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Kaja Skjefstad et al.
Scientific reports, 8(1), 8549-8549 (2018-06-06)
Micro RNAs (miRNA) are small non-coding RNAs that post-transcriptionally regulate gene expression. Dysregulation of miRNA cluster 143/145 has been reported in several malignancies, but their role in non-small cell lung cancer (NSCLC) remains elusive. This study investigates the prognostic impact...
Takanori Katsube et al.
Mutation research, 813, 18-26 (2016-12-25)
Both ionizing radiation (IR) and psychological stress (PS) cause detrimental effects on humans. A recent study showed that chronic restraint-induced PS (CRIPS) diminished the functions of Trp53 and enhanced radiocarcinogenesis in Trp53-heterozygous (Trp53
Teneale A Stewart et al.
ACS pharmacology & translational science, 3(1), 63-75 (2020-04-08)
An essential process in predicting the in vivo pharmacological activity of a candidate molecule involves the evaluation of target responses using established model systems. While these models largely comprise immortalized cells, which are often serially passaged as monolayers on uniformly...
A Islam et al.
European cells & materials, 37, 153-174 (2019-02-21)
Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about...
J A Scare et al.
Parasitology, 147(6), 659-666 (2020-02-13)
Ascarid parasites infect a variety of hosts and regular anthelmintic treatment is recommended for all species. Parascaris spp. is the only ascarid species with widespread anthelmintic resistance, which allows for the study of resistance mechanisms. The purpose of this study...
Sören Twarock et al.
Molecular cancer, 10, 30-30 (2011-03-25)
Oesophageal cancer is a highly aggressive tumour entity with at present poor prognosis. Therefore, novel treatment options are urgently needed. Hyaluronan (HA) is a polysaccharide present in the matrix of human oesophageal squamous cell carcinoma (ESCC). Importantly, in vitro ESCC...
Lin Xu et al.
PloS one, 6(5), e20282-e20282 (2011-06-10)
CD4(+)CD25(+) regulatory T cells (Tregs), a heterogeneous population, were enrichment in tumor mass and played an important role in modulating anti-tumor immunity. Recently, we reported a Treg subset, CCR6(+) Tregs but not CCR6(-)Tregs, were enriched in tumor mass and closely...
Allison Rahtes et al.
Frontiers in immunology, 11, 1478-1478 (2020-08-09)
Subclinical endotoxemia [low levels of bacterial endotoxin (LPS) in the blood stream] has been correlated with chronic inflammatory diseases, with less-understood mechanisms. We have previously shown that chronic exposure to super low doses of LPS polarizes monocytes/macrophages to a pro-inflammatory...
Douglas P Jasmer et al.
Pharmaceuticals (Basel, Switzerland), 14(7) (2021-07-03)
Establishing methods to investigate treatments that induce cell death in parasitic nematodes will promote experimental approaches to elucidate mechanisms and to identify prospective anthelmintics capable of inducing this outcome. Here, we extended recent progress on a method to monitor cell...
Irene Anton-Sales et al.
Biomaterials science, 8(10), 2921-2930 (2020-04-22)
Corneal trauma and ulcerations are leading causes of corneal blindness around the world. These lesions require attentive medical monitoring since improper healing or infection has serious consequences in vision and quality of life. Amniotic membrane grafts represent the common solution...
Wooje Lee et al.
Nature communications, 11(1), 3140-3140 (2020-06-21)
MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA in the regulation of gene expression is well established. However, the widespread distribution of MeCP2 suggests it has additional interactions with chromatin. Here...
Synnøve Magnussen et al.
PloS one, 9(8), e105929-e105929 (2014-08-27)
The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the...
James B Whitney et al.
PloS one, 6(4), e18589-e18589 (2011-05-03)
The serine protease inhibitors (serpins) are anti-inflammatory proteins that have various functions. By screening a diverse panel of viruses, we demonstrate that the serpin antithrombin III (ATIII) has a broad-spectrum anti-viral activity for HIV-1, HCV and HSV. To investigate the...
Hongying Shen et al.
Cell, 171(4), 771-782 (2017-10-24)
CLYBL encodes a ubiquitously expressed mitochondrial enzyme, conserved across all vertebrates, whose cellular activity and pathway assignment are unknown. Its homozygous loss is tolerated in seemingly healthy individuals, with reduced circulating B
Ryosuke Koyama et al.
Bioorganic & medicinal chemistry, 28(11), 115492-115492 (2020-04-16)
Effective chemotherapy for solid cancers is challenging due to a limitation in permeation that prevents anticancer drugs from reaching the center of the tumor, therefore unable to limit cancer cell growth. To circumvent this issue, we planned to apply the...
Hongji Yan et al.
ACS applied materials & interfaces, 12(17), 19324-19336 (2020-04-18)
Mucins are multifunctional glycosylated proteins that are increasingly investigated as building blocks of novel biomaterials. An attractive feature is their ability to modulate the immune response, in part by engaging with sialic acid binding receptors on immune cells. Once assembled...
Elżbieta Łopieńska-Biernat et al.
Pathogens (Basel, Switzerland), 9(12) (2020-12-16)
Anisakis simplex (s.l.) is a complex of three sibling (biological) species of parasitic nematodes of marine mammals, including A. berlandi, A. pegreffii and A. simplex (s.s.). It is characterized by a complex life cycle in which humans can become accidental...
Zhenyu Pan et al.
Frontiers in oncology, 10, 387-387 (2020-04-25)
Background: Leptomeningeal metastasis (LM) has frequently been observed in patients with lung adenocarcinoma. So far, its diagnosis and disease course monitoring are still extremely difficult. Moreover, there is no effective treatment regimen for LM due to a lack knowledge on...
Han Wang et al.
Stem cells and development, 24(21), 2536-2546 (2015-07-02)
Definitive endoderm (DE) is a vital precursor for internal organs such as liver and pancreas. Efficient protocol to differentiate human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs) to DE is essential for regenerative medicine and for modeling...
C P Gonzalez-Hunt et al.
Scientific reports, 10(1), 17293-17293 (2020-10-16)
Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of Parkinson's disease (PD) and LRRK2 kinase inhibitors are currently being tested in early phase clinical trials. In order to ensure the highest chance of success, a...
Min Yong et al.
American journal of cancer research, 10(11), 3737-3751 (2020-12-10)
Circular RNAs, a special class of non-coding RNA with closed circular structure, have been increasingly proven to be involved in the progression of various tumors. However, the biological functions of circular RNAs in epithelial ovarian cancer (EOC) tissues remain a...
A Villasante et al.
Theranostics, 7(17), 4099-4117 (2017-11-22)
Neuroblastoma is a vascularized pediatric tumor derived from neural crest stem cells that displays vasculogenic mimicry and can express a number of stemness markers, such as SOX2 and NANOG. Tumor relapse is the major cause of succumbing to this disease...
Francisco J Alvarez et al.
Molecular biology of the cell, 19(12), 5214-5225 (2008-09-19)
The Candida albicans plasma membrane plays important roles in cell growth and as a target for antifungal drugs. Analysis of Ca-Sur7 showed that this four transmembrane domain protein localized to stable punctate patches, similar to the plasma membrane subdomains known...
Inés Reigada et al.
Microorganisms, 8(11) (2020-11-14)
Nosocomial diseases represent a huge health and economic burden. A significant portion is associated with the use of medical devices, with 80% of these infections being caused by a bacterial biofilm. The insertion of a foreign material usually elicits inflammation...
Hana Ujcikova et al.
Journal of neuroimmunology, 341, 577191-577191 (2020-03-01)
Morphine- and Concanavalin A-induced changes of protein composition of rat spleen lymphocytes were determined by high-resolution proteomic analysis, gel-free, label-free quantification, MaxLFQ. Stimulation by Con A resulted in a major reorganization of spleen cell protein composition evidenced by increased expression...
Kae Nakamura et al.
Cancers, 13(5) (2021-04-04)
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The major cause of EOC's lethality is that intraperitoneal recurrence occurs with high frequency due to occult metastasis. We had demonstrated that plasma-activated medium (PAM) exerts a metastasis-inhibitory effect on...
Letizia Vallino et al.
Journal of traditional and complementary medicine, 10(3), 217-229 (2020-07-17)
Non-coding RNAs control cell functioning through affecting gene expression and translation and their dysregulation is associated with altered cell homeostasis and diseases, including cancer. Nutraceuticals with anti-cancer therapeutic potential have been shown to modulate non-coding RNAs expression that could impact...
Sonam Dhamija et al.
Nature cell biology, 22(8), 999-1010 (2020-07-29)
Nonstop or stop-loss mutations convert a stop into a sense codon, resulting in translation into the 3' untranslated region as a nonstop extension mutation to the next in-frame stop codon or as a readthrough mutation into the poly-A tail. Nonstop...
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