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Branislava Janic et al.
PloS one, 3(6), e2499-e2499 (2008-06-26)
Superparamagnetic Iron Oxide (SPIO) complexed with cationic transfection agent is used to label various mammalian cells. Labeled cells can then be utilized as an in vivo magnetic resonance imaging (MRI) probes. However, certain number of in vivo administered labeled cells
Kan Shida et al.
Immunology, 128(1 Suppl), e858-e869 (2009-09-25)
We previously showed that Lactobacillus strains having a rigid cell wall resistant to intracellular digestion can stimulate macrophages to induce large a quantity of interleukin-12 (IL-12). In this study, we examined the influence of lactobacilli and bacterial cell wall components
Atsushi Iwai et al.
PloS one, 6(6), e20718-e20718 (2011-06-16)
Persistent infections of hepatitis C virus (HCV) are known to be a major risk factor for causing hepatocellular carcinomas. Nonstructural protein 3 (NS3) of HCV has serine protease and RNA helicase domains, and is essential for the viral replication. Further
Pattamawan Chimma et al.
PLoS pathogens, 5(10), e1000631-e1000631 (2009-10-24)
Monocyte (MO) subpopulations display distinct phenotypes and functions which can drastically change during inflammatory states. We hypothesized that discrete MO subpopulations are induced during malaria infection and associated with anti-parasitic activity. We characterized the phenotype of blood MO from healthy
Pragya Srivastava et al.
Reproductive biology and endocrinology : RB&E, 6, 20-20 (2008-05-21)
The magnitude of reproductive morbidity associated with sexually transmitted Chlamydia trachomatis infection is enormous. Association of antibodies to chlamydial heat shock proteins (cHSP) 60 and 10 with various disease sequelae such as infertility or ectopic pregnancy has been reported. Cell-mediated
Adriana S Azevedo et al.
PloS one, 6(7), e20528-e20528 (2011-07-23)
Two DNA vaccines were constructed encoding the ectodomain (domains I, II and III) of the DENV2 envelope protein (pE1D2) or only its domain III (pE2D2), fused to the human tissue plasminogen activator signal peptide (t-PA). The expression and secretion of
M Aoki et al.
British journal of cancer, 104(4), 714-718 (2011-01-13)
Bone morphogenetic protein-7 (BMP-7) is a signalling molecule belonging to the transforming growth factor--superfamily. Recent studies have demonstrated the clinical impact of BMP-7 expression in various human cancers. However, there have been few reports detailing this in gastric cancer. We
Caroline Le Maréchal et al.
Veterinary research, 42, 35-35 (2011-02-18)
Staphylococcus aureus is a major cause of mastitis in ruminants. In ewe mastitis, symptoms range from subclinical to gangrenous mastitis. S. aureus factors or host-factors contributing to the different outcomes are not completely elucidated. In this study, experimental mastitis was
Sören Twarock et al.
Molecular cancer, 10, 30-30 (2011-03-25)
Oesophageal cancer is a highly aggressive tumour entity with at present poor prognosis. Therefore, novel treatment options are urgently needed. Hyaluronan (HA) is a polysaccharide present in the matrix of human oesophageal squamous cell carcinoma (ESCC). Importantly, in vitro ESCC
Lin Xu et al.
PloS one, 6(5), e20282-e20282 (2011-06-10)
CD4(+)CD25(+) regulatory T cells (Tregs), a heterogeneous population, were enrichment in tumor mass and played an important role in modulating anti-tumor immunity. Recently, we reported a Treg subset, CCR6(+) Tregs but not CCR6(-)Tregs, were enriched in tumor mass and closely
James B Whitney et al.
PloS one, 6(4), e18589-e18589 (2011-05-03)
The serine protease inhibitors (serpins) are anti-inflammatory proteins that have various functions. By screening a diverse panel of viruses, we demonstrate that the serpin antithrombin III (ATIII) has a broad-spectrum anti-viral activity for HIV-1, HCV and HSV. To investigate the
Sangyeul Han et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(6), 1940-1946 (2009-03-12)
Chordomas are rare, malignant bone neoplasms in which the pathogenic mechanisms remain unknown. Interestingly, tuberous sclerosis complex (TSC) is the only syndrome in which the incidence of chordomas has been described. We previously reported the pathogenic role of the TSC
M M Thomas et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 12(6), 651-657 (2008-05-22)
Hospital in-patients with suspected tuberculous meningitis (TBM), predominantly in India. To determine whether interferon-gamma (IFN-gamma) secreting Mycobacterium tuberculosis antigen-specific T-cells are present in the cerebrospinal fluid (CSF) of patients with TBM and to evaluate the feasibility of CSF enzyme-linked immunospot
Mikihiko Arikawa et al.
PloS one, 6(7), e20629-e20629 (2011-07-14)
We have previously demonstrated that the chronic intervention in the cholinergic system by donepezil, an acetylcholinesterase inhibitor, plays a beneficial role in suppressing long-term cardiac remodeling after myocardial infarction (MI). In comparison with such a chronic effect, however, the acute
Sreya Chattopadhyay et al.
PloS one, 4(10), e7382-e7382 (2009-10-09)
Many tumors are associated with decreased cellular immunity and elevated levels of prostaglandin E2 (PGE2), a known inhibitor of CD4+ T cell activation and inducer of type-2 cytokine bias. However, the role of this immunomodulator in the survival of T
Fei Liu et al.
World journal of gastroenterology, 14(25), 3990-3996 (2008-07-09)
To investigate the anti-tumor effect of Chinese medicine Gecko on human esophageal carcinoma cell lines and xenografted sarcoma 180 in Kunming mice and its mechanism. The serum pharmacological method was used in vitro. The growth rates of the human esophageal
Maiara G Blagitz et al.
The Journal of dairy research, 82(4), 460-469 (2015-06-30)
Streptococcus dysgalactiae is a bacterium that accounts for a notable proportion of both clinical and subclinical intramammary infections (IMIs). Thus, the present study explores the function of milk neutrophils and the lymphocyte profile in mammary glands naturally infected with Streptococcus
Roman Paduch et al.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 4(2), 187-198 (2011-09-13)
Cyclooxygenases (COX), prostaglandin E(2) (PGE(2)) and nitric oxide (NO) are believed to be some of the most important factors related to colon cancer growth and metastasis. In this study, we aimed to investigate the associations between COX-2, PGE(2) and NO
Francisco J Alvarez et al.
Molecular biology of the cell, 19(12), 5214-5225 (2008-09-19)
The Candida albicans plasma membrane plays important roles in cell growth and as a target for antifungal drugs. Analysis of Ca-Sur7 showed that this four transmembrane domain protein localized to stable punctate patches, similar to the plasma membrane subdomains known
I Marinoni et al.
Endocrine-related cancer, 24(3), 137-146 (2017-01-25)
DAXX and or ATRX loss occur in 40% of pancreatic neuroendocrine tumors (PanNETs). PanNETs negative for DAXX or ATRX show an increased risk of relapse. The tumor-associated pathways activated upon DAXX or ATRX loss and how this event may induce
Yi Wen et al.
Hypertension (Dallas, Tex. : 1979), 75(3), 869-876 (2020-01-28)
Activated T lymphocytes that infiltrate blood pressure control organs make a critical contribution to the pathogenesis of hypertension. Dendritic cells act as potent antigen-presenting cells to stimulate prohypertensive T cells. However, the mechanisms that facilitate the recruitment of prohypertensive T
Tetsuya Adachi et al.
Retrovirology, 8, 84-84 (2011-10-25)
Small chemical compounds which target chemokine receptors have been developed against human immunodeficiency virus type 1 (HIV-1) and are under investigation for use as anti-HIV-1 microbicides. In addition, monoclonal antibodies (mAbs) against chemokine receptors have also been shown to have
Tiffany M DeSimone et al.
International journal for parasitology, 39(4), 399-405 (2008-10-04)
Apicomplexan parasites employ multiple adhesive ligands for recognition and entry into host cells. The Duffy binding-like (DBL) and the reticulocyte binding protein-like (RBL) families are central to the invasion of erythrocytes by the malaria parasite. These type-1 transmembrane proteins are
Dinesh Chandra et al.
Clinical and experimental immunology, 154(2), 224-234 (2008-09-10)
The failure of Leishmania, an intracellular pathogen, to stimulate a pro-inflammatory response following entry into macrophages has been well reported. This occurs in spite of the fact that ligands for the toll-like receptors (TLR) have been recently shown on the
Johan Olerud et al.
Diabetes, 57(7), 1870-1877 (2008-04-19)
Insufficient development of a new intra-islet capillary network after transplantation may be one contributing factor to the failure of islet grafts in clinical transplantation. The present study tested the hypothesis that the angiostatic factor thrombospondin-1 (TSP-1), which is normally present
Yoshifumi Nishikawa et al.
Clinical and vaccine immunology : CVI, 16(6), 792-797 (2009-04-10)
The present study demonstrates that the subcutaneous administration of Neospora caninum dense granule protein 7 (NcGRA7) entrapped in liposomes coated with mannotriose strongly induces the parasite-specific T-helper type 1 immune response and humoral antibody in mice. Although anti-NcGRA7 immunoglobulin G1
Ricardo Araujo et al.
Antimicrobial agents and chemotherapy, 53(11), 4921-4923 (2009-08-26)
Posaconazole MICs for 50 Aspergillus fumigatus isolates with distinct genotypes were determined by three methods. MICs were > or = 0.5 microg/ml for 5, 11, and 15 strains by the CLSI reference M38-A2, Etest (48-h), and oxygen consumption methods, respectively.
Camila R Corrêa et al.
Journal of inflammation (London, England), 8, 23-23 (2011-08-31)
Arterial peripheral disease is a condition caused by the blocked blood flow resulting from arterial cholesterol deposits within the arms, legs and aorta. Studies have shown that macrophages in atherosclerotic plaque are highly activated, which makes these cells important antigen-presenting
Simone Aymanns et al.
PloS one, 6(6), e19822-e19822 (2011-07-07)
Fluorescence labeling of bacterial pathogens has a broad range of interesting applications including the observation of living bacteria within host cells. We constructed a novel vector based on the E. coli streptococcal shuttle plasmid pAT28 that can propagate in numerous
Guowu Hu et al.
The Journal of clinical investigation, 118(3), 1186-1197 (2008-02-09)
Autophagy is a process by which cells recycle cytoplasm and defective organelles during stress situations such as nutrient starvation. It can also be used by host cells as an immune defense mechanism to eliminate infectious pathogens. Here we describe the
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