Showing 1-30 of 12255 results for "rearrangements"
Sven Perner et al.
Urology, 75(4), 762-767 (2009-12-19)
To interrogate multifocal prostate cancer (PCa) to determine its predilection for metastasis, using ERG rearrangement as marker of clonality. A hallmark of PCa is that distinct tumor foci may arise independently, which has important biological and clinical implications. Recent studies...
Mark Kerstjens et al.
Oncotarget, 8(9), 14835-14846 (2016-09-03)
Acute lymphoblastic leukemia (ALL) in infants is an aggressive malignancy with a poor clinical outcome, and is characterized by translocations of the Mixed Lineage Leukemia (MLL) gene. Previously, we identified RAS mutations in 14-24% of infant ALL patients, and showed...
Saaya Hiyoshi et al.
Veterinary immunology and immunopathology, 165(3-4), 138-144 (2015-04-29)
Although definitive diagnosis of chronic enteropathy (CE) and gastrointestinal (GI) lymphoma requires histopathological evaluation of the GI tract, these conditions are often still difficult to differentiate from each other. Polymerase chain reaction (PCR) for antigen receptor gene rearrangements (PARR) has...
F Livák et al.
Journal of immunology (Baltimore, Md. : 1950), 162(5), 2575-2580 (1999-03-11)
Development of the alphabeta and gammadelta T cell lineages is dependent upon the rearrangement and expression of the TCRalpha and beta or gamma and delta genes, respectively. Although the timing and sequence of rearrangements of the TCRalpha and TCRbeta loci...
Huixin Gang et al.
BMC genomics, 20(1), 311-311 (2019-04-25)
Integration of T-DNA into plant genomes via Agrobacterium may interrupt gene structure and generate numerous mutants. The T-DNA caused mutants are valuable materials for understanding T-DNA integration model in plant research. T-DNA integration in plants is complex and still largely...
Balca R Mardin et al.
Molecular systems biology, 11(9), 828-828 (2015-09-30)
A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one-off genomic catastrophe, resulting in massive somatic DNA structural rearrangements (SRs). Largely due to lack of suitable model systems, the mechanistic basis of chromothripsis...
Michelle L Joachims et al.
Journal of immunology (Baltimore, Md. : 1950), 176(3), 1543-1552 (2006-01-21)
To evaluate the role of the TCR in the alphabeta/gammadelta lineage choice during human thymocyte development, molecular analyses of the TCRbeta locus in gammadelta cells and the TCRgamma and delta loci in alphabeta cells were undertaken. TCRbeta variable gene segments...
Su Jin Lee et al.
Oncotarget, 6(36), 39028-39035 (2015-10-17)
We have investigated the incidence of NTRK1 rearrangements in metastatic gastrointestinal cancer patients and demonstrated the potential for clinical response of these patients to targeted therapy. We prospectively collected tumor tissue specimens for one year and simultaneously generated patient-derived tumor...
Laurent Créancier et al.
Cancer letters, 365(1), 107-111 (2015-05-24)
Chromosomal rearrangements of the NTRK1 gene, which encodes the high affinity nerve growth factor receptor (tropomyosin related kinase, TRKA), have been observed in several epithelial cancers, such as colon cancer, papillary thyroid carcinoma or non small cell lung cancer. The...
Mustafa Al-Kawaaz et al.
American journal of clinical pathology, 143(2), 288-299 (2015-01-18)
To demonstrate and confirm the existence of cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) with IGH-CCND1 rearrangement and discuss the rationale of differentiating this entity from blastoid and pleomorphic variants of mantle cell lymphoma (MCL). Two cyclin D1-positive lymphomas with...
M A Bogue et al.
Genes & development, 10(5), 553-565 (1996-03-01)
The murine scid mutation affects both V(D)J recombination and DNA repair. This mutation has been mapped to the gene encoding the catalytic subunit of the DNA-dependent protein kinase (DNA-PK), which is activated by DNA damage in normal cells. In scid...
Bushra Ateeq et al.
The Prostate, 75(10), 1051-1062 (2015-03-27)
Molecular stratification of prostate cancer (PCa) based on genetic aberrations including ETS or RAF gene-rearrangements, PTEN deletion, and SPINK1 over-expression show clear prognostic and diagnostic utility. Gene rearrangements involving ETS transcription factors are frequent pathogenetic somatic events observed in PCa....
Jing Zhao et al.
International journal of clinical and experimental pathology, 8(3), 3344-3348 (2015-06-06)
EML4-ALK rearrangement is detected in 2% to 7% of lung adenocarcinomas, these tumors are sensitive to crizotinib. The histologic feature of ALK translocated non-small-cell lung cancer (NSCLC) has been studied, presence of signet-ring cells was a powerful histologic indicator of...
Ana Eusebio-Cope et al.
Nucleic acids research, 43(7), 3802-3813 (2015-03-25)
Mycoreovirus 1 (MyRV1) has 11 double-stranded RNA genome segments (S1 to S11) and confers hypovirulence to the chestnut blight fungus, Cryphonectria parasitica. MyRV1 genome rearrangements are frequently generated by a multifunctional protein, p29, encoded by a positive-strand RNA virus, Cryphonectria...
F Griesinger et al.
The Journal of clinical investigation, 84(2), 506-516 (1989-08-01)
We have studied recombinatorial events of the T cell receptor delta and gamma chain genes in hematopoietic malignancies and related these to normal stages of lymphoid differentiation. T cell receptor delta gene recombinatorial events were found in 91% of acute...
Zhijun Qiu et al.
Scientific reports, 7, 43156-43156 (2017-02-23)
Gross chromosomal rearrangements (GCRs), including translocations, inversions amplifications, and deletions, can be causal events leading to malignant transformation. GCRs are thought to be triggered by DNA double strand breaks (DSBs), which in turn can be spontaneous or induced by external...
W S Talbot et al.
Genetics, 148(1), 373-380 (1998-02-25)
Genetic screens in zebrafish have provided mutations in hundreds of genes with essential functions in the developing embryo. To investigate the possible uses of chromosomal rearrangements in the analysis of these mutations, we genetically characterized three gamma-ray induced alleles of...
Xiao Chen et al.
Genome biology and evolution, 7(10), 2859-2870 (2015-09-05)
Programmed genome rearrangements in the unicellular eukaryote Oxytricha trifallax produce a transcriptionally active somatic nucleus from a copy of its germline nucleus during development. This process eliminates noncoding sequences that interrupt coding regions in the germline genome, and joins over...
L J Kienker et al.
Journal of immunology (Baltimore, Md. : 1950), 147(12), 4351-4359 (1991-12-15)
The nature of TCR gamma and delta gene rearrangements in 4- to 6-week-old scid thymocytes was examined by using the polymerase chain reaction technique, cloning, and DNA sequencing. Analysis of 78 sequences indicates that TCR gamma and delta gene rearrangements...
J G Noordzij et al.
Blood, 96(1), 203-209 (2000-07-13)
The proteins encoded by RAG1 and RAG2 can initiate gene recombination by site-specific cleavage of DNA in immunoglobulin and T-cell receptor (TCR) loci. We identified a new homozygous RAG1 gene mutation (631delT) that leads to a premature stop codon in...
David Ellis et al.
Familial cancer, 5(4), 323-326 (2006-05-26)
BRCA1 exon deletions and duplications have been reported in a number of studies, and in order to design an effective mutation screening strategy in a diagnostic setting it is import to determine the frequency of this type of mutation in...
S Candéias et al.
Immunology letters, 57(1-3), 9-14 (1997-06-01)
T-cell receptor (TCR) genes need to be rearranged by a site specific-VDJ recombinase before they are expressed. This process, initiated in CD44+25+ thymocytes, takes place during the early stage of T-cell differentiation in the thymus. Interleukin-7 receptor alpha chain knockout...
Bernard Khor et al.
International immunology, 17(3), 225-232 (2005-01-12)
TCRbeta, delta and gamma chain genes are assembled and expressed in double-negative thymocytes prior to alphabeta or gammadelta T cell lineage commitment. Thus, cells committed to the alphabeta T cell lineage can possess completely assembled TCRdelta and/or TCRgamma chain genes....
J Chen et al.
International immunology, 5(6), 647-656 (1993-06-01)
B lymphocyte differentiation is characterized by an ordered series of Ig gene assembly and expression events. In the majority of normal B cells, assembly and expression of Ig heavy (H) chain genes precedes that of light (L) chain genes. To...
Jiaying Tan et al.
Oncotarget, 1(6), 461-465 (2010-11-03)
Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLL-rearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the...
John D Curry et al.
Nucleic acids research, 36(18), 5750-5762 (2008-09-09)
Variable (diversity) joining [V(D)J] recombination of immune gene loci proceeds in an ordered manner with D to J portions recombining first and then an upstream V joins that recombinant. We present evidence that the non-core domain of recombination activating gene...
Diane Beysen et al.
Human mutation, 30(2), 158-169 (2008-08-30)
The FOXL2 gene is one of 10 forkhead genes, the mutations of which lead to human developmental disorders, often with ocular manifestations. Mutations in FOXL2 are known to cause blepharophimosis syndrome (BPES), an autosomal dominant eyelid malformation associated (type I)...
Matthew A Inlay et al.
The Journal of experimental medicine, 203(7), 1721-1732 (2006-06-21)
V(D)J recombination of immunoglobulin (Ig) heavy (IgH) and light chain genes occurs sequentially in the pro- and pre-B cells. To identify cis-elements that dictate this order of rearrangement, we replaced the endogenous matrix attachment region/Igk intronic enhancer (MiE(kappa)) with its...
S Tsukada et al.
Molecular immunology, 29(3), 401-409 (1992-03-01)
In SPL2-1-2, a murine B-committed immature cell line transformed with a temperature-sensitive mutant of Abelson virus, T cell receptor (TCR) gamma gene rearrangements, together with IgH gene rearrangements, were induced during culture at a non-permissive temperature (39 degrees C). During...
Jun Nakajima et al.
Asian cardiovascular & thoracic annals, 13(2), 149-152 (2005-05-21)
To investigate the differentiation stage of tumor-infiltrating lymphocytes in thymoma tissue, we performed Southern blot analysis of T-cell receptor beta and gamma genes in thymomas resected from 19 patients. At the same time, we conducted flow cytometric analysis of T-cell...

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