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Katie May Slattery et al.
Medicine and science in sports and exercise, 46(6), 1114-1123 (2014-03-01)
This investigation examined the ergogenic effect of short-term oral N-acetylcysteine (NAC) supplementation and the associated changes in redox balance and inflammation during intense training. A double-blind randomized placebo-controlled crossover design was used to assess 9 d of oral NAC supplementation
Mohamed Nabil et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-02-04)
We have previously reported that the leaf extract of Albizia anthelmintica exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides derivatives. In the current work
Jean Gaschignard et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 59(2), 244-251 (2014-04-25)
About 10% of pediatric patients with invasive pneumococcal disease (IPD) die from the disease. Some primary immunodeficiencies (PIDs) are known to confer predisposition to IPD. However, a systematic search for these PIDs has never been carried out in children presenting
Monika Bociąga-Jasik et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 23(4), 539-549 (2014-08-29)
Taking into consideration the aging of HIV infected individuals, changes in the metabolism aggravated by the antiretroviral therapy significantly impact their health. Mechanisms responsible for lipodystrophy, dyslipidemia and insulin resistance (IR) occurrence have not been completely understood. Only recently, the
Xiang Gao et al.
Journal of bioscience and bioengineering, 118(4), 476-481 (2014-04-12)
Trimethylamine N-oxide (TMAO) is an oxidation product of trimethylamine (TMA) and is present in many aquatic foods. Here, we investigated the effects of TMAO on glucose tolerance in high fat diet (HFD)-fed mice. Male C57BL/6 mice were randomly assigned to
Qian Zhang et al.
PeerJ, 8, e10310-e10310 (2020-11-27)
Increasing evidence shows that maternal overnutrition may increase the risk of diabetes in offspring. We hypothesized that maternal sitagliptin intervention may improve glucose intolerance through gut targeting. Female Sprague-Dawley (SD) rats were fed a normal diet (ND) or a high-fat
Bing Lin et al.
Journal of ethnopharmacology, 155(1), 248-255 (2014-05-28)
Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the
Ting Shen et al.
Antiviral research, 108, 56-64 (2014-06-20)
Japanese encephalitis virus, a serious mosquito-borne flavivirus, causes acute encephalitis in humans and many animals, with a high fatality rate. RNA interference is a reasonable antiviral mechanism for target gene silencing. In this study, four lentiviral shRNAs (LV-E1, LV-E2, LV-NS3
Xue-Xuan Feng et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 113-123 (2014-07-19)
Ultraviolet (UV) irradiation, known to generate reactive oxygen species (ROS) excessively and elicit inflammatory response, is a potent inducer for skin photoaging. Overproduction of ROS in conjunction with the resulting inflammation stimulate the over-expression of matrix metalloproteinases (MMPs), which in
Wenjing Cheng et al.
Molecular medicine reports, 10(4), 2172-2176 (2014-07-23)
Heat shock protein (HSP)60 is primarily a mitochondrial protein. Previous experiments have found that changes in the location of intracellular HSP60 have been associated with apoptosis. Extracellular HSP60 mediates apoptosis via its ligand, Toll‑like receptor (TLR)-4. TLR-4 is an important
Elodie Décembre et al.
PLoS pathogens, 10(10), e1004434-e1004434 (2014-10-24)
Dengue virus (DENV) is the leading cause of mosquito-borne viral illness and death in humans. Like many viruses, DENV has evolved potent mechanisms that abolish the antiviral response within infected cells. Nevertheless, several in vivo studies have demonstrated a key
Diala El Husseini et al.
Journal of molecular and cellular cardiology, 72, 146-156 (2014-03-19)
Calcific aortic valve disease (CAVD) is a disorder characterized by an abnormal mineralization, which may have intricate links with inflammation. Interleukin-6 (IL-6) and its cognate cytokines are widely expressed and exert pleiotropic effects on different tissues. In this study, we
Maurilio da Silva Morrone et al.
Oxidative medicine and cellular longevity, 2016, 5719291-5719291 (2015-12-08)
The aim of this study was to investigate the potential of curcumin oral supplementation (50 and 100 mg/Kg/day, for 30 days) in circumventing menopause-associated oxidative stress and lipid profile dysfunctions in a rat ovariectomy (OVX) model. Female Wistar rats were operated
May-Lan Liu et al.
Natural product communications, 9(10), 1519-1522 (2014-12-20)
The essential oil from the heartwood of Taiwan fir (EOTC) was demonstrated to exhibit anti-inflammatory activity in lipopolysaccharide (LPS)-activated mouse macrophages. EOTC reduced nitrite oxide levels and inducible nitrite oxide synthase expression in, and tumor necrosis factor-α and interleukin-6 secretion
Hui Xu et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(2), R138-R148 (2014-05-16)
We determined the contribution of vascular large conductance Ca2+-activated K+ (BK) and L-type Ca2+ channel dysregulation to exaggerated mortality in cecal ligation/puncture (CLP)-induced septic BK channel β1-subunit knockout (BK β1-KO, smooth muscle specific) mice. CLP-induced hemodynamic changes and mortality were
Dan Guo et al.
Acta pharmacologica Sinica, 35(6), 770-778 (2014-04-22)
Cyclovirobuxinum D (CVB-D), an alkaloid isolated from the Chinese medicinal plant Buxus microphylla, has been found to be effective to treat cardiac insufficiency, arrhythmias and coronary heart disease. In the present study, we investigated the effects of CVB-D on the
Sita Virakul et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 252(7), 1101-1109 (2014-05-31)
Graves' ophthalmopathy (GO) remains hard to treat. Excessive orbital fibroblast activation by platelet-derived growth factor (PDGF)-BB contributes to GO. The tyrosine kinase inhibitors (TKIs) imatinib mesylate and dasatinib both target PDGF-receptor tyrosine kinase activity, albeit with a different potency. We
Protective Effects of Reduced Beta 2 Glycoprotein I on Liver Injury in Streptozotocin (STZ)-Diabetic Rats by Activation of AMP-Activated Protein Kinase
Zhang JY, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 7577-7577 (2018)
Paulette M Tamashiro et al.
Cancer cell international, 14(1), 76-76 (2014-09-10)
Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive loco-regional invasion. Sphingosine kinase1 (SphK1), an enzyme in sphingolipid metabolism, is emerging as a key player in HNSCC pathology. The observation that SphK1 is overexpressed in all HNSCC stages
Xuefang Jing et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 3055-3069 (2014-08-13)
Aberrant immune response and changes in the gut microflora are the main causes of inflammatory bowel disease (IBD). Peptidoglycan recognition proteins (Pglyrp1, Pglyrp2, Pglyrp3, and Pglyrp4) are bactericidal innate immunity proteins that maintain normal gut microbiome, protect against experimental colitis
Takuma Yoshizumi et al.
Nature communications, 5, 4713-4713 (2014-08-21)
Mitochondria contribute to cellular innate immunity against RNA viruses. Mitochondrial-mediated innate immunity is regulated by signalling molecules that are recruited to the mitochondrial membrane, and depends on the mitochondrial inner membrane potential (Δψm). Here we examine the physiological relevance of
K Hultman et al.
Journal of thrombosis and haemostasis : JTH, 12(5), 701-712 (2014-03-13)
Excess fibrin in blood vessels is cleared by plasmin, the key proteolytic enzyme in fibrinolysis. Neurological disorders and head trauma can result in the disruption of the neurovasculature and the entry of fibrin and other blood components into the brain
ZhanTao Zhu et al.
Alcoholism, clinical and experimental research, 38(6), 1510-1519 (2014-05-07)
Alcoholic liver disease (ALD) continues to be a major cause of morbidity worldwide. The exact mechanisms for ALD pathogenesis are not fully understood. There is currently no known available drug for ALD. Previous studies have suggested that ethanol (EtOH)-induced hepatic
Jason Brocato et al.
Journal of toxicology and environmental health. Part A, 77(13), 751-766 (2014-05-21)
Airborne particulate matter (PM) exposure is a major environmental health concern and is linked to metabolic disorders, such as cardiovascular diseases (CVD) and diabetes, which are on the rise in the Kingdom of Saudi Arabia. This study investigated changes in
Jan M Hughes-Austin et al.
Vascular medicine (London, England), 19(4), 264-271 (2014-06-08)
Adipokines regulate metabolic processes linked to coronary artery (CAC) and abdominal aorta calcification (AAC). Because adipokine and other adiposity-associated inflammatory marker (AAIM) secretions differ between visceral and subcutaneous adipose tissue, we hypothesized that central adiposity modifies associations between AAIMs and
Jie Qian et al.
International immunopharmacology, 21(2), 426-431 (2014-06-04)
Paraquat (PQ) poisoning, with the lung as a primary target organ, is a devastating disease which irreversibly progresses to diffuse alveolitis followed by extensive lung fibrosis. In the present study, we aimed to investigate the effect of FTY720, an immune
Yoshikuni Nagayama et al.
American journal of physiology. Renal physiology, 307(3), F346-F355 (2014-06-06)
Renal inflammation, in particular glomerular, is often characterized by increased IL-6 levels. The in vivo relevance of IL-6 signaling in glomerular podocytes, which play central roles in most glomerular diseases, is unknown. Here, we show that in normal mice, podocytes
Xiaomei Wei et al.
Pain, 155(7), 1238-1244 (2014-03-25)
Nociceptive signaling from the meninges is proposed to contribute to many forms of headache. However, the events within the meninges that drive afferent activity are not clear. Meningeal fibroblasts are traditionally thought to produce extracellular proteins that constitute the meninges
Michael R Flock et al.
Prostaglandins, leukotrienes, and essential fatty acids, 91(4), 161-168 (2014-08-06)
The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA
Ying-Ying Yang et al.
Journal of hepatology, 61(5), 1004-1013 (2014-06-24)
Intestinal hyperpermeability, impaired peritoneal macrophages (PMs) phagocytosis, and bacterial translocation (BT), resulting in increased systemic and local infection/inflammation such as spontaneous bacterial peritonitis (SBP) together with increased tumor necrosis factor-α (TNFα) levels, are all implicated in the pathogenesis of cirrhosis-related
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