential regulation...
Pan Dang et al.
Organic letters, 17(1), 34-37 (2014-12-17)
An efficient copper catalyzed strategy for the synthesis of a variety of benzothiazolethione derivatives has been developed. In the presence of CuCl, the three-component reaction of o-iodoanilines and K2S with p-toluenesulfonylmethyl isocyanide proceeded smoothly to obtain the corresponding benzothiazolethiones in...
Alexandra Erb et al.
PloS one, 9(6), e100971-e100971 (2014-06-25)
Hydrogen sulfide (H2S) is well known as a highly toxic environmental chemical threat. Prolonged exposure to H2S can lead to the formation of pulmonary edema. However, the mechanisms of how H2S facilitates edema formation are poorly understood. Since edema formation...
B Hennig et al.
British journal of pharmacology, 158(5), 1263-1275 (2009-09-30)
The aim of this study was to identify the actions of H(2)S on ion transport across rat distal colon. Changes in short-circuit current (Isc) induced by the H(2)S-donor, NaHS, were measured in Ussing chambers. Cytosolic Ca(2+) concentration was evaluated using...
O M Semenykhina et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(2), 9-17 (2013-07-05)
In experiments on mitochondria isolated from the heart tissue of adult rats we studied the effects of a donor of hydrogen sulfide, NaHS, on the respiratory chain of the organelles. We found that NaHS (10(-9)-10(-6) mol/l) caused a dose-dependent decrease...
Asif K Mustafa et al.
Circulation research, 109(11), 1259-1268 (2011-10-08)
Nitric oxide, the classic endothelium-derived relaxing factor (EDRF), acts through cyclic GMP and calcium without notably affecting membrane potential. A major component of EDRF activity derives from hyperpolarization and is termed endothelium-derived hyperpolarizing factor (EDHF). Hydrogen sulfide (H(2)S) is a...
Ryan A Dombkowski et al.
The Journal of experimental biology, 209(Pt 16), 3234-3240 (2006-08-05)
Hydrogen sulfide (H2S) is a recently identified gasotransmitter that may mediate hypoxic responses in vascular smooth muscle. H2S also appears to be a signaling molecule in mammalian non-vascular smooth muscle, but its existence and function in non-mammalian non-vascular smooth muscle...
Shafaqat Ali et al.
Environmental toxicology and chemistry, 32(10), 2234-2239 (2013-06-19)
A hydroponic experiment was carried out to examine the effect of hydrogen sulfide (H2 S) in alleviating chromium (Cr) stress in barley. A 2-factorial design with 6 replications was selected, including 3 levels of NaHS (0 μM, 100 μM, and...
Daniel Yoo et al.
American journal of physiology. Heart and circulatory physiology, 309(4), H605-H614 (2015-06-14)
Hydrogen sulfide (H2S) is an endogenous gaseous molecule formed from L-cysteine in vascular tissue. In the present study, cardiovascular responses to the H2S donors Na2S and NaHS were investigated in the anesthetized rat. The intravenous injections of Na2S and NaHS...
S Rashid et al.
British journal of pharmacology, 168(8), 1902-1910 (2012-12-12)
Hydrogen sulphide (H2S) is an endogenous gasotransmitter. Although it has been shown to elicit responses in vascular and other smooth muscle preparations, a role for endogenously produced H2S in mediating airway tone has yet to be demonstrated. Therefore, the aim...
Jessica L Kutz et al.
The Journal of physiology, 593(9), 2121-2129 (2015-02-03)
Hydrogen sulphide (H2 S) is vasoprotective, attenuates inflammation and modulates blood pressure in animal models; however, its specific mechanistic role in the human vasculature remains unclear. In the present study, we report the novel finding that the enzymes responsible for...
Huan Li et al.
Plant physiology and biochemistry : PPB, 156, 233-241 (2020-09-26)
Hydrogen sulfide (H2S) plays an important role in the plant salt stress response. The main component of salt stress is neutral salt (NaCl); NaHCO3 and Na2CO3 play a key role in soil alkaline due to the influence of pH. Malus...
Keith J Buckler
Pflugers Archiv : European journal of physiology, 463(5), 743-754 (2012-03-16)
It has been proposed that endogenous H(2)S mediates oxygen sensing in chemoreceptors; this study investigates the mechanisms by which H(2)S excites carotid body type 1 cells. H(2)S caused a rapid reversible increase in intracellular calcium with EC(50) ≈ 6xa0μM. This [Ca(2+)](i) response...
Carolin Köhn et al.
PloS one, 7(8), e41951-e41951 (2012-08-08)
Hydrogen sulfide (H(2)S) is a potent vasodilator. However, the complex mechanisms of vasoregulation by H(2)S are not fully understood. We tested the hypotheses that (1) H(2)S exerts vasodilatory effects by opening KCNQ-type voltage-dependent (K(v)) K(+) channels and (2) that H(2)S-producing...
Louise A Horrigan et al.
Food & function, 4(3), 392-400 (2012-11-24)
The objective of this study was to investigate the in vitro effects of blueberry juice on healthy rat aortic rings, and to explore the roles of potassium channels and of the hydrogen sulphide (H(2)S) pathway in mediating the effects of...
Fen Li et al.
Environmental technology, 35(17-20), 2575-2581 (2014-08-26)
Sludge-activated carbons (SACs) prepared with excess of activated sludge are used to solve the problems of sludge disposal and odour pollution in a sewage treatment plant. For the preparation, ZnCl2, KOH and H2SO4 are used as activators, respectively. The structure...
Ming Lu et al.
Antioxidants & redox signaling, 17(6), 849-859 (2012-03-01)
Hydrogen sulfide (H(2)S), a novel gaseous mediator, has been recognized to protect neurons from overexcitation by enhancing the activity of the adenosine triphosphate-sensitive potassium (K-ATP) channel. However, no direct evidence supports that the K-ATP channel contributes to the neuroprotective effect...
Fang Lei et al.
PloS one, 15(10), e0237643-e0237643 (2020-10-17)
We previously reported that maternal cigarette smoke (CS) exposure resulted in impairment of central chemoreception and induced mitochondrial dysfunction in offspring parafacial respiratory group (pFRG), the kernel for mammalian central chemoreception. We also found that hydrogen sulfide (H2S) could attenuate...
Fatma Aydinoglu et al.
Clinical and experimental pharmacology & physiology, 43(4), 503-511 (2016-02-05)
The aim of this study was to investigate the mechanism of H2 S-induced relaxation in mouse corpus cavernosal tissue. l-cysteine (10(-6) × 10(-3) mol/L) and exogenous H2 S (NaHS; 10(-6) to 10(-3) mol/L) induced concentration-dependent relaxation. l-cysteine-induced relaxations was reduced...
Armen Y Mulkidjanian et al.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 42(5), 507-516 (2012-11-08)
We have recently reconstructed the 'hatcheries' of the first cells by combining geochemical analysis with phylogenomic scrutiny of the inorganic ion requirements of universal components of modern cells (Mulkidjanian et al. Proc Natl Acad Sci U S A 109:E821-830, 2012)....
Vítor S Fernandes et al.
American journal of physiology. Cell physiology, 309(2), C107-C116 (2015-05-08)
Hydrogen sulfide (H2S) is a key signaling molecule regulating important physiological processes, including smooth muscle function. However, the mechanisms underlying H2S-induced detrusor smooth muscle (DSM) contractions are not well understood. This study investigates the cellular and tissue mechanisms by which...
Vladislav V Makarenko et al.
American journal of physiology. Cell physiology, 303(9), C916-C923 (2012-06-30)
H(2)S generated by the enzyme cystathionine-γ-lyase (CSE) has been implicated in O(2) sensing by the carotid body. The objectives of the present study were to determine whether glomus cells, the primary site of hypoxic sensing in the carotid body, generate...
Min-Kyu Ji et al.
Journal of hazardous materials, 229-230, 298-306 (2012-06-26)
The potential of several surface coating agents to inhibit the oxidation of metal sulfide minerals from Young-Dong coal mine and the Il-Gwang gold mine was examined by conducting laboratory scale batch experiments and field tests. Powdered pyrite as a standard...
Ting-Ting Pan et al.
Journal of molecular and cellular cardiology, 40(1), 119-130 (2005-12-06)
The possible role of hydrogen sulfide (H2S) in cardioprotection was investigated in isolated rat ventricular myocytes exposed to severe metabolic inhibition (MI) in glucose-free buffer containing 2-deoxy-D-glucose (2-DOG), an inhibitor of glycolysis. Pretreatment (30 min) with NaHS (a H2S donor)...
Eleonora Distrutti et al.
Molecular pain, 6, 36-36 (2010-06-15)
Hydrogen sulphide (H2S) is a gaseous neuro-mediator that exerts analgesic effects in rodent models of visceral pain by activating KATP channels. A body of evidence support the notion that KATP channels interact with endogenous opioids. Whether H2S-induced analgesia involves opioid...

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