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G Wolf
Nutrition reviews, 58(11), 354-356 (2001-01-05)
A short-chain alcohol dehydrogenase has been discovered that oxidizes 9-cis- and 11-cis-retinol to their corresponding aldehydes. The gene for this enzyme was sequenced and appears to be expressed with highest efficiency in the retinal pigment epithelium of the eye, as...
Takashi Okitsu et al.
Bioorganic & medicinal chemistry, 19(9), 2939-2949 (2011-04-15)
Retinoid X receptor (RXR) agonists are interesting candidates for the treatment of metabolic syndrome. 9-Cis-retinoic acid (9cRA: 1) is a natural RXR agonist, that also works as a retinoic acid receptor (RAR) agonist. This fact prompted us to study the...
Polysialylation at early stages of oligodendrocyte differentiation promotes myelin repair
Werneburg S, et al.
The Journal of Neuroscience, 37(34), 8131-8141 (2017)
9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development
Zapata-Gonzalez F, et al.
Journal of Immunology, 178(10), 6130-6139 (2007)
Michiyasu Ishizawa et al.
Biochemical and biophysical research communications, 418(4), 780-785 (2012-02-09)
Retinoid X receptors (RXRs) are members of the nuclear receptor superfamily and can be activated by 9-cis retinoic acid (9CRA). RXRs form homodimers and heterodimers with other nuclear receptors such as the retinoic acid receptor and NR4 subfamily nuclear receptors...
Marek M Nagiec et al.
PloS one, 10(3), e0120295-e0120295 (2015-03-27)
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasma levels of...
Marcia I Dawson et al.
Current medicinal chemistry, 9(6), 623-637 (2002-04-12)
This review presents a historical overview of the discoveries of retinoic acid receptor (RAR) and retinoid X receptor (RXR) class- and subtype-selective synthetic retinoids. These synthetic retinoids are conformationally restricted by having aromatic rings in place of the tetraene bond...
Kyle A Sharow et al.
The International journal of developmental biology, 56(4), 273-278 (2012-05-09)
It has been reported that retinoids, such as retinoic acid (RA) and retinol (ROL), dissolved in aqueous solutions are susceptible to oxidative damage when exposed to light, air, and relatively high temperatures, conditions that are normal for culturing stem cells....
Inho Choi et al.
Circulation, 125(7), 872-882 (2012-01-26)
The lymphatic system plays a key role in tissue fluid homeostasis and lymphatic dysfunction caused by genetic defects, or lymphatic vessel obstruction can cause lymphedema, disfiguring tissue swelling often associated with fibrosis and recurrent infections with no available cures to...
Alitretinoin for cutaneous lupus erythematosus.
Annegret Kuhn et al.
Journal of the American Academy of Dermatology, 67(3), e123-e126 (2012-08-15)
N Irla et al.
The British journal of dermatology, 167(5), 1170-1174 (2012-05-23)
Palmoplantar pustular psoriasis is often recalcitrant to therapy. Here we evaluated the therapeutic effect of alitretinoin in patients with recalcitrant palmoplantar pustular psoriasis and investigated subsequent immunopathological alterations. Seven patients with palmoplantar pustular psoriasis were treated with oral alitretinoin 30...
Federico Galvagni et al.
Stem cells (Dayton, Ohio), 33(3), 742-750 (2014-12-17)
Although much is known about the pluripotency self-renewal circuitry, the molecular events that lead embryonic stem cells (ESCs) exit from pluripotency and begin differentiation are largely unknown. We found that the zinc finger transcription factor Snai1, involved in gastrulation and...
Anti-inflammatory effect of 9-cis retinoic acid on the human mast cell line, HMC-1
Lee JS and Kim IS
The Journal of Experimental Medicine, 13(2), 149-152 (2007)
Chieko Iwao et al.
PloS one, 10(7), e0132761-e0132761 (2015-07-18)
The acyclic diterpenoid acid geranylgeranoic acid (GGA) has been reported to induce autophagic cell death in several human hepatoma-derived cell lines; however, the molecular mechanism for this remains unknown. In the present study, several diterpenoids were examined for ability to...
Early post-treatment with 9-cis retinoic acid reduces neurodegeneration of dopaminergic neurons in a rat model of Parkinson?s disease
Yin LH, et al.
BMC Neuroscience, 13(1), 120-120 (2012)
Igor Orlov et al.
The EMBO journal, 31(2), 291-300 (2011-12-20)
Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Here, we present the cryo electron microscopy (cryo-EM) structure of the heterodimeric complex of...
Oral alitretinoin in congenital ichthyosis: a pilot study shows variable effects and a risk of central hypothyroidism.
Agneta Gånemo et al.
Acta dermato-venereologica, 92(3), 256-257 (2012-01-27)
Elyse K Paterson et al.
Experimental dermatology, 22(3), 202-209 (2013-03-16)
Aldehyde dehydrogenase 1A1 (ALDH1A1), an enzyme that catalyses the conversion of lipid aldehydes to lipid carboxylic acids, plays pleiotropic roles in UV-radiation resistance, melanogenesis and stem cell maintenance. In this study, a combination of RNAi and pharmacologic approaches were used...
Shuang Liang et al.
Theriogenology, 77(6), 1198-1205 (2012-01-10)
Retinoids have important roles in regulation of oocyte nuclear and cytoplasmic maturation. The present study investigated the effects of a retinoid metabolite on nuclear maturation, cytoplasmic maturation, and gene expression in canine oocytes during in vitro maturation (IVM). Cumulus-oocyte complexes...
Shirin Nkongolo et al.
Antiviral research, 168, 146-155 (2019-04-25)
Chronic infection with the human Hepatitis B virus (HBV) is a major global health problem. Hepatitis D virus (HDV) is a satellite of HBV that uses HBV envelope proteins for cell egress and entry. Using infection systems encoding the HBV/HDV...
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this...
Sejung Maeng et al.
Molecular endocrinology (Baltimore, Md.), 26(11), 1821-1835 (2012-09-06)
There is widespread interest in defining factors and mechanisms that suppress the proliferation of cancer cells. Retinoic acid (RA) is a potent suppressor of mammary cancer and developmental embryonic cell proliferation. However, the molecular mechanisms by which 9-cis-RA signaling induces...
Wai-Ping Lee et al.
Biochemical and biophysical research communications, 464(1), 195-200 (2015-06-28)
The present study investigated human retinoid X receptor alpha (hRXRα) as a substrate for modification with small ubiquitin like modifier (SUMO) and how members of the protein inhibitor of activated STAT (PIAS) family may impact upon this process. In agreement...
Chiaki Sagara et al.
Biochemical and biophysical research communications, 433(1), 102-107 (2013-03-15)
Retinoic acid (RA) signaling is mediated by specific nuclear hormone receptors. Here we examined the effects of 9-cis-RA on adipogenesis in mouse preadipocyte 3T3-L1 cells. 9-cis-RA inhibits the lipid accumulation of adipogenetically induced 3T3-L1 cells. The complex of retinoid X...
Björn Neumann et al.
Cell stem cell, 25(4), 473-485 (2019-10-05)
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show that the differentiation potential of adult...
Ilya Lukonin et al.
Nature, 586(7828), 275-280 (2020-10-09)
The development of intestinal organoids from single adult intestinal stem cells in vitro recapitulates the regenerative capacity of the intestinal epithelium1,2. Here we unravel the mechanisms that orchestrate both organoid formation and the regeneration of intestinal tissue, using an image-based...
Jessica Dal Col et al.
Cancer research, 72(7), 1825-1835 (2012-02-09)
Mantle cell lymphoma (MCL) is characterized by a profound deregulation of the mechanisms controlling cell-cycle progression and survival. We herein show that the combination of 9-cis-retinoic acid (RA) and IFN-α induces marked antiproliferative and proapoptotic effects in MCL cells through...
Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis
Perrault DP, et al.
Lymphatic Research and Biology, 17(1), 19-29 (2019)
Maria Lapteva et al.
Nanoscale, 7(44), 18651-18662 (2015-10-27)
Acne vulgaris is a highly prevalent dermatological disease of the pilosebaceous unit (PSU). An inability to target drug delivery to the PSU results in poor treatment efficacy and the incidence of local side-effects. Cutaneous application of nanoparticulate systems is reported...
A H Schmitt-Hoffmann et al.
Expert review of clinical pharmacology, 5(4), 373-388 (2012-09-05)
Alitretinoin is an endogenous retinoid related to vitamin A. Studies have shown that oral alitretinoin is effective and well tolerated in the treatment of severe chronic hand eczema. This review summarizes the clinical pharmacokinetic and pharmacodynamic data from a number...
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