Showing 1-30 of 10910 results for "

S5150

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Xuelei Xin et al.
Journal of ethnopharmacology, 155(2), 1068-1075 (2014-06-17)
Cichorum glandulosum Boiss. et Huet is a traditional Uygur herbal medicine that has been used as a cholagogic and diuretic agent to improve liver function. However, the mechanism is not known for the liver-protective function. We investigated the antioxidant effects...
Loredana Chierchia et al.
Zygote (Cambridge, England), 23(5), 669-682 (2014-09-18)
Actin-based cytoskeleton (CSK) and microtubules may bind to RNAs and related molecules implicated in translation. However, many questions remain to be answered regarding the role of cytoskeletal components in supporting the proteins involved in steps in the maturation and translation...
Thilak K Mudalige et al.
Journal of chromatography. A, 1420, 92-97 (2015-10-13)
Engineered nanoparticles are available in large numbers of commercial products claiming various health benefits. Nanoparticle absorption, distribution, metabolism, excretion, and toxicity in a biological system are dependent on particle size, thus the determination of size and size distribution is essential...
Takako Naganuma et al.
PloS one, 9(11), e112326-e112326 (2014-11-07)
Nacreous layers of pearl oyster are one of the major functional biominerals. By participating in organic compound-crystal interactions, they assemble into consecutive mineral lamellae-like photonic crystals. Their biomineralization mechanisms are controlled by macromolecules; however, they are largely unknown. Here, we...
Yuan-Hua Chen et al.
Scientific reports, 5, 10871-10871 (2015-06-13)
It is increasingly recognized that vitamin D3 (VitD3) has an anti-inflammatory activity. The present study investigated the effects of maternal VitD3 supplementation during pregnancy on LPS-induced placental inflammation and fetal intrauterine growth restriction (IUGR). All pregnant mice except controls were...
M Nadeem Asghar et al.
PloS one, 10(5), e0127436-e0127436 (2015-05-23)
Keratins (K) are important for epithelial stress protection as evidenced by keratin mutations predisposing to human liver diseases and possibly inflammatory bowel diseases. A role for K8 in the colon is supported by the ulcerative colitis-phenotype with epithelial hyperproliferation and...
Tomasz Gosiewski et al.
BMC microbiology, 14, 313-313 (2015-01-01)
Microbiological diagnosis of sepsis relies primarily on blood culture data. This study compares four diagnostic methods, i.e. those developed by us: nested, multiplex, qPCR (qPCR) and FISH with commercial methods: SeptiFast (Roche) (SF) and BacT/ALERT® 3D blood culture system (bioMérieux)....
Klaus Mayer et al.
International journal of molecular sciences, 16(11), 27497-27507 (2015-11-26)
TriFabs are IgG-shaped bispecific antibodies (bsAbs) composed of two regular Fab arms fused via flexible linker peptides to one asymmetric third Fab-sized binding module. This third module replaces the IgG Fc region and is composed of the variable region of...
Jens U Ponikau et al.
International forum of allergy & rhinology, 5(1), 28-35 (2014-10-01)
A histologic hallmark of chronic rhinosinusitis (CRS) is an eosinophilic inflammation, present with and without nasal polyposis and independent of atopy. Eosinophils migrate through nasal tissue including the epithelium into the nasal airway mucus, where they form clusters and degranulate...
Jaafar O Tindi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(24), 8986-8996 (2015-06-19)
NMDA receptors (NMDARs) are key mediators of glutamatergic transmission and synaptic plasticity, and their dysregulation has been linked to diverse neuropsychiatric and neurodegenerative disorders. While normal NMDAR function requires regulated expression and trafficking of its different subunits, the molecular mechanisms...
Rodrigo M Pereira et al.
Talanta, 147, 76-81 (2015-11-26)
A microwave-induced combustion (MIC) system based on the volatilization process was applied for subsequent halogen determination from noncombustible inorganic matrices. Portland cement samples were selected to demonstrate the feasibility of the proposed method, allowing the subsequent determination of Cl and...
Dongwoo Shin et al.
Chemistry, an Asian journal, 10(8), 1784-1790 (2015-06-23)
Although numerous morphologies of MnO nanostructures have been reported, an exact structural analysis and mechanistic study has been lacking. In the present study, the formation of regular MnO octapods was demonstrated in a simple procedure, comprising the thermal decomposition of...
Lindsay N Deis et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(29), 9028-9033 (2015-07-15)
Staphylococcal protein A (SpA) is an important virulence factor from Staphylococcus aureus responsible for the bacterium's evasion of the host immune system. SpA includes five small three-helix-bundle domains that can each bind with high affinity to many host proteins such...
Hiroko Sugiura et al.
Nature communications, 6, 6842-6842 (2015-04-17)
Rheb is a small GTP-binding protein and its GTPase activity is activated by the complex of Tsc1 and Tsc2 whose mutations cause tuberous sclerosis complex (TSC). We previously reported that cultured TSC neurons showed impaired spine synapse morphogenesis in an...
A Sánchez-Aguilera et al.
The Journal of physiology, 592(13), 2845-2864 (2014-04-24)
Changes in neuronal activity often trigger compensatory mechanisms aimed at regulating network activity homeostatically. Here we have identified and characterized a novel form of compensatory short-term plasticity of membrane excitability, which develops early after the eye-opening period in rats (P16-19...
Gareth W Fearnley et al.
Biology open, 4(6), 731-742 (2015-04-26)
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist but their physiological significance is unclear. Here we evaluated two different VEGF-A isoforms and...
Simona Porcellini et al.
Oncoimmunology, 4(10), e1041700-e1041700 (2015-10-10)
NGR-TNF is a vascular targeting agent in advanced clinical development, coupling tumor necrosis factor-α (TNF) with the CNGRCG peptide, which targets a CD13 isoform specifically expressed by angiogenic vessels. Antitumor efficacy of NGR-TNF has been described in different transplantation tumor...
Dongxia Hou et al.
PloS one, 10(11), e0142442-e0142442 (2015-11-12)
Trophoblasts (TR) are specialized cells of the placenta and play an important role in embryo implantation. The in vitro culture of trophoblasts provided an important tool to investigate the mechanisms of implantation. In the present study, porcine trophoblast cells were...
Daniel J O'Neill et al.
Epigenetics, 9(7), 942-950 (2014-04-23)
The lysine methyltransferase SETD6 modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription. Herein, we report the identification of several factors that associate with SETD6 and are implicated in nuclear hormone receptor signaling. Specifically, SETD6 associates with...
E Bezati et al.
Lupus, 24(1), 32-41 (2014-08-21)
Quinine, a quinoline derivative, is an ancient antipyretic drug with antimalarial properties that has been phased out by more effective synthetic candidates. In previous studies we discovered that hydroxychloroquine (HCQ), a synthetic antimalarial with structural similarities to quinine, reduced the...
Karin Vered et al.
BMC genomics, 15, 865-865 (2014-10-07)
Klebsiella pneumoniae (Kp) is a bacterium causing severe pneumonia in immunocompromised hosts and is often associated with sepsis. With the rise of antibiotic resistant bacteria, there is a need for new effective and affordable control methods; understanding the genetic architecture...
Noriko Shimizu et al.
The New phytologist, 208(4), 1104-1113 (2015-06-18)
Ligand receptor-based signaling is a means of cell-to-cell communication for coordinating developmental and physiological processes in multicellular organisms. In plants, cell-producing meristems utilize this signaling to regulate their activities and ensure for proper development. Shoot and root systems share common...
Alexander G Milbradt et al.
Journal of biomolecular NMR, 62(3), 291-301 (2015-05-11)
For typical globular proteins, contacts involving aromatic side chains would constitute the largest number of distance constraints that could be used to define the structure of proteins and protein complexes based on NOE contacts. However, the (1)H NMR signals of...
Nor Nadiah Abdul Karim Shah et al.
Journal of food science and technology, 52(8), 5057-5065 (2015-08-06)
The purpose of this study is to investigate the changes occured on phenolic compounds between two Malaysian varieties of pummelo fruit juice: Ledang (PO55) and Tambun (PO52) post-enzymatic clarification. The changes in polyphenols composition were monitored using High Performance Liquid...
Nicolás Herranz et al.
Nature cell biology, 17(9), 1205-1217 (2015-08-19)
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and contribute to age-related pathologies. In a drug...
Alisha M Mendonsa et al.
PloS one, 10(4), e0126686-e0126686 (2015-04-29)
Obesity has been implicated as a significant risk factor for development of pancreatic cancer. In the setting of obesity, a systemic chronic inflammatory response is characterized by alterations in the production and secretion of a wide variety of growth factors....
Matthew B Brecher et al.
Protein science : a publication of the Protein Society, 24(1), 117-128 (2014-10-30)
Methylation of flavivirus RNA is vital for its stability and translation in the infected host cell. This methylation is mediated by the flavivirus methyltransferase (MTase), which methylates the N7 and 2'-O positions of the viral RNA cap by using S-adenosyl-l-methionine...
Seryoung Kim et al.
MicrobiologyOpen, 4(4), 632-643 (2015-06-16)
We previously reported that the alaE gene of Escherichia coli encodes the l-alanine exporter AlaE. The objective of this study was to elucidate the mechanism of the AlaE exporter. The minimum inhibitory concentration of l-alanine and l-alanyl-l-alanine in alaE-deficient l-alanine-nonmetabolizing...
Karen Gaester et al.
Scientific reports, 4, 6592-6592 (2014-10-18)
Human papillomavirus is one of the most common sexually transmitted diseases worldwide. The natural history of oral HPV infection is unclear, and its risk factors have not been explored. Immunocompromised individuals, as exemplified by HIV patients, are at high risk...
Saja A Fakhraldeen et al.
The Journal of biological chemistry, 290(21), 13386-13400 (2015-04-12)
CRD-BP/IGF2BP1 has been characterized as an "oncofetal" RNA binding protein typically highly expressed in embryonic tissues, suppressed in normal adult tissues, but induced in many tumor types. In this study, we show that adult breast tissues express ubiquitous but low...