Journal of cell science, 127(Pt 19), 4172-4185 (2014-07-24)
Cell fusion occurs as part of the differentiation of some cell types, including myotubes in muscle and osteoclasts in remodeling bone. In the human placenta, mononuclear cytotrophoblasts in a human chorionic gonadotropin (hCG)-driven process fuse to form multinucleated syncytia that...
Novel insights of the gastric gland organization revealed by chief cell specific expression of moesin
Zhu L, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 296(2), G185-G195 (2009)
Radixin regulates cell migration and cell-cell adhesion through Rac1.
Valderrama F, et al.
Journal of Cell Science, 125(14), 3310-3319 (2012)
Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells.
Ramoni C, et al.
European Journal of Immunology, 32(11), 3059-3065 (2002)
Chloride intracellular channel 5 protein (CLIC5) was originally isolated from microvilli in complex with actin binding proteins including ezrin, a member of the Ezrin-Radixin-Moesin (ERM) family of membrane-cytoskeletal linkers. CLIC5 concentrates at the base of hair cell stereocilia and is...
Staurosporine-induced collapse of cochlear hair bundles
Goodyear RJ, et al.
The Journal of Comparative Neurology, 522(14), 3281-3294 (2014)
Journal of cell science, 125(Pt 14), 3310-3319 (2012-04-03)
The ERM proteins ezrin, radixin and moesin are adaptor proteins that link plasma membrane receptors to the actin cytoskeleton. Ezrin and moesin have been implicated in cell polarization and cell migration, but little is known about the involvement of radixin...
Structural conversion between open and closed forms of radixin: low-angle shadowing electron microscopy.
Ishikawa H, et al.
Journal of molecular biology, 310(5), 973-978 (2001)
GABAA receptor subunit composition is a critical determinant of receptor localization and physiology, with synaptic receptors generating phasic inhibition and extrasynaptic receptors producing tonic inhibition. Extrasynaptically localized α5 GABAA receptors are largely responsible for tonic inhibition in hippocampal neurons. However...
Radixin knockdown by RNA interference suppresses human glioblastoma cell growth in vitro and in vivo
Qin JJ, et al.
Asian Pacific Journal of Cancer Prevention, 15(22), 9805-9812 (2014)
Asian Pacific journal of cancer prevention : APJCP, 13(3), 753-759 (2012-05-29)
Radixin, encoded by a gene on chromosome 11, plays important roles in cell motility, invasion and tumor progression. However, its function in pancreatic cancer remains elusive. In this study, radixin gene expression was suppressed with a lentivirus-mediated short-hairpin RNA (shRNA)...
Genetics and molecular research : GMR, 13(2), 3697-3703 (2014-05-24)
Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated...
American journal of physiology. Gastrointestinal and liver physiology, 296(2), G185-G195 (2008-12-17)
ERM (ezrin, radixin, and moesin) proteins play critical roles in epithelial and endothelial cell polarity, among other functions. In gastric glands, ezrin is mainly expressed in acid-secreting parietal cells, but not in mucous neck cells or zymogenic chief cells. In...
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(1), 282-296 (2012-01-06)
The development of a functioning neural network relies on responses of axonal growth cones to molecular guidance cues that are encountered en route to their target tissue. Nerve growth factor (NGF) and neurotrophin-3 serve as attractive cues for chick embryo...
Frontiers in microbiology, 8, 2230-2230 (2017-12-07)
The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas' disease. In mammalian hosts, T. cruzi alternates between trypomastigote and amastigote forms. Additionally, trypomastigotes can differentiate into amastigotes in the extracellular environment generating infective extracellular amastigotes (EAs). Ezrin-radixin-moesin (ERM)...
Lipopolysaccharide-responsive beige-like anchor protein (LRBA) belongs to the enigmatic class of BEACH domain-containing proteins, which have been attributed various cellular functions, typically involving intracellular protein and membrane transport processes. Here, we show that LRBA deficiency in mice leads to progressive...
The Journal of comparative neurology, 522(14), 3281-3294 (2014-04-05)
Early postnatal mouse cochlear cultures were treated with a small panel of kinase inhibitors to elucidate the mechanisms underlying the maintenance of hair-bundle structure in the developing inner ear. At low concentrations (1-10 nM), staurosporine causes the collapse and loss...
A novel splice site mutation in the RDX gene causes DFNB24 hearing loss in an Iranian family
Shearer AE, et al.
American Journal of Medical Genetics. Part A, 149A(3), 555-558 (2009)
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes.
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