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Hala Nijmeh et al.
American journal of physiology. Lung cellular and molecular physiology, 306(7), L661-L671 (2014-02-11)
Angiogenic expansion of the vasa vasorum (VV) is an important contributor to pulmonary vascular remodeling in the pathogenesis of pulmonary hypertension (PH). High proliferative potential endothelial progenitor-like cells have been described in vascular remodeling and angiogenesis in both systemic and...
Yinghui Li et al.
Cancer research, 74(6), 1639-1644 (2014-03-07)
Telomerase plays a pivotal role in bypassing cellular senescence and maintaining telomere homeostasis, essential properties required for the sustenance and progression of cancer. However, recent investigations have uncovered extratelomeric properties of telomerase that are independent of its role in telomere...
Tai-Yuan Yu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(9), 3377-3382 (2014-02-20)
In human somatic cells or yeast cells lacking telomerase, telomeres are shortened upon each cell division. This gradual shortening of telomeres eventually leads to senescence. However, a small population of telomerase-deficient cells can survive by bypassing senescence through the activation...
Thomas Winkler et al.
The Journal of clinical investigation, 123(5), 1952-1963 (2013-04-16)
Critically short telomeres activate p53-mediated apoptosis, resulting in organ failure and leading to malignant transformation. Mutations in genes responsible for telomere maintenance are linked to a number of human diseases. We derived induced pluripotent stem cells (iPSCs) from 4 patients...
Wan-Long Pan et al.
Bing du xue bao = Chinese journal of virology, 29(2), 218-223 (2013-06-14)
HBV infections leads to severe public health problems around the world, especially in China. Improved understanding of the molecular mechanisms of HBV reverse transcription is fundamental for optimization of treatment and solution to drug-resistance. Recently, the main structural basis involved...
Ricardo Saldaña-Meyer et al.
Genes & development, 28(7), 723-734 (2014-04-04)
The multifunctional CCCTC-binding factor (CTCF) protein exhibits a broad range of functions, including that of insulator and higher-order chromatin organizer. We found that CTCF comprises a previously unrecognized region that is necessary and sufficient to bind RNA (RNA-binding region [RBR])...
Christopher M Bailey et al.
Journal of medicinal chemistry, 56(10), 3959-3968 (2013-05-11)
Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) is a major target for currently approved anti-HIV drugs. These drugs are divided into two classes: nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). This study illustrates the synthesis and...
Tal Biron-Shental et al.
Hepato-gastroenterology, 60(127), 1713-1716 (2014-03-19)
Shortened telomeres reflect genetic instability that might lead to increased aneuploidy and malignant transformations. Chronic hepatitis C (HCV) viral infection is considered a pre-neoplastic condition that might progress to hepatocellular carcinoma. We evaluated telomere length and elongation, in patients with...
Pedro Castelo-Branco et al.
The Lancet. Oncology, 14(6), 534-542 (2013-04-20)
Identification of robust biomarkers of malignancy and methods to establish disease progression is a major goal in paediatric neuro-oncology. We investigated whether methylation of the TERT promoter can be a biomarker for malignancy and patient outcome in paediatric brain tumours....
Sanaa Eissa et al.
Clinical laboratory, 59(3-4), 317-323 (2013-06-04)
Expression of the human telomerase reverse transcriptase (hTERT) gene, which codes for the catalytic subunit of telomerase is considered an important tumor marker used for bladder cancer detection being found in the majority of cancer cells. Scatter Factor (SF) is...
Roderick J O'Sullivan et al.
Nature structural & molecular biology, 21(2), 167-174 (2014-01-15)
The mechanism of activation of the alternative lengthening of telomeres (ALT) pathway of mammalian chromosome-end maintenance has been unclear. We have now discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced all hallmarks of ALT...
G N Odaibo et al.
African journal of medicine and medical sciences, 41 Suppl, 61-63 (2013-05-18)
In Nigeria the Federal Government rolled out antiretroviral drugs for the management of HIV infection in year 2002. This study was carried out to determine the circulating antiviral drug mutations among ARV naïve patients with chronic HIV infection during the...
Danielle P Porter et al.
Journal of acquired immune deficiency syndromes (1999), 65(3), 318-326 (2014-02-15)
The Single-Tablet Regimen (STaR) study (GS-US-264-0110) is a 96-week phase 3b study evaluating the safety and efficacy of 2 single-tablet regimens, rilpivirine/emtricitabine/tenofovir DF (RPV/FTC/TDF), and efavirenz/emtricitabine/tenofovir DF (EFV/FTC/TDF) in treatment-naive HIV-1-infected subjects. Genotypic analyses (population sequencing) of HIV-1 protease and...
Amanda Polson et al.
Gene, 538(1), 138-149 (2014-01-15)
The p53 protein is an important tumor suppressor that regulates many cellular processes including maintenance of the cell cycle and apoptosis. The p53 protein maintains stability of the genome through the induction of several intracellular and extracellular factors in response...
Mrinmay Chakrabarti et al.
Experimental cell research, 319(10), 1575-1585 (2013-04-09)
Decrease in expression of the tumor suppressor microRNA-138 (miR-138) correlates well with an increase in telomerase activity in many human cancers. The ability of almost all human cancer cells to grow indefinitely is dependent on presence of telomerase activity. The...
Andrew B Dalby et al.
RNA (New York, N.Y.), 19(6), 841-851 (2013-04-24)
Most nucleic acid-binding proteins selectively bind either DNA or RNA, but not both nucleic acids. The Saccharomyces cerevisiae Ku heterodimer is unusual in that it has two very different biologically relevant binding modes: (1) Ku is a sequence-nonspecific double-stranded DNA...
Marcel Kool et al.
Cancer cell, 25(3), 393-405 (2014-03-22)
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(s) of primary resistance and identify pathways cooperating with aberrant SHH signaling, we sequenced and profiled a large cohort of SHH-MBs...
M Dono et al.
British journal of cancer, 110(4), 1058-1065 (2014-01-16)
Uveal melanoma is the most frequent primary tumour of the eye. It is molecularly clearly distinct from cutaneous melanoma and shows a different pattern of driver mutations. The influence of sunlight ultraviolet (UV) exposure on the aetiology of uveal melanoma...
Is telomeropathy the explanation for combined pulmonary fibrosis and emphysema syndrome?: report of a family with TERT mutation.
Hilario Nunes et al.
American journal of respiratory and critical care medicine, 189(6), 753-754 (2014-03-19)
Re: telomere length influences cancer cell differentiation in vivo.
Anthony Atala
The Journal of urology, 191(3), 867-868 (2014-02-14)
Toshio Hayashi et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(3), 1168-1173 (2014-01-09)
Senescence of vascular endothelial cells leads to endothelial dysfunction and contributes to the progression of atherosclerosis. Liver X receptors (LXRs) are nuclear receptors whose activation protects against atherosclerosis by transcriptional regulation of genes important in promoting cholesterol efflux and inhibiting...
Heng Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(20), 8290-8295 (2013-05-03)
DNA methylation is an important epigenetic mark in many eukaryotic organisms. De novo DNA methylation in plants can be achieved by the RNA-directed DNA methylation (RdDM) pathway, where the plant-specific DNA-dependent RNA polymerase IV (Pol IV) transcribes target sequences to...
Hamid Saeed et al.
Pakistan journal of pharmaceutical sciences, 27(2), 321-333 (2014-03-01)
Telomere shortening and telomerase deficiency have been linked with several age related degenerative diseases. Moreover, degenerative changes in various tissues/organs have been attributed to derangement of stem cell functions causing regenerative tragedy. Bone marrow stromal cells (BMSCs) are considered the...
The absence of TERT promoter mutations in primary gastric cancer.
Tiantian Liu et al.
Gene, 540(2), 266-267 (2014-03-04)
Absence of TERT promoter mutations in esophageal adenocarcinoma.
A M J van Nistelrooij et al.
International journal of cancer, 134(8), 2014-2015 (2014-02-05)
Ausubel, F., et al.
Short Protocols in Molecular Biology, 14-14 (1995)
Jiansen Jiang et al.
Nature, 496(7444), 187-192 (2013-04-05)
Telomerase adds telomeric repeats to chromosome ends using an internal RNA template and a specialized telomerase reverse transcriptase (TERT), thereby maintaining genome integrity. Little is known about the physical relationships among protein and RNA subunits within a biologically functional holoenzyme....
Cong Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 39(2), 209-215 (2014-04-26)
Using universal primer Ty1-copia retrotransposon RT,43 Ty1-copia like retrotransposon RT with high heterogeneity, stop codon mutation and frameshift mutation were amplified by PCR from genomic DNA of Zhejiang Lin'an (C15) and Yunnan Guangnan (A39) of Dendrobium officinale. The length of...
Imke Listerman et al.
Cancer research, 73(9), 2817-2828 (2013-04-24)
Human telomerase reverse transcriptase (hTERT; the catalytic protein subunit of telomerase) is subjected to numerous alternative splicing events, but the regulation and function of these splice variants is obscure. Full-length hTERT includes conserved domains that encode reverse transcriptase activity, RNA...
TERT hypermethylation: biomarker in paediatric brain tumours.
Scott J Diede
The Lancet. Oncology, 14(6), 447-448 (2013-04-20)
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