Showing 1-30 of 144 results for "


Joanne M Langley et al.
BMC infectious diseases, 12, 279-279 (2012-11-01)
At the time of the influenza A(H1N1)pmd09 pandemic it was not known if concurrent or sequential administration of seasonal trivalent influenza vaccine (TIV) with pandemic vaccine was preferred. Immunogenicity and safety were assessed in 871 healthy subjects aged 19-40 years who...
Akihiro Michihara et al.
Biological & pharmaceutical bulletin, 38(12), 1879-1890 (2015-12-04)
A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously hypertensive rats stroke-prone (SHRSP) have lower serum cholesterol levels than normotensive Wistar-Kyoto rats (WKY). To elucidate the mechanisms responsible...
Christine Durier et al.
AIDS (London, England), 27(1), 87-93 (2012-09-29)
In immunocompromised patients, alternative schedules more immunogenic than the standard influenza vaccine regimen are necessary to enhance and prolong vaccine efficacy. We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one...
Phytochemical Analysis, In Vitro Anti-Inflammatory and Antimicrobial Activity of Piliostigma thonningii Leaf Extracts from Benin.
Marquardt, et al.
Planta Medica, 86, 1269-1277 (2020)
Jean Haensler et al.
International journal of pharmaceutics, 486(1-2), 99-111 (2015-03-22)
We describe the development, analytical characterization, stability and preclinical efficacy of AF04, a combination adjuvant comprising the synthetic toll-like receptor 4 (TLR4) agonist, E6020, formulated in AF03, a thermoreversible squalene emulsion. By using AF04 with the recombinant major outer membrane...
Wenqiang Chang et al.
Biochimica et biophysica acta, 1850(9), 1762-1771 (2015-05-12)
This study is to characterize the antifungal effects of pyridoxatin (PYR), a small natural product isolated from an endolichenic fungus. The susceptibility tests in vitro and in vivo by using Caenorhabditis elegans as an infectious model were performed to evaluate...
Vidyashankara Iyer et al.
Human vaccines & immunotherapeutics, 11(7), 1853-1864 (2015-06-20)
Oil-in-water emulsions have gained consideration as vaccine adjuvants in recent years due to their ability to elicit a differentiated immunogenic response compared to traditional aluminum salt adjuvants. Squalene, a cholesterol precursor, is a natural product with immunostimulatory properties, making it...
Tomonori Takami et al.
PloS one, 7(11), e49004-e49004 (2012-11-13)
Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on...
Andrei Maksimenko et al.
International journal of pharmaceutics, 482(1-2), 38-46 (2014-12-03)
Gemcitabine is currently the most effective agent against advanced pancreatic cancer. However, the major therapeutic hurdles using gemcitabine include rapid inactivation by blood deaminases and fast development of cell chemoresistance, induced by down-regulation of deoxycytidine kinase or nucleoside transporters. To...
Andreas Lauterbach et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 614-624 (2014-12-03)
A novel adapalene-loaded solid lipid microparticle (SLMA) dispersion as a topical drug delivery system (TDDS) for follicular penetration has been introduced. The objective of the present study was to investigate the rheological properties, the follicular penetration with differential tape stripping...
Christopher B Fox
Molecules (Basel, Switzerland), 14(9), 3286-3312 (2009-09-29)
Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of...
Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosis
Lavrijsen APM, et al.
The Journal of Investigative Dermatology, 105(4), 619-624 (1995)
Jih-Jung Chen et al.
Journal of natural products, 72(2), 223-228 (2009-02-06)
Six new compounds, including five new seco-abietane diterpenoids, 12-deoxy-seco-hinokiol methyl ester (1), 12-deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid A (3), 9alpha-hydroxycallicarpic acid A (4), and callicarpic acid B (5), and a new phenylethanoid derivative, 4-hydroxyphenethyl tetradecanoate (6), have been isolated...
Derek T O'Hagan et al.
Expert review of vaccines, 12(1), 13-30 (2012-12-22)
The first clinical trial of an MF59(®)-adjuvanted influenza vaccine (Novartis) was conducted 20 years ago in 1992. The product that emerged (Fluad(®), Novartis) was licensed first in Italy in 1997 and is now licensed worldwide in 30 countries. US licensure is...
Sandra G Gonzalez Malagon et al.
Biochemical pharmacology, 96(3), 267-277 (2015-06-07)
We report the production and metabolic phenotype of a mouse line in which the Fmo5 gene is disrupted. In comparison with wild-type (WT) mice, Fmo5(-/-) mice exhibit a lean phenotype, which is age-related, becoming apparent after 20 weeks of age....
Queries about vaccines containing squalene.
Frances Beck et al.
Immunology and cell biology, 88(5), 497-499 (2010-02-17)
Zih-rou Huang et al.
Acta pharmacologica Sinica, 29(9), 1094-1102 (2008-08-23)
Camptothecin is an anticancer drug that acts against a broad spectrum of tumors. The clinical application of camptothecin is limited by its insolubility, instability, and toxicity problems. The aim of this study was to develop and characterize lipid nanoparticles with...
Yun Ye et al.
Molecular biology reports, 41(9), 6097-6104 (2014-07-06)
Diosgenin is a steroid derived from cholesterol in plants and used as a typical initial intermediate for synthesis of numerous steroidal drugs in the world. Commercially, this compound is extracted mainly from the rhizomes or tubers of some Dioscorea species....
Re: "effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy".
Danuta M Skowronski et al.
American journal of epidemiology, 177(6), 593-594 (2013-02-26)
Jose A Plaza et al.
The American Journal of dermatopathology, 37(11), 809-821 (2015-10-21)
Sebaceous carcinoma (SC) is a relatively uncommon malignant epithelial neoplasm with a predilection for the periocular region. The diagnosis of SC can be difficult to make at initial presentation, as it can clinically and histopathologically resemble other common benign and...
T R Tansey et al.
Biochimica et biophysica acta, 1529(1-3), 49-62 (2000-12-09)
Mammalian squalene synthase (SQS) catalyzes the first reaction of the branch of the isoprenoid metabolic pathway committed specifically to sterol biosynthesis. SQS produces squalene in an unusual two-step reaction in which two molecules of farnesyl diphosphate are condensed head-to-head. Recent...
[Research progress on the squalene synthase].
Mingwen Zhao et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 43(5), 676-680 (2005-11-12)
Ruchi R Shah et al.
Journal of pharmaceutical sciences, 104(4), 1352-1361 (2015-01-21)
Microfluidization is an established technique for preparing emulsion adjuvant formulations for use in vaccines. Although this technique reproducibly yields high-quality stable emulsions, it is complex, expensive, and requires proprietary equipment. For this study, we developed a novel and simple low...
T J Smith
Expert opinion on investigational drugs, 9(8), 1841-1848 (2000-11-04)
Squalene is a triterpene that is an intermediate of the cholesterol biosynthesis pathway and it can be obtained from the diet. Olive oil contains 0.2-0.7% squalene. The average intake of squalene is 30 mg/day in the United States, however, when...
Christine Barrault et al.
The Journal of steroid biochemistry and molecular biology, 152, 34-44 (2015-04-14)
Androgens act through non-genomic and androgen receptor (AR)-dependent genomic mechanisms. AR is expressed in the sebaceous gland and the importance of androgens in the sebaceous function is well established. However, the in vitro models used to date have failed to...
C Scialabba et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 695-705 (2014-10-05)
This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed...
David R Fooshee et al.
Environmental science & technology, 49(22), 13304-13313 (2015-10-23)
Squalene is a major component of skin and plant surface lipids and is known to be present at high concentrations in indoor dust. Its high reactivity toward ozone makes it an important ozone sink and a natural protectant against atmospheric...
Catherine Naughton et al.
Nature structural & molecular biology, 20(3), 387-395 (2013-02-19)
DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human cells is uncharacterized. To map supercoiling, we used biotinylated trimethylpsoralen as a...
Michael R Rasch et al.
Langmuir : the ACS journal of surfaces and colloids, 28(43), 15160-15167 (2012-10-05)
Assemblies of saturated 1,2-diacylphosphatidylcholine lipid and hydrophobic dodecanethiol-capped 1.8 nm diameter gold nanocrystals were studied as a function of lipid chain length and the addition of the naturally occurring oil, squalene. The gold nanocrystals formed various lipid-stabilized agglomerates, sometimes fusing...
Charles Schaub et al.
The Journal of biological chemistry, 295(38), 13138-13149 (2020-07-31)
The human innate immunity factor apolipoprotein L-I (APOL1) protects against infection by several protozoan parasites, including Trypanosoma brucei brucei Endocytosis and acidification of high-density lipoprotein-associated APOL1 in trypanosome endosomes leads to eventual lysis of the parasite due to increased plasma...