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Saidan Ding et al.
The international journal of biochemistry & cell biology, 55, 252-263 (2014-09-16)
We previously demonstrated that dopamine (DA) overload may be a key mechanism behind development of minimal hepatic encephalopathy (MHE) in rats. It has been shown that low-grade cerebral oedema and oxidative stress play important roles in the pathogenesis of MHE.
Katerina D Fagan-Solis et al.
Journal of cellular physiology, 229(9), 1160-1169 (2014-01-21)
S-phase kinase-associated protein 2 (SKP2) is an important cell cycle regulator, targeting the cyclin-dependent kinase (CDK) inhibitor p27 for degradation, and is frequently overexpressed in breast cancer. p27 regulates G1 /S transition by abrogating the activity of cyclin/CDK complexes. p27
Anna Sala-Cunill et al.
The Journal of allergy and clinical immunology, 135(4), 1031-1043 (2014-09-23)
Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast cell-derived mediators into the circulation. We report here that a plasma protease cascade, the factor XII-driven contact system, critically contributes to the pathogenesis of anaphylaxis
Vincent C Luca et al.
Science (New York, N.Y.), 347(6224), 847-853 (2015-02-24)
Notch receptors guide mammalian cell fate decisions by engaging the proteins Jagged and Delta-like (DLL). The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
Dalia El-Ani et al.
Canadian journal of physiology and pharmacology, 92(11), 917-925 (2014-10-29)
This study aims to elucidate the mechanisms by which tumor necrosis factor alpha (TNFα) provides protection from hypoxic damage to neonatal rat cardiomyocyte cultures. We show that when intracellular Ca(2+) ([Ca(2+)]i) levels are elevated by extracellular Ca(2+) ([Ca(2+)]o) or by
Angela C O Menegatti et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(1), 61-75 (2014-11-06)
Serine/threonine protein phosphatases have been described in many pathogenic bacteria as essential enzymes involved in phosphorylation-dependent signal transduction pathways and frequently associated with the virulence of these organisms. An inspection of Mycoplasma synoviae genome revealed the presence of a gene
Siqi Liu et al.
Science (New York, N.Y.), 347(6227), aaa2630-aaa2630 (2015-02-01)
During virus infection, the adaptor proteins MAVS and STING transduce signals from the cytosolic nucleic acid sensors RIG-I and cGAS, respectively, to induce type I interferons (IFNs) and other antiviral molecules. Here we show that MAVS and STING harbor two
Jesús D Rosado-Lugo et al.
The Journal of biological chemistry, 289(49), 33916-33926 (2014-10-24)
Transitions between the different stages of the RNAPII transcription cycle involve the recruitment and exchange of factors, including mRNA capping enzymes, elongation factors, splicing factors, 3'-end-processing complexes, and termination factors. These transitions are coordinated by the dynamic phosphorylation of the
Mitsuaki Ojima et al.
PloS one, 10(2), e0116645-e0116645 (2015-02-28)
We determined the frequencies of dicentric chromosomes per cell in non-dividing confluent normal human fibroblasts (MRC-5) irradiated with a single 1 Gy dose or a fractionated 1 Gy dose (10X0.1 Gy, 5X0.2 Gy, and 2X0.5 Gy). The interval between fractions
Naoyo Motoyama et al.
Anesthesia and analgesia, 119(4), 988-995 (2014-07-31)
Recent studies have revealed the antinociceptive effects of glycine transporter (GlyT) inhibitors in neuropathic pain models such as sciatic nerve-injured and diabetic animals. Bone cancer can cause the most severe pain according to complex mechanisms in which a neuropathic element
M Zhao et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(1), 72-77 (2014-11-06)
Revascularisation of transplanted islets is an essential prerequisite for graft survival and function. However, current islet isolation procedures deprive the islets of endothelial tubulets. This may have a detrimental effect on the revascularisation process of islets following transplantation. We hypothesise
Jingjiao Ma et al.
Journal of virology, 89(5), 2831-2841 (2014-12-30)
At least 10 different genotypes of novel reassortant H3N2 influenza viruses with 2009 pandemic H1N1 [A(H1N1)pdm09] gene(s) have been identified in U.S. pigs, including the H3N2 variant with a single A(H1N1)pdm09 M gene, which has infected more than 300 people.
[Structural and kinetic study on bacterial serine palmitoyltransferase].
Hiroko Ikushiro et al.
Seikagaku. The Journal of Japanese Biochemical Society, 83(2), 105-110 (2011-03-17)
Shiping Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(40), 14460-14465 (2014-09-24)
Lineage-specific microRNAs (miRNAs) may contribute to functions specific to hematophagous mosquitoes and, as such, have potential for contributing to the development of future mosquito control approaches. Here we report that the mosquito- and gut-specific miRNA, miR-1174, is required for proper
Jennifer A Cleary et al.
Biochimica et biophysica acta, 1844(6), 1119-1127 (2014-03-25)
The aldehyde inhibitor Z-Ala-Ala-Phe-CHO has been synthesized and shown by (13)C-NMR to react with the active site serine hydroxyl group of alpha-chymotrypsin to form two diastereomeric hemiacetals. For both hemiacetals oxyanion formation occurs with a pKa value of ~7 showing
Pirjo Pärnänen et al.
Biochemical and biophysical research communications, 457(4), 676-680 (2015-01-27)
We set out to identify the Candida glabrata cell wall attached proteases which may play a role as virulence factors in candidosis, particularly in the immunocompromized host. We studied a clinical C. glabrata strain T-1639, which was isolated from a
Yi-Fang Chang et al.
Oncotarget, 6(1), 85-100 (2014-11-22)
Angiogenesis, one of the major routes for tumor invasion and metastasis represents a rational target for therapeutic intervention. Recent development in drug discovery has highlighted the diverse biological and pharmacological properties of hydroxamate derivatives. In this study, we characterized the
Jacob T Bjerrum et al.
Inflammatory bowel diseases, 20(12), 2340-2352 (2014-10-31)
It is unknown why patients with extensive ulcerative colitis (UC) have a higher risk of colorectal cancer compared with patients with left-sided UC. This study characterizes the inflammatory processes in left-sided UC, pancolitis, and UC-associated dysplasia at the transcriptional level
[A novel metabolic interaction between neurons and glial cells through L-serine: an essential role for astroglia-derived L-serine in the survival and development of CNS neurons].
J Mitoma et al.
Seikagaku. The Journal of Japanese Biochemical Society, 71(7), 536-541 (1999-09-14)
V van Drongelen et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(12), 1515-1524 (2014-10-30)
Atopic dermatitis is an inflammatory skin disease that is characterized by a reduced skin barrier function, reduced filaggrin (FLG) expression as well as increased colonization by Staphylococcus aureus. This study focused on the possible involvement of FLG in epidermal colonization
Fabrizio Montecucco et al.
Thrombosis and haemostasis, 113(4), 838-850 (2014-11-22)
Paradoxically, morbid obesity was suggested to protect from cardiovascular co-morbidities as compared to overweight/obese patients. We hypothesise that this paradox could be inferred to modulation of the "endocannabinoid" system on systemic and subcutaneous adipose tissue (SAT) inflammation. We designed a
Vassiliki Saloura et al.
Molecular cancer research : MCR, 13(2), 293-304 (2014-10-05)
Squamous cell carcinoma of the head and neck (SCCHN) is a relatively common malignancy with suboptimal long-term prognosis, thus new treatment strategies are urgently needed. Over the last decade, histone methyltransferases (HMT) have been recognized as promising targets for cancer
Xinni Xie et al.
Biochimica et biophysica acta, 1850(1), 62-72 (2014-10-12)
Selective PPARγ modulators (sPPARγM) retains insulin sensitizing activity but with minimal side effects compared to traditional TZDs agents, is thought as a promising strategy for development of safer insulin sensitizer. We used a combination of virtual docking, SPR-based binding, luciferase
Franziska Barthel et al.
Anesthesiology, 121(1), 160-169 (2014-03-07)
Dysfunction of spinal glycinergic neurotransmission is a major pathogenetic factor in neuropathic pain. The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2. GlyT inhibitors act antinociceptive in various animal pain models when applied as
Grace Kwan et al.
Applied and environmental microbiology, 81(3), 861-873 (2014-11-25)
Salmonella enterica is a member of the plant microbiome. Growth of S. enterica in sprouting-seed exudates is rapid; however, the active metabolic networks essential in this environment are unknown. To examine the metabolic requirements of S. enterica during growth in
Song-Hee Han et al.
Journal of virology, 88(19), 11240-11252 (2014-07-18)
Hepatitis C virus (HCV) nonstructural protein 5B (NS5B), an RNA-dependent RNA polymerase (RdRp), is the key enzyme for HCV RNA replication. We previously showed that HCV RdRp is phosphorylated by protein kinase C-related kinase 2 (PRK2). In the present study
G William Wong et al.
Biochemical and biophysical research communications, 451(2), 314-318 (2014-08-06)
The sentinel roles of mammalian mast cells (MCs) in varied infections raised the question of their evolutionary origin. We discovered that the test cells in the sea squirt Ciona intestinalis morphologically and histochemically resembled cutaneous human MCs. Like the latter
Natalia S Rozas et al.
Biochemical and biophysical research communications, 457(4), 635-639 (2015-01-24)
The genetic disease tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by loss of function mutations in either TSC1 (hamartin) or TSC2 (tuberin), which serve as negative regulators of mechanistic target of rapamycin complex 1 (mTORC1) activity. TSC
Anna L Greenshields et al.
Cancer letters, 357(1), 129-140 (2014-12-03)
Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC
Matthew D D Miell et al.
Developmental cell, 32(1), 1-2 (2015-01-15)
In this issue of Developmental Cell, Yu et al. (2015) demonstrate that CENP-A phosphorylation by CDK1 inhibits its association with the chaperone protein HJURP and that the removal of this modification at mitotic exit is a key regulatory event that
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