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Ronald Perraut et al.
PloS one, 9(7), e101737-e101737 (2014-07-23)
Plasmodium falciparum merozoite surface protein 5 (PfMSP5) is an attractive blood stage vaccine candidate because it is both exposed to the immune system and well conserved. To evaluate its interest, we investigated the association of anti-PfMSP5 IgG levels, in the
Geetha Kannan et al.
Experimental parasitology, 145, 110-117 (2014-08-19)
We developed a protocol to inactivate Toxoplasma gondii (T. gondii) tachyzoites employing 1 min of ultraviolet (UV) exposure. We show that this treatment completely inhibited parasite replication and cyst formation in vitro and in vivo but did not affect the
D R J Arachchillage et al.
Journal of thrombosis and haemostasis : JTH, 12(11), 1801-1809 (2014-09-10)
Antiphospholipid antibodies may interfere with the anticoagulant activity of activated protein C (APC) to induce acquired APC resistance (APCr). To investigate the frequency and characteristics of APCr by using recombinant human APC (rhAPC) and endogenous protein C activation in antiphospholipid
Kirstin Andersen et al.
Kidney international, 86(5), 965-978 (2014-05-09)
Interleukin (IL)-1β contributes to renal injury in immune complex glomerulonephritis. However, production of mature IL-1β depends on activation of the inflammasome that cleaves pro-IL-1β into its secretable form. A functional role of the NLRP3-containing inflammasome, which responds to various endogenous
Jian Rong Sheng et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2669-2677 (2014-08-20)
IL-10-competent subset within CD1d(hi)CD5(+) B cells, also known as B10 cells, has been shown to regulate autoimmune diseases. Whether B10 cells can prevent or suppress the development of experimental autoimmune myasthenia gravis (EAMG) has not been studied. In this study
Yixuan Wang et al.
Annals of translational medicine, 8(21), 1369-1369 (2020-12-15)
To evaluate circulating T follicular helper (cTfh) cells and characterize their function in chronic-phase recipients after heart transplantation. Participants were divided into healthy control (HC, n=40), preoperative (Pre, n=40), and post-transplantation chronic-phase recipient (1-year, n=40) groups. The percentages of cTfh
Guillaume Spielmann et al.
Brain, behavior, and immunity, 39, 142-151 (2013-05-21)
Dynamic exercise evokes a rapid redeployment of cytotoxic T cell subsets with high expression of β2 adrenergic receptors, presumably to enhance immunosurveillance during acute stress. As this response is affected by age and infection history, this study examined latent CMV
Kentaro Arakawa et al.
PloS one, 14(6), e0218096-e0218096 (2019-06-18)
The interaction between atherosclerosis and commensal microbes through leaky gut syndrome (LGS), which is characterized by impaired intestinal permeability and the introduction of undesired pathogens into the body, has not been fully elucidated. Our aim was to investigate the potential
Ajit Kumar Yadav et al.
PloS one, 9(10), e108815-e108815 (2014-10-11)
Collectins, collagen-containing Ca(2+) dependent C-type lectins and a class of secretory proteins including SP-A, SP-D and MBL, are integral to immunomodulation and innate immune defense. In the present study, we aimed to investigate their placental transcript synthesis, labor associated differential
Jill M Fritz et al.
PloS one, 9(9), e107473-e107473 (2014-09-16)
ERdj4 is a BiP cochaperone regulated by the unfolded protein response to facilitate degradation of unfolded and/or misfolded proteins in the endoplasmic reticulum. As the unfolded protein response plays a critical role in B cell maturation and antibody production, ERdj4
Simone I Richardson et al.
PLoS pathogens, 15(12), e1008064-e1008064 (2019-12-17)
Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with Fc receptors on immune cells. Antibody isotype is a modulator of this binding with the IgG3 subclass mediating potent Fc
C Tørring et al.
Acta neurologica Scandinavica, 130(2), 90-96 (2014-04-02)
Epstein-Barr virus (EBV) infection is associated with multiple sclerosis (MS), and EBV may transform lymphoblastoid cell lines more frequently in MS patients than controls, but it is not clear whether this reflects a higher viral load or an enhanced ability
Chetna Soni et al.
Journal of immunology (Baltimore, Md. : 1950), 193(9), 4400-4414 (2014-09-26)
Spontaneous germinal center (Spt-GC) B cells and follicular helper T cells generate high-affinity autoantibodies that are involved in the development of systemic lupus erythematosus. TLRs play a pivotal role in systemic lupus erythematosus pathogenesis. Although previous studies focused on the
Ricardo Andrade Carmo et al.
General hospital psychiatry, 36(4), 398-405 (2014-04-15)
To assess correlates of hepatitis B among adults with mental illness under care in Brazil. Cross-sectional national multicenter study of 2206 patients with mental illnesses randomly selected from 26 public mental health services. Sociodemographic and behavioral data were obtained from
Vladimir A Ledov et al.
Vaccine, 37(8), 1062-1072 (2019-01-24)
Shigellosis, a major cause of diarrhea worldwide, exhibits high morbidity and mortality in children. Specificity of Shigella immunity is determined by the structure of the main protective O-antigen polysaccharide component incorporated into the lipopolysaccharide (LPS) molecule. Endotoxicity, however, precludes LPS
Yong-tong Zhu et al.
Stem cell research, 13(1), 111-122 (2014-05-31)
The MB49 bladder cancer cell vaccine was effective against bladder cancer in the mice model in previous studies. However, part of the tumors regrew as the vaccine could not eliminate the cancer stem cells (CSCs). MB49 bladder cancer stem cells
Christopher G J McKenzie et al.
Blood, 123(22), 3496-3503 (2014-03-19)
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality and can occur with any type of transfusion. TRALI is thought to be primarily mediated by donor antibodies activating recipient neutrophils resulting in pulmonary endothelial damage. Nonetheless, details
Angela Bikker et al.
PloS one, 9(4), e94756-e94756 (2014-04-18)
To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect. Isolated CD19 B cells and CD4 T cells from healthy donors were co-cultured with TLR7
Xue-Yuan Cao et al.
World journal of gastroenterology, 20(25), 8201-8208 (2014-07-11)
To explore the alteration of DNA methyltransferase expression in gastric cancer and to assess its prognostic value. From April 2000 to December 2010, 227 men and 73 women with gastric cancer were enrolled in the study. The expression of DNA
Miranda J Crouch et al.
Journal of leukocyte biology, 106(2), 241-257 (2018-12-24)
Obesity dysregulates B cell populations, which contributes toward poor immunological outcomes. We previously reported that differing B cell subsets are lowered in the bone marrow of obese male mice. Here, we focused on how lipid metabolites synthesized from docosahexaenoic acid
Daryn Goodwin et al.
Bioorganic & medicinal chemistry, 22(17), 4848-4854 (2014-07-26)
Active immunisation against gonadotropin releasing hormone (GnRH) is a potential alternative to surgical castration. This study focused on the development of a GnRH subunit lipopeptide vaccine. A library of vaccine candidates that contained one or more (up to eight) copies
Arjan van der Flier et al.
PloS one, 10(4), e0124930-e0124930 (2015-04-24)
We recently developed a longer lasting recombinant factor VIII-Fc fusion protein, rFVIIIFc, to extend the half-life of replacement FVIII for the treatment of people with hemophilia A. In order to elucidate the biological mechanism for the elongated half-life of rFVIIIFc
Seung Jun Lee et al.
PloS one, 9(8), e104351-e104351 (2014-08-08)
A key factor in dendritic cell (DC)-based tumor immunotherapy is the identification of an immunoadjuvant capable of inducing DC maturation to enhance cellular immunity. The efficacy of a 50S ribosomal protein L7/L12 (rplL) from Mycobacterium tuberculosis Rv0652, as an immunoadjuvant
Miao Yu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(8), 3609-3617 (2014-05-08)
EphB2 is an important member of the receptor tyrosine kinases. Recently, EphB2 was shown to facilitate T-cell migration and monocyte activation. However, the effects of EphB2 on B cells remain unknown. In this study, the expression of EphB2 on B
B Gao et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(7), 1581-1591 (2014-06-18)
Preexisting serum antibodies have long been associated with graft loss in transplant recipients. While most studies have focused on HLA-specific antibodies, the contribution of non-HLA-reactive antibodies has been largely overlooked. We have recently characterized mAbs secreted by B cell clones
Hiroshi Kataoka et al.
PloS one, 9(8), e104741-e104741 (2014-08-16)
When cells die by necrosis in vivo they stimulate an inflammatory response. It is thought that this response is triggered when the injured cells expose proinflammatory molecules, collectively referred to as damage associated molecular patterns (DAMPs), which are recognized by
Sumi Biswas et al.
PloS one, 9(9), e107903-e107903 (2014-09-26)
The development of protective vaccines against many difficult infectious pathogens will necessitate the induction of effective antibody responses. Here we assess humoral immune responses against two antigens from the blood-stage merozoite of the Plasmodium falciparum human malaria parasite--MSP1 and AMA1.
Toby Clements et al.
Frontiers in immunology, 11, 1920-1920 (2020-10-06)
Transplacental antibody transfer from mother to fetus provides protection from infection in the first weeks of life, and the four different subclasses of IgG (IgG1, IgG2, IgG3, and IgG4) have diverse roles in protection against infection. In this study, we
Christian Körner et al.
European journal of immunology, 44(10), 2938-2948 (2014-07-22)
The acquisition and maintenance of NK-cell function is mediated by inhibitory killer-cell immunoglobulin-like receptors (KIRs) through their interaction with HLA class I molecules. Recently, HLA-C expression levels were shown to be correlated with protection against multiple outcomes of HIV-1 infection;
K A Flintoff et al.
Journal of cellular physiology, 229(10), 1538-1547 (2014-03-04)
Expression studies have implicated FLRT2 in cranial neural crest cell migration and prechondrogenic cell condensation during craniofacial skeletogenesis. We aimed to determine whether FLRT2 was involved in mediating cell-matrix interactions in the ATDC5 chondroprogenitor cell line. Immunolocalization experiments of ATDC5
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