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RAB0312

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Suresh Gopi Kalathil et al.
American journal of respiratory and critical care medicine, 190(1), 40-50 (2014-05-16)
Previous studies from our laboratory have shown that peripheral blood mononuclear cells (PBMCs) from patients with chronic obstructive pulmonary disease (COPD) prone to exacerbations with nontypeable Haemophilus influenzae have impaired responses to lipoprotein P6. We hypothesized that an underlying immunosuppressive
Qingxiu Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(7), 1183-1189 (2014-06-08)
Sevoflurane, one of the most commonly used anesthetics in clinic, induced neuroinflammation and caused cognitive impairment. 2-deoxy-d-glucose (2-DG) is a synthetic analogue of glucose and is clinically used in medical imaging safely. We examined the effect of 2-DG on sevoflurane-induced
Marine Gilabert et al.
Journal of cellular physiology, 229(10), 1437-1443 (2014-03-22)
Cancer cachexia syndrome is observed in 80% of patients with advanced-stage cancer, and it is one of the most frequent causes of death. Severe wasting accounts for more than 80% in patients with advanced pancreatic cancer. Here we wanted to
Spoorthy N Babu et al.
Journal of ethnopharmacology, 272, 113949-113949 (2021-02-22)
The genus Aloe has a long history of usage in medicine. Aloe barbadensis Miller, commonly known as Aloe vera, is said to possess anti-diabetic, anti-inflammatory, anti-cancer, anti-microbial, immunomodulation, wound healing properties. In diabetes mellitus, loss in intestinal permeability is observed
Na-Ra Han et al.
Phytotherapy research : PTR, 28(7), 1077-1081 (2013-12-18)
Hyperoside (HYP) is the principle active component of Crataegus pinnatifida. Thymic stromal lymphopoietin (TSLP) plays a vital role in the pathogenesis of allergic reactions. Here, we investigated how HYP regulates the levels of TSLP in a human mast cell line
Oluwakemi O Ariyo et al.
Journal of ethnopharmacology, 259, 112934-112934 (2020-05-11)
Morus mesozygia Stapf (Moraceae), commonly known as African mulberry, is traditionally used for the treatment of inflammatory disorders such as rheumatism and dermatitis. This work aimed to evaluate the anti-nociceptive and anti-inflammatory effects of its ethanol (EEMm) extract, and ethylacetate
Nan Li et al.
Inflammation, 37(4), 1191-1199 (2014-02-18)
Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the high mortality rate of sepsis. Honokiol, a natural product isolated from Magnolia officinalis (Houpo), has been shown to exhibit anti-inflammatory and antioxidant properties. Here, we
Maximiliano Ormazábal et al.
Vaccine, 32(46), 6084-6090 (2014-09-23)
Pertussis has resurged during the last two decades in different countries. In particular in the 2010-2013 period large outbreaks were detected in US, Australia, UK and The Netherlands with significant mortality in infants. The epidemiological situation of pertussis points out
David A Kaminsky et al.
Journal of alternative and complementary medicine (New York, N.Y.), 23(9), 696-704 (2017-07-18)
Pulmonary rehabilitation improves exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). However, many patients do not have access to pulmonary rehabilitation programs. We hypothesized that an alternative to pulmonary rehabilitation to improve exercise tolerance is the practice of
AT1 receptor blocker losartan protects against mechanical ventilation-induced diaphragmatic dysfunction
Kwon OS, et al.
Journal of Applied Physiology, 119(10), 1033-1041 (2015)
Anil Kumar Sahu et al.
Molecular and cellular biochemistry, 452(1-2), 141-152 (2018-08-08)
Cisplatin has been confined due to the reported cases of nephrotoxicity. In the present study, an active xanthone, Mangiferin (from Mangifera indica) was investigated for its defensive role in cisplatin-induced nephrotoxicity. Male wistar albino rats were divided into six groups
Aly M Abdelrahman et al.
Naunyn-Schmiedeberg's archives of pharmacology, 392(1), 45-53 (2018-09-13)
Canagliflozin is a sodium glucose co-transporter 2 (SGLT2) inhibitor that is currently available for the management of type 2 diabetes mellitus. The present study investigated the effect of canagliflozin on cisplatin (CP)-induced nephrotoxicity in mice. The animals were divided into
Cecilia Hermansson et al.
International immunopharmacology, 22(2), 318-323 (2014-07-22)
CD14 is a predictor of inflammation and associated with atherosclerosis. We analyzed 118 carotid plaques from patients with symptomatic carotid artery stenosis for expression of the macrophage markers CD14, CD68 and the angiotensin II type 1 receptor (AT1-R). CD14 staining
Radhika Joshi et al.
Molecular pharmacology, 96(1), 56-72 (2019-05-01)
The effects of phosphodiesterase (PDE) 4 inhibitors on gene expression changes in BEAS-2B human airway epithelial cells are reported and discussed in relation to the mechanism(s) of action of roflumilast in chronic obstructive pulmonary disease (COPD). Microarray-based gene expression profiling
Panyu Zhou et al.
Cell biochemistry and biophysics, 70(2), 1265-1275 (2014-06-08)
Sepsis is a common and critical complication in surgical patients that often leads to multiple organ failure syndrome (MOFS), including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Despite intensive supportive care and treatment modalities, the mortality of
João Carlos Silva et al.
Archives of gerontology and geriatrics, 59(3), 636-641 (2014-09-23)
Frailty and anemia in the elderly appear to share a common pathophysiology associated with chronic inflammatory processes. This study uses an analytical, cross-sectional, population-based methodology to investigate the probable relationships between frailty, red blood cell parameters and inflammatory markers in
Ling Gao et al.
Asian Pacific journal of cancer prevention : APJCP, 15(15), 6161-6164 (2014-08-16)
We have reported the radiation could activate STAT3, which subsequently promotes the invasion of A549 cells. We here explored the dose- and time-response of STAT3 to radiation and the effect of radiation on upstream signaling molecules. A549 cells were irradiated
Laura Tarancon-Diez et al.
AIDS (London, England), 32(8), 1035-1041 (2018-03-17)
Cardiovascular diseases (CVDs) are one of the main causes of morbimortality in HIV-infected patients on suppressive antiretroviral therapy. The objective of this work was to evaluate the role of single nucleotide polymorphisms (SNPs) in lipopolysaccharide (LPS) Toll-like receptor 4 (TLR4)
Mohan Durga et al.
Environmental toxicology and pharmacology, 38(2), 518-530 (2014-09-01)
Air pollution has persistently been the major cause of respiratory-related illness and death. Environmental pollutants such as diesel and petrol exhaust particles (PEPs) are the major contributors to urban air pollution. The aim of the present study was to characterize
Wenqiang Su et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 134, 246-255 (2019-04-30)
Curcumin attracted attention due to its promising anti-cancer properties and safety performance. However, its poor aqueous solubility and low bioavailability have to be overcome before it goes into clinic use. Here, porous composite particles are prepared by loading curcumin into
Hayoung Yoo et al.
Inflammation, 37(5), 1705-1717 (2014-04-29)
High mobility group box-1 (HMGB1) protein acts as a late mediator of severe vascular inflammatory conditions. Orientin has been known to have anxiolytic and antioxidative activities. However, the effect of orientin on HMGB1-induced inflammatory response has not been studied. We
Bingchang Yang et al.
The Journal of surgical research, 211, 70-78 (2017-05-16)
Intravenous administration of ulinastatin (UTI), a broad spectral protease inhibitor, has been used on an experimental basis with severe sepsis patients in Asia. However, the effects of intraintestinal administration of UTI on intestinal and multiple organ damage in sepsis have
Marietta Charakida et al.
The lancet. Diabetes & endocrinology, 2(8), 648-654 (2014-05-27)
Excess body fat is associated with an increase in risk of type 2 diabetes and hypertension in adulthood and these risks can adversely affect progression of arterial disease. We aimed to assess the impact of lifelong patterns of adiposity on
Rebecca M Foright et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 319(2), R171-R183 (2020-06-20)
Exercise is often used as a strategy for weight loss maintenance. In preclinical models, we have shown that exercise may be beneficial because it counters the biological drive to regain weight. However, our studies have demonstrated sex differences in the
Hun Jai Lim et al.
Journal of ethnopharmacology, 155(2), 1353-1361 (2014-07-30)
The roots of Angelica decursiva Fr. Et Sav (Umbelliferae) have been frequently used in traditional medicine as anti-inflammatory, antitussive, analgesic agents and expectorant, especially for treating cough, asthma, bronchitis and upper respiratory tract infections. To establish the scientific rationale for
Leonie J T Balter et al.
Brain, behavior, and immunity, 82, 298-301 (2019-09-03)
The established link between loneliness and poor health outcomes may stem from aberrant inflammatory regulation. The present study tested whether loneliness predicted the inflammatory response to a standardised in vivo immune challenge. Using a within-subjects double blind placebo-controlled design, 40
Aly M Abdelrahman et al.
Naunyn-Schmiedeberg's archives of pharmacology, 392(8), 1005-1013 (2019-04-27)
The aim of this study was to examine the effect of tocilizumab, an interleukin-6 (IL-6) inhibitor on streptozotocin-induced diabetic nephropathy. Male Sprague-Dawley rats (n = 36) were distributed into six groups and treated for 4 weeks. Groups 1, 3, 5 received either saline
Oliver Koeberling et al.
Vaccine, 32(23), 2688-2695 (2014-04-08)
Neisseria meningitidis causes epidemics of meningitis in sub-Saharan Africa. These have mainly been caused by capsular group A strains, but W and X strains are increasingly contributing to the burden of disease. Therefore, an affordable vaccine that provides broad protection
Detmar Kolijn et al.
Frontiers in physiology, 11, 345-345 (2020-06-12)
Our aim was to investigate the effect of nitric oxide (NO)-independent activation of soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model with diastolic dysfunction and in biopsies from human heart failure with preserved ejection fraction (HFpEF).
Magdalena Jankowska et al.
Nephrology (Carlton, Vic.), 23(1), 31-36 (2016-09-23)
Autosomal dominant polycystic kidney disease (ADPKD), a systemic disorder caused by mutation in genes encoding polycystins, has been reported to lead to metabolic derangements including new-onset diabetes mellitus after kidney transplantation. We analyzed markers of insulin resistance (IR), inflammation, nutritional
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