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G Mark Freeman et al.
Neuron, 78(5), 799-806 (2013-06-15)
Systems of coupled oscillators abound in nature. How they establish stable phase relationships under diverse conditions is fundamentally important. The mammalian suprachiasmatic nucleus (SCN) is a self-sustained, synchronized network of circadian oscillators that coordinates daily rhythms in physiology and behavior.
Sergey N Kolbaev et al.
Scientific reports, 10(1), 18399-18399 (2020-10-29)
Activation of GABAA receptors causes in immature neurons a functionally relevant decrease in the intracellular Cl- concentration ([Cl-]i), a process termed ionic plasticity. Amount and duration of ionic plasticity depends on kinetic properties of [Cl-]i homeostasis. In order to characterize
Amanda L Zimmerman et al.
Neuron, 102(2), 420-434 (2019-03-04)
Presynaptic inhibition (PSI) of primary sensory neurons is implicated in controlling gain and acuity in sensory systems. Here, we define circuit mechanisms and functions of PSI of cutaneous somatosensory neuron inputs to the spinal cord. We observed that PSI can
Petr Unichenko et al.
Cerebral cortex (New York, N.Y. : 1991), 28(8), 2873-2886 (2017-11-07)
Neuroligin-4 (Nlgn4) is a cell adhesion protein that regulates synapse organization and function. Mutations in human NLGN4 are among the causes of autism spectrum disorders. In mouse, Nlgn4 knockout (KO) perturbs GABAergic synaptic transmission and oscillatory activity in hippocampus, and
Georg M Stettner et al.
Journal of applied physiology (Bethesda, Md. : 1985), 114(1), 119-130 (2012-10-30)
The perifornical (PF) region of the posterior hypothalamus promotes wakefulness and facilitates motor activity. In anesthetized rats, local disinhibition of PF neurons by GABA(A) receptor antagonists activates orexin (OX) neurons and elicits a systemic response, including increases of hypoglossal nerve
Betty Jurek et al.
Annals of neurology, 86(5), 656-670 (2019-07-22)
Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N-methyl-d-aspartate receptor (NMDAR) are among the most frequently diagnosed anti-neuronal surface ABs, yet little is known about effects on
M Heaulme et al.
Brain research, 384(2), 224-231 (1986-10-08)
An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA), SR 95103, has been shown to be a selective antagonist of GABA at the GABAA receptor site. Subsequent structure-activity studies showed that suppressing the methyl in the 4-position of the pyridazine ring, and
Vladislav Sekulić et al.
Frontiers in cellular neuroscience, 14, 277-277 (2020-10-24)
Determining biophysical details of spatially extended neurons is a challenge that needs to be overcome if we are to understand the dynamics of brain function from cellular perspectives. Moreover, we now know that we should not average across recordings from
Jason V Thompson et al.
Journal of neurophysiology, 109(3), 721-733 (2012-11-17)
Changes in inhibition during development are well documented, but the role of inhibition in adult learning-related plasticity is not understood. In songbirds, vocal recognition learning alters the neural representation of songs across the auditory forebrain, including the caudomedial nidopallium (NCM)
Ian Duguid et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(32), 11132-11143 (2012-08-10)
Tonic inhibition is a key regulator of neuronal excitability and network function in the brain, but its role in sensory information processing remains poorly understood. The cerebellum is a favorable model system for addressing this question as granule cells, which
Kotaro Takano et al.
Analytical and bioanalytical chemistry, 412(17), 4037-4043 (2020-04-25)
A convenient analytical system for protein-ligand interactions under crude conditions was developed using native mass spectrometry (MS). As a model protein, Escherichia coli (E. coli) dihydrofolate reductase (DHFR) with and without a histidine tag was used for the study. First
Hannah J Seong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(31), 10516-10521 (2012-08-03)
Dopamine modulation in the prefrontal cortex is important for cognitive processing and disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to enable working memory by enhancing the firing properties of pyramidal neurons. However, these receptors are only
Rebecca Lethbridge et al.
PloS one, 7(4), e35024-e35024 (2012-04-13)
Rat pup odor preference learning follows pairing of bulbar beta-adrenoceptor activation with olfactory input. We hypothesize that NMDA receptor (NMDAR)-mediated olfactory input to mitral cells is enhanced during training, such that increased calcium facilitates and shapes the critical cAMP pattern.
Edmund Cauley et al.
American journal of physiology. Heart and circulatory physiology, 309(8), H1281-H1287 (2015-09-16)
Hypertension, cardiac hypertrophy, and heart failure (HF) are widespread and debilitating cardiovascular diseases that affect nearly 23 million people worldwide. A distinctive hallmark of these cardiovascular diseases is autonomic imbalance, with increased sympathetic activity and decreased parasympathetic vagal tone. Recent
Amanda Borgquist et al.
Journal of neurophysiology, 113(3), 904-914 (2014-11-14)
Since estradiol attenuates cannabinoid-induced increases in energy intake, energy expenditure, and transmission at proopiomelanocortin (POMC) synapses in the hypothalamic arcuate nucleus (ARC), we tested the hypothesis that neuronal nitric oxide synthase (nNOS) plays an integral role. To this end, whole
Latefa Yekhlef et al.
Scientific reports, 7, 43230-43230 (2017-02-24)
We investigated whether an anti-epileptic effect is obtained by selectively activating excitatory neurons expressing ChR2 under the promoter for the synaptic vesicular glutamate transporter 2 (VGLUT2). VGLUT2-expressing cells were optically stimulated while local field potential and whole-cell patch-clamp recordings were
Miguel Angel Garcia-Bereguiain et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(16), 6791-6799 (2013-04-19)
When spiking activity within a network is perturbed for hours to days, compensatory changes in synaptic strength are triggered that are thought to be important for the homeostatic maintenance of network or cellular spiking activity. In one form of this
Lucille A Moore et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(39), 9453-9464 (2017-08-30)
The central nucleus of the inferior colliculus (ICC) of the auditory midbrain, which integrates most ascending auditory information from lower brainstem regions, receives prominent long-range inhibitory input from the ventral nucleus of the lateral lemniscus (VNLL), a region thought to
Quentin Gaucher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10713-10728 (2013-06-28)
In all sensory modalities, intracortical inhibition shapes the functional properties of cortical neurons but also influences the responses to natural stimuli. Studies performed in various species have revealed that auditory cortex neurons respond to conspecific vocalizations by temporal spike patterns
G C Gregoriou et al.
Molecular pharmacology, 98(4), 454-461 (2020-07-02)
Endogenous opioid peptides in the amygdala regulate many of our behaviors and emotional responses. In particular, the endogenous opioid enkephalin plays a significant role in regulating amygdala activity, but its action is strongly limited by peptidases, which degrade enkephalin into
Alexander Thiele et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(47), 16602-16615 (2012-11-24)
Previous studies have investigated the effects of acetylcholine (ACh) on neuronal tuning, coding, and attention in primary visual cortex, but its contribution to coding in extrastriate cortex is unexplored. Here we investigate the effects of ACh on tuning properties of
Cole W Graydon et al.
Current biology : CB, 28(17), 2739-2751 (2018-08-21)
To understand computation in a neural circuit requires a complete synaptic connectivity map and a thorough grasp of the information-processing tasks performed by the circuit. Here, we dissect a microcircuit in the mouse retina in which scotopic visual information (i.e.
Violeta G López-Huerta et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4964-4975 (2013-03-15)
Inhibitory connections among striatal projection neurons (SPNs) called "feedback inhibition," have been proposed to endow the striatal microcircuit with computational capabilities, such as motor sequence selection, filtering, and the emergence of alternating network states. These properties are disrupted in models
Yvonne Johansson et al.
Cell reports, 30(4), 1178-1194 (2020-01-30)
To understand striatal function, it is essential to know the functional organization of the numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we activated terminals from ipsi- or contralateral primary somatosensory cortex (S1) or primary motor cortex
Yu-Ting Mao et al.
Neural plasticity, 2013, 530651-530651 (2013-11-30)
Loss of sensory input from peripheral organ damage, sensory deprivation, or brain damage can result in adaptive or maladaptive changes in sensory cortex. In previous research, we found that auditory cortical tuning and tonotopy were impaired by cross-modal invasion of
Roman U Goz et al.
Journal of neurophysiology, 123(6), 2449-2464 (2020-05-14)
Somatic mutations have emerged as the likely cause of focal epilepsies associated with developmental malformations and epilepsy-associated glioneuronal tumors (GNT). Somatic BRAFV600E mutations in particular have been detected in the majority of low-grade neuroepithelial tumors (LNETS) and in neurons in
Patricia Kreis et al.
PloS one, 8(8), e71957-e71957 (2013-08-14)
Defects in actin dynamics affect activity-dependent modulation of synaptic transmission and neuronal plasticity, and can cause cognitive impairment. A salient candidate actin-binding protein linking synaptic dysfunction to cognitive deficits is Drebrin (DBN). However, the specific mode of how DBN is
Asha K Lahiri et al.
Neuron, 106(2), 277-290 (2020-02-23)
Substantia nigra dopamine neurons have been implicated in the initiation and invigoration of movement, presumably through their modulation of striatal projection neuron (SPN) activity. However, the impact of native dopaminergic transmission on SPN excitability has not been directly demonstrated. Using
Daniel A Llano et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(46), 16141-16148 (2012-11-16)
Flavoprotein autofluorescence imaging was used to examine auditory cortical synaptic responses in aged animals with behavioral evidence of tinnitus and hearing loss. Mice were exposed to noise trauma at 1-3 months of age and were assessed for behavioral evidence of
Gubbi Govindaiah et al.
eNeuro, 7(6) (2020-10-25)
Retinofugal synapses serve as models for understanding how sensory signals from the periphery are relayed to the brain. Past studies have focused primarily on understanding the postsynaptic glutamatergic receptor subtypes involved in signal transmission, but the mechanisms underlying glutamate release
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