Showing 1-30 of 93 results for "


J Travis et al.
BMC microbiology, 20(1), 163-163 (2020-06-18)
Health-care professionals need to collect wound samples to identify potential pathogens that contribute to wound infection. Obtaining appropriate samples from diabetic foot ulcers (DFUs) where there is a suspicion of infection is of high importance. Paired swabs and tissue biopsies...
The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types.
Forget MA
British Journal of Cancer, 96(4), 646-653 (2007)
Pablo Pinto et al.
Scientific reports, 10(1), 12648-12648 (2020-07-30)
Leprosy, which is caused by the human pathogen Mycobacterium leprae, causes nerve damage, deformity and disability in over 200,000 people every year. Because of the long doubling time of M. leprae (13 days) and the delayed onset of detectable symptoms, which...
Arabinda Mahanty et al.
Fish physiology and biochemistry, 43(4), 1131-1141 (2017-03-21)
Heat stress is one of the major environmental concerns in global warming regime and rising temperature has resulted in mass mortalities of animals including fishes. Therefore, strategies for high temperature stress tolerance and ameliorating the effects of heat stress are...
High-resolution in situ hybridization to whole-mount zebrafish embryos.
Thisse C and Thisse B
Nature Protocols, 3(1), 59-69 (2008)
Marta J Siemieniuch et al.
Journal of equine veterinary science, 77, 107-113 (2019-05-28)
Endometritis is one of the most important causes of infertility in mares. Mares may suffer from endometritis outside the breeding season; however, pathological condition is often undiagnosed in anestrus. The aim of this study was to examine whether the secretion...
Nicole Perfito et al.
Endocrinology, 156(2), 694-706 (2014-12-10)
With final maturation of ovarian follicles, birds are committed to a major energetic investment: egg laying. Follicles develop in a 2-step process: 1) initial development of regressed follicles stimulated by long days and 2) yolk incorporation into hierarchical follicles, ovulation...
Tina Jorsal et al.
Diabetologia, 61(2), 284-294 (2017-09-29)
Enteroendocrine K and L cells are pivotal in regulating appetite and glucose homeostasis. Knowledge of their distribution in humans is sparse and it is unknown whether alterations occur in type 2 diabetes. We aimed to evaluate the distribution of enteroendocrine...
Sidra Shafique et al.
Neurotoxicology and teratology, 83, 106941-106941 (2020-11-20)
Nuclear factor kappa B (NF-κB) is a heterodimer of protein subunits p65 and p50, that regulates the expression of a large number of genes related to cell growth and proliferation. The p65 subunit is activated after phosphorylation by Pim-1, while...
Marta Cosín-Tomàs et al.
Nutrients, 11(8) (2019-08-03)
Oxidative damage is involved in the pathophysiology of age-related ailments, including Alzheimer's disease (AD). Studies have shown that the brain tissue and also lymphocytes from AD patients present increased oxidative stress compared to healthy controls (HCs). Here, we use lymphoblastoid...
Sara R van Boeckel et al.
Scientific reports, 9(1), 7356-7356 (2019-05-16)
Preterm birth, defined as delivery before 37 weeks of gestation, is the leading cause of neonatal mortality and morbidity. Infection and inflammation are frequent antecedents of spontaneous preterm birth. Cathelicidin, an antimicrobial host defence peptide, is induced by infection and...
The Venus flytrap trigger hair-specific potassium channel KDM1 can reestablish the K+ gradient required for hapto-electric signaling.
Iosip, et al.
PLoS Biology, 18, e3000964-e3000964 (2021)
Jaret P Bilewitch et al.
BMC evolutionary biology, 11, 228-228 (2011-08-02)
The mitochondrial genome of the Octocorallia has several characteristics atypical for metazoans, including a novel gene suggested to function in DNA repair. This mtMutS gene is favored for octocoral molecular systematics, due to its high information content. Several hypotheses concerning...
Songjie Cai et al.
Scientific reports, 10(1), 14249-14249 (2020-08-30)
Solid organ transplantation is a lifesaving therapy for patients with end-organ disease. Current immunosuppression protocols are not designed to target antigen-specific alloimmunity and are uncapable of preventing chronic allograft injury. As myeloid-derived suppressor cells (MDSCs) are potent immunoregulatory cells, we...
Christopher R Schlieve et al.
PloS one, 11(3), e0151396-e0151396 (2016-03-16)
Vascular endothelial growth factor (VEGF) is a highly conserved, master regulatory molecule required for endothelial cell proliferation, organization, migration and branching morphogenesis. Podocoryne carnea and drosophila, which lack endothelial cells and a vascular system, express VEGF homologs, indicating potential roles...
Timothy H Helms et al.
Scientific reports, 11(1), 3646-3646 (2021-02-13)
A promotional role for androgen receptor (AR) signaling in hepatocellular carcinogenesis is emerging. In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis. However, pharmacologic anti-androgen therapy in advanced HCC patients fails, suggesting that AR plays...
Victor Cervera-Carrascon et al.
Molecular therapy oncolytics, 17, 47-60 (2020-04-24)
Despite some promising results, the majority of patients do not benefit from T cell therapies, as tumors prevent T cells from entering the tumor, shut down their activity, or downregulate key antigens. Due to their nature and mechanism of action, oncolytic viruses...
Hannah R Wardill et al.
Molecular cancer therapeutics, 15(11), 2767-2779 (2016-11-04)
We have previously shown increased intestinal permeability, to 4-kDa FITC-dextran, in BALB/c mice treated with irinotecan. Importantly, genetic deletion of Toll-like receptor 4 (TLR4; Tlr4
Hannah C Zierden et al.
The American journal of pathology, 190(2), 295-305 (2019-12-15)
Preterm birth (PTB) affects nearly 15 million infants each year. Of these PTBs, >25% are a result of inflammation or infection. Animal models have improved our understanding of the mechanisms leading to PTB. Prior work has described induction of intrauterine...
Gangappa Kiran et al.
Journal of physiology and biochemistry, 73(4), 539-550 (2017-08-02)
Glycosaminoglycans (GAGs) play an important role in lipoprotein metabolism. In liver, it facilitates the uptake of remnants through receptor-independent endocytosis. However, changes in liver GAGs during diet-induced hypercholesterolemia with normal levels of fat feeding are unknown. Present paper highlights the...
Annette B Steffensen et al.
Nature communications, 9(1), 2167-2167 (2018-06-06)
Cerebrospinal fluid (CSF) production occurs at a rate of 500 ml per day in the adult human. Conventional osmotic forces do not suffice to support such production rate and the molecular mechanisms underlying this fluid production remain elusive. Using ex vivo...
Roisin Sullivan et al.
PloS one, 15(3), e0229791-e0229791 (2020-03-10)
Saliva represents an ideal matrix for diagnostic biomarker development as it is readily available and requires no invasive collection procedures. However, salivary RNA is labile and rapidly degrades. Previous attempts to isolate RNA from saliva have yielded poor quality and...
Issa Layali et al.
Immunopharmacology and immunotoxicology, 40(4), 290-296 (2018-04-21)
Sulfur mustard (SM) is a lipophilic and reactive chemical compound that targets human airway system. Glutathione (GSH) depletion, oxidative stress (OS) status, and changes in expression of GSH-dependent antioxidant enzymes were considered in human mustard lungs. Lung biopsies and bronchoalveolar...
Bruno M D C Godinho et al.
Nucleic acid therapeutics, 27(6), 323-334 (2017-10-13)
Therapeutic oligonucleotides, such as small interfering RNAs (siRNAs), hold great promise for the treatment of incurable genetically defined disorders by targeting cognate toxic gene products for degradation. To achieve meaningful tissue distribution and efficacy in vivo, siRNAs must be conjugated...
J S Yokhana et al.
Poultry science, 95(3), 550-559 (2015-11-18)
Two experiments were conducted to study effects of dietary insoluble fiber (IF) on digestive enzyme function in layer poultry. In Experiment 1, 8 wk old pullets were fed a control diet (Group C) or a diet (Group IF) supplemented with...
Stelina Drimousis et al.
The Journal of pharmacology and experimental therapeutics, 375(1), 28-39 (2020-08-09)
The tachykinin NK2 receptor plays a key role in gastrointestinal motor function. Enteric neurons release neurokinin A (NKA), which activates NK2 receptors on gastrointestinal smooth muscle, leading to contraction and increased motility. In patients with diarrhea-predominant irritable bowel syndrome, the...
Kazuhito Morioka et al.
Scientific reports, 9(1), 12199-12199 (2019-08-23)
Polytraumatic injuries, specifically long bone fracture and traumatic brain injury (TBI), frequently occur together. Clinical observation has long held that TBI can accelerate fracture healing, yet the complexity and heterogeneity of these injuries has produced conflicting data with limited information...
Zachary D Urdang et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 41(1), 123-132 (2019-10-01)
Both toll-like receptor 4 (TLR4) and downstream neutrophil activity are required for endotoxemia-enhanced blood-labyrinth barrier (BLB) trafficking. Aminoglycoside and cisplatin are valuable clinical therapies; however, these drugs often cause life-long hearing loss. Endotoxemia enhances the ototoxicity of aminoglycosides and cisplatin...
Peter Tougaard et al.
Inflammatory bowel diseases, 25(3), 510-523 (2018-11-22)
The tumor necrosis factor alpha (TNFα)-homologous cytokine TL1A is emerging as a major player in intestinal inflammation. From in vitro experiments on human lymphocytes, TNF-like molecule 1A (TL1A) is known to activate a highly inflammatory lymphoid response in synergy with...