Showing 1-30 of 122 results for "R3255"
Lizzia Raffaghello et al.
Journal of leukocyte biology, 94(1), 183-191 (2013-04-24)
OMS is a rare paraneoplastic disorder that affects adults and children. Pediatric OMS is often associated with NB, a common, solid tumor of childhood, derived from the sympathetic nervous system. The detection of autoantibodies and lymphocytic infiltration in NB patients...
Live multicellular tumor spheroid models for high-content imaging and screening in cancer drug discovery
Reid B G, et al.
Current Chemical Genomics and Translational Medicine, 8(Suppl-1), 27-27 (2014)
Marius Rademaker
The Australasian journal of dermatology, 54(3), 157-162 (2012-09-28)
With 30 years of clinical use, it is appropriate to review the use of isotretinoin. We now understand that retinoids influence cellular growth, differentiation, morphogenesis and apoptosis, inhibit tumour promotion and malignant cell growth, exert immuno-modulatory actions and alter cellular...
P K Datta et al.
Kidney international, 56(2), 486-493 (1999-08-05)
Nitric oxide (NO) release as a result of cytokine-mediated activation of inducible nitric oxide synthase (iNOS) in mesangial cells can be sustained and lead to oxidative injury in various forms of glomerular inflammation. Inhibition of iNOS expression and/or activity could...
Challenges in optimizing isotretinoin use for acne vulgaris.
Thomas J McIntee et al.
JAMA dermatology, 149(12), 1398-1398 (2013-11-01)
F L Meyskens et al.
Critical reviews in oncology/hematology, 3(1), 75-101 (1985-01-01)
Retinoids, particularly 13-cis-retinoic acid, have shown great promise against a number of benign, but serious dermatological conditions. In animal models, 13-cis-retinoic acid functions is a potent antipromoter whether a cancer has been initiated by chemical, physical, or viral agents. Additionally...
Acne vulgaris.
Faisal R Ali et al.
British journal of hospital medicine (London, England : 2005), 74(5), C78-C80 (2013-05-10)
Juan Ding et al.
Investigative ophthalmology & visual science, 54(6), 4341-4350 (2013-06-01)
Meibomian gland dysfunction (MGD) is a primary cause of dry eye disease. One of the risk factors for MGD is exposure to 13-cis retinoic acid (13-cis RA), a metabolite of vitamin A. However, the mechanism is not well understood. We...
Induction of pronephric tubules by activin and retinoic acid in presumptive ectoderm of Xenopus laevis
Moriya N, et al.
Development, Growth & Differentiation, 35(2), 123-128 (1993)
Concomitant antibiotic usage does not augment the risk of inflammatory bowel disease with isotretinoin treatment for acne: a review of the Food and Drug Administration Adverse Event Reporting System.
Derrick J Stobaugh et al.
European journal of clinical pharmacology, 69(4), 1041-1042 (2012-10-12)
A Segaran et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 66(12), e370-e372 (2013-06-14)
Pyoderma gangrenosum (PG) is an unusual skin condition causing inflammation and sterile ulceration. It may occur in the context of a systemic disease or in otherwise healthy patients following trauma. Treatment is immunosuppression. Surgical debridement may worsen the disease. Post-surgical...
G Konjevic et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 17(4), 761-769 (2013-01-22)
Considering tumor-induced suppression of natural killer (NK) cell activity the aim of this study was to investigate the in vitro effect of a standard immunotherapeutic cytokine, interferon (IFN)α, and a less investigated agent, 13-cis retinoic acid (RA) on the functional...
Philip A Ruzycki et al.
Genome biology, 16, 171-171 (2015-09-02)
Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity. Five well-characterized mouse models carrying different Crx mutations show a wide range of disease phenotypes. To determine if the phenotype...
The role and mechanism of action of 13-cis-retinoic acid in the treatment of severe (nodulocystic) acne.
D H Jones
Pharmacology & therapeutics, 40(1), 91-106 (1989-01-01)
Reply to L. Moreno et al.
Nai-Kong V Cheung et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(5), 650-651 (2013-03-23)
Eruption in a patient with Crohn disease.
Maria Gavrilova et al.
JAMA dermatology, 149(1), 97-102 (2013-01-18)
Minerva Gómez-Flores et al.
Revista medica del Instituto Mexicano del Seguro Social, 49(3), 281-288 (2011-08-16)
Isotretinoin was authorized since 1982 for the treatment of acne vulgaris associated to severe cutaneous lesions. It has been used in others clinical conditions in various plans of prescription. Since the Isotretinoin was launched, it caused controversies in our country...
Fatma Cetinözman et al.
The Journal of dermatological treatment, 25(2), 119-122 (2012-11-21)
Androgens appear to play a role in the development of acne, and presence of acne is a potential marker of hyperandrogenism. The authors evaluated androgens and insulin sensitivity markers before and after treatment with isotretinoin in women with post-adolescent severe...
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds...
Amir Feily et al.
Journal of drugs in dermatology : JDD, 10(7), 793-794 (2011-07-02)
Isotretinoin and its desirable effects have received tremendous attention in recent years by scientists. This article reviews the evidence that decrease of insulin growth factor-1 is implicated as a novel mechanism of anti androgenic effect and its reported association with...
George Magoulas et al.
European journal of medicinal chemistry, 44(6), 2689-2695 (2009-02-14)
Novel mono- and diacylated spermines, readily obtained using isolable succinimidyl active esters of acidic retinoids for the selective acylation of free spermine or in situ activated acidic retinoids for acylating selectively protected spermine followed by deprotection, were shown to inhibit...
Raoud Marayati et al.
Translational oncology, 14(1), 100893-100893 (2020-10-04)
Retinoic acid (RA) therapy has been utilized as maintenance therapy for high-risk neuroblastoma, but over half of patients treated with RA relapse. Neuroblastoma stem cell-like cancer cells (SCLCCs) are a subpopulation of cells characterized by the expression of the cell...
Aslı Gürbüz et al.
Archives of dermatological research, 307(7), 607-615 (2015-04-24)
Acne vulgaris is the chronical, multifactorial and complex disease of the pilosebaceous unit in the skin. The main goal of the topical therapy in acne is to target the drug to epidermal and deep dermal regions by minimizing systemic absorption...
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential...
Zuzana Nevoralová et al.
International journal of dermatology, 52(2), 163-168 (2013-01-26)
Depression and mood changes appear as potentional side effects of isotretinoin in the Summary of Product Characteristics. There have been many studies treating this topic but in most cases not identifying any significant depression or suicide risk. To further investigate...
Maria Lapteva et al.
Nanoscale, 7(44), 18651-18662 (2015-10-27)
Acne vulgaris is a highly prevalent dermatological disease of the pilosebaceous unit (PSU). An inability to target drug delivery to the PSU results in poor treatment efficacy and the incidence of local side-effects. Cutaneous application of nanoparticulate systems is reported...
Isotretinoin and pregnancy prevention: do we need to take a long, hard look at ourselves?
Emily M Altman
JAMA dermatology, 150(4), 361-362 (2013-11-22)
Michael Maschan et al.
Pediatric blood & cancer, 61(10), 1871-1873 (2014-03-05)
We describe an infant who developed juvenile myelomonocytic leukemia (JMML) at the age of 6 months. Myeloproliferation was effectively controlled by low-dose cytosine arabinoside and 13-cis retinoic acid therapy. Two years after therapy for JMML was stopped, at the age...
H J M J Crijns et al.
The British journal of dermatology, 164(2), 238-244 (2010-08-19)
Most of the publications on isotretinoin, pregnancy and compliance with the pregnancy prevention programme (PPP) originate from North America. Information specific for the European situation is very limited. The aim of this study was to identify publications describing the use...
Alexander Stratigos et al.
European journal of cancer (Oxford, England : 1990), 51(14), 1989-2007 (2015-07-30)
Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in Caucasian populations, accounting for 20% of all cutaneous malignancies. A unique collaboration of multi-disciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO)...

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