Showing 1-30 of 30 results for "RTN10"
Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines
Stephen Wilson
Scientific Reports, 6 (2016)
A I Potapovich et al.
British journal of pharmacology, 158(5), 1236-1247 (2009-09-30)
The immunomodulatory effects of alpha-fetoprotein (AFP) on lymphocytes and macrophages have been described in vitro and in vivo. Recombinant forms of human AFP have been proposed as potential therapeutic entities for the treatment of autoimmune diseases. We examined the effects...
Danielle M Bouchard et al.
Journal of gastrointestinal oncology, 10(5), 821-830 (2019-10-12)
Sumoylation is an important post-translational modification that involves the conjugation of the Small Ubiquitin-related Modifier (SUMO) onto target proteins. This modification is reversed through the catalytic activity of SUMO isopeptidases, known as SENPs. One of these SENPs, SENP1, was reported...
Subramaniam Barathi et al.
Diabetes care, 33(9), 2031-2037 (2010-06-17)
Paraoxonase (PON) exhibits esterase activity (PON-AREase) and lactonase activity (PON-HCTLase), which prevent LDL oxidation and detoxify homocysteine thiolactone (HCTL). The role of HCTL and PON-HCTLase as a risk factor for the microvascular complication in diabetic retinopathy at the level of...
Tsubasa Munakata et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(50), 18159-18164 (2005-12-08)
The retinoblastoma tumor-suppressor protein (Rb) plays a critical role in controlling cellular proliferation and apoptosis by regulating E2F transcription factors. Rb is a key target of oncoproteins expressed by DNA tumor viruses, but RNA viruses are not known to regulate...
Hao Liu et al.
Neurology India, 62(1), 53-56 (2014-03-13)
Craniopharyngioma is a benign tumor, but recurrences are common and prognosis is poor. The pathologic mechanism underlying the high recurrence is still unknown. We hypothesized that there are hypoxic microenvironments within craniopharyngiomas and hypoxia inducible factor-1 alpha (HIF-1α) and its...
B Bahar et al.
Journal of animal science, 90 Suppl 4, 22-24 (2013-02-13)
Surgical removal of porcine intestinal tissue followed by an ex vivo challenge is an alternative technique of testing the anti-inflammatory effect of bioactive compounds in the intestine of live pigs. We investigated the effects of ex vivo incubation of porcine...
DNA cloning, structural analysis, SNP detection and tissue expression
profile of the IGF1 gene in Malabari and Attappady Black goats of India
THOMAS NAICY
Journal of genetics null
Masaaki Murakami et al.
The Journal of experimental medicine, 208(1), 103-114 (2011-01-12)
Cognate antigen recognition by CD4(+) T cells is thought to contribute to the tissue specificity of various autoimmune diseases, particularly those associated with class II MHC alleles. However, we show that localized class II MHC-dependent arthritis in F759 mice depends...
Fei Lan et al.
Diabetes, 63(5), 1649-1664 (2014-01-31)
Recent articles have reported an association between fatty liver disease and systemic insulin resistance in humans, but the causal relationship remains unclear. The liver may contribute to muscle insulin resistance by releasing secretory proteins called hepatokines. Here we demonstrate that...
Andrés J López-Contreras et al.
The Journal of biological chemistry, 283(30), 20761-20769 (2008-05-30)
One of the processes that regulate intracellular levels of polyamines in mammalian cells is polyamine uptake. We have measured polyamine uptake in COS7 cells for putrescine, spermidine, and spermine, obtaining K(m) values of 4.5, 1.0, and 0.8 mum, respectively. Treatment...
Lack of protease activated receptor (PAR) expression in purified human basophils.
F H Falcone et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 54 Suppl 1, S13-S14 (2005-06-02)
Anders Eriksson et al.
BMC gastroenterology, 8, 34-34 (2008-08-14)
The cause and pathophysiology of ulcerative colitis are both mainly unknown. We have previously used whole-genome microarray technique on biopsies obtained from patients with ulcerative colitis to identify 5 changed mucosal transcripts. The aim of this study was to compare...
Karen Zwaenepoel et al.
BMC genomics, 9, 393-393 (2008-08-22)
Protein phosphatase 2A (PP2A) is a serine/threonine-specific phosphatase displaying vital functions in growth and development through its role in various signalling pathways. PP2A holoenzymes comprise a core dimer composed of a catalytic C and a structural A subunit, which can...
D Tempé et al.
Oncogene, 33(7), 921-927 (2013-02-12)
The inducible proto-oncogenic (c-Fos:c-Jun)/AP-1 transcription complex binds 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) in its target genes. It is tightly controlled at multiple levels to avoid the deleterious effects of its inappropriate activation. In particular, SUMOylation represses its transactivation capacity in...
Elena Kashuba et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(47), 19866-19871 (2009-11-12)
We report that the overexpression of mitochondrial ribosomal protein MRPS18-2 (S18-2) can immortalize primary rat embryonic fibroblasts (REFs). The immortalized cells (18IM) lose contact inhibition, form foci, and are capable of anchorage-independent growth. Concurrently, mesodermal markers, such as vimentin, smooth...
Hiroki Matsumoto et al.
Biology open, 2(10), 1084-1090 (2013-10-30)
Cells exposed to ER-stress undergo the Unfolded Protein Response (UPR) to avoid apoptosis, but may also activate autophagy. However, the signal for selection of one of these two protective responses is unknown. To clarify the key switch between autophagy and...
Maryse Paquet et al.
Molecular brain, 6, 9-9 (2013-02-15)
Group I metabotropic glutamate receptors (mGluR) are coupled via Gαq/11 to the activation of phospholipase Cβ, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. In addition to functioning as neurotransmitter receptors to modulate synaptic activity, pathological mGluR5...
Jenny U Johansson et al.
PLoS genetics, 4(11), e1000278-e1000278 (2008-12-02)
Alternative splicing is an evolutionary innovation to create functionally diverse proteins from a limited number of genes. SNAP-25 plays a central role in neuroexocytosis by bridging synaptic vesicles to the plasma membrane during regulated exocytosis. The SNAP-25 polypeptide is encoded...
Qiang Gao et al.
Experimental and therapeutic medicine, 9(3), 947-954 (2015-02-11)
Integrated traditional Chinese medicine (ITCM) is known to improve health in patients with acute pancreatitis (AP); however, the molecular mechanisms underlying this effect are unknown. AP is associated with the expression of PRSS1 and SPINK1. Thus, the present study aimed...
Casper B Foldager et al.
Acta orthopaedica, 82(2), 234-240 (2011-03-26)
In vitro expansion of autologous chondrocytes is an essential part of many clinically used cartilage repair treatments. Native chondrocytes reside in a 3-dimensional (3D) network and are exposed to low levels of oxygen. We compared monolayer culture to combined 3D...
Martijn A Langereis et al.
Nucleic acids research, 42(4), 2473-2482 (2013-11-19)
Picornaviruses constitute a large group of viruses comprising medically and economically important pathogens such as poliovirus, coxsackievirus, rhinovirus, enterovirus 71 and foot-and-mouth disease virus. A unique characteristic of these viruses is the use of a viral peptide (VPg) as primer...
Erkko Ylösmäki et al.
Journal of virology, 87(1), 335-344 (2012-10-19)
Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their...
Mahroo Mofarrahi et al.
PloS one, 6(7), e22882-e22882 (2011-08-11)
Angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2) are angiogenesis factors that modulate endothelial cell differentiation, survival and stability. Recent studies have suggested that skeletal muscle precursor cells constitutively express ANGPT1 and adhere to recombinant ANGPT1 and ANGPT2 proteins. It remains unclear whether...
Marilena Lupu et al.
Journal of cellular and molecular medicine, 15(9), 1914-1926 (2010-10-30)
The umbilical cord blood derived endothelial progenitor cells (EPCs) contribute to vascular regeneration in experimental models of ischaemia. However, their ability to participate in cardiovascular tissue restoration has not been elucidated yet. We employed a novel coculture system to investigate...
Boling Qiao et al.
Carcinogenesis, 32(4), 516-521 (2011-01-29)
The XPC gene is involved in repair of bulky DNA adducts formed by carcinogenic metabolites and oxidative DNA damage, both known bladder cancer risk factors. Single nucleotide polymorphisms (SNPs) in XPC have been associated with increased bladder cancer risk. Recently...
Qian Feng et al.
Cell reports, 2(5), 1187-1196 (2012-11-13)
RIG-I and MDA5 are cytosolic RNA sensors that play a critical role in innate antiviral responses. Major advances have been made in identifying RIG-I ligands, but our knowledge of the ligands for MDA5 remains restricted to data from transfection experiments...
Elisabeth Mayer et al.
PloS one, 7(1), e29355-e29355 (2012-01-25)
Upon antigen exposure, cord blood derived T cells respond to ubiquitous environmental antigens by high proliferation. To date it remains unclear whether these "excessive" responses relate to different regulatory properties of the putative T regulatory cell (Treg) compartment or even...
Amelia Barilli et al.
Orphanet journal of rare diseases, 5, 32-32 (2010-11-30)
In the recessive aminoaciduria Lysinuric Protein Intolerance (LPI), mutations of SLC7A7/y+LAT1 impair system y+L transport activity for cationic amino acids. A severe complication of LPI is a form of Pulmonary Alveolar Proteinosis (PAP), in which alveolar spaces are filled with...
Gianpiero Marconi et al.
PloS one, 8(9), e75597-e75597 (2013-10-03)
Excessive soil salinity is a major ecological and agronomical problem, the adverse effects of which are becoming a serious issue in regions where saline water is used for irrigation. Plants can employ regulatory strategies, such as DNA methylation, to enable...

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