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Guillaume Spielmann et al.
Brain, behavior, and immunity, 39, 142-151 (2013-05-21)
Dynamic exercise evokes a rapid redeployment of cytotoxic T cell subsets with high expression of β2 adrenergic receptors, presumably to enhance immunosurveillance during acute stress. As this response is affected by age and infection history, this study examined latent CMV
Ting-Yu Cheng et al.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 32(4), 535-541 (2020-05-27)
We evaluated the detection of pseudorabies virus (PRV) antibodies in swine oral fluid. Oral fluid and serum samples were obtained from 40 pigs allocated to 4 treatment groups (10 pigs/group): negative control (NC); wild-type PRV inoculation (PRV 3CR Ossabaw; hereafter
Raffael Nachbagauer et al.
Nature medicine, 27(1), 106-114 (2020-12-09)
Seasonal influenza viruses constantly change through antigenic drift and the emergence of pandemic influenza viruses through antigenic shift is unpredictable. Conventional influenza virus vaccines induce strain-specific neutralizing antibodies against the variable immunodominant globular head domain of the viral hemagglutinin protein.
Shigeyuki Tamiya et al.
Frontiers in cellular and infection microbiology, 10, 602453-602453 (2021-02-02)
Mycoplasma pneumoniae (Mp) is a highly contagious respiratory pathogen responsible for human community-acquired pneumonia. The number of antibiotic-resistant Mp strains is increasing; therefore, to develop novel therapeutics, it is crucial to precisely understand the pathogenesis of mycoplasma pneumonia. Herein, we
Sathi Babu Chodisetti et al.
Journal of immunology (Baltimore, Md. : 1950), 204(4), 796-809 (2020-01-05)
TLR7 is associated with development of systemic lupus erythematosus (SLE), but the underlying mechanisms are incompletely understood. Although TLRs are known to activate type I IFN (T1IFN) signaling, the role of T1IFN and IFN-γ signaling in differential regulation of TLR7-mediated
N P Sunil-Chandra et al.
Frontiers in cellular and infection microbiology, 10, 556737-556737 (2020-10-30)
Chronic Kidney disease of uncertain etiology (CKDu) has become a significant disease burden, affecting farming community of Sri Lanka and the exact etiology, which could be multifactorial, is not hitherto established. This study is aimed to determine the association of
Tania García-Maceira et al.
BMC biotechnology, 20(1), 41-41 (2020-08-21)
The enzyme-linked immunosorbent assay (ELISA), is the most widely used and reliable clinical routine method for the detection of important protein markers in healthcare. Improving ELISAs is crucial for detecting biomolecules relates to health disorders and facilitating diagnosis at the
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Rajesh P Ringe et al.
Journal of virology, 94(6) (2019-12-20)
We covalently attached human immunodeficiency virus type 1 (HIV-1) Env SOSIP trimers to iron oxide nanoparticles (IO-NPs) to create a particulate immunogen for neutralizing antibody (NAb) induction. The attached trimers, ∼20 per particle, retained native-like antigenicity, judged by reactivity with
Abhinendra Kumar et al.
Indian journal of medical microbiology, 37(4), 514-520 (2020-05-22)
Identifying infectious pathogens by collecting intravenous blood (IVB) is a well-established procedure, however, the collection of IVB in field epidemiological study is challenging. The dried blood spot (DBS) as an alternative to IVB has been introduced, although, there is a
Saravana Murali Krishnan et al.
Pathogens (Basel, Switzerland), 10(2) (2021-02-10)
Chikungunya (CHIKV) and Dengue (DENV) viruses cause an acute febrile illness which is hard to clinically differentiate and treat since both exhibit similar symptoms. Hence, this study was aimed at identifying the expression profiles of cytokines on co-infected samples and
Tao Cheng et al.
Theranostics, 11(2), 893-905 (2021-01-05)
Rationale: Although human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation has been proved to be an effective therapeutic approach to treat systemic lupus erythematosus (SLE), the detailed underlying mechanisms are not fully understood. Transferring miRNAs is one mean by which
Yasuaki Yanagawa et al.
BMJ open, 10(2), e031605-e031605 (2020-02-28)
Amebiasis, which is caused by Entamoeba histolytica, is a re-emerging public health issue owing to sexually transmitted infection (STI) in Japan. However, epidemiological data are quite limited. To reveal the relative prevalence of sexually transmitted E. histolytica infection to other
Meret Huber et al.
Frontiers in neurology, 11, 576153-576153 (2020-10-31)
Objective: We report the case of a young woman with postinfectious onset of myasthenia gravis after COVID-19 with mild respiratory symptoms and anosmia/ageusia 1 month before admission to our neurological department. Methods: Patient data were derived from medical records of
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Jonathan M Ciencewicki et al.
Scientific reports, 10(1), 6850-6850 (2020-04-24)
Human-plasma-derived immune globulin (IG) is used in augmentation therapy to provide protective levels of antibodies to patients with primary immune deficiency diseases (PIDD) and for prophylaxis against infectious diseases. To maintain the breadth of antibodies necessary for clinical protection, it
Shigeyuki Tamiya et al.
Vaccine, 38(32), 4979-4987 (2020-06-17)
Mycoplasma pneumoniae (Mp) is one of the most common causes of community-acquired pneumonia. Given the emergence and high rates of antibiotic-resistant Mp strains, vaccines that prevent the pneumonia and secondary complications due to Mp infection are urgently needed. Although several
Irina Chis Ster et al.
BMJ open, 10(10), e040735-e040735 (2020-10-18)
There are few population-based estimates for prevalence of past exposure to dengue and chikungunya viruses despite common epidemiological features. Here, we have developed a novel statistical method to study patterns of age-dependent prevalence of immunity in a population following exposures
Robert T Cartee et al.
PLoS neglected tropical diseases, 14(1), e0007912-e0007912 (2020-01-07)
Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. Although the widely available unconjugated Vi polysaccharide vaccines are efficacious, they confer limited, short-term protection and are not approved for young
Hadeel T Al-Jighefee et al.
Pathogens (Basel, Switzerland), 10(2) (2021-02-07)
This study aims to study the immune response and evaluate the performances of four new IgM and five IgG enzyme-linked immunosorbent assay (ELISA) kits for detecting anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies against different antigens in symptomatic and
Theodore A Gobillot et al.
The Journal of infectious diseases, 222(5), 847-852 (2020-04-04)
Zika virus (ZIKV) was discovered over 70 years ago in East Africa, but little is known about its circulation and pathogenesis there. We screened 327 plasma samples collected 2-12 months after febrile illness in Western and coastal Kenya (1993-2016) for
Scott J C Pallett et al.
The Lancet. Respiratory medicine, 8(9), 885-894 (2020-07-28)
Health-care workers constitute a high-risk population for acquisition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Capacity for acute diagnosis via PCR testing was limited for individuals with mild to moderate SARS-CoV-2 infection in the early phase of the
Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies.
Hock, et al.
Cancer Immunology, Immunotherapy, 69, 2453-2464 (2020)
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Kirstin Andersen et al.
Kidney international, 86(5), 965-978 (2014-05-09)
Interleukin (IL)-1β contributes to renal injury in immune complex glomerulonephritis. However, production of mature IL-1β depends on activation of the inflammasome that cleaves pro-IL-1β into its secretable form. A functional role of the NLRP3-containing inflammasome, which responds to various endogenous
Michele L Donato et al.
JCI insight, 6(6) (2021-02-12)
Here, we report on a phase IIa study to determine the intubation rate, survival, viral clearance, and development of endogenous Abs in patients with COVID-19 pneumonia treated with convalescent plasma (CCP) containing high levels of neutralizing anti-SARS-CoV-2 Abs. Radiographic and
Bong-Ha Shin et al.
Transplantation, 104(4), 856-863 (2019-08-07)
Chronic antibody-mediated rejection (cAMR) results in the majority of renal allograft losses. Currently, there are no approved therapies. We recently reported on clinical use of tocilizumab (TCZ) for treatment of cAMR in HLA-sensitized kidney transplant patients. IgG1 and IgG3 subclasses
Lin Luo et al.
Journal of neuroinflammation, 18(1), 27-27 (2021-01-21)
Follicular regulatory T (TFR) cells are essential for the regulation of germinal center (GC) response and humoral self-tolerance. Dysregulated follicular helper T (TFH) cell-GC-antibody (Ab) response secondary to dysfunctional TFR cells is the root of an array of autoimmune disorders.
Sebastian Molnar et al.
mAbs, 12(1), 1802187-1802187 (2020-08-25)
SERINC5 is a multi-pass transmembrane protein that is thought to play a role in serine incorporation during cellular membrane biosynthesis. This protein has also been identified as a human immunodeficiency virus Type 1 (HIV-1) restriction factor. The paucity of monoclonal
Svetlana Di Benedetto et al.
Immunity & ageing : I & A, 16, 31-31 (2019-12-13)
Cytokines are signaling molecules operating within complex cascade patterns and having exceptional modulatory functions. They impact various physiological processes such as neuroendocrine and metabolic interactions, neurotrophins' metabolism, neuroplasticity, and may affect behavior and cognition. In our previous study, we found
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