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Wipaporn Phatvej et al.
Materials (Basel, Switzerland), 12(10) (2019-05-28)
Freely-dissolved silicon quantum dots were prepared by thermal hydrosilation of 1-undecene at high-porosity porous silicon under reflux in toluene. This reaction produces a suspension of alkyl-capped silicon quantum dots (alkyl SiQDs) with bright orange luminescence, a core Si nanocrystal diameter
Tiffany M DeSimone et al.
International journal for parasitology, 39(4), 399-405 (2008-10-04)
Apicomplexan parasites employ multiple adhesive ligands for recognition and entry into host cells. The Duffy binding-like (DBL) and the reticulocyte binding protein-like (RBL) families are central to the invasion of erythrocytes by the malaria parasite. These type-1 transmembrane proteins are
Timurs Maculins et al.
Scientific reports, 6, 18940-18940 (2016-01-09)
Ubiquitin signalling regulates most aspects of cellular life, thus deregulation of ubiquitylation has been linked with a number of diseases. E3 ubiquitin ligases provide substrate selectivity in ubiquitylation cascades and are therefore considered to be attractive targets for developing therapeutic
Stefan Kluge et al.
MethodsX, 7, 100865-100865 (2020-04-11)
Since elevated plasma triglycerides are an independent risk factor for cardiovascular diseases, lipoprotein lipase (LPL) is an interesting target for drug development. However, investigation of LPL remains challenging, as most of the commercially available assays are limited to the determination
Joke Patou et al.
Journal of inflammation (London, England), 6, 11-11 (2009-04-22)
The mast cell is a crucial effector cell in allergic rhinitis and other inflammatory diseases. During the acute allergic reaction preformed mediators such as histamine, but also de novo produced mediators such as leukotrienes (LTC4/D4/E4) and prostaglandins (PGD2) are released.
Maike Bublitz et al.
PloS one, 13(1), e0188620-e0188620 (2018-01-03)
We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using functional assays, crystallographic data and computational modeling. We found that tetrahydrocarbazoles inhibit adenosine triphosphate
Pattamawan Chimma et al.
PLoS pathogens, 5(10), e1000631-e1000631 (2009-10-24)
Monocyte (MO) subpopulations display distinct phenotypes and functions which can drastically change during inflammatory states. We hypothesized that discrete MO subpopulations are induced during malaria infection and associated with anti-parasitic activity. We characterized the phenotype of blood MO from healthy
Simone Aymanns et al.
PloS one, 6(6), e19822-e19822 (2011-07-07)
Fluorescence labeling of bacterial pathogens has a broad range of interesting applications including the observation of living bacteria within host cells. We constructed a novel vector based on the E. coli streptococcal shuttle plasmid pAT28 that can propagate in numerous
Yoshifumi Nishikawa et al.
Clinical and vaccine immunology : CVI, 16(6), 792-797 (2009-04-10)
The present study demonstrates that the subcutaneous administration of Neospora caninum dense granule protein 7 (NcGRA7) entrapped in liposomes coated with mannotriose strongly induces the parasite-specific T-helper type 1 immune response and humoral antibody in mice. Although anti-NcGRA7 immunoglobulin G1
Camila R Corrêa et al.
Journal of inflammation (London, England), 8, 23-23 (2011-08-31)
Arterial peripheral disease is a condition caused by the blocked blood flow resulting from arterial cholesterol deposits within the arms, legs and aorta. Studies have shown that macrophages in atherosclerotic plaque are highly activated, which makes these cells important antigen-presenting
Elamurugan Appavoo et al.
Microbiology and immunology, 60(3), 196-202 (2015-12-08)
High-mobility group box 1 (HMGB1) is one of the potent endogenous adjuvants released by necrotic and activated innate immune cells. HMGB1 modulates innate and adaptive immune responses in humans and mice by mediating immune cells crosstalk. However, the immuno-modulatory effects
Carey L Ford et al.
Life sciences, 222, 69-77 (2019-03-03)
In addition to absorptive disturbances, inflammatory bowel diseases (IBD) perturb normal contractility of intestinal smooth muscle. Such motility disturbances may reflect both nervous alterations and increased abundance of cytokines (e.g. IL-1β, TNF-α, and IFN-γ), which impair normal intestinal smooth muscle
Sevi Giakoumelou et al.
Scientific reports, 7(1), 2001-2001 (2017-05-19)
Miscarriage affects ~20% of pregnancies and maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires endometrial stromal cell (ESC) decidualisation. Maintenance of pregnancy requires
Guowu Hu et al.
The Journal of clinical investigation, 118(3), 1186-1197 (2008-02-09)
Autophagy is a process by which cells recycle cytoplasm and defective organelles during stress situations such as nutrient starvation. It can also be used by host cells as an immune defense mechanism to eliminate infectious pathogens. Here we describe the
Ricardo Araujo et al.
Antimicrobial agents and chemotherapy, 53(11), 4921-4923 (2009-08-26)
Posaconazole MICs for 50 Aspergillus fumigatus isolates with distinct genotypes were determined by three methods. MICs were > or = 0.5 microg/ml for 5, 11, and 15 strains by the CLSI reference M38-A2, Etest (48-h), and oxygen consumption methods, respectively.
Tetsuya Adachi et al.
Retrovirology, 8, 84-84 (2011-10-25)
Small chemical compounds which target chemokine receptors have been developed against human immunodeficiency virus type 1 (HIV-1) and are under investigation for use as anti-HIV-1 microbicides. In addition, monoclonal antibodies (mAbs) against chemokine receptors have also been shown to have
Alyson A Fiorillo et al.
Frontiers in immunology, 11, 151-151 (2020-03-11)
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate important intracellular biological processes. In myasthenia gravis (MG), a disease-specific pattern of elevated circulating miRNAs has been found, and proposed as potential biomarkers. These elevated miRNAs include miR-150-5p, miR-21-5p, and miR-30e-5p
Johan Olerud et al.
Diabetes, 57(7), 1870-1877 (2008-04-19)
Insufficient development of a new intra-islet capillary network after transplantation may be one contributing factor to the failure of islet grafts in clinical transplantation. The present study tested the hypothesis that the angiostatic factor thrombospondin-1 (TSP-1), which is normally present
Steven C Pino et al.
PloS one, 4(5), e5468-e5468 (2009-05-09)
Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the Gimap5 gene
Riina-A Kekkonen et al.
World journal of gastroenterology, 14(13), 2029-2036 (2008-04-09)
To evaluate the effects of three potentially anti-inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. A total of 62 volunteers participated in
Dinesh Chandra et al.
Clinical and experimental immunology, 154(2), 224-234 (2008-09-10)
The failure of Leishmania, an intracellular pathogen, to stimulate a pro-inflammatory response following entry into macrophages has been well reported. This occurs in spite of the fact that ligands for the toll-like receptors (TLR) have been recently shown on the
Sandra Karch et al.
Journal of medicinal chemistry, 61(14), 6121-6139 (2018-06-26)
β-site APP-cleaving enzyme 1 (BACE1) is a major player in the pathogenesis of Alzheimer's disease. Structural and functional fluorescence microscopy offers a powerful approach to learn about the physiology and pathophysiology of this protease. Up to now, however, common labeling
M Aoki et al.
British journal of cancer, 104(4), 714-718 (2011-01-13)
Bone morphogenetic protein-7 (BMP-7) is a signalling molecule belonging to the transforming growth factor--superfamily. Recent studies have demonstrated the clinical impact of BMP-7 expression in various human cancers. However, there have been few reports detailing this in gastric cancer. We
Caroline Le Maréchal et al.
Veterinary research, 42, 35-35 (2011-02-18)
Staphylococcus aureus is a major cause of mastitis in ruminants. In ewe mastitis, symptoms range from subclinical to gangrenous mastitis. S. aureus factors or host-factors contributing to the different outcomes are not completely elucidated. In this study, experimental mastitis was
Kan Shida et al.
Immunology, 128(1 Suppl), e858-e869 (2009-09-25)
We previously showed that Lactobacillus strains having a rigid cell wall resistant to intracellular digestion can stimulate macrophages to induce large a quantity of interleukin-12 (IL-12). In this study, we examined the influence of lactobacilli and bacterial cell wall components
Atsushi Iwai et al.
PloS one, 6(6), e20718-e20718 (2011-06-16)
Persistent infections of hepatitis C virus (HCV) are known to be a major risk factor for causing hepatocellular carcinomas. Nonstructural protein 3 (NS3) of HCV has serine protease and RNA helicase domains, and is essential for the viral replication. Further
Michiyuki Hakozaki et al.
PloS one, 9(2), e88035-e88035 (2014-02-12)
Cyclooxygenase-2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostanoids, and its activation is associated with carcinogenesis as well as inflammation. The antitumor effect of selective COX-2 inhibitors has been noted in various malignancies. Malignant peripheral
Branislava Janic et al.
PloS one, 3(6), e2499-e2499 (2008-06-26)
Superparamagnetic Iron Oxide (SPIO) complexed with cationic transfection agent is used to label various mammalian cells. Labeled cells can then be utilized as an in vivo magnetic resonance imaging (MRI) probes. However, certain number of in vivo administered labeled cells
Marina Wright Muelas et al.
Metabolomics : Official journal of the Metabolomic Society, 16(10), 107-107 (2020-10-08)
It is widely but erroneously believed that drugs get into cells by passing through the phospholipid bilayer portion of the plasma and other membranes. Much evidence shows, however, that this is not the case, and that drugs cross biomembranes by
Andrew S Flies et al.
Bio-protocol, 10(13), e3696-e3696 (2021-03-05)
This protocol provides a step-by-step method to create recombinant fluorescent fusion proteins that can be secreted from mammalian cell lines. This builds on many other recombinant protein and fluorescent protein techniques, but is among the first to harness fluorescent fusion
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