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Lei Zhang et al.
The international journal of biochemistry & cell biology, 87, 69-76 (2017-04-12)
Adipose-derived stem cells (ADSCs) are multipotent stromal cells that can differentiate into a variety of cell types, including skin cells, and they can provide an abundant source of cells for skin tissue engineering and skin wound healing. The purpose of...
Masahiro Shin et al.
Development (Cambridge, England), 143(20), 3796-3805 (2016-11-02)
Vascular endothelial growth factor a (Vegfa) is essential for blood vessel formation and can induce activation of numerous signaling effectors in endothelial cells. However, it is unclear how and where these function in developmental contexts during vascular morphogenesis. To address...
Artur Wnorowski et al.
Cellular signalling, 36, 176-188 (2017-05-13)
Activation of β
Abdelhalim Azzi
Archives of biochemistry and biophysics, 697, 108667-108667 (2020-11-13)
Cell apoptosis is an important process that occurs during development or in response to stress stimuli such as oxidative stress. The serine-threonine kinase Akt enhances survival and suppress apoptosis. SHIP2 is known as a negative regulator of Akt. In addition...
Valentina Forni et al.
Integrated blood pressure control, 4, 17-26 (2011-09-29)
In this review, we discuss the pharmacological and clinical properties of irbesartan, a noncompetitive angiotensin II receptor type 1 antagonist, successfully used for more than a decade in the treatment of essential hypertension. Irbesartan exerts its antihypertensive effect through an...
Jason E Fish et al.
Development (Cambridge, England), 144(13), 2428-2444 (2017-05-26)
The transcriptional pathways activated downstream of vascular endothelial growth factor (VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the signals responsible for induction of the Notch ligand delta-like 4 (DLL4) in endothelial cells, we find that activation of the...
Stephanie M Fernandez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(35), 8660-8667 (2008-08-30)
The extracellular signal-regulated kinase (ERK) pathway is critical for various forms of learning and memory, and is activated by the potent estrogen 17beta-estradiol (E(2)). Here, we asked whether E(2) modulates memory via ERK activation and putative membrane-bound estrogen receptors (ERs)....
Ariel Diaz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(43), 10310-10322 (2017-09-22)
Urokinase-type plasminogen activator (uPA) is a serine proteinase that, upon binding to its receptor (uPAR), catalyzes the conversion of plasminogen into plasmin on the cell surface. Our previous studies indicate that uPA and uPAR expression increase in the ischemic brain...
Mi-Jeong Kim et al.
European journal of pharmacology, 852, 25-33 (2019-02-25)
The effects of candesartan and irbesartan, antagonists of the type I angiotensin II receptor, were investigated on allergic asthma. The antigen-induced degranulation was measured by evaluating β-hexosaminidase activity in vitro. Additionally, a murine ovalbumin-induced allergic asthma model was used to...
Jong Hoon Won et al.
Biological & pharmaceutical bulletin, 38(2), 169-178 (2014-12-09)
In the present study, we examined the mechanisms underlying the effect of DA-9801 on neurite outgrowth. We found that DA-9801 elicits its effects via the mitogen-activated protein kinase (MEK) extracellular signal-regulated kinase (ERK)1/2-cAMP response element-binding protein (CREB) pathway. DA-9801, an...
Giuseppe Gangarossa et al.
Hippocampus, 24(12), 1466-1481 (2014-07-22)
The acute activation of the dopamine D1-like receptors (D1R) is involved in a plethora of functions ranging from increased locomotor activity to the facilitation of consolidation, storage, and retrieval of memories. Although much less characterized, epileptiform activities, usually triggered by...
Satish Casie Chetty et al.
Developmental biology, 465(1), 11-22 (2020-07-07)
ETS transcription factors play an important role in the specification and differentiation of endothelial cells during vascular development. Despite previous studies, the role of the founding member of the ETS family, Ets1, in vascular development in vivo is only partially...
Shinya Yufune et al.
Scientific reports, 6, 21859-21859 (2016-02-26)
In animal models, neonatal exposure to general anesthetics significantly increased neuronal apoptosis with subsequent behavioral deficits in adulthood. Although the underlying mechanism is largely unknown, involvement of extracellular signal-regulated kinases (ERKs) is speculated since ERK phosphorylation is decreased by neonatal...
Activin B promotes BMSC-mediated cutaneous wound healing by regulating cell migration via the JNK-ERK signaling pathway.
Zhang M, Sun L, Wang X, et al.
Cell Transplantation, 23(9), 1061-1073 (2014)
Abigail E Agoglia et al.
Alcoholism, clinical and experimental research, 39(3), 463-475 (2015-02-24)
Binge alcohol drinking is a particularly risky pattern of alcohol consumption that often precedes alcohol dependence and addiction. The transition from binge alcohol drinking to alcohol addiction likely involves mechanisms of synaptic plasticity and learning in the brain. The mitogen-activated...
Y Komatsu et al.
Oncogene, 34(30), 3985-3993 (2014-10-28)
Oncolytic viruses exploit common molecular changes in cancer cells, which are not present in normal cells, to target and kill cancer cells. Ras transformation and defects in type I interferon (IFN)-mediated antiviral responses are known to be the major mechanisms...
Lin Grimm et al.
eLife, 8 (2019-05-01)
Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature. The Hippo pathway and effectors Yap and Taz control organ growth and regulate morphogenesis and cellular proliferation....
Hideo Kubota et al.
PloS one, 9(9), e106316-e106316 (2014-09-03)
Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces slow excitatory responses through activation of transient receptor potential canonical (TRPC) channels. GABAergic cerebellar molecular layer interneurons (MLIs) modulate firing patterns of Purkinje cells (PCs), which play...
Michela Rosas et al.
Journal of psychopharmacology (Oxford, England), 31(1), 105-114 (2017-01-11)
The involvement of mitogen-activating extracellular kinase (MEK) in place conditioning may vary depending on the motivational sign (positive or negative) and nature (pharmacological or nociceptive) of the unconditioned stimulus (US) and on the phase (acquisition or expression) of the learning...
Jeong Hwan Oh et al.
Molecular nutrition & food research, 62(8), e1700469-e1700469 (2018-02-23)
Glutamate excitotoxicity has been observed in association with neurodegenerative disorders. This study aimed to investigate whether a phycoerythrin-derived tryptic peptide of Pyropia yezoensis (PYP) reduces glutamate-induced excitotoxicity and neuronal senescence in primary rat hippocampal neurons. Glutamate exposure (100 μm) decreased cell...
Gisela Borges et al.
The international journal of neuropsychopharmacology, 20(6), 463-463 (2017-02-06)
There is increasing evidence suggesting that the Locus Coeruleus plays a role in pain-related anxiety. Indeed, we previously found that prolonged arthritis produces anxiety-like behavior in rats, along with enhanced expression of phosphorylated extracellular signal-regulated kinase 1/2 (a marker of...
Daniel T Barkmeier et al.
Neurobiology of disease, 47(1), 92-101 (2012-04-05)
Epilepsy is a disease characterized by chronic seizures, but is associated with significant comorbidities between seizures including cognitive impairments, hyperactivity, and depression. To study this interictal state, we characterized the electrical, molecular, and behavior effects of chronic, neocortical interictal spiking...
Wei Wang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 88, 985-990 (2017-02-09)
Receptor tyrosine kinases (RTKs) play crucial roles in numerous cancer cell processes including cell survival, proliferation, and migration. MEK1/2 MAPK kinases are very important for cancer survival and development. Anaplastic thyroid carcinoma (ATC) is a deadly type of thyroid cancer...
Shirley C Mills et al.
Cellular signalling, 28(4), 316-324 (2016-01-26)
Chemotaxis or directed cell migration is mediated by signalling events initiated by binding of chemokines to their cognate receptors and the activation of a complex signalling cascade. The molecular signalling pathways involved in cell migration are important to understand cancer...
Enhanced neurogenesis is involved in neuroprotection provided by rottlerin against trimethyltin-induced delayed apoptotic neuronal damage.
Hwang, et al.
Life Sciences, 262, 118494-118494 (2020)
Jeong Hwan Oh et al.
Molecular medicine reports, 15(5), 2583-2587 (2017-03-06)
Perfluorooctane sulfonate (PFOS) is a stable fluorosurfactant, which causes adverse effects in various organisms. The present study was designed to investigate the effects of Pyropia yezoensis peptide (PYP), a peptide comprised of 11 residues (ALEGGKSSGGG), on PFOS-induced endoplasmic reticulum (ER) stress...
Malgorzata Zakrzewska et al.
International journal of molecular sciences, 20(8) (2019-04-25)
Mitogen-activated protein kinases (MAPK): Erk1 and Erk2 are key players in negative-feedback regulation of fibroblast growth factor (FGF) signaling. Upon activation, Erk1 and Erk2 directly phosphorylate FGF receptor 1 (FGFR1) at a specific serine residue in the C-terminal part of...
Davide D'Amico et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(2), 462-472 (2016-08-19)
The inability to properly extinguish fear memories constitutes the foundation of several anxiety disorders, including panic disorder. Recent findings show that boosting prefrontal cortex synaptic plasticity potentiates fear extinction, suggesting that therapies that augment synaptic plasticity could prove useful in...
Cong Wang et al.
The Journal of biological chemistry, 293(38), 14839-14849 (2018-08-11)
Initiation of expression of fibroblast growth factor receptor 1 (FGFR1) concurrent with loss of FGFR2 expression is a well-documented event in the progression of prostate cancer (PCa). Although it is known that some FGFR isoforms confer advantages in cell proliferation...
Masahiro Shin et al.
Development (Cambridge, England), 143(20), 3785-3795 (2016-11-02)
Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in this context in vivo remain unclear. To understand Flt4 signaling better, we generated zebrafish bearing a deletion...
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