Showing 1-30 of 94 results for "ppar-and-rxr-regulators"
Thierry Fournier et al.
Annals of the New York Academy of Sciences, 973, 26-30 (2002-12-18)
PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that...
Constantinos Giaginis et al.
Medical science monitor : international medical journal of experimental and clinical research, 15(5), BR148-BR156 (2009-04-28)
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a ligand-activated transcription factor that forms heterodimers with the retinoid X receptors (RXRs), is overexpressed in various tumors, regulating many aspects of cancer biology. The aim of the present study was to evaluate the clinical significance...
J DiRenzo et al.
Molecular and cellular biology, 17(4), 2166-2176 (1997-04-01)
As the obligate member of most nuclear receptor heterodimers, retinoid X receptors (RXRs) can potentially perform two functions: cooperative binding to hormone response elements and coordinate regulation of target genes by RXR ligands. In this paper we describe allosteric interactions...
Lajos Széles et al.
Molecular endocrinology (Baltimore, Md.), 24(11), 2218-2231 (2010-09-24)
Retinoid X receptors (RXRs) are heterodimerization partners for many nuclear receptors and also act as homodimers. Heterodimers formed by RXR and a nonpermissive partner, e.g. retinoic acid receptor (RAR) and vitamin D receptor (VDR), can be activated only by the...
Q Wang et al.
Placenta, 23(8-9), 661-671 (2002-10-04)
Placental fatty acid transfer is critical to meet the foetal requirements necessary for the biosynthesis of biological membranes, myelin, and various signaling molecules. The primary objective of this research was to elucidate the placental expression patterns of genes that may...
Norman E Buroker et al.
The protein journal, 31(1), 75-83 (2011-12-14)
A peroxisome proliferator-actived receptor (PPAR) response element (RE) in the promoter region of the adaptor-related protein complex 2, alpha 2 subunit (AP2α2) of mouse heart has been identified. The steroid hormone nuclear PPARs and the retinoid X receptors (RXRs) are...
Mahshid Nickkho-Amiry et al.
Molecular cancer research : MCR, 10(3), 441-453 (2011-12-30)
Peroxisome proliferator-activated receptors (PPAR) and retinoid X receptors (RXR) are implicated in the development of several obesity-related cancers. Little is known of either the expression or function of PPARs and RXRs in endometrial cancer although this increasingly common disease is...
Vikas Chandra et al.
Nature, 456(7220), 350-356 (2008-12-02)
Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome proliferator-activated receptors (PPARs) form heterodimers with the retinoid X receptor (RXR), and PPAR-gamma has been intensively studied as a drug target...
Constantinos Giaginis et al.
Medical science monitor : international medical journal of experimental and clinical research, 17(7), CR381-CR391 (2011-06-29)
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its nuclear partners, the Retinoid X Receptors (RXRs), have been recognized as crucial players in the pathogenesis of atherosclerosis. The present study aimed to assess the clinical significance of PPAR-gamma and RXR-alpha expression in different...
E Treuter et al.
Molecular endocrinology (Baltimore, Md.), 12(6), 864-881 (1998-06-17)
Transcriptional regulation of gene expression by nuclear receptors requires negatively and positively acting cofactors. Recent models for receptor activation propose that certain receptors in the absence of ligands can recruit corepressors while ligand binding results in conformational changes leading to...
A Gorla-Bajszczak et al.
Molecular and cellular endocrinology, 147(1-2), 37-47 (1999-04-09)
The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. These ligand-activated transcription factors are implicated in the regulation of lipid metabolism and adipocyte differentiation and in the regulation of anti-inflammatory processes. In order to bind to...
S L Marcus et al.
Gene expression, 4(4-5), 227-239 (1995-01-01)
Peroxisome proliferator-activated receptors (PPARs) are orphan members of the nuclear hormone receptor superfamily. PPARs bind to cognate response elements through heterodimerization with retinoid X receptors (RXRs). Together PPAR/RXR regulate the transcription of genes for which products are involved in lipid...
H Keller et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(6), 2160-2164 (1993-03-15)
The nuclear hormone receptors called PPARs (peroxisome proliferator-activated receptors alpha, beta, and gamma) regulate the peroxisomal beta-oxidation of fatty acids by induction of the acyl-CoA oxidase gene that encodes the rate-limiting enzyme of the pathway. Gel retardation and cotransfection assays...
Kyuyong Han et al.
The Journal of endocrinology, 192(3), 539-551 (2007-03-03)
Various nuclear receptors form dimers to activate target genes via specific response elements located within promoters or enhancers. Retinoid X receptor (RXR) serves as a dimerization partner for many nuclear receptors including retinoic acid receptor (RAR) and peroxisome proliferator-activated receptor...
G Martin et al.
The Journal of biological chemistry, 275(17), 12612-12618 (2000-04-25)
The intracellular fatty acid content of insulin-sensitive target tissues determines in part their insulin sensitivity. Uptake of fatty acids into cells is a controlled process determined in part by a regulated import/export system that is controlled at least by two...
Christine Chao et al.
Mechanisms of ageing and development, 123(11), 1469-1476 (2002-11-12)
Aging is associated with alterations in hepatic peroxisomal metabolism and susceptibility to hepatocarcinogenicity produced by agonists of peroxisome proliferator-activated receptor alpha (PPAR alpha). Mechanisms involved in these effects are not well understood. However, as a heterodimer with retinoid X receptor...
J F Landrier et al.
Biochimica et biophysica acta, 1735(1), 41-49 (2005-06-07)
Peroxisome proliferator-activator receptors (PPAR) are involved in cholesterol homeostasis through the regulation of bile acids synthesis, composition, and reclamation. As ileal bile acid-binding protein (I-BABP) is thought to play a crucial role in the enterohepatic circulation of bile acids, we...
Liliane Michalik et al.
Pharmacological reviews, 58(4), 726-741 (2006-11-30)
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology with all members of the superfamily, particularly in the DNA-binding domain and ligand- and cofactor-binding domain....
Teresa Teruel et al.
The Journal of biological chemistry, 278(1), 263-269 (2002-11-05)
Brown adipose tissue expresses the thermogenic uncoupling protein-1 (UCP-1), which is positively regulated by peroxisome proliferator-activated receptor (PPAR) agonists and retinoids through the activation of the heterodimers PPAR/retinoid X receptor (RXR) and retinoic acid receptor (RAR)/RXR and binding to specific...
Marius R Robciuc et al.
PloS one, 7(10), e46212-e46212 (2012-10-12)
Peroxisome proliferator-activated receptor (PPAR) delta is an important regulator of fatty acid (FA) metabolism. Angiopoietin-like 4 (Angptl4), a multifunctional protein, is one of the major targets of PPAR delta in skeletal muscle cells. Here we investigated the regulation of Angptl4...
P Neugebauer et al.
Vnitrni lekarstvi, 55(12), 1135-1140 (2010-01-15)
Hereditary factors connected with inflammation and fibroproliferation may play important role in restenotic process after coronary stenting. Peroxisome proliferator-activated receptors (PPAR) and retinoic X receptors (RXR) regulate the transcription of crucial genes involved in the glucose and lipid metabolism, inflammation...
Karla A Temple et al.
The Journal of biological chemistry, 280(5), 3529-3540 (2004-12-02)
Peroxisome proliferator-activated receptor gamma (PPARgamma) interacts with retinoid X receptor (RXR) on PPAR response elements (PPREs) to regulate transcription of PPAR-responsive genes. To investigate the binding of PPARgamma and RXR to PPREs, three mutations were constructed in the DNA-binding domains...
Michael Boergesen et al.
Molecular and cellular biology, 32(4), 852-867 (2011-12-14)
The liver X receptors (LXRs) are nuclear receptors that form permissive heterodimers with retinoid X receptor (RXR) and are important regulators of lipid metabolism in the liver. We have recently shown that RXR agonist-induced hypertriglyceridemia and hepatic steatosis in mice...
Yan J Jiang et al.
Experimental dermatology, 20(7), 595-599 (2011-04-05)
Aquaporin 3 (AQP3), a member of the aquaglyceroporin family, which transports water and glycerol, is robustly expressed in epidermis and plays an important role in stratum corneum hydration, permeability barrier function and wound healing. PPAR and LXR activation regulates the...
D D Patel et al.
The Biochemical journal, 351 Pt 3, 747-753 (2000-10-24)
Cholesterol 7 alpha-hydroxylase (Cyp7a1) plays a central role in the regulation of bile acid and cholesterol metabolism, and transcription of the gene is controlled by bile acids and hormones acting through a complex interaction with a number of potential steroid-hormone-binding...
S J Holdsworth-Carson et al.
Placenta, 30(2), 176-186 (2008-12-17)
Peroxisome proliferator-activated receptors (PPARs) and their transcriptional partner retinoid X receptor (RXR) are involved in transcriptionally regulating the events that contribute to the control of parturition in humans. Definitive data, however, are lacking with respect to PPAR and RXR expression...
Shih-Chen Chang et al.
Carcinogenesis, 29(5), 944-948 (2008-04-01)
Biliary tract cancer, encompassing tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, is a rare but highly fatal malignancy. Obesity and gallstones, both related to insulin resistance, are linked to an elevated risk of biliary cancer. The...
Gemma Austin et al.
European journal of haematology, 94(1), 74-78 (2014-07-22)
The expression and activity of the uptake transporter human organic cation transporter 1 (hOCT1; SLC22A1) is an independent predictor of response to imatinib treatment in patients with chronic myeloid leukaemia (CML). We have recently shown that peroxisome proliferator-activated receptor (PPAR)...
Natacha Rochel et al.
Nature structural & molecular biology, 18(5), 564-570 (2011-04-12)
Nuclear hormone receptors (NHRs) control numerous physiological processes through the regulation of gene expression. The present study provides a structural basis for understanding the role of DNA in the spatial organization of NHR heterodimers in complexes with coactivators such as...
Anthony M Flores et al.
The Journal of investigative dermatology, 123(6), 1092-1101 (2004-12-22)
Keratinocyte (KC) gene expression is regulated by members of the nuclear receptor (NR) superfamily including retinoic acid receptors, retinoid X receptors (RAR and RXR, respectively), and peroxisome proliferator activated receptors (PPAR). In addition to ligand, NR transcriptional activity is controlled...

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