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Shun Li et al.
Nature communications, 10(1), 1693-1693 (2019-04-14)
Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAFV600E-melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated
Benjamin P Sullivan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1163, 122494-122494 (2021-01-06)
Nucleic acid amplification tests (NAATs) are a crucial diagnostic and monitoring tool for infectious diseases. A key procedural step for NAATs is sample preparation: separating and purifying target nucleic acids from crude biological samples prior to nucleic acid amplification and
Timothy D Calamaras et al.
American journal of physiology. Heart and circulatory physiology, 316(1), H145-H159 (2018-10-27)
Myocardial hypertrophy is an independent risk factor for heart failure (HF), yet the mechanisms underlying pathological cardiomyocyte growth are incompletely understood. The c-Jun NH2-terminal kinase (JNK) signaling cascade modulates cardiac hypertrophic remodeling, but the upstream factors regulating myocardial JNK activity
Min-Hee Kang et al.
Theranostics, 7(19), 4735-4752 (2017-12-01)
Rationale: Dimethyl sulfoxide (DMSO) is commonly used as a solvent for water-insoluble substances, a vehicle for drug therapy, and a cryoprotectant for cultured cells. DMSO induced embryonic defects and its mechanism of action remains unclear. The rationale is based on
Zhi Chen et al.
International journal of biological sciences, 15(12), 2627-2640 (2019-11-23)
Emerging evidence indicates that microRNAs (miRNAs) play fundamental roles in the pathogenesis of multiple diseases, including acute lung injury (ALI). Here, we discovered that miR-199a-3p was significantly downregulated in ALI lung tissues using a microarray analysis. In vitro lipopolysaccharide (LPS)
Angeliki M Nikolakopoulou et al.
ASN neuro, 8(1), 1-18 (2016-03-02)
Traumatic brain injury (TBI) can result in tissue alterations distant from the site of the initial injury, which can trigger pathological changes within hippocampal circuits and are thought to contribute to long-term cognitive and neuropsychological impairments. However, our understanding of
Ji Woong Lee et al.
Frontiers in physiology, 11, 1083-1083 (2020-09-29)
Cold weather is one of the biggest challenges in establishing a large-scale microalgae culture facility in temperate regions. In order to develop a strain that is resistant to low temperatures and still maintains high photosynthetic efficiency, transgenic studies have been
Nathan Huerzeler et al.
Audiology & neuro-otology, 24(2), 65-76 (2019-05-23)
Insulin receptors are expressed on nerve cells in the mammalian brain, but little is known about insulin signaling and the expression of the insulin receptor (IR) and glucose transporters in the cochlea. We performed immunohistochemistry and gene/protein expression analysis to
Qi Lu et al.
Molecular therapy. Methods & clinical development, 18, 15-23 (2020-06-18)
The loss of photoreceptors in individuals with retinal degenerative diseases leads to partial or complete blindness. Optogenetic therapy is a promising approach for restoring vision to the blind. Multiple strategies have been employed by targeting genetically encoded light sensors, particularly
C Fourie et al.
Journal of neurodegenerative diseases, 2014, 938530-938530 (2014-01-01)
NMDA and AMPA-type glutamate receptors and their bound membrane-associated guanylate kinases (MAGUKs) are critical for synapse development and plasticity. We hypothesised that these proteins may play a role in the changes in synapse function that occur in Huntington's disease (HD)
Rachel Caines et al.
Journal of cell science, 132(16) (2019-07-25)
Dysfunction of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) leads to ischaemia, the central pathology of cardiovascular disease. Stem cell technology will revolutionise regenerative medicine, but a need remains to understand key mechanisms of vascular differentiation. RNA-binding proteins have
Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model.
Sidhu H, et al.
The Journal of Neuroscience, 34, 9867-9879 (2014)
Jia Zou et al.
Epilepsia, 58(12), 2053-2063 (2017-10-13)
Epilepsy is one of the most prominent symptoms of tuberous sclerosis complex (TSC), a genetic disorder, and may be related to developmental defects resulting from impaired TSC1 or TSC2 gene function in astrocytes and neurons. Inactivation of the Tsc1 gene
Olivér Rosero et al.
Surgery, 161(4), 1004-1015 (2016-11-16)
Postconditioning may prove to be a suitable method to decrease ischemia-reperfusion injury of intestine after mesenteric arterial occlusion. Toll-like-receptor-4 is involved in the pathophysiology of organ damage after ischemia-reperfusion; therefore, the aim of our study was to investigate the effect
Natalja Funk et al.
Scientific reports, 9(1), 4515-4515 (2019-03-16)
Mutations within Leucine-rich repeat kinase 2 (LRRK2) are associated with late-onset Parkinson's disease. The physiological function of LRRK2 and molecular mechanism underlying the pathogenic role of LRRK2 mutations remain uncertain. Here, we investigated the role of LRRK2 in intracellular signal
Yang Yang et al.
Experimental and therapeutic medicine, 21(2), 137-137 (2021-01-19)
Vagus nerve activation may have important therapeutic significance for myocardial ischemia-reperfusion (IR) injury. Nitric oxide (NO) plays a vital role in the cardioprotective effects of anesthetic preconditioning (APC). Moreover, acetylcholine (ACh) prevents cardiomyocyte damage by activating AMP-activated protein kinase (AMPK)
Lauren J Cator et al.
Scientific reports, 5, 11947-11947 (2015-07-15)
Malaria parasites alter mosquito feeding behaviour in a way that enhances parasite transmission. This is widely considered a prime example of manipulation of host behaviour to increase onward transmission, but transient immune challenge in the absence of parasites can induce
Hyun Lyung Jung et al.
Korean diabetes journal, 34(4), 244-252 (2010-09-14)
We evaluated the effects of endurance exercise and a high-fat diet on insulin resistance and ceramide contents of skeletal muscle in Sprague-Dawley rats. We randomly divided 32 rats into four groups: control (CON, n = 8), high fat diet (HF
A functional assay for microRNA target identification and validation
Gaken, J., et al.
Nucleic Acids Research, 10 (2012)
Alicia M Bostwick et al.
Biochemical and biophysical research communications, 528(3), 580-585 (2020-06-09)
Mammalian cells contain genetic information in two compartments, the nucleus and the mitochondria. Mitochondrial gene expression must be coordinated with nuclear gene expression to respond to cellular energetic needs. To gain insight into the coordination between the nucleus and mitochondria
Bashar M Thejer et al.
BMC molecular and cell biology, 21(1), 24-24 (2020-04-05)
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. We demonstrate that manipulating PGRMC1 phosphorylation status
Samit Ghosh et al.
PloS one, 6(3), e18399-e18399 (2011-04-13)
Sickle cell disease (SCD) is characterized by hemolysis, vaso-occlusion and ischemia reperfusion injury. These events cause endothelial dysfunction and vasculopathies in multiple systems. However, the lack of atherosclerotic lesions has led to the idea that there are adaptive mechanisms that
Miaozong Wu et al.
Diabetes/metabolism research and reviews, 25(3), 279-286 (2009-01-30)
Aging-related hyperglycemia is associated with increased oxidative stress and diminished muscle glucose transporter-4 (Glut4) that may be regulated, at least in part, by the mitogen-activated protein kinases (MAPK). To test the possibility that aging-related hyperglycemia can be prevented by pharmacological
Gianluca Fulgenzi et al.
Nature communications, 11(1), 1950-1950 (2020-04-25)
BDNF signaling in hypothalamic circuitries regulates mammalian food intake. However, whether BDNF exerts metabolic effects on peripheral organs is currently unknown. Here, we show that the BDNF receptor TrkB.T1 is expressed by pancreatic β-cells where it regulates insulin release. Mice
Houda Hanana et al.
Biology open, 1(12), 1192-1199 (2012-12-22)
Okadaic acid (OA) is one of the main diarrhetic shellfish poisoning toxins and a potent inhibitor of protein phosphatases 1 and 2A. The downstream signal transduction pathways following the protein phosphatase inhibition are still unknown and the results of most
M Popek et al.
Neuroscience, 446, 124-136 (2020-08-29)
Glutamine is an astroglia-derived precursor of the neurotransmitter glutamate, and its astroglia-to-neuron transfer is controlled by distinct glutamine transporters on the astrocytic and neuronal sites. In this study, we focused on the role of astrocytic glutamine efflux-mediating system N transporter
Jordan Koeppen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(25), 5710-5726 (2018-05-26)
Astrocyte-derived factors can control synapse formation and functions, making astrocytes an attractive target for regulating neuronal circuits and associated behaviors. Abnormal astrocyte-neuronal interactions are also implicated in neurodevelopmental disorders and neurodegenerative diseases associated with impaired learning and memory. However, little
Ivana Sirangelo et al.
Nutrients, 12(8) (2020-08-06)
Doxorubicin (doxo) is an effective anticancer compound in several tumor types. However, as a consequence of oxidative stress induction and ROS overproduction, its high cardiotoxicity demands urgent attention. Vanillin possesses antioxidant, antiproliferative, antidepressant and anti-glycating properties. Therefore, we investigated the
Bo Wang et al.
Molecular cell, 74(4), 742-757 (2019-04-14)
Disturbances in autophagy and stress granule dynamics have been implicated as potential mechanisms underlying inclusion body myopathy (IBM) and related disorders. Yet the roles of core autophagy proteins in IBM and stress granule dynamics remain poorly characterized. Here, we demonstrate
Mi Jung Park et al.
Yonsei medical journal, 49(6), 1008-1016 (2008-12-25)
Effect of recombinant human growth hormone (rhGH) administration on lipid storage, and its subsequent effect on insulin sensitivity have not yet been adequately examined. Thus, we investigated the effects of rhGH treatment on muscle triglyceride (TG) and ceramide content, and
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