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R8129

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Danielle S Trentin et al.
PloS one, 8(6), e66257-e66257 (2013-06-19)
Plants produce many compounds that are biologically active, either as part of their normal program of growth and development or in response to pathogen attack or stress. Traditionally, Anadenanthera colubrina, Commiphora leptophloeos and Myracrodruon urundeuva have been used by communities...
Stanislav S Rubakhin et al.
Analytical chemistry, 80(18), 7128-7136 (2008-08-19)
Cell-to-cell signaling peptides play important roles in neurotransmission, neuromodulation, and hormonal signaling. Significant progress has been achieved in qualitative investigations of signaling peptides in the nervous system using single cell matrix-assisted laser desorption/ionization mass spectrometry. However, quantitative information about signaling...
Tomoaki Ishigami et al.
Hypertension (Dallas, Tex. : 1979), 64(1), 125-133 (2014-04-30)
Renin belongs to a family of aspartyl proteases and is the rate-limiting enzyme in the synthesis of the potent vasoactive peptide angiotensin II. Processing of renal renin has been extensively investigated in juxtaglomerular granular cells, in which prorenin and active...
Györgyi Horváth et al.
Molecules (Basel, Switzerland), 26(2) (2021-01-23)
Melilotus officinalis is known to contain several types of secondary metabolites. In contrast, the carotenoid composition of this medicinal plant has not been investigated, although it may also contribute to the biological activities of the drug, such as anti-inflammatory effects....
Chuanming Xu et al.
American journal of physiology. Renal physiology, 313(3), F641-F656 (2016-07-22)
(Pro)renin receptor (PRR) is highly expressed in the distal nephron, but it has an unclear functional implication. The present study was conducted to explore a potential role of renal PRR during high K+ (HK) loading. In normal Sprague-Dawley rats, a...
Syed Ghulam Musharraf et al.
Journal of pharmaceutical and biomedical analysis, 132, 190-194 (2016-10-18)
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) being soft ionization technique, has become a method of choice for high-throughput analysis of proteins and peptides. In this study, we have explored the potential of atypical anti-psychotic drug olanzapine (OLZ) as a matrix...
Daniel J Orton et al.
Analytical chemistry, 90(1), 737-744 (2017-11-22)
To better understand disease conditions and environmental perturbations, multiomic studies combining proteomic, lipidomic, and metabolomic analyses are vastly increasing in popularity. In a multiomic study, a single sample is typically extracted in multiple ways, and various analyses are performed using...
Eric J Lanni et al.
Journal of the American Society for Mass Spectrometry, 25(11), 1897-1907 (2014-09-04)
We describe a hybrid MALDI/C(60)-SIMS Q-TOF mass spectrometer and corresponding sample preparation protocols to image intact biomolecules and their fragments in mammalian spinal cord, individual invertebrate neurons, and cultured neuronal networks. A lateral spatial resolution of 10 μm was demonstrated...
Ania Stefanska et al.
Kidney international, 90(6), 1251-1261 (2016-09-30)
Pericytes, perivascular cells embedded in the microvascular wall, are crucial for vascular homeostasis. These cells also play diverse roles in tissue development and regeneration as multi-lineage progenitors, immunomodulatory cells and as sources of trophic factors. Here, we establish that pericytes are renin...
Endang Purwantini et al.
PloS one, 8(12), e81985-e81985 (2013-12-19)
The ability of Mycobacterium tuberculosis to manipulate and evade human immune system is in part due to its extraordinarily complex cell wall. One of the key components of this cell wall is a family of lipids called mycolic acids. Oxygenation...
K A Rolls et al.
Clinical and experimental pharmacology & physiology, 21(3), 227-230 (1994-03-01)
1. Since plasma renin activity is increased in cyclosporin A (CsA)-induced hypertension in the rat, the role of the vascular renin-angiotensin system (RAS) in CsA-induced hypertension was investigated in rat mesenteric resistance vessels. 2. Female Wistar rats received CsA (10...
Khalid M Elased et al.
Hypertension (Dallas, Tex. : 1979), 46(4), 953-959 (2005-08-17)
This article demonstrates the applicability of quantitative proteomics to assays of proteolytic enzyme activity. A novel assay was developed for measurement of renin and angiotensin-converting enzyme (ACE) activity in plasma. The method was validated in animal models associated with alterations...
Fei Wang et al.
American journal of physiology. Renal physiology, 307(1), F25-F32 (2014-04-18)
(Pro)renin receptor (PRR) is predominantly expressed in the distal nephron where it is activated by angiotensin II (ANG II), resulting in increased renin activity in the renal medulla thereby amplifying the de novo generation and action of local ANG II....
Gustavo J Cavallero et al.
Journal of proteomics, 162, 20-29 (2017-04-24)
In Gram-positive bacteria, such as lactic acid bacteria, general glycosylation systems have not been documented so far. The aim of this work was to characterize in detail the glycosylation of the S-layer protein of Lactobacillus kefiri CIDCA 83111. A reductive...
Stanislav S Rubakhin et al.
Journal of the American Society for Mass Spectrometry, 26(6), 958-966 (2015-03-31)
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has evolved to become an effective discovery tool in science and clinical diagnostics. Here, chemical imaging approaches are applied to well-defined regions of the mammalian peripheral sensory-motor system, including the dorsal root...
Ziwei Fu et al.
American journal of physiology. Renal physiology, 316(3), F530-F538 (2018-11-01)
The (pro)renin receptor (PRR) is a new component of the renin-angiotensin-aldosterone system (RAAS) and regulates renin activity. The objective of the present study was to test potential roles of the renal PRR and intrarenal RAAS in the physiological status of...
Marie-Jia Gou et al.
Journal of chromatography. A, 1618, 460873-460873 (2020-01-29)
Capillary electrophoresis tandem mass spectrometry (CE-MS/MS) is an interesting tool for proteomic analysis as the separation principle is orthogonal to liquid chromatography tandem mass spectrometry (LC-MS/MS). The combination of both techniques can bring complementary information to enlarge proteome coverage. In...
Wiliam A Prado et al.
Brain research, 972(1-2), 207-215 (2003-04-25)
The intracerebroventricular administration of renin substrate or angiotensin II evokes antinociception in rodents, but the brain sites where most of the renin-angiotensin system peptides act are not yet known. This study describes the antinociceptive effects of microinjecting porcine renin substrate...
S Kvist et al.
European journal of pharmacology, 198(1), 77-83 (1991-05-30)
The responses to angiotensinogen, angiotensinogen-(1-14) (tetradecapeptide, TDP), angiotensin I, and angiotensin II and the effect of the renin inhibitor, CH-66, the angiotensin-converting enzyme (ACE) inhibitor, perindopril, and the receptor antagonist, saralasin, were investigated in isolated femoral resistance arteries of the...
Craig R Johnson et al.
The Journal of general virology, 92(Pt 5), 1107-1116 (2011-02-11)
Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus that emerged in the late 1980s in both Europe and North America as the causative agent of porcine reproductive and respiratory syndrome (PRRS), now the most important disease of swine...
Soma Jobbagy et al.
JCI insight, 5(1) (2020-01-17)
Lithium (Li) is the mainstay pharmacotherapeutic mood stabilizer in bipolar disorder. Its efficacious use is complicated by acute and chronic renal side effects, including nephrogenic diabetes insipidus (NDI) and progression to chronic kidney disease (CKD). The nuclear factor erythroid-derived 2-related...
D Ciavardelli et al.
Cell death & disease, 1, e90-e90 (2011-03-04)
The triple-transgenic Alzheimer (3 × Tg-AD) mouse expresses mutant PS1(M146V), APP(swe), and tau(P301L) transgenes and progressively develops plaques and neurofibrillary tangles with a temporal- and region-specific profile that resembles the neuropathological progression of Alzheimer's disease (AD). In this study, we...
Syed Ghulam Musharraf et al.
Chemistry Central journal, 7(1), 77-77 (2013-04-30)
Matrix-assisted laser desorption/ionization (MALDI) is a soft ionization mass spectrometric technique, allowing the analysis of bio-molecules and other macromolecules. The matrix molecules require certain characteristic features to serve in the laser desorption/ionization mechanism. Therefore, only a limited number of compounds...
Christian Schmidt et al.
Analytical and bioanalytical chemistry, 406(21), 5171-5185 (2014-03-22)
Toxic organophosphorus compounds (e.g., pesticides and nerve agents) are known to react with nucleophilic side chains of different amino acids (phosphylation), thus forming adducts with endogenous proteins. Most often binding to serine, tyrosine, or threonine residues is described as being...
Alexis A Gonzalez et al.
The American journal of the medical sciences, 348(5), 416-422 (2014-09-25)
Evidence indicates that chronic angiotensin II (AngII) infusion increases (pro)renin receptor ((P)RR) expression in renal inner medullary collecting duct (IMCD) cells. Recently, it has been shown that renal (P)RR expression is augmented during a low-salt (LS) diet. However, the role...
Laura J Castellanos-García et al.
Journal of the American Society for Mass Spectrometry, 28(12), 2548-2560 (2017-09-08)
Phenylenevinylene oligomers (PVs) have outstanding photophysical characteristics for applications in the growing field of organic electronics. Yet, PVs are also versatile molecules, the optical and physicochemical properties of which can be tuned by manipulation of their structure. We report the...
Rita de Cássia Lemos Lima et al.
Food & function, 10(3), 1619-1628 (2019-03-02)
Inhibition of dipeptidyl peptidase IV (DPP-IV) and stimulation of muscle glucose uptake are two of the key strategies for management of type-2-diabetes (T2D). In the present study, four protein hydrolysates generated by enzymatic hydrolysis of chicken by-product, i.e., mechanical chicken...
Lena R Thurner et al.
Naunyn-Schmiedeberg's archives of pharmacology, 392(11), 1401-1410 (2019-06-28)
It has been reported that the serine protease kallikrein stimulates and that aprotinin, a protease inhibitor, inhibits renal renin secretion. Since direct stimulation of the protease-activated receptor (PAR) 2 increases renin secretion in isolated perfused mouse kidneys, we hypothesized that...
Adriana C Casabuono et al.
Journal of the American Society for Mass Spectrometry, 30(9), 1679-1689 (2019-06-14)
Bordetella bronchiseptica, known to infect animals and rarely humans, expresses a lipopolysaccharide that plays an essential role in host interactions, being critical for early clearance of the bacteria. On a B. bronchiseptica 9.73 isolate, mutants defective in the expression of...
Emanuele Pignatti et al.
Cell reports, 31(3), 107524-107524 (2020-04-23)
Activating mutations in the canonical Wnt/β-catenin pathway are key drivers of hyperplasia, the gateway for tumor development. In a wide range of tissues, this occurs primarily through enhanced effects on cellular proliferation. Whether additional mechanisms contribute to β-catenin-driven hyperplasia remains...
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