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Joshua J Creelman et al.
Sensors (Basel, Switzerland), 21(18) (2021-09-29)
A novel microfluidic optical cell is presented that enables simultaneous measurement of both light absorbance and fluorescence on microlitre volumes of fluid. The chip design is based on an inlaid fabrication technique using clear and opaque poly(methyl methacrylate) or PMMA
Aaron C Anselmo et al.
ACS nano, 9(3), 3169-3177 (2015-02-27)
The impact of physical and chemical modifications of nanoparticles on their biological function has been systemically investigated and exploited to improve their circulation and targeting. However, the impact of nanoparticles' flexibility (i.e., elastic modulus) on their function has been explored
Afaf Al-Haddad et al.
Dental materials journal, 34(4), 516-521 (2015-08-04)
This study evaluated and compared the sealer thickness and interfacial adaptation of bioceramic sealers (Sankin Apatite III, MTA Fillapex(®), EndoSequence(®) BC) to root dentin against AH Plus(®) sealer. Sixty extracted single-root premolars were prepared and equally divided into four groups.
Photocatalytic degradation of Rhodamine B dye under UV/solar light using ZnO nanopowder synthesized by solution combustion route
Nagaraja R, et al.
Powder Technology, 215, 91-97 (2012)
Joaquim T Marquês et al.
Langmuir : the ACS journal of surfaces and colloids, 31(34), 9410-9421 (2015-08-12)
Phytoceramide is the backbone of major sphingolipids in fungi and plants and is essential in several tissues of animal organisms, such as human skin. Its sphingoid base, phytosphingosine, differs from that usually found in mammals by the addition of a
Xuejuan Wan et al.
Macromolecular rapid communications, 34(4), 341-347 (2012-12-12)
The fabrication of photo-degradable, protein-polyelectrolyte complex (PPC)-coated, mesoporous silica nanoparticles (MSNs) and their controlled co-release of protein and model drugs is reported. Random copolymers composed of oligo(ethylene glycol) monomethyl ether methacrylate (OEGMA), and a photolabile o-nitrobenzyl-containing monomer, 5-(2'-(dimethylamino)ethoxy)-2-nitrobenzyl methacrylate (DENBMA)
Xiupei Yang et al.
Journal of pharmaceutical and biomedical analysis, 117, 118-124 (2015-09-10)
An internal standard method has been developed for the simultaneous determination of anthracycline antibiotics, doxorubicin (DOX) and daunorubicin (DAN), in rabbit plasma using capillary electrophoresis (CE) with in-column double optical-fiber LED-induced fluorescence detection (CE-ICDOF-LED-FLD). Rhodamine B (RhB) was selected as
S Uday Kumar et al.
Colloids and surfaces. B, Biointerfaces, 131, 170-181 (2015-05-20)
Since the turn of the 21st century, nanofiber based drug delivery systems have evolved drastically to attain controlled and sustained delivery of various bioactive molecules. In spite of such efforts, the tangible interface existing between the target cells and the
Woan-Ruoh Lee et al.
Journal of pharmaceutical sciences, 103(11), 3542-3552 (2014-09-05)
Alopecia usually cannot be cured because of the available drug therapy being unsatisfactory. To improve the efficiency of treatment, erbium-yttrium-aluminum-garnet (Er-YAG) laser treatment was conducted to facilitate skin permeation of antialopecia drugs such as minoxidil (MXD), diphencyprone (DPCP), and peptide.
Kristo Nuutila et al.
Bioactive materials, 8, 296-308 (2021-09-21)
Acute and chronic wounds affect millions of people around the world, imposing a growing financial burden on patients and hospitals. Despite the application of current wound management strategies, the physiological healing process is disrupted in many cases, resulting in impaired
Monaam Ben Ali et al.
Journal of colloid and interface science, 457, 360-369 (2015-07-22)
Zinc stannate (Zn2SnO4 or ZTO) nanoparticles were synthesized via hydrothermal method using NaOH as a mineralizer. X-ray diffraction (XRD), transmission electron microscopy (TEM) and high-resolution transmission electron microscopy (HRTEM) of the synthesized ZTO nanoparticles revealed the formation of highly pure
Yichen Wang et al.
Environmental science & technology, 49(10), 6294-6303 (2015-04-16)
Perfluorooctane sulfate (PFOS), a persistent organic pollutant, has recently been closely linked with an increased risk of tumorigenesis. However, PFOS has yielded negative results in various tests of genotoxicity. The present study aimed to investigate the mutagenic response to PFOS
Yanuar Dwi Putra Limasale et al.
International journal of pharmaceutics, 479(2), 364-373 (2015-01-18)
Cyclooxygenase-2 (COX-2) is highly expressed in many different cancers. Therefore, the inhibition of the COX-2 pathway by a selective COX-2 inhibitor, celecoxib (CLX), may be an alternative strategy for cancer prevention and therapy. Liposomal drug delivery systems can be used
M Lupi et al.
Nanotechnology, 25(33), 335706-335706 (2014-07-31)
One of the major drawbacks that limits the clinical application of nanoparticles is the lack of preliminary investigations related to their biocompatibility, biodegradability and biodistribution. In this work, biodegradable PEGylated polymer nanoparticles (NPs) have been synthesized by using macromonomers based
Shayna L McGill et al.
Molecular pharmaceutics, 7(6), 2280-2288 (2010-10-06)
The mucus barrier is well established as a formidable barrier to exogenous substances and forms the first line of defense for mucosal surfaces. Drugs and particle systems are known to be significantly hindered via a variety of interactions with mucus
Young Soo Joung et al.
Nature communications, 6, 6083-6083 (2015-01-15)
Aerosols are investigated because of their significant impact on the environment and human health. To date, windblown dust and sea salt from sea spray through bursting bubbles have been considered the chief mechanisms of environmental aerosol dispersion. Here we investigate
Jae Youn Hwang et al.
Biomedical optics express, 6(1), 11-22 (2015-02-07)
We demonstrate a novel non-contact method: acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), capable of probing cell mechanics. A 30 MHz lithium niobate ultrasound transducer is utilized for both detection of phatoacoustic signals and generation of acoustic radiation
Silvia Minardi et al.
ACS applied materials & interfaces, 7(30), 16364-16373 (2015-06-26)
In regenerative medicine, the temporospatially controlled delivery of growth factors (GFs) is crucial to trigger the desired healing mechanisms in the target tissues. The uncontrolled release of GFs has been demonstrated to cause severe side effects in the surrounding tissues.
Yun Hu et al.
Acta biomaterialia, 28, 149-159 (2015-10-03)
Lipid-polymer hybrid nanoparticles (NPs), consisting of a polymeric core and a lipid shell, have been intensively examined as delivery systems for cancer drugs, imaging agents, and vaccines. For applications in vaccine particularly, the hybrid NPs need to be able to
Matteo Bolomini-Vittori et al.
Scientific reports, 9(1), 3556-3556 (2019-03-07)
Local membrane phospholipid enrichment serves as docking platform for signaling proteins involved in many processes including cell adhesion and migration. Tissue-resident dendritic cells (DCs) assemble actomyosin-based structures called podosomes, which mediate adhesion and degradation of extracellular matrix for migration and
Sangwon Min et al.
PloS one, 13(2), e0192775-e0192775 (2018-02-21)
A better understanding of the normal and diseased biology of salivary glands (SG) has been hampered, in part, due to difficulties in cultivating and maintaining salivary epithelial cells. Towards this end, we have generated a mouse salivary gland epithelial cell
Sandeep Kumar Dash et al.
Journal of applied toxicology : JAT, 34(11), 1130-1144 (2014-01-31)
The aim of the present study was to develop zinc sulfide nanoparticles (ZnS NPs) and to study their cytotoxicity against the KG-1A (human acute myeloid leukemia) cell line. ZnS NPs were synthesized using the pyrolytic method and characterized by X-ray
Javad Hassanzadeh et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 107, 296-302 (2013-02-26)
A novel enhanced chemiluminescence system was developed by applying gold nanorods (Au NRs) as catalysts in rhodamine B-permanganate reaction. Au NRs with three different aspect ratios were synthesized by seed mediated growth method and characterized by UV-Vis spectra and transmission
German A Parada et al.
Advanced healthcare materials, 6(19) (2017-07-18)
Hydrogels have been proposed for sensing, drug delivery, and soft robotics applications, yet most of these materials suffer from low mechanical robustness and high permeability to small molecules, limiting their widespread use. This study reports a general strategy and versatile
Xingyun Qi et al.
eLife, 9 (2020-08-17)
Receptor endocytosis is important for signal activation, transduction, and deactivation. However, how a receptor interprets conflicting signals to adjust cellular output is not clearly understood. Using genetic, cell biological, and pharmacological approaches, we report here that ERECTA-LIKE1 (ERL1), the major
Qiaoya Lin et al.
Pharmaceutical research, 31(6), 1438-1449 (2013-04-30)
Molecular therapeutics often require an effective nanoparticle-based delivery strategy to transport them to cytosolic organelles to be functional. Recently, a cytosolic delivery strategy based on the scavenger receptor class B type I (SR-BI) mediated pathway has shown great potential for
Alexander V Pichugin et al.
The American journal of pathology, 174(6), 2190-2201 (2009-05-16)
Significant host heterogeneity in susceptibility to tuberculosis exists both between and within mammalian species. Using a mouse model of infection with virulent Mycobacterium tuberculosis (Mtb), we identified the genetic locus sst1 that controls the progression of pulmonary tuberculosis in immunocompetent
Aline N Rabaça et al.
FEBS open bio, 6(9), 885-901 (2016-09-20)
Antibody-derived peptides modulate functions of the immune system and are a source of anti-infective and antitumor substances. Recent studies have shown that they comprise amino acid sequences of immunoglobulin complementarity-determining regions, but also fragments of constant regions. VH CDR3 of
Yoshiyuki Hattori et al.
Journal of liposome research, 25(2), 131-140 (2014-09-10)
In this study, we investigated the possibility of whether depletion of tumor-associated macrophages (TAMs) by zoledronic acid (ZOL) entrapped in folate-linked liposome could inhibit tumor angiogenesis and consequently tumor growth. Abundant expression of folate receptor β (FRβ) mRNA was detected
Oscar Castaño et al.
Frontiers in bioengineering and biotechnology, 9, 627805-627805 (2021-04-09)
(Following spinal cord injury, olfactory ensheathing cell (OEC) transplantation is a promising therapeutic approach in promoting functional improvement. Some studies report that the migratory properties of OECs are compromised by inhibitory molecules and potentiated by chemical concentration differences. Here we
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