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Sajjida Jaffer et al.
Visual neuroscience, 29(4-5), 247-253 (2012-08-14)
Monocular deprivation (MD) by lid suture is one of the classic paradigms for the study of developmental plasticity in the cerebral cortex, and we have detailed knowledge of its anatomical and physiological consequences as well as underlying molecular and cellular...
Renjie Wang et al.
Biophysical journal, 118(11), 2718-2725 (2020-05-12)
The bacterial flagellar motor generates the torque that drives the rotation of bacterial flagellar filaments. The torque it generates depends sensitively on the frictional viscous drag on the motor, which includes the frictional viscous drag on the filaments (external load)...
Tadao Maeda et al.
The Journal of biological chemistry, 288(48), 34484-34493 (2013-10-17)
Differentiated retinal pigmented epithelial (RPE) cells have been obtained from human induced pluripotent stem (hiPS) cells. However, the visual (retinoid) cycle in hiPS-RPE cells has not been adequately examined. Here we determined the expression of functional visual cycle enzymes in...
Tadao Maeda et al.
Photochemistry and photobiology, 88(6), 1309-1319 (2012-03-21)
Accumulation of all-trans-retinal (all-trans-RAL), reactive vitamin A aldehyde, is one of the key factors in initiating retinal photodamage. This photodamage is characterized by progressive retinal cell death evoked by light exposure in both an acute and chronic fashion. Photoactivated rhodopsin...
Yang Li et al.
PloS one, 7(9), e45210-e45210 (2012-10-03)
The roles of vitamin A (VA) in the development of metabolic diseases remain unanswered. We have reported that retinoids synergized with insulin to induce the expression of sterol-regulatory element-binding protein 1c gene (Srebp-1c) expression in primary rat hepatocytes. Additionally, the...
Martyna J Grabowska et al.
The Journal of experimental biology, 221(Pt 23) (2018-10-17)
Visual decision making in animals is influenced by innate preferences as well as experience. Interaction between hard-wired responses and changing motivational states determines whether a visual stimulus is attractive, aversive or neutral. It is, however, difficult to separate the relative...
Yu-Chieh David Chen et al.
Cell reports, 29(4), 961-973 (2019-10-24)
Taste drives appropriate food preference and intake. In Drosophila, taste neurons are housed in both external and internal organs, but the latter have been relatively underexplored. Here, we report that Poxn mutants with a minimal taste system of pharyngeal neurons...
Johnny Cruz-Corchado et al.
G3 (Bethesda, Md.), 10(4), 1225-1246 (2020-01-31)
Serotonin (5-hydroxytryptamine, 5-HT), is a phylogenetically ancient molecule best characterized as a neurotransmitter that modulates multiple aspects of mood and social cognition. The roles that 5-HT plays in normal and abnormal behavior are not fully understood but have been posited...
Nicholas M Tefft et al.
ACS synthetic biology, 8(7), 1590-1600 (2019-06-28)
Microbial electrosynthesis is an emerging technology with the potential to simultaneously store renewably generated energy, fix carbon dioxide, and produce high-value organic compounds. However, limited understanding of the route of electrons into the cell remains an obstacle to developing a...
J Y Hilary Wong et al.
Learning & memory (Cold Spring Harbor, N.Y.), 28(2), 53-71 (2021-01-17)
Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by...
Thomas Kowatz et al.
Archives of biochemistry and biophysics, 539(2), 214-222 (2013-06-04)
The formal first step in in vitamin A metabolism is the conversion of its natural precursor β,β-carotene (C40) to retinaldehyde (C20). This reaction is catalyzed by the enzyme β,β-carotene-15,15'-monooxygenase (BCMO1). BCMO1 has been cloned from several vertebrate species, including humans....
Elena G Govorunova et al.
Scientific reports, 7, 43358-43358 (2017-03-04)
Natural anion channelrhodopsins (ACRs) discovered in the cryptophyte alga Guillardia theta generate large hyperpolarizing currents at membrane potentials above the Nernst equilibrium potential for Cl
James M Jeanne et al.
Neuron, 98(6), 1198-1213 (2018-06-19)
Each odorant receptor corresponds to a unique glomerulus in the brain. Projections from different glomeruli then converge in higher brain regions, but we do not understand the logic governing which glomeruli converge and which do not. Here, we use two-photon...
Ying-Chou Chen et al.
Molecular cell, 68(1), 247-257 (2017-10-07)
The genome-wide perturbation of transcriptional networks with CRISPR-Cas technology has primarily involved systematic and targeted gene modulation. Here, we developed PRISM (Perturbing Regulatory Interactions by Synthetic Modulators), a screening platform that uses randomized CRISPR-Cas transcription factors (crisprTFs) to globally perturb...
Minjuan Bian et al.
Journal of neuroinflammation, 13, 50-50 (2016-02-28)
Photoreceptor death leads to vision impairment in several retinal degenerative disorders. Therapies protecting photoreceptor from degeneration remain to be developed. Anti-inflammation, anti-oxidative stress, and neuroprotective effects of celastrol have been demonstrated in a variety of disease models. The current study...
Jannik N Pedersen et al.
Biochemistry, 54(31), 4815-4823 (2015-07-15)
Recently, it has been shown that different complexes consisting of protein and fatty acids, which we call liprotides, have common functional and structural features. Liprotides can transfer their fatty acid content to membranes, highlighting the potential to incorporate other small...
Ricardo Zacarias et al.
Nature communications, 9(1), 3697-3697 (2018-09-14)
The most fundamental choice an animal has to make when it detects a threat is whether to freeze, reducing its chances of being noticed, or to flee to safety. Here we show that Drosophila melanogaster exposed to looming stimuli in...
Eric S Luth et al.
PLoS genetics, 17(2), e1009375-e1009375 (2021-02-10)
Several intracellular trafficking pathways contribute to the regulation of AMPA receptor (AMPAR) levels at synapses and the control of synaptic strength. While much has been learned about these intracellular trafficking pathways, a major challenge is to understand how extracellular factors...
Hui Chiu et al.
Cell, 184(2), 507-520 (2021-01-01)
Aggression involves both sexually monomorphic and dimorphic actions. How the brain implements these two types of actions is poorly understood. We have identified three cell types that regulate aggression in Drosophila: one type is sexually shared, and the other two...
Tivadar Orban et al.
Current opinion in cell biology, 27, 32-43 (2014-04-01)
The past decade has witnessed an impressive expansion of our knowledge of retinal photoreceptor signal transduction and the regulation of the visual cycle required for normal eyesight. Progress in human genetics and next generation sequencing technologies have revealed the complexity...
Antoine Gautier
Biochimica et biophysica acta, 1837(5), 578-588 (2013-07-09)
The biochemical processes of living cells involve a numerous series of reactions that work with exceptional specificity and efficiency. The tight control of this intricate reaction network stems from the architecture of the proteins that drive the chemical reactions and...
Marc C Liggins et al.
Journal of immunology (Baltimore, Md. : 1950), 203(6), 1589-1597 (2019-08-20)
A subset of dermal fibroblasts undergo rapid differentiation into adipocytes in response to infection and acutely produce the cathelicidin antimicrobial peptide gene Camp Vitamin A and other retinoids inhibit adipogenesis yet can show benefit to skin disorders, such as cystic...
Lisha Shao et al.
Neuron, 102(5), 1025-1036 (2019-05-11)
Female behavior changes profoundly after mating. In Drosophila, the mechanisms underlying the long-term changes led by seminal products have been extensively studied. However, the effect of the sensory component of copulation on the female's internal state and behavior remains elusive....
Keiichi Inoue et al.
Biochimica et biophysica acta, 1837(5), 562-577 (2013-06-05)
Retinal proteins (~rhodopsins) are photochemically reactive membrane-embedded proteins, with seven transmembrane α-helices which bind the chromophore retinal (vitamin A aldehyde). They are widely distributed through all three biological kingdoms, eukarya, bacteria and archaea, indicating the biological significance of the retinal...
Roberto Rodríguez-Ortiz et al.
Molecular genetics and genomics : MGG, 288(3-4), 157-173 (2013-04-02)
The ascomycete fungus Fusarium fujikuroi is a model system in the investigation of the biosynthesis of some secondary metabolites, such as gibberellins, bikaverin, and carotenoids. Carotenoid-overproducing mutants, generically called carS, are easily obtained in this fungus by standard mutagenesis procedures....
Song-Qi Gao et al.
Investigative ophthalmology & visual science, 53(10), 6314-6323 (2012-08-25)
To design and develop a drug-delivery system containing a combination of poly(D,L-lactide-co-glycolide) (PLGA) microparticles and alginate hydrogel for sustained release of retinoids to treat retinal blinding diseases that result from an inadequate supply of retinol and generation of 11-cis-retinal. To...
RubyACRs, nonalgal anion channelrhodopsins with highly red-shifted absorption.
Govorunova, et al.
Proceedings of the National Academy of Sciences of the USA, 117, 22833-22840 (2021)
Javier Valdes-Aleman et al.
Neuron, 109(1), 105-122 (2020-10-30)
The mechanisms by which synaptic partners recognize each other and establish appropriate numbers of connections during embryonic development to form functional neural circuits are poorly understood. We combined electron microscopy reconstruction, functional imaging of neural activity, and behavioral experiments to...
Jeffrey L Rhoades et al.
Cell, 176(1-2), 85-97 (2018-12-26)
Animals must respond to the ingestion of food by generating adaptive behaviors, but the role of gut-brain signaling in behavioral regulation is poorly understood. Here, we identify conserved ion channels in an enteric serotonergic neuron that mediate its responses to...
Eugenia Poliakov et al.
PloS one, 7(11), e49975-e49975 (2012-12-05)
In order to maintain visual sensitivity at all light levels, the vertebrate eye possesses a mechanism to regenerate the visual pigment chromophore 11-cis retinal in the dark enzymatically, unlike in all other taxa, which rely on photoisomerization. This mechanism is...
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