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r8004

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Plamena R Angelova et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(29), 10460-10473 (2015-07-24)
In terrestrial mammals, the oxygen storage capacity of the CNS is limited, and neuronal function is rapidly impaired if oxygen supply is interrupted even for a short period of time. However, oxygen tension monitored by the peripheral (arterial) chemoreceptors is
Jiansheng Liu et al.
Biomaterials, 74, 64-76 (2015-10-09)
Despite optimal therapeutic regimen with currently available antiepileptic drugs (AEDs), approximately a third of epilepsy patients remain drug refractory. Region-specific overexpression of multidrug efflux transporters at the blood-brain barrier, such as P-glycoprotein (P-gp), might contribute to multidrug resistance (MDR) by
Huihui Bu et al.
International journal of pharmaceutics, 471(1-2), 206-213 (2014-05-29)
Paclitaxel resistance is usually developed in clinical chemotherapy, which remains a major obstacle for successful cancer treatment. Herein, we attempted to develop a TPGS incorporating nanoemulsion of paclitaxel (NE-PTX) to circumvent the drug resistance in breast cancer. NE-PTX was prepared
A H Alhebshi et al.
Biochemical and biophysical research communications, 433(4), 362-367 (2013-03-30)
Thymoquinone (TQ) is the main constituent of the oil extracted from Nigella sativa seeds, which is known to be the active constituent responsible for many of the seed antioxidant and anti-inflammatory effects. The present study was designed to investigate whether
Chunbo Zhang et al.
Epilepsia, 54(7), 1154-1160 (2013-04-05)
Antiepileptic drugs (AEDs) do not effectively treat 30-40% of patients with epilepsy. Export of AEDs by P-glycoprotein (Pgp, ABCB1, or MDR1), which is overexpressed in the blood-brain barrier in drug-resistant patients, may be a mechanism for resistance to AEDs. For
Chubiao Zhao et al.
Cellular signalling, 26(10), 2223-2233 (2014-07-16)
Our recent studies have demonstrated the key roles of reactive oxygen species (ROS)-mediated caspase-8- and Bax-dependent apoptotic pathways in dihydroartemisinin (DHA)-induced apoptosis of A549 cells. This report is designed to investigate the proapoptotic mechanisms of DHA in gemcitabine (Gem)-resistant A549
Siyuan Sun et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(12), 1197-1205 (2012-08-21)
Tetrahydropalmatine (THP), with one chiral centre, is one of the major constituents of Rhizoma corydalis. THP is considered to possess analgesic, sedative, hypnotic actions and cardiac protection. The aim of this study was to elucidate the stereoselective interaction between THP
I Gañán-Gómez et al.
Annals of hematology, 94(3), 379-392 (2014-10-18)
Current frontline therapies have improved overall survival in acute promyelocytic leukemia (APL) patients to exceptional rates; however, relapse is still a problem among high-risk and old patients. Therefore, the development of better and safer therapies continues to be a goal
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Z-B Sun et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 26(1), 187-197 (2014-08-13)
In this study, we found out a previously undefined function of icariin which restored the dynamic balance between osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs) in patients with osteonecrosis of femoral head (ONFH) via ABCB1-promoter demethylation. These findings
Annika Reddig et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 87(8), 724-732 (2015-04-08)
The efficacy of many chemotherapeutic agents relies on the preferential destruction of rapidly dividing cancer cells by inducing various kinds of DNA damage. The most deleterious type of DNA lesions are DNA double-strand breaks (DSB), which can be detected by
Weibin Zha et al.
PloS one, 8(1), e54349-e54349 (2013-02-02)
HIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophages.
Davide Tamburro et al.
Journal of the American Chemical Society, 133(47), 19178-19188 (2011-10-18)
Many low-abundance biomarkers for early detection of cancer and other diseases are invisible to mass spectrometry because they exist in body fluids in very low concentrations, are masked by high-abundance proteins such as albumin and immunoglobulins, and are very labile.
Xing Tian et al.
Cellular and molecular neurobiology, 35(3), 335-344 (2014-10-30)
Accumulated evidence has shown that excessive reactive oxygen species (ROS) have been implicated in neuronal cell death related with various chronic neurodegenerative disorders. This study was designed to explore neuroprotective effects of ethyl acetate extract of Arctium lappa L. roots
Bing Zhao et al.
Oncology reports, 31(6), 2769-2775 (2014-04-05)
Human bladder cancer is an aggressive tumor which frequently resists chemotherapy. Therefore, the search for new therapeutic agents is of great importance. Altholactone, isolated from Goniothalamus sp., has been reported to inhibit the growth of various types of cancer cells.
Sheng-lie Zhang et al.
Chemical biology & drug design, 81(3), 349-358 (2012-10-26)
Overexpression of ABCB1 is one of major barriers for multidrug resistance in chemotherapy and limits drug oral bioavailability. Inhibition of ABCB1 would sensitize multidrug resistance in clinical cancer chemotherapy. With this aim, a 3D pharmacophore model was created based on
Martin Michaelis et al.
Oncotarget, 6(19), 17605-17620 (2015-03-10)
The PKCβ inhibitor enzastaurin was tested in parental neuroblastoma and rhabdomyosarcoma cell lines, their vincristine-resistant sub-lines, primary neuroblastoma cells, ABCB1-transduced, ABCG2-transduced, and p53-depleted cells. Enzastaurin IC50s ranged from 3.3 to 9.5 μM in cell lines and primary cells independently of
Bing-Feng Zhang et al.
Biomaterials, 61, 178-189 (2015-05-26)
The mitochondria-mediated apoptosis pathway is an effective option for cancer therapy due to the presence of cell-suicide weapons in mitochondria. However, anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as Bcl-2 protein, could allow the
Shengliang Liu et al.
PloS one, 9(9), e107865-e107865 (2014-09-24)
Various solutions are utilized widely for the isolation, harvesting, sorting, testing and transplantation of neural stem cells (NSCs), whereas the effects of harvesting media on the biological characteristics and repair potential of NSCs remain unclear. To examine some of these
Robert O'Connor et al.
Cancer chemotherapy and pharmacology, 71(5), 1357-1368 (2013-04-17)
Bortezomib is an important agent in multiple myeloma treatment, but resistance in cell lines and patients has been described. The main mechanisms of resistance described in cancer fall into one of two categories, pharmacokinetic resistance (PK), e.g. over expression of
Shang-jun Tang et al.
Biochemical pharmacology, 91(2), 144-156 (2014-07-25)
The overexpression of ATP-binding cassette (ABC) transporters often leads to the development of multidrug resistance (MDR), which is the major factor contributing to the failure of chemotherapy. The objective of this study was to investigate the enhancement of CEP-33779, a
Claudia Meindl et al.
PloS one, 10(8), e0135690-e0135690 (2015-08-15)
Pulmonary drug delivery is characterized by short onset times of the effects and an increased therapeutic ratio compared to oral drug delivery. This delivery route can be used for local as well as for systemic absorption applying drugs as single
Xing Tian et al.
Environmental toxicology and pharmacology, 38(1), 189-198 (2014-06-24)
Many studies have shown that glutamate-induced oxidative stress can lead to neuronal cell death involved in the development of neurodegenerative diseases. In this work, protective effects of ethyl acetate extract (EAE) of Arctium lappa L. roots against glutamate-induced oxidative stress
Jieun Kang et al.
International journal of molecular sciences, 22(22) (2021-11-28)
Fungicides often cause genotoxic stress and neurodevelopmental disorders such as autism (ASD). Fungicide-azoxystrobin (AZOX) showed acute and chronic toxicity to various organisms, and remained a concern for ill effects in developing neurons. We evaluated the neurotoxicity of AZOX in developing
Severin Mairinger et al.
Nuclear medicine and biology, 39(8), 1219-1225 (2012-09-18)
With the aim to develop a PET tracer to visualize P-glycoprotein (Pgp) expression levels in different organs, the Pgp inhibitor MC113 was labeled with (11)C and evaluated using small-animal PET. [(11)C]MC113 was synthesized by reaction of O-desmethyl MC113 with [(11)C]methyl
Jiaqi Lu et al.
Experimental cell research, 334(2), 194-206 (2015-04-19)
As a widely used anti-bacterial agent and a metabolic inhibitor as well as AMP-activated protein kinase (AMPK) activator, berberine (BBR) has been shown to cross the blood-brain barrier. Its efficacy has been investigated in various disease models of the central
Nidhi Puri et al.
European journal of medicinal chemistry, 45(11), 4813-4826 (2010-08-27)
In this study, we have explored the structure activity relationships of substrates of two major, promiscuous, multidrug transporters of an opportunistic human pathogen Candida albicans namely, CaCdr1p and CaMdr1p. To differentiate between substrates and non-substrates, the susceptibilities of the Saccharomyces
Chakravarthy Garlapati et al.
Theranostics, 11(18), 9089-9106 (2021-09-16)
Rationale: Cancer cells rely on glucose metabolism for fulfilling their high energy demands. We previously reported that monoethanolamine (Etn), an orally deliverable lipid formulation, reduced intracellular glucose and glutamine levels in prostate cancer (PCa). Glucose deprivation upon Etn treatment exacerbated
Xiu-Mei Li et al.
Journal of ethnopharmacology, 166, 205-210 (2015-03-23)
Hypericum ascyron L. (H. ascyron L.) has been used as a traditional medicine for the treatment of wounds, swelling, headache, nausea, stomach ache, abscesses, dysentery and chronic bronchitis. Pharmacological studies are necessary to provide a scientific basis to substantiate their
Ningning Liu et al.
Oncotarget, 5(14), 5453-5471 (2014-07-01)
Proteasomes are attractive emerging targets for anti-cancer therapies. Auranofin (Aur), a gold-containing compound clinically used to treat rheumatic arthritis, was recently approved by US Food and Drug Administration for Phase II clinical trial to treat cancer but its anti-cancer mechanism
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