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Suresh Gopi Kalathil et al.
American journal of respiratory and critical care medicine, 190(1), 40-50 (2014-05-16)
Previous studies from our laboratory have shown that peripheral blood mononuclear cells (PBMCs) from patients with chronic obstructive pulmonary disease (COPD) prone to exacerbations with nontypeable Haemophilus influenzae have impaired responses to lipoprotein P6. We hypothesized that an underlying immunosuppressive
Qingxiu Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(7), 1183-1189 (2014-06-08)
Sevoflurane, one of the most commonly used anesthetics in clinic, induced neuroinflammation and caused cognitive impairment. 2-deoxy-d-glucose (2-DG) is a synthetic analogue of glucose and is clinically used in medical imaging safely. We examined the effect of 2-DG on sevoflurane-induced
Marine Gilabert et al.
Journal of cellular physiology, 229(10), 1437-1443 (2014-03-22)
Cancer cachexia syndrome is observed in 80% of patients with advanced-stage cancer, and it is one of the most frequent causes of death. Severe wasting accounts for more than 80% in patients with advanced pancreatic cancer. Here we wanted to
Na-Ra Han et al.
Phytotherapy research : PTR, 28(7), 1077-1081 (2013-12-18)
Hyperoside (HYP) is the principle active component of Crataegus pinnatifida. Thymic stromal lymphopoietin (TSLP) plays a vital role in the pathogenesis of allergic reactions. Here, we investigated how HYP regulates the levels of TSLP in a human mast cell line
Nan Li et al.
Inflammation, 37(4), 1191-1199 (2014-02-18)
Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the high mortality rate of sepsis. Honokiol, a natural product isolated from Magnolia officinalis (Houpo), has been shown to exhibit anti-inflammatory and antioxidant properties. Here, we
Maximiliano Ormazábal et al.
Vaccine, 32(46), 6084-6090 (2014-09-23)
Pertussis has resurged during the last two decades in different countries. In particular in the 2010-2013 period large outbreaks were detected in US, Australia, UK and The Netherlands with significant mortality in infants. The epidemiological situation of pertussis points out
Cecilia Hermansson et al.
International immunopharmacology, 22(2), 318-323 (2014-07-22)
CD14 is a predictor of inflammation and associated with atherosclerosis. We analyzed 118 carotid plaques from patients with symptomatic carotid artery stenosis for expression of the macrophage markers CD14, CD68 and the angiotensin II type 1 receptor (AT1-R). CD14 staining
Panyu Zhou et al.
Cell biochemistry and biophysics, 70(2), 1265-1275 (2014-06-08)
Sepsis is a common and critical complication in surgical patients that often leads to multiple organ failure syndrome (MOFS), including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Despite intensive supportive care and treatment modalities, the mortality of
Zhiyan Tian et al.
Medical science monitor : international medical journal of experimental and clinical research, 24, 3922-3928 (2018-06-11)
BACKGROUND Ginsenoside is the major bioactive component of ginseng, which has been proven to be a neuroprotective drug. The aim of this study was to evaluate the therapeutic effect of ginsenoside in a diabetic Goto-Kakizaki (GK) rat model. MATERIAL AND
João Carlos Silva et al.
Archives of gerontology and geriatrics, 59(3), 636-641 (2014-09-23)
Frailty and anemia in the elderly appear to share a common pathophysiology associated with chronic inflammatory processes. This study uses an analytical, cross-sectional, population-based methodology to investigate the probable relationships between frailty, red blood cell parameters and inflammatory markers in
Ling Gao et al.
Asian Pacific journal of cancer prevention : APJCP, 15(15), 6161-6164 (2014-08-16)
We have reported the radiation could activate STAT3, which subsequently promotes the invasion of A549 cells. We here explored the dose- and time-response of STAT3 to radiation and the effect of radiation on upstream signaling molecules. A549 cells were irradiated
Mohan Durga et al.
Environmental toxicology and pharmacology, 38(2), 518-530 (2014-09-01)
Air pollution has persistently been the major cause of respiratory-related illness and death. Environmental pollutants such as diesel and petrol exhaust particles (PEPs) are the major contributors to urban air pollution. The aim of the present study was to characterize
Hayoung Yoo et al.
Inflammation, 37(5), 1705-1717 (2014-04-29)
High mobility group box-1 (HMGB1) protein acts as a late mediator of severe vascular inflammatory conditions. Orientin has been known to have anxiolytic and antioxidative activities. However, the effect of orientin on HMGB1-induced inflammatory response has not been studied. We
Marietta Charakida et al.
The lancet. Diabetes & endocrinology, 2(8), 648-654 (2014-05-27)
Excess body fat is associated with an increase in risk of type 2 diabetes and hypertension in adulthood and these risks can adversely affect progression of arterial disease. We aimed to assess the impact of lifelong patterns of adiposity on
Felipe Bichi Strela et al.
Life sciences, 241, 117098-117098 (2019-12-04)
Sepsis survivors are at higher risk for cardiovascular events. Lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4) in sepsis. Activation of TLR4 modulates vascular smooth muscle cells (VSMCs) phenotype and contributes to cardiovascular changes after sepsis. Investigate changes in VSMCs phenotype
Hun Jai Lim et al.
Journal of ethnopharmacology, 155(2), 1353-1361 (2014-07-30)
The roots of Angelica decursiva Fr. Et Sav (Umbelliferae) have been frequently used in traditional medicine as anti-inflammatory, antitussive, analgesic agents and expectorant, especially for treating cough, asthma, bronchitis and upper respiratory tract infections. To establish the scientific rationale for
Oliver Koeberling et al.
Vaccine, 32(23), 2688-2695 (2014-04-08)
Neisseria meningitidis causes epidemics of meningitis in sub-Saharan Africa. These have mainly been caused by capsular group A strains, but W and X strains are increasingly contributing to the burden of disease. Therefore, an affordable vaccine that provides broad protection
Kuo-Feng Hua et al.
Natural product communications, 9(6), 869-872 (2014-08-15)
The essential oil from Liquidambar formosana leaves (EOLF) was demonstrated to exhibit anti-inflammatory activity in mouse macrophages. EOLF reduced nitrite oxide generation, secretion levels of tumor necrosis factor-alpha and interleukin-6, and expression levels of prointerleukin-beta, inducible nitric oxide synthase, and
Dongmei Liu et al.
Acta histochemica, 116(4), 654-662 (2014-01-01)
(-)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenolic compound present in green tea and has been shown to possess anti-inflammatory and anti-oxidative properties. In this study, we investigated the protective effects of EGCG against concanavalin A (ConA)-induced liver injury and the
Elena Magrini et al.
The Journal of clinical investigation, 124(10), 4335-4350 (2014-08-27)
While tumor blood vessels share many characteristics with normal vasculature, they also exhibit morphological and functional aberrancies. For example, the neural adhesion molecule L1, which mediates neurite outgrowth, fasciculation, and pathfinding, is expressed on tumor vasculature. Here, using an orthotopic
Claudia Zannetti et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3398-3408 (2014-09-07)
The stimulation of TLRs by pathogen-derived molecules leads to the production of proinflammatory cytokines. Because uncontrolled inflammation can be life threatening, TLR regulation is important; however, few studies have identified the signaling pathways that contribute to the modulation of TLR
Bora Kim et al.
Journal of drug targeting, 22(8), 739-747 (2014-05-17)
High mobility group box 1 (HMGB1) is not only a non-histone nuclear protein but also a pro-inflammatory cytokine. Previously, it has been shown that HMGB1 box A domain (HMGB1A) is an antagonist of HMGB1. HMGB1A can deliver plasmid DNA (pDNA)
Marina Delgobo et al.
The Journal of nutritional biochemistry, 67, 190-200 (2019-04-06)
Sexual hormone deficiency has been associated with metabolic changes, oxidative stress and subclinical inflammation in postmenopausal women. Hormone replacement therapies are effective in many instances, even though some patients either do not respond or are not eligible. The aim of
Yuan-yuan Ma et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(7), 527-537 (2014-03-08)
Mast cell (MC) degranulation can break peripheral immune tolerance. However, its mechanism remains unclear. Our goal was to study the stabilization of MC membranes by heme oxygenase-1 (HO-1) in order to influence dendritic cell (DC) function. Mast cells and dendritic
Nicolas Desbenoit et al.
The international journal of biochemistry & cell biology, 52, 77-82 (2014-02-12)
A consistent body of research has linked cystic fibrosis (CF) with variations in the tissue and fluid content in a number of lipid molecules. However, little is known about the spatial localization of those variations. We have recently applied TOF-SIMS
Agnieszka Greń
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 83(3), 168-175 (2014-05-23)
The main objective of the study was to analyze the potential ability of vitamins E, C, and D, used as nutritional supplements, in averting inflammation and oxidative stress in the course of diabetes mellitus. Male mice were divided into eight
Limin Liu et al.
Immunological investigations, 43(7), 693-704 (2014-06-25)
17β-estradiol (E2)-signaling is widely considered to be mediated through the transcription-regulating intracellular estrogen receptor (iER). In this study, using the cell-impermeable E2-BSA, we investigated the nongenomic effects of E2 on the IL-6 production, MAPK and transcription factor activation following LPS
Ling Li et al.
Oncology letters, 15(2), 2550-2554 (2018-02-13)
The present study aimed to investigate the effect of tanshinone II, isolated from Salvia miltiorrhiza Bunge, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. Male Sprague-Dawley rats were divided into three groups: Control, LPS and tanshinone II. Animals in
RuiJin Xie et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 1877-1887 (2019-05-14)
Hepatitis is a severe liver disease with worldwide distribution. This study explored the anti-inflammatory influence of Emodin on LPS-triggered liver injury in vitro and in vivo. In vitro, we discovered that LPS treatment triggered L-02 cell and primary hepatocyte inflammatory
Flor P Castro-García et al.
Immunology, 143(4), 578-587 (2014-06-20)
Hepatitis A virus (HAV) infection is the major cause of acute liver failure in paediatric patients. The clinical spectrum of infection is variable, and liver injury is determined by altered hepatic enzyme function and bilirubin concentration. We recently reported differences
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