Timothy D Calamaras et al.
American journal of physiology. Heart and circulatory physiology, 316(1), H145-H159 (2018-10-27)
Myocardial hypertrophy is an independent risk factor for heart failure (HF), yet the mechanisms underlying pathological cardiomyocyte growth are incompletely understood. The c-Jun NH2-terminal kinase (JNK) signaling cascade modulates cardiac hypertrophic remodeling, but the upstream factors regulating myocardial JNK activity