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R5010

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Chunfang Ma et al.
International journal of molecular medicine, 39(1), 231-237 (2016-12-23)
Resveratrol is a polyphenolic compound extracted from grapes and the Chinese herb, Polygonum cuspidatum. In the present study, in order to elucidate the molecular mechanisms of action of resveratrol in host immune cells, we examined the effects of resveratrol on...
Salah O Bashir
Archives of physiology and biochemistry, 125(2), 104-113 (2018-02-14)
This study investigated if a combination of resveratrol (RES) and insulin could reverse type 1 diabetic mellitus-induced (T1DM) nephropathy and illustrates mechanism of action. Rats were divided into six groups (n = 10/group) as follows: control, control + RES (20 mg/kg), T1DM, T1DM + RES, T1DM + insulin (1 U/g)...
Yusufhan Yazir et al.
Physiology & behavior, 138, 297-304 (2014-12-03)
A number of studies have recently focused on the neuroprotective and anti-inflammatory effects of resveratrol. In prior studies, we described its beneficial effects on scopolamine-induced learning deficits in rats. The aim of this study was to investigate the effects of...
Jie Yang et al.
Bioorganic & medicinal chemistry letters, 21(21), 6420-6425 (2011-09-17)
Based on the observed biological activities of coumarins and resveratrol, we synthesized fourteen hydroxylated 3-phenylcoumarins (stilbene-coumarin hybrids) including six novel ortho-hydroxy-methoxy substituted derivatives, 1-14, by Perkin reaction. We characterized these compounds concerning their antioxidant activity against 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH)-induced pBR322...
Geon-Hee Kim et al.
International journal of molecular sciences, 21(18) (2020-09-17)
Constitutive activation of the β-catenin dependent canonical Wnt signaling pathway, which enhances tumor growth and progression in multiple types of cancer, is commonly observed in melanoma. LEF1 activates β-catenin/TCF4 transcriptional activity, promoting tumor growth and progression. Although several reports have...
Vanessa Ferreira et al.
BMC genomics, 20(1), 952-952 (2019-12-10)
Somatic mutations occurring within meristems of vegetative propagation material have had a major role in increasing the genetic diversity of the domesticated grapevine (Vitis vinifera subsp. vinifera). The most well studied somatic variation in this species is the one affecting...
Anna Ferretta et al.
Biochimica et biophysica acta, 1842(7), 902-915 (2014-03-04)
Mitochondrial dysfunction and oxidative stress occur in Parkinson's disease (PD), but the molecular mechanisms controlling these events are not completely understood. Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) is a transcriptional coactivator known as master regulator of mitochondrial functions and oxidative metabolism....
Susan J Zunino et al.
The British journal of nutrition, 112(3), 369-380 (2014-05-17)
Obese individuals are at an increased risk of developing CVD, hypertension, type 2 diabetes, and bacterial and viral infections when compared with the normal-weight population. In a 9-week randomised, double-blind, cross-over study, twenty-four obese subjects aged between 20 and 60...
Johdi-Ann Francis et al.
Molecular and cellular biochemistry, 410(1-2), 121-129 (2015-09-12)
The objective of this study is to compare the antioxidant activity of a whole-grape suspension with the antioxidant activity or pure resveratrol on the effect of hydrogen peroxide (H2O2) on malondialdehyde (MDA) generation, choline acetyltransferase (ChAT) activity, calcium ATPase activity...
Yuan Chen et al.
Journal of cancer research and clinical oncology, 146(6), 1489-1499 (2020-04-05)
To investigate the synergistic effect of resveratrol on the bystander effect of TK/GCV suicide gene system in melanoma cells. The effect of resveratrol on the growth of B16 cells and the synergistic effect of resveratrol with or without GCV were...
George R Pettit et al.
Journal of natural products, 72(9), 1637-1642 (2009-09-02)
As an extension of our earlier structure/activity investigation of resveratrol (1a) cancer cell growth inhibitory activity compared to the structurally related stilbene combretastatin series (e.g., 2a), an efficient synthesis of E-stilstatin 3 (3a) and its phosphate prodrug 3b was completed....
Philippe de Medina et al.
Journal of medicinal chemistry, 48(1), 287-291 (2005-01-07)
We developed new stilbene derivatives of resveratrol (E)-1-(4'-hydroxyphenyl)-2-(3,5-dihydroxyphenyl)ethene) selective for AhR and devoid of affinity for ER. Among the 24 stilbenes synthesized, all display a higher affinity than resveratrol for AhR. (E)-1-(4'-Trifluoromethylphenyl)-2-(3,5-ditrifluoromethylphenyl)ethene (4e), (E)-1-(4'-methoxyphenyl)-2-(3,5-dichlorophenyl)ethene (4j), and (E)-1-(4'-chlorophenyl)-2-(3,5-dichlorophenyl)ethene (4b) are selective...
Aldo Calliari et al.
Experimental neurology, 251, 91-100 (2013-11-21)
Axonal degeneration is a central process in the pathogenesis of several neurodegenerative diseases. Understanding the molecular mechanisms that are involved in axonal degeneration is crucial to developing new therapies against diseases involving neuronal damage. Resveratrol is a putative SIRT1 activator...
Nurcan Değirmencioğlu et al.
Food chemistry, 194, 587-594 (2015-10-17)
In this study, the changes in phenolic composition, total phenolic content, and antioxidant capacity of tarhanas supplemented with oat flour (OF) at the levels of 20-100% (w/w) after three drying treatments (sun-, oven-, and microwave drying) were investigated. A total...
Douglas R Davies et al.
Journal of medicinal chemistry, 52(15), 4694-4715 (2009-07-22)
We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small molecules of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of protein...
Vaclav Vetvicka et al.
Anticancer research, 34(5), 2275-2282 (2014-04-30)
Natural immunomodulators are getting more and more popular. The popularity, however, often brings over-optimistic claims and mediocre effects. The purpose of the present study was to directly compare eleven most commonly used immunomodulators. Through testing both cellular and humoral branches...
Victoria H J Roberts et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(6), 2466-2477 (2014-02-25)
Resveratrol has been proposed as a potential therapeutic to improve metabolic health during pregnancy, yet little is known about the fetal effects of this maternal dietary supplement. We hypothesized that when administered to pregnant nonhuman primates (NHPs), resveratrol would increase...
Marinella Roberti et al.
Journal of medicinal chemistry, 49(10), 3012-3018 (2006-05-12)
To further explore the SAR of resveratrol-related trans-stilbene derivatives, here we describe the synthesis of (a) a series of 3,5-dimethoxy analogues in which a variety of substituents were introduced at positions 2', 3', 4', and 5' of the stilbene scaffold...
Michael Adams et al.
Journal of natural products, 68(1), 83-85 (2005-02-01)
Fifteen stilbenoids and two alkaloids from Stemona collinsae, S. tuberosa, and S. peirrei were tested alongside the commercially available stilbenoids resveratrol and pinosylvin for inhibition of leukotriene formation in an ex vivo test system based on activated human neutrophilic granulocytes....
Cedric J Lion et al.
Journal of medicinal chemistry, 48(4), 1292-1295 (2005-02-18)
The parallel solution-phase synthesis of a series of 30 monohydroxylated (E)-stilbene analogues is described. In vitro screening revealed low micromolar activity (GI(50)) against the MDA MB 468 breast cancer cell line. Activity in MDA MB 468 cells correlated with the...
Stephanie Lemmo Ham et al.
Integrative biology : quantitative biosciences from nano to macro, 7(7), 792-800 (2015-06-30)
Cell migration is a major process that drives metastatic progression of cancers, the major cause of cancer death. Existing chemotherapeutic drugs have limited efficacy to prevent and/or treat metastasis, emphasizing the need for new treatments. We focus on triple negative...
Kahlilia C Morris-Blanco et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(6), 1024-1032 (2014-03-29)
Preserving mitochondrial pools of nicotinamide adenine dinucleotide (NAD) or nicotinamide phosphoribosyltransferase (Nampt), an enzyme involved in NAD production, maintains mitochondrial function and confers neuroprotection after ischemic stress. However, the mechanisms involved in regulating mitochondrial-localized Nampt or NAD have not been...
Bui Thanh Tung et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 69(4), 398-409 (2013-07-19)
Aging is a multifactorial process in which oxidative damage plays an important role. Resveratrol (RSV) and exercise delay some of the damages occurring during aging and increase life span and health span. We treated mice at different ages with RSV...
Mar Larrosa et al.
Journal of medicinal chemistry, 53(20), 7365-7376 (2010-09-28)
There is no pharmaceutical or definitive surgical cure for inflammatory bowel diseases (IBDs). The naturally occurring polyphenol resveratrol exerts anti-inflammatory properties. However, its rapid metabolism diminishes its effectiveness in the colon. The design of prodrugs to targeting active molecules to...
Chen Huang et al.
Oncology reports, 33(2), 875-884 (2014-12-09)
Solid tumors grow faster and need more glucose than normal tissue; however, due to poor angiogenesis and excessive growth, tumors remote from blood vessels are always under glucose starvation. Even so, cancer cells remain alive in vivo. Thus, making cancer...
Jyun-Bin Huang et al.
International journal of molecular sciences, 21(19) (2020-10-04)
Status epilepticus may cause molecular and cellular events, leading to hippocampal neuronal cell death. Peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) is an important regulator of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2), also known as fetal...
Min Li Liu et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 19(3), 713-717 (2014-09-28)
This study aimed to investigate the effects of resveratrol on cell proliferation, apoptosis and protein expression of survivin in human gastric cancer (SGC7901) cell line. SGC7901 cell proliferation and G0/G1 phase of the cell cycle induced by resveratrol (treatment group)...
Wei Zhu et al.
Nutrition & metabolism, 11, 35-35 (2014-08-21)
The exact mechanism of the protective role of Resveratrol (Res) in lipid metabolism and oxidative stress is not well elucidated. The present study aimed to investigate the potential benefits and possible mechanisms of Res on the amelioration of oxidative stress...
Young-Hee Kim et al.
Diabetes, 59(7), 1825-1835 (2010-04-29)
This study investigated the effects of resveratrol, a natural polyphenol with neuroprotective properties, on retinal neuronal cell death mediated by diabetes-induced activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of...
Anne Marie Thompson et al.
American journal of physiology. Heart and circulatory physiology, 307(4), H533-H541 (2014-06-29)
Loss of vascular smooth muscle cell (VSMC) function is a hallmark of vascular disease. VSMCs become increasingly dysregulated, apoptotic, and senescent as we age. Sirtuin 1 (SirT1) is a deactylase that regulates substrates associated with stress mitigation, metabolism, and aging....
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