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Xiaopeng Li et al.
Cell communication and signaling : CCS, 19(1), 80-80 (2021-07-30)
Hhex(human hematopoietically expressed homeobox), also known as PRH, is originally considered as a transcription factor to regulate gene expression due to its homebox domain. Increasing studies show that Hhex plays a significant role in development, including anterior-posterior axis formation, vascular
Hao Lu et al.
Molecular biology of the cell, 19(5), 1893-1902 (2008-02-22)
GRIM-19 was found to copurify with complex I of mitochondrial respiratory chain and subsequently was demonstrated to be involved in complex I assembly and activity. To further understand its function in complex I, we dissected its functional domains by generating
Ryoichi Arita et al.
Diabetes, 58(1), 215-226 (2008-10-09)
Leukocyte adhesion in retinal microvasuculature substantially contributes to diabetic retinopathy. Involvement of the Rho/Rho kinase (ROCK) pathway in diabetic microvasculopathy and therapeutic potential of fasudil, a selective ROCK inhibitor, are investigated. Localization of RhoA/ROCK and Rho activity were examined in
Dani Osman et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(29), 12043-12048 (2009-07-08)
The t(8:21)(q22;q22) translocation is 1 of the most common chromosomal abnormalities linked to acute myeloid leukemia (AML). AML1-ETO, the product of this translocation, fuses the N-terminal portion of the RUNX transcription factor AML1 (also known as RUNX1), including its DNA-binding
Juan Pablo Pratt et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 75(9), 734-742 (2009-07-30)
Monoclonal antibodies (Mab) are an important resource for defining molecular expression and probing molecular function. The characterization of Mab reactivity patterns, however, can be costly and inefficient in nonhuman experimental systems. To develop a computational approach to the pattern analysis
Liesbeth Demuyser et al.
Antimicrobial agents and chemotherapy, 63(5) (2019-02-21)
Fungal infections pose a substantial threat to the human population. They can cause either mild and relatively harmless infections or invasive and often lethal diseases in patients with a weakened immune system. The majority of these human fungal infections are
Annabel Guttentag et al.
Pathogens (Basel, Switzerland), 10(2) (2021-03-07)
Superficial dermatophyte infections, commonly known as tineas, are the most prevalent fungal ailment and are increasing in incidence, leading to an interest in alternative treatments. Many floral honeys possess antimicrobial activity due to high sugar, low pH, and the production
Maria Toloudi et al.
Case reports in oncology, 4(1), 44-54 (2011-04-29)
The scientific community has proven the value of circulating tumor cells (CTCs) as a prognostic factor in the development of cancer and progress to metastases [1, 2, 3, 4]. Simultaneously, a new type of cancer stem cell-like (CSC-like) cells has
Jinfei Fu et al.
American journal of cancer research, 10(12), 4234-4250 (2021-01-09)
Cytotoxic CD8+ T cell exhaustion is one of the mechanisms underlying the tumor immune escape. The paradigm-shifting immune checkpoint therapy can mitigate CD8+ T lymphocyte exhaustion, reinvigorate the anticancer immunity, and achieve durable tumor regression for some patients. Emerging evidence
Fhernanda R Smiderle et al.
BMC complementary and alternative medicine, 11, 58-58 (2011-07-27)
Mushroom polysaccharides have traditionally been used for the prevention and treatment of a multitude of disorders like infectious illnesses, cancers and various autoimmune diseases. Crude mushroom extracts have been tested without detailed chemical analyses of its polysaccharide content. For the
Uta Bussmeyer et al.
Infection and immunity, 78(1), 358-363 (2009-10-28)
Anaplasma phagocytophilum, the causative agent of tick-borne human granulocytic anaplasmosis (HGA), is an intracellular bacterium which survives and multiplies inside polymorphonuclear neutrophil granulocytes (PMN). Increased bacterial burden in gamma interferon (IFN-gamma)-deficient mice suggested a major role of IFN-gamma in the
Ellen Menkhorst et al.
Biology of reproduction, 80(5), 920-927 (2009-01-16)
Hormonal contraceptives are unsuitable for many women; thus, the development of new, nonhormonal contraceptives is of great interest. In women, uterine epithelial expression of interleukin 11 (IL11) and its receptor (IL11RA) suggests IL11 is critical for blastocyst attachment during implantation.
Tássia Joi Martins et al.
Frontiers in molecular biosciences, 7, 595830-595830 (2021-01-30)
This work presents a new procedure to synthesize ruthenium-phthalocyanine complexes and uses diverse spectroscopic techniques to characterize trans-[RuCl(Pc)DMSO] (I) (Pc = phthalocyanine) and trans-[Ru(Pc)(4-ampy)2] (II) (4-ampy = 4-aminopyridine). The triplet excited-state lifetimes of (I) measured by nanosecond transient absorption showed
Dariush Mokhtari et al.
Diabetes, 57(7), 1896-1904 (2008-04-19)
The transcription factor nuclear factor-kappaB (NF-kappaB) and the mitogen-activated protein kinases (MAPKs) c-Jun NH(2)-terminal kinase (JNK) 1/2 are known to play decisive roles in cytokine-induced damage of rodent beta-cells. The upstream events by which these factors are activated in response
Tamara Veiga-Parga et al.
PLoS pathogens, 7(12), e1002427-e1002427 (2011-12-17)
Ocular herpes simplex virus infection can cause a blinding CD4⁺ T cell orchestrated immuno-inflammatory lesion in the cornea called Stromal Keratitis (SK). A key to controlling the severity of SK lesions is to suppress the activity of T cells that
Wong Yau Hsiung et al.
Evidence-based complementary and alternative medicine : eCAM, 2011, 293060-293060 (2011-03-23)
The anticancer potential of Leea indica, a Chinese medicinal plant was investigated for the first time. The crude ethanol extract and fractions (ethyl acetate, hexane, and water) of Leea indica were evaluated their cytotoxicity on various cell lines (Ca Ski
R Roubenoff et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 53(1), M20-M26 (1998-02-19)
To determine the association among aging, inflammation, and cytokine production by peripheral blood mononuclear cells. We examined production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), IL-1 receptor antagonist (IL-1Ra), and IL-6 in 711 elderly participants in the Framingham
Rizky Abdulah et al.
BMC cancer, 9, 414-414 (2009-12-01)
Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts. Selenium-enriched broccoli sprouts were
Yoichi Matsuo et al.
International journal of cancer, 124(4), 853-861 (2008-11-28)
CXC-chemokines are involved in the chemotaxis of neutrophils, lymphocytes and monocytes. However, role of these chemokines in tumorigenesis, especially with regard to interaction between tumor and its microenvironment, has not been clearly elucidated. The purpose of this study was to
David M Waag et al.
Clinical and vaccine immunology : CVI, 15(10), 1505-1512 (2008-08-15)
Although the phase I Coxiella burnetii cellular vaccine is completely efficacious in humans, adverse local and systemic reactions may develop if immune individuals are inadvertently vaccinated. The phase I chloroform-methanol residue (CMRI) vaccine was developed as a potentially safer alternative.
Evgeny S Gerasimov et al.
Nucleic acids research, 46(2), 765-781 (2017-12-09)
RNA editing by targeted insertion and deletion of uridine is crucial to generate translatable mRNAs from the cryptogenes of the mitochondrial genome of kinetoplastids. This type of editing consists of a stepwise cascade of reactions generally proceeding from 3' to
Mariafrancesca Hyeraci et al.
ChemMedChem, 16(12), 1956-1966 (2021-03-23)
Resistance to platinum-based anticancer drugs represents an important limit for their clinical effectiveness and one of the most important field of investigation in the context of platinum compounds. From our previous studies, PtII complexes containing the triphenylphosphino moiety have been
Chun-Ming Wang et al.
Oxidative medicine and cellular longevity, 2021, 9877170-9877170 (2021-11-23)
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely related to the site of generation. Xanthohumol (XN) is an important natural product of hops (Humulus lupulus L.) and
Toshihiro Ito et al.
American journal of respiratory and critical care medicine, 180(12), 1227-1238 (2009-10-03)
Accumulating evidence supports the hypothesis that the continuous host response to a persistent challenge can polarize the cytokine environment toward a Th2 cytokine phenotype, but the mechanisms responsible for this skewing are not clear. We investigated the role of Toll-like
Hemalata Deshmukh et al.
Frontiers in immunology, 11, 550827-550827 (2020-10-31)
Invasive fungal infections caused by Aspergillus (A.) and Mucorales species still represent life-threatening diseases in immunocompromised individuals, and deeper knowledge about fungal interactions with elements of innate immunity, such as complement and platelets, appears essential for optimized therapy. Previous studies
Oleh Taratula et al.
Journal of controlled release : official journal of the Controlled Release Society, 140(3), 284-293 (2009-07-02)
Low penetration ability of Small Interfering RNA (siRNA) through the cellular plasma membrane combined with its limited stability in blood, limits the effectiveness of the systemic delivery of siRNA. In order to overcome such difficulties, we constructed a nanocarrier-based delivery
Jian Zhang et al.
BMC medical genetics, 10, 62-62 (2009-07-02)
T-cell immunoglobulin mucin-3 (TIM3) is a TH1-specific type 1 membrane protein that regulates TH1 proliferation and the development of immunological tolerance. TIM3 and its genetic variants have been suggested to play a role in regulating allergic diseases. Polymorphisms in the
Atis Muehlenbachs et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(38), 14488-14491 (2008-09-10)
Placental malaria (PM) caused by Plasmodium falciparum contributes significantly to infant mortality in sub-Saharan Africa and is associated with pregnancy loss. We hypothesized that fetal genes that modify PM would be associated with fetal fitness. During PM, placental trophoblasts produce
Maria Sara Remedi et al.
PLoS medicine, 5(10), e206-e206 (2008-10-31)
Pancreatic beta-cell ATP-sensitive potassium (K ATP) channels are critical links between nutrient metabolism and insulin secretion. In humans, reduced or absent beta-cell K ATP channel activity resulting from loss-of-function K ATP mutations induces insulin hypersecretion. Mice with reduced K ATP
Li Wang et al.
PloS one, 6(11), e27289-e27289 (2011-11-17)
Our previous work showed that mice immunized with attenuated activated syngeneic T cells (aTCV) led to damping Treg function which resulted in enhancing anti-tumor immunity. It is well known that DC plays a very important role in controlling Th cell
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