Showing 1-30 of 75 results for "PZ0014"
Melanie R Woytowish et al.
The Annals of pharmacotherapy, 47(3), 388-397 (2013-02-21)
To evaluate and review the literature surrounding serotonin toxicity in patients receiving linezolid and determine the clinical relevance of this reaction. Literature was accessed via MEDLINE/PubMed and Google Scholar (both through February 2013) using the search terms linezolid, serotonin syndrome...
Tian Shen et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 15(5), 486-489 (2012-01-11)
Nocardia infection is rare but potentially fatal. Therapy of Nocardia infection remains difficult. Linezolid, a novel oxazolidinone antibiotic, has proven to be effective, but clinical data are limited. Here we describe a case of a 45-year-old man with pulmonary N....
[The analysis of clinical data about the treatment of linezolid against tuberculosis].
Wen-juan Nie et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 36(8), 601-603 (2013-11-21)
Emergence of mutation-based linezolid-resistant invasive Enterococcus faecalis in a haemodialysis patient in Norway.
Carina M Thilesen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(1), 83-84 (2013-05-10)
Shashank Kraleti et al.
The Journal of the Arkansas Medical Society, 110(4), 62-63 (2013-10-02)
To describe a patient who developed pancytopenia and lactic acidosis after receiving linezolid therapy. A 32-year-old man with past medical history of heart failure, hypertension received a 14-day course of linezolid for treatment of empyema with broncho-pleural fistula. During his...
Jirong Yue et al.
The Cochrane database of systematic reviews, 7(7), CD008056-CD008056 (2013-07-13)
The morbidity and treatment costs associated with skin and soft tissue infections (SSTIs) are high. Linezolid and vancomycin are antibiotics that are commonly used in treating skin and soft-tissue infections, specifically those infections due to methicillin-resistant Staphylococcus aureus (MRSA). To...
Bing Gu et al.
The Journal of antimicrobial chemotherapy, 68(1), 4-11 (2012-09-06)
The oxazolidinone antibiotic linezolid has demonstrated potent antimicrobial activity against Gram-positive bacterial pathogens, including methicillin-resistant staphylococci. This article systematically reviews the published literature for reports of linezolid-resistant Staphylococcus (LRS) infections to identify epidemiological, microbiological and clinical features for these infections....
Katie M Muzevich et al.
The Annals of pharmacotherapy, 47(6), e25-e25 (2013-05-16)
To report a case of subtherapeutic linezolid concentrations in a patient with morbid obesity. A 34-year-old male with morbid obesity (265 kg, body mass index 82 kg/m(2)) was admitted for severe sepsis due to respiratory failure requiring emergent intubation and...
Maiko Kojiro et al.
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 86(6), 778-783 (2013-02-02)
A 76-year-old woman undergoing hemodialysis and having a permanent pacemaker during care elsewhere developed a shunt infection with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Vancomycin (VCM) and other antimicrobial agents were not effective even after her artificial shunt vessel was removed....
Jagmohan S Saini et al.
Biological chemistry, 394(11), 1529-1541 (2013-09-06)
Oxazolidinone antibiotics bind to the highly conserved peptidyl transferase center in the ribosome. For developing selective antibiotics, a profound understanding of the selectivity determinants is required. We have performed for the first time technically challenging molecular dynamics simulations in combination...
Tangjuan Liu et al.
Microbial pathogenesis, 147, 104411-104411 (2020-08-04)
Methicillin-resistant Staphylococcus aureus (MRSA) can form biofilms, which prevents the penetration of antibiotics, decreasing their efficacy. This study investigated whether baicalein has synergistic antibacterial effects with linezolid in vivo. We cultivated MRSA 17546 biofilms on silicone implants and inserted them...
[Mechanisms and epidemiology of linezolid resistance in staphylococci].
Mu-zhi He et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 35(5), 360-362 (2012-08-14)
Sanjay Chhibber et al.
PloS one, 8(2), e56022-e56022 (2013-02-19)
Staphylococcus aureus remains the predominant pathogen in diabetic foot infections and prevalence of methicillin resistant S.aureus (MRSA) strains further complicates the situation. The incidence of MRSA in infected foot ulcers is 15-30% and there is an alarming trend for its...
Gregory J Moran et al.
The Lancet. Infectious diseases, 14(8), 696-705 (2014-06-10)
New antibiotics are needed to treat infections caused by drug-resistant bacteria. Tedizolid is a novel oxazolidinone antibacterial drug designed to provide enhanced activity against Gram-positive pathogens. We aimed to assess the efficacy and safety of intravenous to oral tedizolid for...
New antibiotics for skin and skin-structure infections.
Evelina Tacconelli et al.
The Lancet. Infectious diseases, 14(8), 659-661 (2014-06-10)
The Synthesis And Characterization Of Poly(γ-glutamic Acid)-coated Magnetite Nanoparticles And Their Effects On Antibacterial Activity And Cytotoxicity.
Inbaraj, B.S., et al.
Nanotechnology, 22, 75101-75101 (2011)
Lorena Diaz et al.
The Journal of infectious diseases, 208(1), 83-91 (2013-04-03)
Mini-host models are simple experimental systems to study host-pathogen interactions. We adapted a Drosophila melanogaster infection model to evaluate the in vivo effect of different mechanisms of linezolid (LNZ) resistance in Staphylococcus aureus. Fly survival was evaluated after infection with...
Giovanni Sotgiu et al.
The European respiratory journal, 40(6), 1430-1442 (2012-04-13)
Linezolid is used off-label to treat multidrug-resistant tuberculosis (MDR-TB) in absence of systematic evidence. We performed a systematic review and meta-analysis on efficacy, safety and tolerability of linezolid-containing regimes based on individual data analysis. 12 studies (11 countries from three...
Andreas Puyskens et al.
Cell host & microbe, 27(2), 238-248 (2020-01-07)
Antimicrobial resistance in tuberculosis (TB) is a public health threat of global dimension, worsened by increasing drug resistance. Host-directed therapy (HDT) is an emerging concept currently explored as an adjunct therapeutic strategy for TB. One potential host target is the...
Ashwati Raghunath
BMJ case reports, 2013, doi:10-doi:10 (2013-01-04)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyramidal side...
Matthew S Dryden
The Journal of antimicrobial chemotherapy, 66 Suppl 4, iv7-iv15 (2011-05-06)
Linezolid has been widely used in the treatment of Gram-positive infections for more than a decade. It is unique amongst antibiotics active against most multiply-resistant Gram-positive bacteria in that there is an oral preparation with 100% bioavailability and an extensive...
Hironori Matsumoto et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 39(12), 2441-2443 (2012-12-27)
We report a case of methicillin-resistant Staphylococcus aureus(MRSA) surgical site infection successfully treated with linezolid. A 66-year-old man had undergone total gastrectomy for gastric cancer after neoadjuvant chemotherapy. Three days after the operation, he was diagnosed with deep incisional surgical...
M Marian Ijzerman et al.
Clinical therapeutics, 32(13), 2198-2206 (2011-02-15)
Antimicrobial resistance among Streptococcus pneumoniae is of concern. Up to 30% of pneumococcal isolates worldwide are multidrug resistant. The objective of this analysis was to assess the effectiveness of linezolid for the treatment of pneumonia caused by S pneumoniae, including...
Xinyan Liu et al.
PloS one, 8(3), e57483-e57483 (2013-03-13)
Excessive inflammation contributes to the severity of post influenza pneumonia caused by methicillin resistant S.aureus (MRSA). Linezolid, vancomycin, and clindamycin are antibiotics used for MRSA infections. Linezolid has immunomodulatory properties. We report on the effects of the three antibiotics on...
Rubén B Moreno et al.
Pediatric blood & cancer, 60(9), E103-E105 (2013-06-19)
Central venous catheter (CVC) removal is indicated when persistent catheter-related bloodstream infection (CRBSI) occurs. This is a retrospective study to analyze the use of linezolid as a salvage therapy for CRBSIs due to coagulase-negative Staphylococci in children diagnosed with acute...
Vasilios Karavasilis et al.
The Journal of antimicrobial chemotherapy, 70(6), 1625-1629 (2015-02-26)
Dependence on linezolid was recently described as significant growth acceleration of linezolid-resistant Staphylococcus epidermidis (LRSE) isolates upon linezolid exposure. We investigated the possible contribution of linezolid dependence to LRSE dissemination in Greece. Linezolid resistance rates were estimated in six tertiary...
Karen L Leach et al.
Annals of the New York Academy of Sciences, 1222, 49-54 (2011-03-26)
Linezolid (Zyvox) is the first member of an entirely new class of antibiotics to reach the market in over 35 years; it was approved for use in 2000. A member of the oxazolidinone class of antibiotics, linezolid is highly effective...
Leah R Reznikov et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 13(5), 515-519 (2014-03-13)
Ivacaftor increases CFTR channel activity and improves pulmonary function for individuals bearing a G551D mutation. Because ivacaftor structurally resembles quinolone antibiotics, we tested the hypothesis that ivacaftor possesses antibacterial properties. Bioluminescence, colony forming unit, and minimal inhibitory concentration assays were...
Donald W Whang et al.
Antimicrobial agents and chemotherapy, 57(10), 5013-5018 (2013-07-31)
Bloodstream infections due to vancomycin-resistant enterococci (VRE-BSI) result in substantial patient mortality and cost. Daptomycin and linezolid are commonly prescribed for VRE-BSI, but there are no clinical trials to determine optimal antibiotic selection. We conducted a systematic review for investigations...
Malgorzata Szultka et al.
Journal of chromatography. A, 1272, 41-49 (2012-12-25)
Sensitive and selective analytical procedures based on high performance liquid chromatography with mass spectrometric detection were developed for the determination of linezolid (LIN) and amoxicillin (AMOX) in human plasma samples. Samples were prepared by applying protein precipitation (PP), solid phase...

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