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RES3077T-A7

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Hannes Steinkellner et al.
European journal of human genetics : EJHG, 23(9), 1186-1191 (2014-12-04)
Weill-Marchesani syndrome is a rare disorder of the connective tissue. Functional variants in ADAMTS10 are associated with Weill-Marchesani syndrome-1. We identified a homozygous missense mutation, c.41T>A, of the ADAMTS10 gene in a 19-year-old female with typical symptoms of WMS1: proportionate...
Afshin Beheshti et al.
Cancer research, 75(6), 1134-1143 (2015-03-04)
Aging is the major determinant of cancer incidence, which, in turn, is likely dictated in large part by processes that influence the progression of early subclinical (occult) cancers. However, there is little understanding of how aging informs changes in aggregate...
Dagan Wells et al.
Journal of medical genetics, 51(8), 553-562 (2014-07-18)
The majority of human embryos created using in vitro fertilisation (IVF) techniques are aneuploid. Comprehensive chromosome screening methods, applicable to single cells biopsied from preimplantation embryos, allow reliable identification and transfer of euploid embryos. Recently, randomised trials using such methods...
Ming-Hsuan Ou-Yang et al.
Neurobiology of aging, 36(2), 801-811 (2014-12-03)
Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid-β (Aβ) in the brain. Previously, myelin basic protein (MBP) was identified to be a potent inhibitor to Aβ fibril formation, and this inhibitory activity...
Kristoffer Graham et al.
Dalton transactions (Cambridge, England : 2003), 40(13), 3125-3127 (2011-02-25)
We describe an enneanuclear Fe(III) complex with an unusual boat-shaped core topology and an S=11/2 ground state, assembled using the ligands tricine {N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine, H(4)L} and 2-phenoxybenzoate.
Jan Darius Unterlauft et al.
Experimental eye research, 127, 206-214 (2014-08-17)
The death of retinal ganglion cells (RGC) leads to visual impairment and blindness in ocular neurodegenerative diseases, primarily in glaucoma and diabetic retinopathy; hence, mechanisms that contribute to protecting RGC from ischemia/hypoxia are of great interest. We here address the...
Igor Cestari et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(21), E2803-E2812 (2015-05-13)
African trypanosomes evade clearance by host antibodies by periodically changing their variant surface glycoprotein (VSG) coat. They transcribe only one VSG gene at a time from 1 of about 20 telomeric expression sites (ESs). They undergo antigenic variation by switching...
Thierry Rabilloud
Journal of proteomics, 73(8), 1562-1572 (2010-04-17)
Electrophoretic separations of proteins are widely used in proteomic analyses, and rely heavily on SDS electrophoresis. This mode of separation is almost exclusively used when a single dimension separation is performed, and generally represents the second dimension of two-dimensional separations....
Minal J Menezes et al.
Human molecular genetics, 24(8), 2297-2307 (2015-01-04)
Functional defects of the mitochondrial translation machinery, as a result of mutations in nuclear-encoded genes, have been associated with combined oxidative phosphorylation (OXPHOS) deficiencies. We report siblings with congenital sensorineural deafness and lactic acidemia in association with combined respiratory chain...
Bao Teng et al.
Bioorganic & medicinal chemistry letters, 17(12), 3440-3444 (2007-04-24)
The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of...
[Translational molecular imaging: an investment for the future].
I Peñuelas et al.
Revista espanola de medicina nuclear e imagen molecular, 31(2), 59-60 (2012-01-10)
Mahmoud M A Mohamed
Annali di chimica, 97(8), 759-770 (2007-09-29)
Equilibrium studies for the heavy metal ions La(III), Ce(III), Th(IV) and UO2(IV) (M) complexes of the zwitterionic buffer tricine (L) in aqueous solution are investigated. Stoichiometry and stability constants for the different complexes formed as well as hydrolysis products of...
Vijaya R Dirisala et al.
Mediators of inflammation, 2015, 619480-619480 (2015-05-23)
Tumor necrosis factor alpha (TNF-α) is a cytokine which plays opposing roles in the context of infectious disease pathogenesis. TNF-α is essential for the development of a protective immune response to some pathogens, for example, Mycobacterium tuberculosis, by synergizing with...
Franziska S Hoffmann et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 542-552 (2014-12-17)
BAFF and a proliferation-inducing ligand (APRIL), which control B cell homeostasis, are therapeutic targets in autoimmune diseases. TACI-Fc (atacicept), a soluble fusion protein containing the extracellular domain of the BAFF-APRIL receptor TACI, was applied in clinical trials. However, disease activity...
Duygu Yilmaz et al.
European biophysics journal : EBJ, 44(7), 557-565 (2015-08-20)
A number of techniques developed to investigate protein structure and function depend on chemically modifying and/or labeling of proteins. However, in the case of homooligomeric proteins, the presence of multiple identical subunits obstructs the introduction of residue-specific labels to only...
Haiqiang Wu et al.
PloS one, 9(10), e109438-e109438 (2014-10-03)
Inhibition of β-amyloid (Aβ) aggregation is an attractive therapeutic and preventive strategy for the discovery of disease-modifying agents in Alzheimer's disease (AD). Phomopsis occulta is a new, salt-tolerant fungus isolated from mangrove Pongamia pinnata (L.) Pierre. We report here the...
Charbel Eid et al.
Analytical chemistry, 87(13), 6736-6743 (2015-05-30)
We present an on-chip electrophoretic assay for rapid protein detection with a SOMAmer (Slow Off-Rate Modified Aptamer) reagent. We used isotachophoresis (ITP) coupled with an ionic spacer to both react and separate SOMAmer-protein complex from free SOMAmer reagent. ITP accelerates...
Yu Liu et al.
Nuclear medicine and biology, 41(6), 450-456 (2014-04-29)
EphA2, one member of the Eph receptor family, is widely expressed in multiple aggressive cancers. SWL, a small peptide identified by phage display, has high binding affinity to EphA2, suggesting that it could be exploited for targeted molecular imaging. Therefore...
Grazia Biosa et al.
Journal of proteomics, 75(1), 93-99 (2011-07-16)
Characterisation of blood serum peptides can provide valuable information on physiological and pathological processes. However, the analysis of raw serum samples by MS results in the identification of a limited number of peptides. In order to improve sensitivity, many peptide...
Jeong-Im Woo et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3953-3961 (2015-03-18)
Cochlear inflammatory diseases, such as tympanogenic labyrinthitis, are associated with acquired sensorineural hearing loss. Although otitis media is extremely frequent in children, tympanogenic labyrinthitis is not commonly observed, which suggests the existence of a potent anti-inflammatory mechanism modulating cochlear inflammation....
Christian Nilsson et al.
Electrophoresis, 31(3), 459-464 (2010-02-02)
Totally porous lipid-based liquid crystalline nanoparticles were used as pseudostationary phase for capillary electroseparation with LIF detection of proteins at physiological conditions using unmodified cyclic olefin copolymer capillaries (Topas, 6.7 cm effective length). In the absence of nanoparticles, i.e. in...
Christine Burkard et al.
PLoS pathogens, 10(11), e1004502-e1004502 (2014-11-07)
Enveloped viruses need to fuse with a host cell membrane in order to deliver their genome into the host cell. While some viruses fuse with the plasma membrane, many viruses are endocytosed prior to fusion. Specific cues in the endosomal...
Diletta Scaccabarozzi et al.
PloS one, 10(12), e0143195-e0143195 (2015-12-02)
Malaria-associated acute lung injury (MA-ALI) and its more severe form malaria-associated acute respiratory distress syndrome (MA-ARDS) are common, often fatal complications of severe malaria infections. However, little is known about their pathogenesis. In this study, biochemical alterations of the lipid...
Marco Diociaiuti et al.
Biochimica et biophysica acta, 1842(9), 1622-1629 (2014-06-17)
Many proteins belonging to the amyloid family share the tendency to misfold and aggregate following common steps, and display similar neurotoxicity. In the aggregation pathway different kinds of species are formed, including several types of oligomers and eventually mature fibers....
Haoqian Wang et al.
Applied and environmental microbiology, 81(8), 2706-2716 (2015-02-11)
We report the identification, characterization, and gene cloning of a novel protein elicitor (PeBL1) secreted from Brevibacillus laterosporus strain A60. Through a purification process consisting of ion-exchange chromatography and high-performance liquid chromatography (HPLC), we isolated a protein that was identified...
Anna M Knapinska et al.
Journal of medicinal chemistry, 58(15), 5808-5824 (2015-07-21)
ADAM17 is implicated in several debilitating diseases. However, drug discovery efforts targeting ADAM17 have failed due to the utilization of zinc-binding inhibitors. We previously reported discovery of highly selective nonzinc-binding exosite-targeting inhibitors of ADAM17 that exhibited not only enzyme isoform...
Hua Wang et al.
Analytical biochemistry, 467, 75-83 (2014-09-15)
Owing to the mounting evidence of serum lipid changes in atherosclerosis, there has been increasing interest in developing new methods for analyzing atherogenic lipoprotein profiles. The separation of lipoprotein and lipoprotein subclasses has been demonstrated using a microchip capillary electrophoresis...
Nathalie J Plundrich et al.
Food & function, 6(7), 2145-2154 (2015-05-27)
Allergenic peanut proteins are relatively resistant to digestion, and if digested, metabolized peptides tend to remain large and immunoreactive, triggering allergic reactions in sensitive individuals. In this study, the stability of hypoallergenic peanut protein-polyphenol complexes was evaluated during simulated in...
Martin M Vila-Aiub et al.
Journal of experimental botany, 66(15), 4711-4718 (2015-05-29)
The rate of herbicide resistance evolution in plants depends on fitness traits endowed by alleles in both the presence and absence (resistance cost) of herbicide selection. The effect of two Lolium rigidum spontaneous homozygous target-site resistance-endowing mutations (Ile-1781-Leu, Asp-2078-Gly) on...
Irina V Mikheyeva et al.
PLoS genetics, 10(10), e1004740-e1004740 (2014-10-31)
Histone modifiers are critical regulators of chromatin-based processes in eukaryotes. The histone methyltransferase Set1, a component of the Set1C/COMPASS complex, catalyzes the methylation at lysine 4 of histone H3 (H3K4me), a hallmark of euchromatin. Here, we show that the fission...
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