Search Within
Applied Filters:
Keyword:'S3929'
Showing 1-30 of 2810 results for "

S3929

" within Papers
O Chudomel et al.
Neurochemical research, 40(4), 747-757 (2015-02-04)
Previous studies have shown that the pharmacologic effects of GABAergic drugs and the postsynaptic phasic GABAAergic inhibitory responses in the anterior part of the rat substantia nigra pars reticulata (SNRA) are age- and sex-specific. Here, we investigate whether there are...
Cecilia Rodrigues Silva et al.
Archivos latinoamericanos de nutricion, 55(1), 23-27 (2005-09-29)
Eleven diabetic patients: 5, type 1 and 6, type 2 received a low-fiber diet (I) during 1 week and during the next 7 days the same diet, enriched with 40 g of fiber (30.6% insoluble and 11.7% soluble components) from...
Daniel Kanmert et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(30), 10851-10865 (2015-08-01)
Recent evidence suggests that tau aggregation may spread via extracellular release and subsequent uptake by synaptically connected neurons, but little is known about the processes by which tau is released or the molecular forms of extracellular tau. To gain insight...
Marta Palusinska-Szysz et al.
International journal of molecular sciences, 15(5), 8256-8279 (2014-05-14)
Phosphatidycholine (PC) is the major membrane-forming phospholipid in eukaryotes but it has been found in only a limited number of prokaryotes. Bacteria synthesize PC via the phospholipid N-methylation pathway (Pmt) or via the phosphatidylcholine synthase pathway (Pcs) or both. Here...
Matthias Buntru et al.
Biotechnology and bioengineering, 112(5), 867-878 (2014-11-26)
Cell-free protein synthesis is a powerful method for the high-throughput production of recombinant proteins, especially proteins that are difficult to express in living cells. Here we describe a coupled cell-free transcription-translation system based on tobacco BY-2 cell lysates (BYLs). Using...
Alessandro Pristerà et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(35), E4929-E4938 (2015-08-19)
Midbrain dopaminergic (mDA) neurons are implicated in cognitive functions, neuropsychiatric disorders, and pathological conditions; hence understanding genes regulating their homeostasis has medical relevance. Transcription factors FOXA1 and FOXA2 (FOXA1/2) are key determinants of mDA neuronal identity during development, but their...
Min-Cheol Kang et al.
Carbohydrate polymers, 127, 38-46 (2015-05-13)
In this study, the antioxidative effects of a purified polysaccharide isolated from the stems of Acanthopanax koreanum Nakai (ASP) on hydrogen peroxide-induced oxidative stress was investigated both in vitro and in vivo using a zebrafish model. A. koreanum Nakai stem...
Chan-Sik Kim et al.
Molecular medicine reports, 12(5), 7279-7284 (2015-10-16)
In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood‑retinal barrier (BRB) and retinal neovascularization;...
Qing-Bo Tang et al.
Neuroreport, 26(12), 703-711 (2015-07-15)
The medial and lateral styloconic sensilla, constituting the main taste organs of lepidopterous caterpillars, were investigated in the oligophagous species, Helicoverpa assulta (Guenée) (Lepidoptera: Noctuidae). In this paper, the two sensilla were morphologically and physiologically characterized by scanning electron microscopy...
Valeriy Kuznyetsov et al.
Systems biology in reproductive medicine, 61(1), 13-17 (2014-11-22)
Despite broad utilization of sperm cryopreservation, little progress has been made to modify freezing protocols or to improve rates of sperm survival. Vitrification is an alternative method for freezing human spermatozoa without toxic permeable cryoprotectants (CPAs). The purpose of our...
Jing Zhou et al.
Autophagy, 11(8), 1259-1279 (2015-06-27)
Autophagy inhibition has been widely accepted as a promising therapeutic strategy in cancer, while the lack of effective and specific autophagy inhibitors hinders its application. Here we found that liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome...
Masanori Fujii et al.
Experimental dermatology, 24(2), 108-113 (2014-11-13)
Hairless mice fed with a special diet (named HR-AD) show atopic dermatitis (AD)-like pruritic skin inflammation that is almost completely resolved with the supplementation of an unsaturated fatty acid (UFA), the linoleic acid (LA). This suggests that the dietary deficiency...
Kelly Michel et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(20), 7850-7865 (2015-05-23)
Successful myelin repair in the adult CNS requires the robust and timely production of myelin proteins to generate new myelin sheaths. The underlying regulatory mechanisms and complex molecular basis of myelin regeneration, however, remain poorly understood. Here, we investigate the...
Su Cao et al.
Molecular medicine reports, 12(1), 829-836 (2015-03-12)
The aim of the present study was to evaluate the influence of the microenvironment around an incision site, on peripheral and central sensitization. The effects of pinacidil activation of ATP-sensitive potassium (KATP) channels prior to skin/muscle incision and retraction (SMIR)...
Ke Li et al.
Plant & cell physiology, 56(6), 1205-1214 (2015-03-31)
Boron (B) is an essential element for plants; its deficiency causes rapid cessation of root elongation. In addition, B influences auxin accumulation in plants. To assess the importance of auxin transport in B-dependent root elongation, Arabidopsis thaliana pin1-pin4 mutants were...
V Bjerre-Harpøth et al.
Journal of dairy science, 98(12), 8581-8596 (2015-10-12)
Our objective was to investigate the quantitative and qualitative effects of propylene glycol (PG) allocation on postpartum adipose tissue mobilization in over-conditioned Holstein cows. Nine ruminally cannulated and arterially catheterized cows were, at parturition, randomly assigned to a ruminal pulse...
Takahito Miyake et al.
Glia, 63(10), 1870-1882 (2015-05-27)
Microglia, the resident immune cells in the brain, survey the environment of the healthy brain. Microglial migration is essential for many physiological and pathophysiological processes. Although microglia express some members of the transient receptor potential (TRP) channel family, there is...
Lisa Kolden Midtbø et al.
The Journal of nutritional biochemistry, 26(6), 585-595 (2015-03-18)
Introduction of vegetable ingredients in fish feed has affected the fatty acid composition in farmed Atlantic salmon (Salmo salar L). Here we investigated how changes in fish feed affected the metabolism of mice fed diets containing fillets from such farmed...
Xiao-Jing Wu et al.
Pediatric research, 78(5), 585-588 (2015-07-23)
Uridine diphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene mutation was shown to be responsible for neonatal hyperbilirubinemia. This study aimed to investigate whether UGT1A1 gene mutation is associated with neonatal hyperbilirubinemia in Guangxi Heiyi Zhuang and Han populations. Two hundred and eighteen infants...
P Avalle et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 244-251 (2014-02-08)
This work focused on the control of the manufacturing process for a controlled release (CR) pellet product, within a Quality by Design (QbD) framework. The manufacturing process was Wurster coating: firstly layering active pharmaceutical ingredient (API) onto sugar pellet cores...
M Jarpa-Parra et al.
Colloids and surfaces. B, Biointerfaces, 132, 45-53 (2015-05-26)
The capacity of a protein to form and stabilize foams and emulsions depends on its structural characteristics and its physicochemical properties. The structural properties of lentil legumin-like protein including molecular weight, hydrodynamic size, surface charge and hydrophobicity, and conformation were...
Martine C Morrison et al.
Journal of hepatology, 62(5), 1180-1186 (2014-12-17)
Anthocyanins may have beneficial effects on lipid metabolism and inflammation and are demonstrated to have hepatoprotective properties in models of restraint-stress- and chemically-induced liver damage. However, their potential to protect against non-alcoholic steatohepatitis (NASH) under conditions relevant for human pathogenesis...
Sung Won Youn et al.
Cell transplantation, 24(8), 1469-1479 (2014-06-17)
Stem cell therapy is currently being studied with a view to rescuing various neurological diseases. Such studies require not only the discovery of potent candidate cells but also the development of methods that allow optimal delivery of those candidates to...
Jianqiang Ye et al.
Virology, 482, 234-243 (2015-04-23)
Vaccination is the primary strategy for the prevention and control of influenza outbreaks. However, the manufacture of influenza vaccine requires a high-yield seed strain, and the conventional methods for generating such strains are time consuming. In this study, we developed...
Xiao-Hui Dong et al.
Stroke, 46(6), 1714-1718 (2015-04-25)
In our current food supply, sugar substitutes are widely used in beverages and other food products. However, there is limited information about the link between dietary consumption of sugar substitutes and stroke to date. This study sought to determine the...
Sebastian Daum et al.
Biological chemistry, 395(7-8), 801-812 (2014-07-09)
As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because biochemical experiments are not...
Qiongxian Yan et al.
Journal of agricultural and food chemistry, 63(33), 7388-7398 (2015-08-04)
The mammary gland of dairy cows is a formidable lipid-synthesizing machine for lactation. This unique function depends on the activities of plasma membrane (PM) proteins in mammary cells. Little information is known about the expression profiles of PM proteins and...
Ding Yuan Oh et al.
PloS one, 10(3), e0118780-e0118780 (2015-03-05)
Ferrets are the preferred animal model to assess influenza virus infection, virulence and transmission as they display similar clinical symptoms and pathogenesis to those of humans. Measures of disease severity in the ferret include weight loss, temperature rise, sneezing, viral...
Céline Schwalm et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3515-3526 (2015-05-10)
In humans, nutrient deprivation and extreme endurance exercise both activate autophagy. We hypothesized that cumulating fasting and cycling exercise would potentiate activation of autophagy in skeletal muscle. Well-trained athletes were divided into control (n = 8), low-intensity (LI, n =...
Anne M Terrell et al.
Experimental eye research, 131, 42-55 (2014-12-23)
The discovery of cytosolic RNA granule (RG) component proteins associated with human cataract has initiated investigations on post-transcriptional mechanisms of gene expression control in the lens. Application of established mouse lens epithelial cell lines (LECs) can provide rapid insights on...
Page 1 of 94
Page 1 of 94