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Mariama Jaiteh et al.
Journal of medicinal chemistry, 61(12), 5269-5278 (2018-05-25)
Modulation of multiple biological targets with a single drug can lead to synergistic therapeutic effects and has been demonstrated to be essential for efficient treatment of CNS disorders. However, rational design of compounds that interact with several targets is very...
Sean P Heffron et al.
Journal of thrombosis and haemostasis : JTH, 19(2), 562-573 (2020-11-11)
Platelets are increasingly recognized as immune cells. As such, they are commonly seen to induce and perpetuate inflammation; however, anti-inflammatory activities are increasingly attributed to them. Atherosclerosis is a chronic inflammatory condition. Similar to other inflammatory conditions, the resolution of...
Maria S Spagnuolo et al.
Journal of cellular physiology, 233(9), 6925-6943 (2018-01-13)
In the central nervous system, cholesterol is critical to maintain membrane plasticity, cellular function, and synaptic integrity. In recent years, much attention was focused on the role of cholesterol in brain since a breakdown of cholesterol metabolism has been associated...
Corrine R Kliment et al.
Journal of cell science, 134(4) (2021-02-03)
Airway hydration and ciliary function are critical to airway homeostasis and dysregulated in chronic obstructive pulmonary disease (COPD), which is impacted by cigarette smoking and has no therapeutic options. We utilized a high-copy cDNA library genetic selection approach in the...
Danbi Lee et al.
Experimental & molecular medicine, 50(7), 88-88 (2018-07-29)
Hepatocellular carcinoma (HCC), a representative example of a malignancy with a poor prognosis, is characterized by high mortality because it is typically in an advanced stage at diagnosis and leaves very little hepatic functional reserve. Despite advances in medical and...
Tao Shu et al.
Neuroscience letters, 671, 154-160 (2018-02-09)
Salvianolic acid B (Sal B), a water-soluble component mainly extracted from the traditional Chinese medicine Salvia miltiorrhiza, has potential anti-inflammatory, anti-oxidative and anti-apoptotic actions to protect neural cells. Here, we explore the effects and mechanisms of Sal B on the...
Juthathip Poofery et al.
Molecules (Basel, Switzerland), 25(1) (2020-01-16)
The incidence of lung cancer has increased while the mortality rate has continued to remain high. Effective treatment of this disease is the key to survival. Therefore, this study is a necessity in continuing research into new effective treatments. In...
Munenari Itoh et al.
Journal of dermatological science, 98(3), 163-172 (2020-05-08)
Recessive dystrophic epidermolysis bullosa (RDEB) is a monogenic skin blistering disorder caused by mutations in the type VII collagen gene. A combination of biological technologies, including induced pluripotent stem cells (iPSCs) and several gene-editing tools, allows us to develop gene...
Alyssa Kallman et al.
Communications biology, 3(1), 82-82 (2020-02-23)
Photoreceptor loss is a leading cause of blindness, but mechanisms underlying photoreceptor degeneration are not well understood. Treatment strategies would benefit from improved understanding of gene-expression patterns directing photoreceptor development, as many genes are implicated in both development and degeneration....
Farjam Goudarzi et al.
Archives of physiology and biochemistry, 124(2), 109-118 (2017-08-30)
It has been shown that adipogenesis can be modulated by factors such as all-trans retinoic acid (ATRA) and calcium. To determine, the combined effect of ATRA and calcium on the differentiation of human adipose-derived stem cells (hADSCs). Mesenchymal stem cells...
Gonghua Huang et al.
Journal of immunology (Baltimore, Md. : 1950), 191(2), 650-659 (2013-06-12)
Dendritic cells (DCs) play a crucial role in launching protective adaptive immunity against pathogens while maintaining immune tolerance to self-Ags. However, how intracellular signaling pathways program DCs to mediate tolerogenic responses remains largely unexplored. In this study, we describe that...
Samuel A Myers et al.
Molecular & cellular proteomics : MCP, 18(5), 995-1009 (2019-02-23)
Proteomic profiling describes the molecular landscape of proteins in cells immediately available to sense, transduce, and enact the appropriate responses to extracellular queues. Transcriptional profiling has proven invaluable to our understanding of cellular responses; however, insights may be lost as...
Aleksandra Cvoro et al.
Stem cells (Dayton, Ohio), 33(2), 416-428 (2014-10-22)
Biological processes require close cooperation of multiple transcription factors that integrate different signals. Thyroid hormone receptors (TRs) induce Krüppel-like factor 9 (KLF9) to regulate neurogenesis. Here, we show that triiodothyronine (T3) also works through TR to induce KLF9 in HepG2...
Islam M Saadeldin et al.
Animals : an open access journal from MDPI, 9(6) (2019-06-23)
Elite camels often suffer from massive injuries. Thus, there is a pivotal need for a cheap and readily available regenerative medicine source. We isolated novel stem-like cells from camel skin and investigated their multipotency and resistance against various stresses. Skin...
Yasuyo Suzuki et al.
The Journal of biological chemistry, 289(35), 24374-24382 (2014-07-17)
Multiple system atrophy (MSA) is a neurodegenerative disease caused by α-synuclein aggregation in oligodendrocytes and neurons. Using a transgenic mouse model overexpressing human α-synuclein in oligodendrocytes, we previously demonstrated that oligodendrocytic α-synuclein inclusions induce neuronal α-synuclein accumulation and progressive neuronal...
Venu Seenappa et al.
Current molecular medicine, 19(4), 247-272 (2019-04-06)
The phosphoenolpyruvate carboxykinase (PEPCK) isoforms are considered as rate-limiting enzymes for gluconeogenesis and glyceroneogenesis pathways. PEPCK exhibits several interesting features such as a) organelle-specific isoforms (cytosolic and a mitochondrial) in vertebrate clade, b) tissue-specific expression of isoforms and c) organism-specific...
Leslie Crews et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(16), 4250-4260 (2008-04-18)
Altered expression and mutations in alpha-synuclein (alpha-syn) have been linked to Parkinson's disease (PD) and related disorders. The neurological alterations in PD patients have been associated with degeneration of dopaminergic cells and other neuronal populations. Moreover, recent studies in murine...
Ken Suzawa et al.
Anticancer research, 37(1), 301-307 (2016-12-25)
Reduced expression in immortalized cell (REIC)/Dickkoph-3 (DKK3) is a tumor-suppressor gene, and its overexpression by adenovirus vector (Ad-REIC) exhibits a remarkable therapeutic effect on various human cancer types through a mechanism triggered by endoplasmic reticulum stress. We examined the direct...
Alistair Noble et al.
Journal of Crohn's & colitis, 14(4), 525-537 (2019-10-31)
The intestinal microbiota is closely associated with resident memory lymphocytes in mucosal tissue. We sought to understand how acquired cellular and humoral immunity to the microbiota differ in health versus inflammatory bowel disease [IBD]. Resident memory T cells [Trm] in...
Renske Oegema et al.
PLoS genetics, 13(5), e1006809-e1006809 (2017-05-26)
Integrator is an RNA polymerase II (RNAPII)-associated complex that was recently identified to have a broad role in both RNA processing and transcription regulation. Importantly, its role in human development and disease is so far largely unexplored. Here, we provide...
Luis Muniz-Feliciano et al.
Autophagy, 13(12), 2072-2085 (2017-09-22)
Macroautophagy/autophagy is an intracellular stress survival and recycling system whereas phagocytosis internalizes material from the extracellular milieu; yet, both pathways utilize lysosomes for cargo degradation. Whereas autophagy occurs in all cells, phagocytosis is performed by cell types such as macrophages...
Samir Devalaraja et al.
Cell, 180(6), 1098-1114 (2020-03-15)
The immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor-associated macrophages (TAMs) rather than immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine sarcoma models, we find that the...
Wen Wen et al.
Frontiers in molecular neuroscience, 13, 560020-560020 (2020-10-20)
Neurite outgrowth is essential for brain development and the recovery of brain injury and neurodegenerative diseases. In this study, we examined the role of the neurotrophic factor MANF in regulating neurite outgrowth. We generated MANF knockout (KO) neuro2a (N2a) cell...
Chia-Yu Tsai et al.
The Journal of dairy research, 87(4), 416-423 (2020-11-11)
The study included two experiments. In the first, 24 lactating Saanen dairy goats received low-energy diet without vitamin supplements. Twelve goats received a daily IV injection of 2,4- thiazolidinedione (TZD), others received saline injection. A week later, 6 goats from...
Shi-Ying Cai et al.
The Journal of pharmacology and experimental therapeutics, 349(1), 94-98 (2014-02-05)
Chronic cholestasis results in liver injury and eventually liver failure. Although ursodeoxycholic acid (UDCA) showed limited benefits in primary biliary cirrhosis, there is an urgent need to develop alternative therapy for chronic cholestatic disorders. Previous studies from our laboratory demonstrated...
Ricardo M Gouveia et al.
Biomaterials, 121, 205-219 (2017-01-17)
Ideally, biomaterials designed to play specific physical and physiological roles in vivo should comprise components and microarchitectures analogous to those of the native tissues they intend to replace. For that, implantable biomaterials need to be carefully designed to have the correct...
Natália Chermont Dos Santos Moreira et al.
Journal of Alzheimer's disease : JAD, 78(1), 353-370 (2020-09-29)
Alzheimer's disease (AD) is characterized by a progressive loss of episodic memory associated with amyloid-β peptide aggregation and the abnormal phosphorylation of the tau protein, leading to the loss of cholinergic function. Acetylcholinesterase (AChE) inhibitors are the main class of...
Wanli Gao et al.
Neurotoxicity research, 38(4), 859-870 (2020-05-18)
Duloxetine is a clinical drug that is primarily used for treatment of depression and pain, but it has side effects of addiction and tolerance. Cytochrome P450 (CYP) is its metabolic enzyme, and the drug's biofunction results from its neuro-protective effect...
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