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Megan Culler Freeman et al.
eLife, 10 (2021-07-02)
Enterovirus D68 (EV-D68) has been implicated in outbreaks of severe respiratory illness and is associated with acute flaccid myelitis (AFM). EV-D68 is often detected in patient respiratory samples but has also been detected in stool and wastewater, suggesting the potential...
Subramaniam Barathi et al.
Diabetes care, 33(9), 2031-2037 (2010-06-17)
Paraoxonase (PON) exhibits esterase activity (PON-AREase) and lactonase activity (PON-HCTLase), which prevent LDL oxidation and detoxify homocysteine thiolactone (HCTL). The role of HCTL and PON-HCTLase as a risk factor for the microvascular complication in diabetic retinopathy at the level of...
Zheng Z Zhang et al.
Nucleic acids research, 42(21), 13186-13193 (2014-11-08)
The boundaries of R-loops are well-documented at immunoglobulin heavy chain loci in mammalian B cells. Within primary B cells or B cell lines, the upstream boundaries of R-loops typically begin early in the repetitive portion of the switch regions. Most...
Jerfiz D Constanzo et al.
Developmental biology, 415(1), 98-110 (2016-05-08)
The protein inhibitor of activated STAT-1 (PIAS1) is one of the few known SUMO E3 ligases. PIAS1 has been implicated in several biological processes including repression of innate immunity and DNA repair. However, PIAS1 function during development and tissue differentiation...
Chun-Chun Cheng et al.
eLife, 9 (2020-09-30)
Cancer testis antigens (CTAs) are proteins whose expression is normally restricted to the testis but anomalously activated in human cancer. In sperm, a number of CTAs support energy generation, however, whether they contribute to tumor metabolism is not understood. We...
B Bahar et al.
Journal of animal science, 90 Suppl 4, 22-24 (2013-02-13)
Surgical removal of porcine intestinal tissue followed by an ex vivo challenge is an alternative technique of testing the anti-inflammatory effect of bioactive compounds in the intestine of live pigs. We investigated the effects of ex vivo incubation of porcine...
A I Potapovich et al.
British journal of pharmacology, 158(5), 1236-1247 (2009-09-30)
The immunomodulatory effects of alpha-fetoprotein (AFP) on lymphocytes and macrophages have been described in vitro and in vivo. Recombinant forms of human AFP have been proposed as potential therapeutic entities for the treatment of autoimmune diseases. We examined the effects...
Tsubasa Munakata et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(50), 18159-18164 (2005-12-08)
The retinoblastoma tumor-suppressor protein (Rb) plays a critical role in controlling cellular proliferation and apoptosis by regulating E2F transcription factors. Rb is a key target of oncoproteins expressed by DNA tumor viruses, but RNA viruses are not known to regulate...
Adil Mohamed et al.
PLoS pathogens, 16(9), e1008803-e1008803 (2020-09-22)
The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host relationships and a candidate oncolytic virotherapy. Closely related laboratory strains of T3D, originating from the same ancestral T3D isolate, were recently found to exhibit significantly different oncolytic...
Louise von Gersdorff Jørgensen et al.
Veterinary immunology and immunopathology, 211, 25-34 (2019-05-16)
Red Mark Syndrome (RMS) is a skin disease reported from farmed rainbow trout. Since the turn of the millennium it has been spreading through Europe. RMS is probably a bacterial disease caused by a Midichloria-like organism (MLO). It is non-lethal...
Hao Liu et al.
Neurology India, 62(1), 53-56 (2014-03-13)
Craniopharyngioma is a benign tumor, but recurrences are common and prognosis is poor. The pathologic mechanism underlying the high recurrence is still unknown. We hypothesized that there are hypoxic microenvironments within craniopharyngiomas and hypoxia inducible factor-1 alpha (HIF-1α) and its...
Chronic Inflammation in CF Airways - A Persistent Issue for A20
McCallum K
Journal of Genetic Syndromes & Gene Therapy, 7(5) (2016)
Masaaki Murakami et al.
The Journal of experimental medicine, 208(1), 103-114 (2011-01-12)
Cognate antigen recognition by CD4(+) T cells is thought to contribute to the tissue specificity of various autoimmune diseases, particularly those associated with class II MHC alleles. However, we show that localized class II MHC-dependent arthritis in F759 mice depends...
Chaofan Li et al.
Immunity, 51(3), 491-507 (2019-09-19)
Tissue-resident memory CD8+ T (Trm) cells share core residency gene programs with tumor-infiltrating lymphocytes (TILs). However, the transcriptional, metabolic, and epigenetic regulation of Trm cell and TIL development and function is largely undefined. Here, we found that the transcription factor...
Ramona Romeo et al.
Frontiers in cellular neuroscience, 14, 567253-567253 (2021-02-02)
The low-density lipoprotein receptor-related protein 1 (LRP1) is a transmembrane receptor that binds over 40 potential ligands and is involved in processes such as cell differentiation, proliferation, and survival. LRP1 is ubiquitously expressed in the organism and enriched among others...
Anna Smielewska et al.
Wellcome open research, 3, 119-119 (2019-01-29)
Background: Human parainfluenza viruses (HPIVs) are significant causes of both upper and lower respiratory tract infections with type 3 (HPIV3) causing the most severe disease in the immunocompromised cohorts.  The objective of this study was to analyse the epidemiological nature...
Daniel Strebinger et al.
Molecular systems biology, 15(9), e9002-e9002 (2019-09-27)
SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self-renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock-in reporter fusion ES cell lines...
Andrés J López-Contreras et al.
The Journal of biological chemistry, 283(30), 20761-20769 (2008-05-30)
One of the processes that regulate intracellular levels of polyamines in mammalian cells is polyamine uptake. We have measured polyamine uptake in COS7 cells for putrescine, spermidine, and spermine, obtaining K(m) values of 4.5, 1.0, and 0.8 mum, respectively. Treatment...
Lack of protease activated receptor (PAR) expression in purified human basophils.
F H Falcone et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 54 Suppl 1, S13-S14 (2005-06-02)
Anders Eriksson et al.
BMC gastroenterology, 8, 34-34 (2008-08-14)
The cause and pathophysiology of ulcerative colitis are both mainly unknown. We have previously used whole-genome microarray technique on biopsies obtained from patients with ulcerative colitis to identify 5 changed mucosal transcripts. The aim of this study was to compare...
Fei Lan et al.
Diabetes, 63(5), 1649-1664 (2014-01-31)
Recent articles have reported an association between fatty liver disease and systemic insulin resistance in humans, but the causal relationship remains unclear. The liver may contribute to muscle insulin resistance by releasing secretory proteins called hepatokines. Here we demonstrate that...
Stefan Reber et al.
Molecular biology of the cell, 29(2), 75-83 (2017-11-24)
CRISPR/Cas9-based genome editing offers the possibility to knock out almost any gene of interest in an affordable and simple manner. The most common strategy is the introduction of a frameshift into the open reading frame (ORF) of the target gene...
K Birkenkamp-Demtroder et al.
British journal of cancer, 105(4), 552-561 (2011-07-21)
The KIAA1199 transcript is upregulated in colon adenomas and downregulated upon β-catenin knockdown. Transcript profiling was performed on >500 colon biopsies, methylation profiling data were compared with transcript data. Immunohistochemistry assessed KIAA1199 protein expression in 270 stage II/III tumours (>3...
Zheng Z Zhang et al.
Molecular immunology, 66(2), 284-289 (2015-04-23)
Immunoglobulin (Ig) heavy chains undergo class switch recombination (CSR) to change the heavy chain isotype from IgM to IgG, A or E. The switch regions are several kilobases long, repetitive, and G-rich on the nontemplate strand. They are also relatively...
Emily L Vernon et al.
Journal of environmental radioactivity, 213, 106120-106120 (2019-11-30)
Anthropogenic radionuclides can enter water bodies through accidental or controlled discharges. In order to assess their potential impact, understanding the link between exposure, tissue specific bioaccumulation and radiation dose rate, to biological or biomarker responses in aquatic biota is required....
David Sabater et al.
Scientific reports, 4, 3663-3663 (2014-01-15)
White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the...
Amit U Joshi et al.
Nature neuroscience, 22(10), 1635-1648 (2019-09-26)
In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated neuroinflammation, thus increasing neuronal death. Here we show that the expression of neurotoxic proteins associated with these diseases in microglia alone is sufficient to directly trigger death of...
Tatiana Shorstova et al.
Cancer research, 79(10), 2761-2774 (2019-03-17)
The antitumor activity of bromodomain and extraterminal motif protein inhibitors (BETi) has been demonstrated across numerous types of cancer. As such, these inhibitors are currently undergoing widespread clinical evaluation. However, predictive biomarkers allowing the stratification of tumors into responders and...
Gradient Fractionated Separation of Chondrogenically Committed Cells Derived from Human Embryonic Stem Cells
Natasja Leth Joergensen
BioResearch Open Access, 4(1) (2015)
Thomas R Jørgensen et al.
Folia parasitologica, 56(4), 251-258 (2010-02-05)
Response mechanisms of rainbow trout Oncorhynchus mykiss (Walbaum), experimentally infected with a Danish strain of Gyrodactylus salaris Malmberg, 1957 were investigated using molecular tools (qPCR) and immunohistochemistry. Expression of ten immune-relevant genes and reactivity with five different antibodies in the...
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