Related Product Categories
Organism
Showing 1-30 of 1341 results for "protein kinase"
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
Synonyms:
GCKR, KHS, KHS1, MAPKKKK5
Species:
Human MAP4K5 (11183), Mouse Map4k5 (399510), Rat Map4k5 (503027), sheep MAP4K5 (101103818), domestic guinea pig Map4k5 (100727959), naked mole-rat Map4k5 (101697393), Domestic Rabbit MAP4K5 (100346909), Zebrafish map4k5 (334565), cow MAP4K5 (781335), Horse MAP4K5 (100066454), domestic cat MAP4K5 (101095501), dog MAP4K5 (490685), chicken MAP4K5 (423576)
Summary:
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008
Products:
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
Synonyms:
FLH21957, HGK, MEKKK4, NIK
Species:
Human MAP4K4 (9448), Mouse Map4k4 (26921), Rat Map4k4 (301363), chicken MAP4K4 (418714), cow MAP4K4 (509109), domestic cat MAP4K4 (101081214), dog MAP4K4 (481331), naked mole-rat Map4k4 (101707800), domestic guinea pig Map4k4 (100723651), sheep MAP4K4 (101109789)
Summary:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008
Products:
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
Synonyms:
BL44, GCK, RAB8IP
Species:
Human MAP4K2 (5871), Mouse Map4k2 (26412), Rat Map4k2 (293694), Zebrafish map4k2 (100538181), cow MAP4K2 (520058), Horse MAP4K2 (100056001), domestic cat MAP4K2 (101094701), dog MAP4K2 (483759), naked mole-rat Map4k2 (101710953), domestic guinea pig Map4k2 (100722708), sheep MAP4K2 (101118145)
Summary:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008
Products:
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
Synonyms:
GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1
Species:
Human MAP4K3 (8491), Mouse Map4k3 (225028), Rat Map4k3 (170920), chicken MAP4K3 (425965), cow MAP4K3 (507624), Horse MAP4K3 (100069835), domestic cat MAP4K3 (101098622), dog MAP4K3 (475734), sheep MAP4K3 (101118350), domestic guinea pig Map4k3 (100716179), naked mole-rat Map4k3 (101709571), Domestic Rabbit MAP4K3 (100356354)
Summary:
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012
Products:
MAP3K2
mitogen-activated protein kinase kinase kinase 2
Synonyms:
MEKK2, MEKK2B
Species:
Human MAP3K2 (10746), Mouse Map3k2 (26405), Rat Map3k2 (171492), Zebrafish map3k2 (558321), chicken MAP3K2 (424225), domestic cat MAP3K2 (101096406), Horse MAP3K2 (100050628), cow MAP3K2 (504592), dog MAP3K2 (612902), sheep MAP3K2 (101109858), domestic guinea pig Map3k2 (100723690), naked mole-rat Map3k2 (101726195)
Summary:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008
Products:
MAP3K6
mitogen-activated protein kinase kinase kinase 6
Synonyms:
ASK2, MAPKKK6, MEKK6
Species:
Human MAP3K6 (9064), Mouse Map3k6 (53608), Rat Map3k6 (313022), chicken MAP3K6 (100858193), cow MAP3K6 (614598), Horse MAP3K6 (100070933), domestic cat MAP3K6 (101081315), dog MAP3K6 (487345), sheep MAP3K6 (101113737), domestic guinea pig Map3k6 (100724385), naked mole-rat Map3k6 (101697616), Domestic Rabbit MAP3K6 (100343069)
Summary:
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008
Products:
MAP3K11
mitogen-activated protein kinase kinase kinase 11
Synonyms:
MEKK11, MLK-3, MLK3, PTK1, SPRK
Species:
Human MAP3K11 (4296), Mouse Map3k11 (26403), Rat Map3k11 (309168), sheep MAP3K11 (101108969), domestic guinea pig Map3k11 (100730722), naked mole-rat Map3k11 (101718575), Domestic Rabbit MAP3K11 (100356691), cow MAP3K11 (514210), dog MAP3K11 (483732), domestic cat MAP3K11 (101098654)
Summary:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008
Products:
MAP3K5
mitogen-activated protein kinase kinase kinase 5
Synonyms:
ASK1, MAPKKK5, MEKK5
Species:
Human MAP3K5 (4217), Mouse Map3k5 (26408), Rat Map3k5 (365057), naked mole-rat Map3k5 (101712051), domestic guinea pig Map3k5 (100722979), sheep MAP3K5 (101121018), Zebrafish map3k5 (555703), chicken MAP3K5 (421688), dog MAP3K5 (476215), Horse MAP3K5 (100073186), cow MAP3K5 (537380), domestic cat MAP3K5 (101082912)
Summary:
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008
Products:
MAP3K4
mitogen-activated protein kinase kinase kinase 4
Synonyms:
MAPKKK4, MEKK4, MTK1, PRO0412
Species:
Human MAP3K4 (4216), Mouse Map3k4 (26407), Rat Map3k4 (308106), Zebrafish map3k4 (325488), cow MAP3K4 (511779), Horse MAP3K4 (100058153), domestic cat MAP3K4 (101097977), dog MAP3K4 (476262), chicken MAP3K4 (421579), sheep MAP3K4 (101113246), domestic guinea pig Map3k4 (100724828), naked mole-rat Map3k4 (101701961), Domestic Rabbit MAP3K4 (100358104)
Summary:
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008
Products:
MAP3K12
mitogen-activated protein kinase kinase kinase 12
Synonyms:
DLK, MEKK12, MUK, ZPK, ZPKP1
Species:
Human MAP3K12 (7786), Mouse Map3k12 (26404), Rat Map3k12 (25579), Zebrafish map3k12 (404626), chicken MAP3K12 (101669120), cow MAP3K12 (505427), Horse MAP3K12 (100064002), domestic cat MAP3K12 (101087164), dog MAP3K12 (607170), chicken MAP3K12 (101750914), Domestic Rabbit MAP3K12 (100358158), naked mole-rat Map3k12 (101702332), domestic guinea pig Map3k12 (100731317), sheep MAP3K12 (101102889)
Summary:
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010
Products:
MAP3K15
mitogen-activated protein kinase kinase kinase 15
Synonyms:
ASK3, bA723P2.3
Species:
Human MAP3K15 (389840), Mouse Map3k15 (270672), Rat Map3k15 (501558), chicken MAP3K15 (418609), cow MAP3K15 (529335), Horse MAP3K15 (100058434), domestic cat MAP3K15 (101089836), dog MAP3K15 (491765), sheep MAP3K15 (101104888), domestic guinea pig Map3k15 (100720130), naked mole-rat Map3k15 (101702514), Domestic Rabbit MAP3K15 (100357608)
Summary:
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010
Products:
MAP3K7
mitogen-activated protein kinase kinase kinase 7
Synonyms:
MEKK7, TAK1, TGF1a
Species:
Human MAP3K7 (6885), Mouse Map3k7 (26409), Rat Map3k7 (313121), Domestic Rabbit MAP3K7 (100343571), naked mole-rat Map3k7 (101718269), domestic guinea pig Map3k7 (100718100), sheep MAP3K7 (101108056), sheep MAP3K7 (100294587), Zebrafish map3k7 (553788), cow MAP3K7 (529146), Horse MAP3K7 (100065841), domestic cat MAP3K7 (101095899), dog MAP3K7 (474996), chicken MAP3K7 (421808)
Summary:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008
Products:
MAP3K13
mitogen-activated protein kinase kinase kinase 13
Synonyms:
LZK, MEKK13, MLK
Species:
Human MAP3K13 (9175), Mouse Map3k13 (71751), Rat Map3k13 (303823), sheep MAP3K13 (101117036), domestic guinea pig Map3k13 (100727150), naked mole-rat Map3k13 (101700680), Domestic Rabbit MAP3K13 (100345602), chicken MAP3K13 (424876), cow MAP3K13 (505369), Horse MAP3K13 (100059237), domestic cat MAP3K13 (101093205), dog MAP3K13 (100685499)
Summary:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008
Products:
MAP3K14
mitogen-activated protein kinase kinase kinase 14
Synonyms:
FTDCR1B, HS, HSNIK, NIK
Species:
Human MAP3K14 (9020), Mouse Map3k14 (53859), Rat Map3k14 (360640), chicken MAP3K14 (419964), domestic cat MAP3K14 (101083468), Horse MAP3K14 (100050140), cow MAP3K14 (508367), dog MAP3K14 (490926), Domestic Rabbit MAP3K14 (100351032), naked mole-rat Map3k14 (101703313), domestic guinea pig Map3k14 (100719582), sheep MAP3K14 (101118799)
Summary:
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008
Products:
MAP3K10
mitogen-activated protein kinase kinase kinase 10
Synonyms:
MEKK10, MLK2, MST
Species:
Human MAP3K10 (4294), Mouse Map3k10 (269881), Rat Map3k10 (308463), Zebrafish map3k10 (560932), domestic cat MAP3K10 (101089731), cow MAP3K10 (781037), Horse MAP3K10 (100067981), dog MAP3K10 (484504), Domestic Rabbit MAP3K10 (100343621), naked mole-rat Map3k10 (101718471), domestic guinea pig Map3k10 (100716869), sheep MAP3K10 (101118723)
Summary:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008
Products:
MAP3K8
mitogen-activated protein kinase kinase kinase 8
Synonyms:
COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
Species:
Human MAP3K8 (1326), Mouse Map3k8 (26410), Rat Map3k8 (116596), Zebrafish map3k8 (563727), cow MAP3K8 (535622), Horse MAP3K8 (100063602), domestic cat MAP3K8 (101090624), dog MAP3K8 (487085), chicken MAP3K8 (420479), naked mole-rat Map3k8 (101710286), Domestic Rabbit MAP3K8 (100355566), domestic guinea pig Map3k8 (100725834), sheep MAP3K8 (101117094)
Summary:
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011
Products:
MAP3K3
mitogen-activated protein kinase kinase kinase 3
Synonyms:
MAPKKK3, MEKK3
Species:
Human MAP3K3 (4215), Mouse Map3k3 (26406), Rat Map3k3 (303604), naked mole-rat Map3k3 (101704335), domestic guinea pig Map3k3 (100731994), sheep MAP3K3 (101122537), Zebrafish map3k3 (560211), chicken MAP3K3 (419954), domestic cat MAP3K3 (101083633), cow MAP3K3 (508943), Horse MAP3K3 (100064751), dog MAP3K3 (480481)
Summary:
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008
Products:
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1
Species:
Human MAP4K1 (11184), Mouse Map4k1 (26411), Rat Map4k1 (292763), sheep MAP4K1 (101111480), domestic guinea pig Map4k1 (100732370), naked mole-rat Map4k1 (101709569), cow MAP4K1 (522002), Horse MAP4K1 (100064279), domestic cat MAP4K1 (101101431), dog MAP4K1 (484527)
Products:
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Synonyms:
MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
Species:
Human MAP3K1 (4214), Mouse Map3k1 (26401), Rat Map3k1 (116667), sheep MAP3K1 (101112260), domestic guinea pig Map3k1 (100723456), naked mole-rat Map3k1 (101720769), Domestic Rabbit MAP3K1 (100328655), Zebrafish map3k1 (100334486), chicken MAP3K1 (427144), cow MAP3K1 (523962), Horse MAP3K1 (100061688), domestic cat MAP3K1 (101090328), dog MAP3K1 (478061)
Summary:
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012
Products:
MAP3K19
mitogen-activated protein kinase kinase kinase 19
Synonyms:
RCK, YSK4
Species:
Human MAP3K19 (80122), Mouse Map3k19 (22625), Rat Map3k19 (289001), naked mole-rat Map3k19 (101725578), domestic guinea pig Map3k19 (100733643), sheep MAP3K19 (101106493), Zebrafish map3k19 (572217), domestic cat MAP3K19 (101090454)
Products:
MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
Synonyms:
MAPKAP-K5, MK-5, MK5, PRAK
Species:
Human MAPKAPK5 (8550), Mouse Mapkapk5 (17165), Rat Mapkapk5 (498183), naked mole-rat Mapkapk5 (101703557), domestic guinea pig Mapkapk5 (100730794), sheep MAPKAPK5 (101116258), Zebrafish mapkapk5 (436608), chicken MAPKAPK5 (373929), dog MAPKAPK5 (477480), cow MAPKAPK5 (535625), Horse MAPKAPK5 (100057579), domestic cat MAPKAPK5 (101082699)
Summary:
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012
Products:
MAP3K9
mitogen-activated protein kinase kinase kinase 9
Synonyms:
MEKK9, MLK1, PRKE1
Species:
Human MAP3K9 (4293), Mouse Map3k9 (338372), Rat Map3k9 (500690), sheep MAP3K9 (101103160), domestic guinea pig Map3k9 (100715894), Domestic Rabbit MAP3K9 (100341731), naked mole-rat Map3k9 (101696673), chicken MAP3K9 (776822), dog MAP3K9 (490765), Horse MAP3K9 (100054289), cow MAP3K9 (538340), domestic cat MAP3K9 (101084717)
Products:
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
Synonyms:
3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3
Species:
Human MAPKAPK3 (7867), Mouse Mapkapk3 (102626), Rat Mapkapk3 (315994), Zebrafish mapkapk3 (790934), chicken MAPKAPK3 (415917), dog MAPKAPK3 (484756), cow MAPKAPK3 (615215), domestic cat MAPKAPK3 (101096794), sheep MAPKAPK3 (101118996), domestic guinea pig Mapkapk3 (100719631), Domestic Rabbit MAPKAPK3 (100342292), naked mole-rat Mapkapk3 (101717099)
Summary:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011
Products:
MAPKAPK2
mitogen-activated protein kinase-activated protein kinase 2
Synonyms:
MAPKAP-K2, MK-2, MK2
Species:
Human MAPKAPK2 (9261), Mouse Mapkapk2 (17164), Rat Mapkapk2 (289014), chicken MAPKAPK2 (419847), cow MAPKAPK2 (788091), dog MAPKAPK2 (490263), domestic cat MAPKAPK2 (101090833), naked mole-rat Mapkapk2 (101708612), Domestic Rabbit MAPKAPK2 (100009438), domestic guinea pig Mapkapk2 (100715906), sheep MAPKAPK2 (101118118)
Summary:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008
Products:
MAP2K5
mitogen-activated protein kinase kinase 5
Synonyms:
HsT17454, MAPKK5, MEK5, PRKMK5
Species:
Human MAP2K5 (5607), Mouse Map2k5 (23938), Rat Map2k5 (29568), Zebrafish map2k5 (100007679), domestic cat MAP2K5 (101100725), cow MAP2K5 (100295732), Horse MAP2K5 (100052849), dog MAP2K5 (609559), chicken MAP2K5 (415557), sheep MAP2K5 (101104069), Domestic Rabbit MAP2K5 (100358715), naked mole-rat Map2k5 (101711080), domestic guinea pig Map2k5 (100732076)
Summary:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011
Products:
MAP2K1
mitogen-activated protein kinase kinase 1
Synonyms:
CFC3, MAPKK1, MEK1, MKK1, PRKMK1
Species:
Human MAP2K1 (5604), Mouse Map2k1 (26395), Rat Map2k1 (170851), Zebrafish map2k1 (406728), chicken MAP2K1 (415549), dog MAP2K1 (478347), Horse MAP2K1 (100065996), cow MAP2K1 (533199), domestic cat MAP2K1 (101081387), sheep MAP2K1 (101123635), naked mole-rat Map2k1 (101715628), Domestic Rabbit MAP2K1 (100009316), domestic guinea pig Map2k1 (100712888)
Summary:
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008
Products:
MAP2K3
mitogen-activated protein kinase kinase 3
Synonyms:
MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
Species:
Human MAP2K3 (5606), Mouse Map2k3 (26397), Rat Map2k3 (303200), chicken MAP2K3 (416496), dog MAP2K3 (489547), domestic cat MAP2K3 (101082274), Horse MAP2K3 (100053481), cow MAP2K3 (516039), sheep MAP2K3 (101122959), naked mole-rat Map2k3 (101718318), domestic guinea pig Map2k3 (100726100)
Summary:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008
Products:
MAP2K6
mitogen-activated protein kinase kinase 6
Synonyms:
MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
Species:
Human MAP2K6 (5608), Mouse Map2k6 (26399), Rat Map2k6 (114495), domestic guinea pig Map2k6 (100731419), naked mole-rat Map2k6 (101703028), Domestic Rabbit MAP2K6 (100355230), sheep MAP2K6 (101115047), Zebrafish map2k6 (65239), cow MAP2K6 (286883), Horse MAP2K6 (100053056), domestic cat MAP2K6 (101089813), chicken MAP2K6 (417445), dog MAP2K6 (480454)
Summary:
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008
Products:
MAP2K7
mitogen-activated protein kinase kinase 7
Synonyms:
Jnkk2, MAPKK7, MKK7, PRKMK7, SAPKK-4, SAPKK4
Species:
Human MAP2K7 (5609), Mouse Map2k7 (26400), Rat Map2k7 (363855), Zebrafish map2k7 (560913), dog MAP2K7 (485004), cow MAP2K7 (787278), domestic cat MAP2K7 (101095157), sheep MAP2K7 (100302082), naked mole-rat Map2k7 (101710666), domestic guinea pig Map2k7 (100731057)
Summary:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008
Products:
MAP2K2
mitogen-activated protein kinase kinase 2
Synonyms:
CFC4, MAPKK2, MEK2, MKK2, PRKMK2
Species:
Human MAP2K2 (5605), Mouse Map2k2 (26396), Rat Map2k2 (58960), chicken MAP2K2 (396349), dog MAP2K2 (611939), cow MAP2K2 (510434), domestic guinea pig Map2k2 (100728923), naked mole-rat Map2k2 (101707562), sheep MAP2K2 (101113846)
Summary:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008
Products:

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.